Inflammation
Decoding the Immune System's Role in Health and Disease
Advancing knowledge of the body’s immune response to disease threats
Inflammation occurs when the body’s immune system responds to a perceived threat. While beneficial in most cases, too much inflammation underlies a host of health conditions, from cardiovascular disease to arthritis to asthma.
Michigan Medicine researchers are engaged in understanding the immune system and its response at the molecular, cellular, and systemic levels, as well as actively pursuing new therapies that can regulate inflammation that causes disease.
Professor of Ophthalmology
Professor of Visual Sciences
Professor of Visual Sciences
Bertram Pitt M.D.
Collegiate Professor of Cardiovascular Medicine
Professor of Internal Medicine
Medical Director
Cardiology Transplant
Collegiate Professor of Cardiovascular Medicine
Professor of Internal Medicine
Medical Director
Cardiology Transplant
Research Professor
Ophthalmology and Visual Sciences
Ophthalmology and Visual Sciences
Clinical Professor of Internal Medicine and Program Director
Internal Medicine
Internal Medicine
Research Assistant Professor
Physical Medicine and Rehabilitation
Physical Medicine and Rehabilitation
Assistant Professor of Cardiac Surgery
Clinical Professor of Pediatrics
Interim Section Head, CHEAR
General Pediatrics
Interim Section Head, CHEAR
General Pediatrics
Assistant Professor of Internal Medicine
Assistant Professor of Epidemiology
Assistant Professor of Epidemiology
Assistant Professor of Obstetrics and Gynecology
Assistant Professor of Internal Medicine
Assistant Professor of Internal Medicine
Clinical Professor of Radiology and Section Head
Cardiothoracic Radiology
Cardiothoracic Radiology
World Health Organization Classification and Diagnosis of Mastocytosis: Update 2023 and Future Perspectives
Valent, P,
Sotlar, K,
Horny, H-P,
Arock, M,
Akin, C,
Immunol Allergy Clin North Am, 2023 Nov; DOI:10.1016/j.iac.2023.04.011 Predictors of performance and perceived fatigability in people with multiple sclerosis
Abou, L,
Fritz, NE,
Kratz, AL,
Neurol Res, 2023 Nov; DOI:10.1080/01616412.2023.2252283 Higher mitochondrial oxidative capacity is the primary molecular differentiator in muscle of rats with high and low intrinsic cardiorespiratory fitness
Fleischman, JY,
Van den Bergh, F,
Collins, NL,
Bowers, M,
Beard, DA,
Burant, CF,
Mol Metab, 2023 Oct; DOI:10.1016/j.molmet.2023.101793 Extracellular Matrix–Derived Damage-Associated Molecular Patterns (DAMP): Implications in Systemic Sclerosis and Fibrosis
Bale, S,
Verma, P,
Varga, J,
Bhattacharyya, S,
J Invest Dermatol, 2023 Oct; DOI:10.1016/j.jid.2023.04.030 Cooling Down Inflammation in the Cardiovascular System via the Nicotinic Acetylcholine Receptor.
Kaplan, A,
Lakkis, B,
El-Samadi, L,
Karaayvaz, EB,
Booz, GW,
Zouein, FA,
J Cardiovasc Pharmacol, 2023 Oct; DOI:10.1097/FJC.0000000000001455 Gene Expression Signatures in Inflammatory and Sclerotic Morphea Skin and Sera Distinguish Morphea from Systemic Sclerosis
Chen, HW,
Zhu, JL,
Martyanov, V,
Tsoi, LC,
Johnson, ME,
Barber, G,
Popovich, D,
O'Brien, JC,
Coias, J,
Cyrus, N,
Malviya, N,
Florez-Pollack, S,
Kunzler, E,
Hosler, GA,
Gudjonsson, JE,
Khanna, D,
Whitfield, M,
Jacobe, HT,
J Invest Dermatol, 2023 Oct; DOI:10.1016/j.jid.2023.02.036 Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury
Rhee, J,
Freeman, R,
Roh, K,
Lyons, M,
Xiao, C,
Zlotoff, D,
Yeri, A,
Li, H,
Guerra, J,
Guseh, JS,
Kuznetsov, A,
Houstis, N,
Roh, J,
Damilano, F,
Liu, X,
Silverman, M,
Kwong, R,
Das, S,
Rosenzweig, A,
Circ Res, 2023 Sep; DOI:10.1161/CIRCRESAHA.123.322640 Inhibition of SIRT2 promotes death of human cytomegalovirus-infected peripheral blood monocytes via apoptosis and necroptosis
Cheung, J,
Remiszewski, S,
Chiang, LW,
Ahmad, E,
Pal, M,
Rahman, SA,
Nikolovska-Coleska, Z,
Chan, GC,
Antiviral Res, 2023 Sep; DOI:10.1016/j.antiviral.2023.105698 Department of Biological Chemistry
Department of Biomedical Engineering
Department of Computational Medicine and Bioinformatics
Department of Learning Health Sciences
Department of Microbiology and Immunology
Department of Emergency Medicine
Department of Internal Medicine
Department of Obstetrics and Gynecology
Department of Orthopaedic Surgery
Department of Otolaryngology-Head and Neck Surgery
Health Lab
The findings may support the immune pathway as a bridge between diet and neurologic disease
Health Lab
Cases of a bacterial lung infection known as whooping cough, or pertussis, have been on the rise, with more than double the number of cases compared to last year.
