Gary D Hammer

Gary Hammer
Millie Schembechler Professor of Adrenal Cancer
Professor of Internal Medicine
Program Director, Internal Medicine
Professor of Molecular and Integrative Physiology
Professor of Cell and Developmental Biology
Medical School
Available to mentor
Gary D Hammer
Gary Hammer
Professor
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  • About

    Gary D. Hammer, M.D., Ph.D. is a Professor in the Departments of Internal Medicine (MEND), Cell & Developmental Biology, and Molecular & Integrative Physiology. He currently serves as the Director of Endocrine Oncology Program in the Rogel Cancer Center where he holds the Millie Schembechler Professorship in Adrenal Cancer. He is the past Director of The Center for Organogenesis: Stem Cells & Regenerative Medicine. He has brokered the recent renaissance of the current Michigan team of adrenal scientists that includes a who’s who in the study of adrenal disease. Research projects in his own laboratory are aimed at elucidating the mechanisms by which growth factor signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on dysregulated adrenocortical stem cells in development and homeostasis with implications for regenerative medicine and cancer. He received the UofM Jerome Conn Award for Outstanding Research in Internal Medicine, the Endocrine Society Edwin B. Astwood Award for Outstanding Research and is a member of ASCI and AAP. He has served in numerous leadership roles at U of M and in the public and private sectors including recent tenure on Board of Scientific Advisors for NCI. He has served in numerous capacities for the world’s largest endocrine organization, the Endocrine Society, including his most recent role as President of the Society (2020-2021). As Advisor to the Congressional H.E.L.P. committee, he co-authored “The 21st Century Cancer ALERT (Access to Life-Saving Early detection, Research and Treatment) Act’’ introduced in Congress in 2009. He is the editor of four textbooks: Adrenocortical Carcinoma: Basic Science and Clinical Concepts (Springer, 2011), Pathophysiology of Disease: An Introduction to Clinical Medicine (Harper Row, 2014; 2018; 2026), Genetics Steroid Disorders 2nd edition (Elsevier, 2023) and the Adrenal Section Editor for Degroot’s Endocrinology, 8th and 9th edition (Elsevier, 2022; 2026). He has been catalyst for the formation of two international cooperative groups, most recently the American Australian Asian Adrenal Alliance (A5) that leverages collaboration to secure projects from Pharma and funding agencies across the spectrum of adrenal diseases. Such work with colleagues has led to the development of new national and international therapeutic trials with biological-based therapies while sparing normal tissue. He is a co-founder of two companies - MILLENDO and SLING THERAPEUTICS, that focus on rare endocrine diseases.

    Links

    • Hammer lab website

    Center Memberships

    • Center Member
      Global REACH
    • Center Member
      Rogel Cancer Center
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Cell Plasticity and Organ Design

    Recent Publications

    See All Publications
    • Journal Article
      The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion
      Dumontet T, Basham KJ, Foster MC, Silverman E, Heard KA, Johnson D, Lee C, Plaska SW, Breault DT, Penton D, Beuschlein F, Turcu AF, LaPensee CR, Marcondes Lerario A, Hammer GD. Nature Communications, 2026 Dec 1; 17 (1): DOI:10.1038/s41467-025-68257-4
      PMID: 41519914
    • Journal Article
      Integrated system for characterization of malignant and benign adrenal lesions and differentiation of high‑ and low‑risk adrenal cancer on CT scans using radiomics‑based decision support
      Yordanova A, Hadjiiski L, Day R, Fiori S, Caoili EM, Cohan RH, Chan H-P, Worden F, Hammer G, Wilms M, Zhou C. 2026 Apr 30; 93 - 93. DOI:10.1117/12.3087435
    • Journal Article
      EndoBridge 2024: pearls and highlights
      Yildiz BO, Armeni E, Balodimou C, Biondi B, Ciudin A, Frühbeck G, Fuleihan GEH, Geer EB, Gillard P, Gordon CM, Goulis D, Hammer GD, Höybye C, Langdahl BL, Laufer AB, van der Lely AJ, Macut D, Mader JK, McGowan B, Novac E, Pignatelli D, Pfeifer M, Radić L, Shah V, Stratakis CA, Treiber G, Vrachnis DN, Wilding J, Yazici D, Celik O. Hormones, 2025 Dec 1; 24 (4): 923 - 946. DOI:10.1007/s42000-025-00708-5
      PMID: 40768135
    • Additional Scholarship
      Data from β-Catenin–Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer
      Mohan DR, Borges KS, Finco I, LaPensee CR, Rege J, Solon AL, Little DW, Else T, Almeida MQ, Dang D, Haggerty-Skeans J, Apfelbaum AA, Vinco M, Wakamatsu A, Mariani BMP, Amorim LC, Latronico AC, Mendonca BB, Zerbini MCN, Lawlor ER, Ohi R, Auchus RJ, Rainey WE, Marie SKN, Giordano TJ, Venneti S, Fragoso MCBV, Breault DT, Lerario AM, Hammer GD. 2025 Nov 24; DOI:10.1158/0008-5472.c.6711185
    • Journal Article
      MON-502 Evaluating the Response of Immunotherapy in Metastatic Adrenocortical Carcinoma - A Single Institution Retrospective Review
      Wolf KI, Hesseltine EA, Hammer GD, Worden F, Else T. Journal of the Endocrine Society, 2025 Oct 24; 9 (Supplement_1): bvaf149.257 DOI:10.1210/jendso/bvaf149.257
      PMID: PMC12544851
    • Journal Article
      Adrenocortical Stem Cells in Health and Disease. Nature Reviews Endocrinology
      Chu Y, Setayesh J, Krumeich LN, Werner J, Moretti IF, De Sousa K, Kennedy C, La Pensee C, Lerario A, Hammer G. 2025 Jan 23;
    • Journal Article
      β-catenin functions as a molecular adapter for disordered cBAF interactions
      Chan YS, Gao Q, Robinson SA, Wang W, Filandrova R, Weinhold LM, Cabrera ML, Zhang M, Ambati CSR, Lerario AM, Putluri N, Kiseljak-Vassiliades K, Wierman ME, Habra MA, Hammer GD, Veverka V, Cermakova K, Hodges HC. Molecular Cell, 2025 Aug 21; 85 (16): 3041 - 3056.e9. DOI:10.1016/j.molcel.2025.06.026
      PMID: 40695292
    • Journal Article
      Adrenocortical stem cells in health and disease
      Chu Y, Setayesh J, Dumontet T, Krumeich L, Werner J, Moretti IF, De Sousa K, Kennedy C, La Pensee C, Lerario AM, Hammer GD. Nature Reviews Endocrinology, 2025 Aug 1; 21 (8): 464 - 481. DOI:10.1038/s41574-025-01091-2
      PMID: 40065108

    Featured News & Stories

    Department News

    New Publication by the Hammer Lab

    "Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner," was published in Nature Aging.