Scott Soleimanpour Lab

Our research focuses on the genetic causes of diabetes through the study of pancreatic islet beta cell function in all aspects of the mitochondrial life cycle.

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Dr. Scott Soleimanpour
Principal Investigator
Scott Soleimanpour, MD

Associate Professor, Departments of Molecular & Integrative Physiology and Internal Medicine, Division of Metabolism, Endocrinology & Diabetes
Director, Michigan Diabetes Research Center
Associate Director, Elizabeth Weiser Caswell Diabetes Institute (T1D Basic Research and Islet Biology Programs)

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Brehm Tower, Room 6454
1000 Wall Street
Ann Arbor, MI 48105
Phone: 734-232-8150
Current Research
In the Soleimanpour Lab

Our lab focuses on the molecular and genetic regulation of the mitochondrial life cycle, with a focus on mitophagy, a pathway to dispose of unhealthy or damaged mitochondria. Our studies also concentrate on novel genetic targets affecting the mitophagy pathway, which are also associated with diabetes in humans, through studies in cellular and mouse genetic model systems, as well as isolated human islets. Our goal is to discover how the dysregulation of mitochondrial respiration and mitophagy leads to diabetes pathogenesis, along with determining strategies to improve mitophagy to prevent or treat diabetes.

Research Areas
  • Genetic causes of pancreatic beta cell failure and its role in the pathogenesis of type 1 diabetes
  • Role of the mitochondrial life cycle in diabetes and beta cell biology
  • Molecular function of the diabetes susceptibility gene, Clec16a

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Support Our Work

Making a gift to our lab will support and further our research work in diabetes and help us work towards new and better treatments for people living with the disease. To make a gift, please contact Andrea LaFave at the University of Michigan Office of Development.

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News & Stories
Research News
Unraveling the Secrets Behind Beta Cells
Unraveling the Secrets Behind Beta Cells
Research News
What to Know About COVID-19 if You Have Diabetes
What to Know About COVID-19 if You Have Diabetes
Research News
5 Questions with a Diabetes Physician Who Has Type 1
5 Questions with a Diabetes Physician Who Has Type 1
Learning to Live with Diabetes

Photographer Liz Moughon was in the hospital, struggling to breathe. That's when she learned she had Type 1 diabetes.

15 Things Diabetes Doctors Do to Keep Their Own Blood Sugar Under Control

Steal a trick or two from these diabetes experts to keep your blood sugar on track.

Investigating Our Genes to Turn Type One into Type None

Dr. Scott Soleimanpour is deeply immersed in research for type 1 diabetes (T1D).

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