Mark E P Prince, MD, FRCS(C), FACS

2019-Prince-Mark.jpeg
Charles J Krause M.D.
Legacy Professor of Otolaryngology
Chair, Department of Otolaryngology-Head and Neck Surgery
Professor of Otolaryngology-Head and Neck Surgery
Otolaryngology Adult Service Chief
Medical School
University of Michigan Medical School
Otolaryngology-Head and Neck Surgery
1500 East Medical Center Dr. - SPC 5312, 1904 Taubman Center
Ann Arbor, MI 48109
[email protected]
Available to mentor
Mark E P Prince, MD, FRCS(C), FACS
2019-Prince-Mark.jpeg
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Dr. Mark Prince joined the Royal Canadian Navy after high school and completed a degree in chemical engineering at the Technical University of Nova Scotia. After earning his medical degree at Dalhousie University Medical School in Halifax, Nova Scotia, Prince went on to serve with the Canadian Armed Forces as a medical officer where he received specialized training in hyperbaric and diving medicine. Prince returned to Dalhousie University and completed a residency in otolaryngology-head and neck Surgery, followed by a two-year fellowship in advanced head and neck oncology and microvascular reconstructive surgery at the University of Michigan.

    In 1998, Prince accepted an appointment at Dalhousie as an assistant professor and served as their otolaryngology residency director before joining the University of Michigan faculty in 2000. He also served as the chief of the section of otolaryngology at the Ann Arbor VA Medical Center from 2000 until 2014; he continues to serve there as an active part time staff member.

    Most recently, Prince was appointed as the chair of the Department of Otolaryngology-Head and Neck Surgery after serving as the interim chair for almost 2 years. He is the author of over 160 scientific papers and several book chapters. His research laboratory published the first report of the identification of cancer stem cells in head and neck squamous cell cancer and continues to conduct research in this exciting field.

    Dr. Prince remains actively involved in resident and medical student education. He served as the department's residency program director until 2016 and as the associate chair for education from 2009-2016. He also served as the assistant dean for graduate medical education until 2018. He continues to co-lead a collaborative education initiative with the ENT department at Komfo Anokye Teaching Hospital in Kumasi, Ghana.

    Dr. Mark Prince cares for patients with a wide variety of otolaryngology problems. He has a special interest and advanced training in the treatment of patients with head and neck cancer and in reconstruction of complex defects in the head and neck including the mouth, jaw, pharynx, larynx and skull.

    Clinical
    Head and neck cancer, reconstructive surgery, thyroid cancer and nodules, salivary glands disease and cancer, swallowing disorder, and general otolaryngology.

    Qualifications

    • MD
      Dalhousie University Medical School, Halifax, Nova Scotia,, Canada
      1984 - 1988
    • Bachelor of Engineering, Chemical Engineering
      Technical University of Nova Scotia, Halifax, Canada
      1982 - 1984
    • Diploma in Engineering
      Dalhousie University, Halifax, Canada
      1979 - 1982

    Center Memberships

    • Center Member
      Center for Global Health Equity
    • Center Member
      Global REACH

    Research Overview

    Cancer stem cells, cancer vaccines, and novel cancer therapies.

    Recent Publications

    See All Publications
    • Presentation
      Ascent and Academy Survey, Work RVU
      2025 Nov 14;
    • Proceeding / Abstract / Poster
      Postoperative shoulder dysfunction following latissimus dorsi versus pectoralis major flap reconstruction
      Tikhtman R, Hasan D, Gao R, Buchakjian M, Casper K, Chinn S, Forner D, Malloy K, Prince M, Stucken C, Yalamanchi P, Heft Neal M. 2025 Oct 13;
    • Journal Article
      Prospective Phase II Trial of Definitive Chemoradiation and Concurrent Nivolumab in Locally Advanced p16+ Oropharynx Cancer
      Regan SN, Shah J, Suresh K, Morales KA, Cao Y, Aryal M, Rosen BS, Walline H, Lee C, Aldous J, Swiecicki PL, Casper KA, Chinn SB, Malloy KM, Prince MEP, Stucken CL, Shuman AG, Heft-Neal M, Lyden TH, Blakely A, Ambrose M, Chad Brenner J, Worden FP, Mierzwa ML. Advances in Radiation Oncology, 2025 Oct 1; 10 (10): DOI:10.1016/j.adro.2025.101832
    • Journal Article
      Tumor Hypoxia and CD8+ T-Cell Infiltration in Patients With Advanced Laryngeal Cancer
      Smith JD, Gensterblum-Miller E, Forner DWA, Yalamanchi P, Buchakjian MR, Chinn SB, Shuman AG, Casper KA, Malloy KM, Stucken CL, Mclean SA, Mierzwa ML, Shah J, Swiecicki PL, Worden FP, Prince MEP, Spector ME, Brenner JC, Heft Neal ME. Otolaryngology Head and Neck Surgery United States, 2025 Sep 1; 173 (3): 645 - 650. DOI:10.1002/ohn.1291
      PMID: 40323140
    • Journal Article
      Prospective Phase II Trial of Definitive Chemoradiation and Concurrent Nivolumab in Locally Advanced p16+ Oropharynx Cancer
      Regan SN, Shah J, Suresh K, Morales KA, Cao Y, Aryal M, Rosen BS, Walline H, Lee C, Aldous J, Swiecicki PL, Casper KA, Chinn SB, Malloy KM, Prince MEP, Stucken CL, Shuman AG, Heft-Neal M, Lyden TH, Blakely A, Ambrose M, Brenner JC, Worden FP, Mierzwa M. Advances in Radiation Oncology, 2025 Aug 15; 101832 - 101832. DOI:10.1016/j.adro.2025.101832
    • Journal Article
      Parotidectomy Trends Toward Outpatient for Benign Disease
      Prince ADP, Oslin K, Smith JD, Hershey E, Chionis L, Allevato M, Chinn SB, Prince MEP. Otolaryngology Head and Neck Surgery United States, 2025 Mar 1; 172 (3): 905 - 912. DOI:10.1002/ohn.1061
      PMID: 39550622
    • Proceeding / Abstract / Poster
      Creating a Sense of Belonging in Otolaryngology - Head & Neck Surgery: A Department-Wide Assessment of Culture
      Kupfer R, Prince ADP, Brenner MJ, Sheedy C, Anderson R, Rutherford H, Prince ME, Zacharek MA. 2025 May 13;
    • Journal Article
      Follow-up for human papillomavirus-related oropharynx cancer concentrated on unequal symptom change (FOCUS): Prospective patient-reported outcome collection
      Edwards DM, Gharzai LA, Wang W, Mayo C, Suresh K, Schipper M, Evans JR, Malloy K, Chinn SB, Prince M, Spector M, Shuman A, Stucken C, Swiecicki PL, Worden F, Jarema J, Henderson C, Kovach A, Brenner C, Shah JL, Mierzwa ML, Casper K. Head and Neck, 2024 Nov 1; 46 (11): 2687 - 2698. DOI:10.1002/hed.27778
      PMID: 38680087