Clifford S Cho

clifford_suhyun_cho_md
Professor of Surgery
Medical School
Chief Medical Officer - Health Systems
University of Michigan Medical School
Surgery
1500 East Medical Center Drive, Taubman Center 2210
Ann Arbor, MI 48109
[email protected]
Available to mentor
Clifford S Cho
clifford_suhyun_cho_md
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Dr. Cho is an Honors graduate of Brown University and AOA graduate of the Vanderbilt University School of Medicine. He completed his general surgery residency and transplantation immunology postdoctoral research fellowship at the University of Wisconsin, where he served as Chief Administrative Resident. He completed his surgical oncology fellowship at the Memorial Sloan-Kettering Cancer Center, where he served as Chief Administrative Fellow. He joined the faculty of the University of Wisconsin School of Medicine and Public Health in 2006, where he was promoted to Associate Professor with Tenure and named the Ronald and Patricia Kissinger Professor of Surgical Oncology. He served as Chief of the Division of Surgical Oncology, Associate Residency Program Director, and co-Director of the Gastrointestinal Disease Oriented Team in the University of Wisconsin Carbone Cancer Center. He moved to the University of Michigan in 2016 as the C. Gardner Child Professor of Surgery and Chief of the Division of Hepatopancreatobiliary and Advanced Gastrointestinal Surgery, and has held several administrative roles including Executive Director of the Cancer Network of West Michigan, Vice Chair of Surgical Oncology, and Ambulatory Clinical Care Chief at the University of Rogel Cancer Center. In 2024, he was appointed Chief Medical Officer at the University of Michigan Health West and received a joint appointment as Professor of Cell Biology at the Van Andel Institute.

    Dr. Cho’s academic focus is on hepatopancreatobiliary and gastrointestinal malignancies, cancer immunology, and the mentorship of clinical and research trainees. He has lectured on these academic interests in over 15 national and international visiting professorships and was named the James IV Traveler in 2014. He has published over 180 peer-reviewed manuscripts and book chapters and currently serves on the editorial boards of Surgery and the Journal of Gastrointestinal Surgery. He is the Principal Investigator of a National Cancer Institute-funded cancer immunology laboratory that is working to understand the immunostimulatory effects of a novel mode of non-invasive focused ultrasound tumor therapy called histotripsy. His laboratory has been continuously funded since 2006 by extramural support from the National Institutes of Health, Veteran's Administration, American College of Surgeons, and Central Surgical Association, and is a member of the National Cancer Institute Cellular Immunotherapy of Cancer study section. He has held a number of national academic leadership positions and is a member of over 15 surgical societies, including the American Surgical Association, James IV Surgical Society, Society of Clinical Surgery, Society of University Surgeons, and Surgical Biology Club II.

    Qualifications

    • Surgical Oncology Fellowship
      Memorial Sloan Kettering Cancer Center, Surgery, New York, United States
      2004 - 2006
      Clinical Fellowship
    • Administrative Chief Fellow
      Memorial Sloan Kettering Cancer Center, Surgery, New York, United States
      2005 - 2006
      Chief Fellow
    • General Surgery Residency
      University of Wisconsin Hospital and Clinics, Surgery, Madison, United States
      1997 - 2004
      Residency
    • Administrative Chief Resident
      University of Wisconsin Hospital and Clinics, Madison, United States
      2003 - 2004
      Chief Resident
    • Immunology Research Fellowship
      University of Wisconsin Hospital and Clinics, Madison, United States
      1999 - 2001
      Postdoctoral Research
    • Postgraduate Coursework
      Harvard University, Cambridge, United States
      1992 - 1992
    • ScB, Psychology
      Brown University, Providence, United States
      1987 - 1991

    Center Memberships

    • Center Member
      Rogel Cancer Center
    • Center Member
      MM-PKUHSC Joint Institute

    Research Overview

    Dr. Cho is the Principal Investigator of a cancer immunology laboratory that is working to understand the immunological and tumor microenvironmental effects of histotripsy focused ultrasound tumor therapy. He has led several clinical trials in novel cancer therapies, and his laboratory has been continuously funded since 2006 by extramural support from the National Institutes of Health, Veteran’s Administration, American College of Surgeons, and Central Surgical Association.

