Clifford S Cho
Surgery
1500 East Medical Center Drive, Taubman Center 2210
Ann Arbor, MI 48109
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About
Dr. Cho is an Honors graduate of Brown University and AOA graduate of the Vanderbilt University School of Medicine. He completed his general surgery residency and transplantation immunology postdoctoral research fellowship at the University of Wisconsin, where he served as Chief Administrative Resident. He completed his surgical oncology fellowship at the Memorial Sloan-Kettering Cancer Center, where he served as Chief Administrative Fellow. He joined the faculty of the University of Wisconsin School of Medicine and Public Health in 2006, where he was promoted to Associate Professor with Tenure and named the Ronald and Patricia Kissinger Professor of Surgical Oncology. He served as Chief of the Division of Surgical Oncology, Associate Residency Program Director, and co-Director of the Gastrointestinal Disease Oriented Team in the University of Wisconsin Carbone Cancer Center. He moved to the University of Michigan in 2016 as the C. Gardner Child Professor of Surgery and Chief of the Division of Hepatopancreatobiliary and Advanced Gastrointestinal Surgery, and has held several administrative roles including Executive Director of the Cancer Network of West Michigan, Vice Chair of Surgical Oncology, and Ambulatory Clinical Care Chief at the University of Rogel Cancer Center. In 2024, he was appointed Chief Medical Officer at the University of Michigan Health West and received a joint appointment as Professor of Cell Biology at the Van Andel Institute.
Dr. Cho’s academic focus is on hepatopancreatobiliary and gastrointestinal malignancies, cancer immunology, and the mentorship of clinical and research trainees. He has lectured on these academic interests in over 15 national and international visiting professorships and was named the James IV Traveler in 2014. He has published over 180 peer-reviewed manuscripts and book chapters and currently serves on the editorial boards of Surgery and the Journal of Gastrointestinal Surgery. He is the Principal Investigator of a National Cancer Institute-funded cancer immunology laboratory that is working to understand the immunostimulatory effects of a novel mode of non-invasive focused ultrasound tumor therapy called histotripsy. His laboratory has been continuously funded since 2006 by extramural support from the National Institutes of Health, Veteran's Administration, American College of Surgeons, and Central Surgical Association, and is a member of the National Cancer Institute Cellular Immunotherapy of Cancer study section. He has held a number of national academic leadership positions and is a member of over 15 surgical societies, including the American Surgical Association, James IV Surgical Society, Society of Clinical Surgery, Society of University Surgeons, and Surgical Biology Club II.
Qualifications
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Surgical Oncology FellowshipMemorial Sloan Kettering Cancer Center, Surgery, New York, United States
2004 - 2006
Clinical Fellowship
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Administrative Chief FellowMemorial Sloan Kettering Cancer Center, Surgery, New York, United States
2005 - 2006
Chief Fellow
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General Surgery ResidencyUniversity of Wisconsin Hospital and Clinics, Surgery, Madison, United States
1997 - 2004
Residency
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Administrative Chief ResidentUniversity of Wisconsin Hospital and Clinics, Madison, United States
2003 - 2004
Chief Resident
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Immunology Research FellowshipUniversity of Wisconsin Hospital and Clinics, Madison, United States
1999 - 2001
Postdoctoral Research
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Postgraduate CourseworkHarvard University, Cambridge, United States
1992 - 1992
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ScB, PsychologyBrown University, Providence, United States
1987 - 1991
Center Memberships
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Center MemberRogel Cancer Center
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Center MemberMM-PKUHSC Joint Institute
Research Overview
Dr. Cho is the Principal Investigator of a cancer immunology laboratory that is working to understand the immunological and tumor microenvironmental effects of histotripsy focused ultrasound tumor therapy. He has led several clinical trials in novel cancer therapies, and his laboratory has been continuously funded since 2006 by extramural support from the National Institutes of Health, Veteran’s Administration, American College of Surgeons, and Central Surgical Association.
