Opportunities to participate in ongoing studies in our lab!
CANSLEEP-MS
Study Overview:
The majority of people with MS experience problems with sleep, pain, or both. Sleep problems affect more than half of people with MS. Sleep problems also have the potential to worsen chronic pain, which affects about half of people with MS. We hope to learn more about the pain-sleep connection.
What do I have to do?
If you participate in this study, you will start off with a 2-3 hour in-person visit, your first overnight sleep study, and your first 14-day “home monitoring” session with the PRO-Diary watch. We will ask you to provide about three teaspoons of blood at your initial visit and at the mid-treatment and final treatment timepoints.
After the 14-day home monitoring (PRO-Diary watch), you will be assigned 1 of 4 treatments as detailed below. Randomization and treatment delivery may be in person, or done virtually (without an in-person visit). If done virtually, study drug may be shipped directly to your home.
1) Prescription CBD (in the form of liquid Epidiolex) + a placebo (inactive) version of THC capsule,
2) Prescription THC (in the form of dronabinol capsule) + a placebo (inactive) version of CBD liquid,
3) A combination of both prescription CBD and THC (in the form of liquid Epidiolex and dronabinol capsule),
4) Placebo (inactive) versions of both CBD and THC (capsule + liquid with no active drug in either product).
Complete two online surveys at about 6 and 12 weeks after you begin treatment.
Begin a second 14-day session of “home monitoring” 10 week after treatment starts.
Complete a second overnight sleep study just before the end of your 12 weeks of treatment.
You will also complete several scheduled follow-up phone calls with the study team (lasting about 15 minutes each).
These activities will occur over a duration of about 14 weeks (with treatment lasting 12 weeks). Additional unscheduled in-person or phone assessments may occur. We will also do a final follow-up call about 30 days after your treatment ends.
Participants will receive up to $400 for full study completion.
Who is eligible?
- Must be between 18 and 65 years old.
- Must have MS.
- Must have chronic pain.
Contact:
CANSLEEP-MS Study Staff: David Johnson
Phone: (734) 936-2844
Email: [email protected]
Study ID: HUM00190734 IRB: IRBMED Date Approved: 11/3/2020
CogDetect-MS
*NOT currently recruiting*
Study Overview:
Cognitive dysfunction is common in many different clinical conditions, including multiple Multiple Sclerosis (MS). Little is known about the impact of cognitive dysfunction where it matters most – in the everyday lives of people with these conditions. This study is designed to examine the cognitive function in real-world settings in people with MS. We expect the knowledge gained in this study will lead us to new insights about how to measure cognitive functioning in daily life and better ways to improve overall health-related quality of life of people with MS.
What do I have to do?
- Participants in this study will complete 3 in-person study visits and 3 “home-monitoring periods” over the course of 2 years. Each in-person study visit is followed by a 14-day home-monitoring period.
- During the home-monitoring period, participants will wear an activity monitor on their wrist and use a study-provided smartphone to complete brief surveys and thinking tests 4 times per day.
- At the end of the home-monitoring period, participants will mail the devices back using pre-paid study-provided shipping boxes.
Participants will receive up to $600 for full study completion.
Who is eligible?
- Must be at least 18 years old.
- Must have MS.
- Must ambulate independently at least 50% of the time.
Contact:
CogDetect-MS Study Staff: Keara Ginell or Josiah Goga
Phone: (734) 936-2844
Email: [email protected]
Study ID: HUM00199732 IRB: IRBMED Date Approved: 04/26/2022
*NOT currently recruiting*
My SCI Toolkit
*NOT currently recruiting*
Study Overview/Purpose:
Individuals with spinal cord injury (SCI) frequently suffer from pain. Evidence suggests that patients themselves can have a significant and positive impact on their own quality of life by taking an active role in the self-management of their pain.
The purpose of this study is to improve management of pain through the use of a newly developed web-based program called My SCI Toolkit. The My SCI Toolkit provides education, guidance, and skill-building exercises that are specifically tailored for people with SCI and pain. (IRBMED: HUM00192610)
What Does Study Participation Involve?
Study participants will be randomized to one of 3 groups:
(a) Unguided: Participants will use the newly developed web-based symptom self-management program called the My SCI Toolkit on their own, following the prompt and guides built into the website for 8 weeks, OR
(b)Coached: Participants will use a newly developed web-based symptom self-management program called the My SCI Toolkit and have weekly phone calls with a study coach for 8 weeks, OR
(c) Continue with their care as usual.
All participants will be asked to complete online surveys at baseline, 4-weeks, and 8-weeks.
Participants will receive up to $150 for completing the study.
Who is Eligible?
Participants must meet all of the following criteria:
1. Have a diagnosis of SCI.
2. Be at least 18 years old.
3. Have access to a reliable, internet-connected device (e.g. computer, tablet) and telephone.
4. Read, speak and understand English.
5. Have clinically significant pain.
6. Willing to maintain stable pain medication regimen during the study period.
7. Not currently in inpatient care or intensive outpatient physical therapy.
8. Be willing to complete all study assessments.
What are the Potential Risks/Benefits?
There may not be any direct benefits to you for participating in the study, however, you may see an improvement in your pain self-management skills as a result of being in this study.
This is a web-based behavioral intervention so the known or expected risks are minor and infrequent and include breach of confidentiality, and fatigue and frustration. Researchers take precautions to minimize these risks. This study may limit your participation in other research studies."
*NOT currently recruiting*
Focus Group Study in MS Caregiving (HUM00237494)
Study Overview/Purpose:
This is a study to learn more about the caregiving experiences, friendship patterns, and how these link to health and well-being among African American and European American MS caregivers.
What Does Study Participation Involve?
Caregivers will participate in a focus group study lasting 60-90 minutes. Questions include their caregiving experiences, friendship patterns, and their implications for health and well-being.
Participants will receive a compensation of $60.
How can I join?
Interested MS caregivers, please fill in this screening survey [https://umich.qualtrics.com/jfe/form/SV_1BL0GzaUMHmHG86] for eligibility. We will follow up with eligible participants to provide more information.
Principal Investigator: Crystal Ng, PhD
Email: [email protected]
IRB#: HUM00237494
