Inflammation
Decoding the Immune System's Role in Health and Disease
Advancing knowledge of the body’s immune response to disease threats
Inflammation occurs when the body’s immune system responds to a perceived threat. While beneficial in most cases, too much inflammation underlies a host of health conditions, from cardiovascular disease to arthritis to asthma.
Michigan Medicine researchers are engaged in understanding the immune system and its response at the molecular, cellular, and systemic levels, as well as actively pursuing new therapies that can regulate inflammation that causes disease.
Health Lab
Photosensitivity is a common occurrence in patients with autoimmune disorders, especially lupus and dermatomyositis. The only treatment for this currently is diligent sunscreen use, but research is leading to new insights in how photosensitivity is created on a cellular level.
Health Lab
Michigan Medicine becomes leader in treating severe ulcerative colitis with JAK inhibitors.
Health Lab
A multicenter study compared patients with irritable bowel syndrome on Immunoglobulin G-based elimination diets to patients on sham diets.
The Fundamentals
Today on The Fundamentals, we have a conversation with Dr. Sonya Wolf-Fortune, Assistant Professor of Pharmacology, whose work focuses on investigating the underlying mechanisms of psoriasis, diabetes, and other inflammatory conditions. Dr. Wolf-Fortune is trying to uncover what sets off the cascades of inflammation related to these conditions and related diseases.
Health Lab Podcast
Researchers try to simplify the low-FODMAP diet in hopes of making it easier for patients to follow without sacrificing effectiveness.
The Fundamentals
Today on The Fundamentals, our guest is Dr. Michelle Kahlenberg, an Associate Professor of Internal Medicine and Dermatology, the Giles Bole and Dorothy Mulkey Research Professor of Rheumatology and the Vice Chair for Basic and Translational Research in Internal Medicine.
Her clinical work is centered on the care of patients with lupus, including those with refractory skin disease. In addition to running her lab, she's an active member of the Immunology Training Program and has received national recognition for her research.
Meet the Experts
Researchers at Michigan Medicine investigate the complex biological processes that drive inflammation, uncovering insights into its connection to chronic illnesses, autoimmune conditions, and infection response.
World Health Organization Classification and Diagnosis of Mastocytosis: Update 2023 and Future Perspectives
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Immunol Allergy Clin North Am, 2023 Nov; DOI:10.1016/j.iac.2023.04.011 Predictors of performance and perceived fatigability in people with multiple sclerosis
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Neurol Res, 2023 Nov; DOI:10.1080/01616412.2023.2252283 Higher mitochondrial oxidative capacity is the primary molecular differentiator in muscle of rats with high and low intrinsic cardiorespiratory fitness
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Mol Metab, 2023 Oct; DOI:10.1016/j.molmet.2023.101793 Extracellular Matrix–Derived Damage-Associated Molecular Patterns (DAMP): Implications in Systemic Sclerosis and Fibrosis
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J Invest Dermatol, 2023 Oct; DOI:10.1016/j.jid.2023.04.030 Cooling Down Inflammation in the Cardiovascular System via the Nicotinic Acetylcholine Receptor.
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J Cardiovasc Pharmacol, 2023 Oct; DOI:10.1097/FJC.0000000000001455 Gene Expression Signatures in Inflammatory and Sclerotic Morphea Skin and Sera Distinguish Morphea from Systemic Sclerosis
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J Invest Dermatol, 2023 Oct; DOI:10.1016/j.jid.2023.02.036 Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury
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