Inflammation
Decoding the Immune System's Role in Health and Disease
Advancing knowledge of the body’s immune response to disease threats
Inflammation occurs when the body’s immune system responds to a perceived threat. While beneficial in most cases, too much inflammation underlies a host of health conditions, from cardiovascular disease to arthritis to asthma.
Michigan Medicine researchers are engaged in understanding the immune system and its response at the molecular, cellular, and systemic levels, as well as actively pursuing new therapies that can regulate inflammation that causes disease.
Featured News & Stories
Health Lab
IBS treatment response predicted by gut microbiome in new study
A Michigan Medicine study finds the low FODMAP diet and the antibiotic rifaximin provided similar and significant relief for patients with irritable bowel syndrome with diarrhea (IBS-D).
Health Lab
Researchers discover what may be the root cause of preeclampsia, and how to fix it
After years of research, a large team of multidisciplinary scientists from Michigan Medicine has identified a key molecular driver of preeclampsia, and demonstrated a potential way to counteract it in both mouse models and human placental tissue.
Health Lab
Single-cell RNA sequencing gives insight to dermatomyositis treatment
Comparing skin lesions in dermatomyositis and lupus using single-cell RNA sequencing gives rheumatology researchers at University of Michigan Health new insight into treatment targets for dermatomyositis patients.
Recent Podcast Episodes in Inflammation
Health Lab Podcast
Could preeclampsia become a thing of the past?
The findings position VGLL3 as a promising novel treatment target for the pregnancy-related condition.
The Fundamentals
Psoriasis, Diabetes and Other Inflammatory Conditions
Today on The Fundamentals, we have a conversation with Dr. Sonya Wolf-Fortune, Assistant Professor of Pharmacology, whose work focuses on investigating the underlying mechanisms of psoriasis, diabetes, and other inflammatory conditions. Dr. Wolf-Fortune is trying to uncover what sets off the cascades of inflammation related to these conditions and related diseases.
Health Lab Podcast
Simplifying the low-FODMAP diet to help manage IBS
Researchers try to simplify the low-FODMAP diet in hopes of making it easier for patients to follow without sacrificing effectiveness.
Featured Researchers
Meet the Experts
Researchers at Michigan Medicine investigate the complex biological processes that drive inflammation, uncovering insights into its connection to chronic illnesses, autoimmune conditions, and infection response.
Latest Publications
Predictors of performance and perceived fatigability in people with multiple sclerosis
Abou, L,
Fritz, NE,
Kratz, AL,
Neurol Res, 2023 Nov; DOI:10.1080/01616412.2023.2252283 World Health Organization Classification and Diagnosis of Mastocytosis: Update 2023 and Future Perspectives
Valent, P,
Sotlar, K,
Horny, H-P,
Arock, M,
Akin, C,
Immunol Allergy Clin North Am, 2023 Nov; DOI:10.1016/j.iac.2023.04.011 Cooling Down Inflammation in the Cardiovascular System via the Nicotinic Acetylcholine Receptor.
Kaplan, A,
Lakkis, B,
El-Samadi, L,
Karaayvaz, EB,
Booz, GW,
Zouein, FA,
J Cardiovasc Pharmacol, 2023 Oct; DOI:10.1097/FJC.0000000000001455 Extracellular Matrix–Derived Damage-Associated Molecular Patterns (DAMP): Implications in Systemic Sclerosis and Fibrosis
Bale, S,
Verma, P,
Varga, J,
Bhattacharyya, S,
J Invest Dermatol, 2023 Oct; DOI:10.1016/j.jid.2023.04.030 Higher mitochondrial oxidative capacity is the primary molecular differentiator in muscle of rats with high and low intrinsic cardiorespiratory fitness
Fleischman, JY,
Van den Bergh, F,
Collins, NL,
Bowers, M,
Beard, DA,
Burant, CF,
Mol Metab, 2023 Oct; DOI:10.1016/j.molmet.2023.101793 Gene Expression Signatures in Inflammatory and Sclerotic Morphea Skin and Sera Distinguish Morphea from Systemic Sclerosis
Chen, HW,
Zhu, JL,
Martyanov, V,
Tsoi, LC,
Johnson, ME,
Barber, G,
Popovich, D,
O'Brien, JC,
Coias, J,
Cyrus, N,
Malviya, N,
Florez-Pollack, S,
Kunzler, E,
Hosler, GA,
Gudjonsson, JE,
Khanna, D,
Whitfield, M,
Jacobe, HT,
J Invest Dermatol, 2023 Oct; DOI:10.1016/j.jid.2023.02.036 Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury
Rhee, J,
Freeman, R,
Roh, K,
Lyons, M,
Xiao, C,
Zlotoff, D,
Yeri, A,
Li, H,
Guerra, J,
Guseh, JS,
Kuznetsov, A,
Houstis, N,
Roh, J,
Damilano, F,
Liu, X,
Silverman, M,
Kwong, R,
Das, S,
Rosenzweig, A,
Circ Res, 2023 Sep; DOI:10.1161/CIRCRESAHA.123.322640 A Cross-Trait Genetic Correlation Study Identified Eight Diseases and Traits Associated with Psoriasis
Ogawa, K,
Tsoi, LC,
Tanaka, H,
Kanai, M,
Stuart, PE,
Nair, RP,
Tanaka, Y,
Mochizuki, H,
Elder, JT,
Okada, Y,
J Invest Dermatol, 2023 Sep; DOI:10.1016/j.jid.2023.01.037 