Haoming Zhang

 headshot of Haoming-Zhang
Research Associate Professor
Pharmacology
Medical School
University of Michigan Medical School
Pharmacology
1150 West Medical Center Drive, MSRB3 RmA312A
Ann Arbor, Michigan 48109
[email protected]
Available to mentor
Haoming Zhang
headshot of Haoming-Zhang
Research Associate Professor
  • About
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  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    Our research is aimed to understand drug metabolism by cytochrome P450 enzymes with focus on their structure function and translational research for development of new therapeutic agents.

    Links
    • https://medschool.umich.edu/profile/2601/haoming-zhang

    Qualifications
    • Postdoctoral Fellow
      University of British Columbia, Biochemistry, Vancouver, Canada
      1998 - 2000

    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      MM-PKUHSC Joint Institute

    Research Overview

    Drug metabolism and discovery, P450 function and structure, cardiovascular diseases, chaperone Hsp70

    Recent Publications

     See All Publications
    • Journal Article
      High-level expression of full-length human CYP2E1 in E. coli: Comparison of full-length human CYP2E1 to truncated counterpart shows enhanced association with redox partners
      Sun Y, Amunugama P, Osawa Y, Zhang H. Drug Metabolism and Disposition, 2026 Jun 15; 100344 - 100344. DOI:10.1016/j.dmd.2026.100344
    • Journal Article
      Computational Design of CYP102A1 Variants for Biosynthesis of a Next-Generation Antiplatelet Drug DT-678.
      Sun Y, Huang X, Zhang J, Osawa Y, Chen YE, Zhang H. ACS Synth Biol, 2026 Mar 6; DOI:10.1021/acssynbio.5c00768
      PMID: 41791881
    • Preprint
      Computational design of CYP102A1 variants for the biosynthesis of a next-generation antiplatelet drug DT-678
      Sun Y, Huang X, Zhang J, Osawa Y, Chen YE, Zhang H. 2025 Dec 10; bioRxiv, DOI:10.64898/2025.12.04.692440
    • Proceeding / Abstract / Poster
      Development of nanobodies and truncated heterodimers of nNOS as approaches for biochemical and structural analysis
      Martinez-Ramos C, Morishima Y, Sun Y, Zhang H, Lau M, Osawa Y. Journal of Pharmacology and Experimental Therapeutics, 2025 Apr 3; 392 (3): 1A - 1A.
    • Proceeding / Abstract / Poster
      Development of Nanobodies and Truncated Heterodimers of nNOS as Approaches for Biochemical and Structural Analysis (Abstract ID: 161582)
      Martinez-Ramos C, Morishima Y, Sun Y, Zhang H, Lau M, Osawa Y. Journal of Pharmacology and Experimental Therapeutics, 2025 Mar 29; 392 (3): 100675 DOI:10.1016/j.jpet.2024.100675
    • Journal Article
      High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase
      Garcia AM, Davis AK, Martinez-Ramos C, Morishima Y, Lau M, Xu E, Sunil A, Zhang H, Alt A, Lieberman AP, Osawa Y. Molecular Pharmacology, 2025 Feb 1; 107 (2): DOI:10.1016/j.molpha.2024.100008
      PMID: 40023517
    • Journal Article
      The first in-human study to evaluate the antiplatelet properties of the clopidogrel conjugate DT-678 in acute coronary syndrome patients and healthy volunteers
      Liu Z, Liu S, Gong Y, Chi X, Wang T, Fan F, Qu C, Lou Y, Zhang L, Zhang B, Yang F, Mohetaboer M, Wang J, Qiu L, Miao L, Lu Y, You R, He P, Li Y, Yi T, Weng H, Xia Y, Wang C, Shi Q, Wang Z, Jiang Y, Li Y, Han C, Wang Y, Wang X, Yang C, Chen YE, Eitzman DT, Zhang H, Li J. British Journal of Pharmacology, 2025 Jan 1; 182 (1): 131 - 141. DOI:10.1111/bph.17355
      PMID: 39367653
    • Journal Article
      Bacterial expression, purification, and characterization of human cytochrome P450 3A4 without N-terminal modifications
      Sun Y, Osawa Y, Zhang H. Archives of Biochemistry and Biophysics, 2024 Dec 1; 762: DOI:10.1016/j.abb.2024.110208
      PMID: 39522857