Recent Publications
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Xu H, Hou JJ, Xiang JX, Lopez-Aguiar AG, Poultsides G, Rocha F, Weber S, Fields R, Idrees K, Cho C, Maithel SK, Lv Y, Zhang XF, Pawlik TM. Annals of Surgical Oncology, 2026 Feb 1; 33 (2): 1655 - 1656.Journal ArticleASO Visual Abstract: Perineural Invasion Worsens Long-Term Outcome of Pancreatic Neuroendocrine Tumors following Surgical Resection
DOI:10.1245/s10434-025-18725-4 PMID: 41217677 -
Mirza MB, Baechle JJ, Smith PM, Ali D, Dillhoff M, Poultsides G, Rocha FG, Cho CS, Winslow ER, Fields RC, Maithel SK, Idrees K. Journal of Surgical Oncology, 2026 Feb 1; 133 (2): 153 - 160.Journal ArticleInsulin-Dependence and Survival in Pancreatic Neuroendocrine Tumors: Results From the US-NTSG Group
DOI:10.1002/jso.70174 PMID: 41520322 -
Xu H, Hou JJ, Xiang JX, Lopez-Aguiar AG, Poultsides G, Rocha F, Weber S, Fields R, Idrees K, Cho C, Maithel SK, Lv Y, Zhang XF, Pawlik TM. Annals of Surgical Oncology, 2026 Feb 1; 33 (2): 1586 - 1594.Journal ArticlePerineural Invasion Worsens Long-Term Outcomes of Pancreatic Neuroendocrine Tumors Following Surgical Resection
DOI:10.1245/s10434-025-18561-6 PMID: 41102572 -
Foltz GM, Kisting AL, Falk KL, Golden E, Laeseke P, Cho CS, Ziemlewicz T, Hinshaw JL, Koepsel EK, Lee FT. Journal of Vascular and Interventional Radiology, 2025 Dec 1; 36 (12): 1868 - 1875.Journal ArticleAn Emerging Paradigm Shift in Liver Ablation: The Potential for Clinical Impact of Nonthermal Ablation Technologies
DOI:10.1016/j.jvir.2025.09.005 PMID: 41276365 -
McGinnis R, Song B, Kim H, Lorenzon A, Shi J, Zhao L, Cho CS, Ganguly A, Xu Z. Cancers, 2025 Dec 1; 17 (23):Journal ArticleHistotripsy Dose Impacts Treated Tumor Immune Infiltration and Survival Outcomes in a Murine B16F10 Melanoma Model
DOI:10.3390/cancers17233773 -
Daguplo HQ, Song B, Kim H, Xu Z, Olszewski M, Cho CS, Ganguly A. The Journal of Immunology, 2025 Nov 23; 214 (Supplement_1):Journal ArticleVascular normalization through histotripsy ablation therapy promotes anti-tumor immunity and enhances drug delivery in solid tumors 3610
DOI:10.1093/jimmun/vkaf283.1390 -
Li H, Hissong R, Goughenour KD, Sinitsyna Y, Lintner M, Song B, Daguplo HQ, Cho CS, Ganguly A, Chen GY, Hargarten JC, Williamson PR, Xu J, Olszewski MA. Res Sq, 2025 Jul 30;Journal ArticleFoxp3+ Regulatory T Cells Restrain Th1 Response Shielding the Brain from Lethal Inflammatory Damage during Cryptococcal Meningoencephalitis.
DOI:10.21203/rs.3.rs-7142999/v1 PMID: PMC12324597 -
Song B, Queen H, Ferris SF, McGinnis R, Karanam C, Gatteno N, Buglak K, Kim H, Xu J, Goughenour KD, Xu Z, Olszewski MA, Cho CS, Ganguly A. 2025 Jul 2;Proceeding / Abstract / PosterData from Histotripsy-Focused Ultrasound Treatment Abrogates Tumor Hypoxia Responses and Stimulates Antitumor Immune Responses in Melanoma
DOI:10.1158/1535-7163.c.7906472
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