    Recent Publications

    See All Publications
    • Journal Article
      ASO Visual Abstract: Perineural Invasion Worsens Long-Term Outcome of Pancreatic Neuroendocrine Tumors following Surgical Resection
      Xu H, Hou JJ, Xiang JX, Lopez-Aguiar AG, Poultsides G, Rocha F, Weber S, Fields R, Idrees K, Cho C, Maithel SK, Lv Y, Zhang XF, Pawlik TM. Annals of Surgical Oncology, 2026 Feb 1; 33 (2): 1655 - 1656. DOI:10.1245/s10434-025-18725-4
      PMID: 41217677
    • Journal Article
      Insulin-Dependence and Survival in Pancreatic Neuroendocrine Tumors: Results From the US-NTSG Group
      Mirza MB, Baechle JJ, Smith PM, Ali D, Dillhoff M, Poultsides G, Rocha FG, Cho CS, Winslow ER, Fields RC, Maithel SK, Idrees K. Journal of Surgical Oncology, 2026 Feb 1; 133 (2): 153 - 160. DOI:10.1002/jso.70174
      PMID: 41520322
    • Journal Article
      Perineural Invasion Worsens Long-Term Outcomes of Pancreatic Neuroendocrine Tumors Following Surgical Resection
      Xu H, Hou JJ, Xiang JX, Lopez-Aguiar AG, Poultsides G, Rocha F, Weber S, Fields R, Idrees K, Cho C, Maithel SK, Lv Y, Zhang XF, Pawlik TM. Annals of Surgical Oncology, 2026 Feb 1; 33 (2): 1586 - 1594. DOI:10.1245/s10434-025-18561-6
      PMID: 41102572
    • Journal Article
      An Emerging Paradigm Shift in Liver Ablation: The Potential for Clinical Impact of Nonthermal Ablation Technologies
      Foltz GM, Kisting AL, Falk KL, Golden E, Laeseke P, Cho CS, Ziemlewicz T, Hinshaw JL, Koepsel EK, Lee FT. Journal of Vascular and Interventional Radiology, 2025 Dec 1; 36 (12): 1868 - 1875. DOI:10.1016/j.jvir.2025.09.005
      PMID: 41276365
    • Journal Article
      Histotripsy Dose Impacts Treated Tumor Immune Infiltration and Survival Outcomes in a Murine B16F10 Melanoma Model
      McGinnis R, Song B, Kim H, Lorenzon A, Shi J, Zhao L, Cho CS, Ganguly A, Xu Z. Cancers, 2025 Dec 1; 17 (23): DOI:10.3390/cancers17233773
    • Journal Article
      Vascular normalization through histotripsy ablation therapy promotes anti-tumor immunity and enhances drug delivery in solid tumors 3610
      Daguplo HQ, Song B, Kim H, Xu Z, Olszewski M, Cho CS, Ganguly A. The Journal of Immunology, 2025 Nov 23; 214 (Supplement_1): DOI:10.1093/jimmun/vkaf283.1390
    • Journal Article
      Foxp3+ Regulatory T Cells Restrain Th1 Response Shielding the Brain from Lethal Inflammatory Damage during Cryptococcal Meningoencephalitis.
      Li H, Hissong R, Goughenour KD, Sinitsyna Y, Lintner M, Song B, Daguplo HQ, Cho CS, Ganguly A, Chen GY, Hargarten JC, Williamson PR, Xu J, Olszewski MA. Res Sq, 2025 Jul 30; DOI:10.21203/rs.3.rs-7142999/v1
      PMID: PMC12324597
    • Proceeding / Abstract / Poster
      Data from Histotripsy-Focused Ultrasound Treatment Abrogates Tumor Hypoxia Responses and Stimulates Antitumor Immune Responses in Melanoma
      Song B, Queen H, Ferris SF, McGinnis R, Karanam C, Gatteno N, Buglak K, Kim H, Xu J, Goughenour KD, Xu Z, Olszewski MA, Cho CS, Ganguly A. 2025 Jul 2; DOI:10.1158/1535-7163.c.7906472

    Featured News & Stories

    Patient receiving histotripsy treatment with health care providers using equipment
    Great Minds, Greater Discoveries Stories

    Research Impact: Histotripsy

    In late 2023, the United States Food and Drug Administration (FDA) approved the use of sound waves to break down tumors — a technique called histotripsy — in humans for liver treatment, a new therapy developed at the University of Michigan and with support from the National Institutes of Health.