Decoding the Immune System's Role in Health and Disease

Advancing knowledge of the body’s immune response to disease threats


Inflammation occurs when the body’s immune system responds to a perceived threat. While beneficial in most cases, too much inflammation underlies a host of health conditions, from cardiovascular disease to arthritis to asthma. 

Michigan Medicine researchers are engaged in understanding the immune system and its response at the molecular, cellular, and systemic levels, as well as actively pursuing new therapies that can regulate inflammation that causes disease.

Featured Researchers
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Vinay Aakalu, MD, MPH Vinay Aakalu
Professor of Ophthalmology
Professor of Visual Sciences
aaronson-keith Keith D Aaronson
Bertram Pitt M.D.
Collegiate Professor of Cardiovascular Medicine
Professor of Internal Medicine
Medical Director
Cardiology Transplant
labcoat Steven Abcouwer
Research Professor
Ophthalmology and Visual Sciences
Ahmed AbdelLatif Ahmed Abdel-latif
Professor of Internal Medicine
Program Director, Internal Medicine
labcoat Goncalo Abecasis
Felix E Moore Collegiate Professor of Biostatistics
Professor of Biostatistics
Professor of Computational Medicine and Bioinformatics
Libak Libak Abou
Research Assistant Professor
Physical Medicine and Rehabilitation
Ashraf S. Abou El Ela Ashraf S Abou El Ela
Assistant Professor of Cardiac Surgery
Jeremy Adler, MD, Mac Jeremy Adler
Professor of Pediatrics and Interim Section Head
General Pediatrics
Andrew Admin Andrew J Admon, MD, MPH, MS
Assistant Professor of Internal Medicine
Assistant Professor of Epidemiology
Lindsay Admon headshot Lindsay K Admon, MD, MSc, FACOG
Assistant Professor of Obstetrics and Gynecology
Alison Affnati Alison Holley Affinati
Assistant Professor of Internal Medicine
labcoat Farsad Afshinnia, MD MS
Assistant Professor of Internal Medicine
Latest Publications
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World Health Organization Classification and Diagnosis of Mastocytosis: Update 2023 and Future Perspectives
Valent, P, Sotlar, K, Horny, H-P, Arock, M, Akin, C, Immunol Allergy Clin North Am, 2023 Nov; DOI:10.1016/j.iac.2023.04.011
PMID: 37758403
Predictors of performance and perceived fatigability in people with multiple sclerosis
Abou, L, Fritz, NE, Kratz, AL, Neurol Res, 2023 Nov; DOI:10.1080/01616412.2023.2252283
PMID: 37655601
Higher mitochondrial oxidative capacity is the primary molecular differentiator in muscle of rats with high and low intrinsic cardiorespiratory fitness
Fleischman, JY, Van den Bergh, F, Collins, NL, Bowers, M, Beard, DA, Burant, CF, Mol Metab, 2023 Oct; DOI:10.1016/j.molmet.2023.101793
PMID: 37625738
Extracellular Matrix–Derived Damage-Associated Molecular Patterns (DAMP): Implications in Systemic Sclerosis and Fibrosis
Bale, S, Verma, P, Varga, J, Bhattacharyya, S, J Invest Dermatol, 2023 Oct; DOI:10.1016/j.jid.2023.04.030
PMID: 37452808
Cooling Down Inflammation in the Cardiovascular System via the Nicotinic Acetylcholine Receptor.
Kaplan, A, Lakkis, B, El-Samadi, L, Karaayvaz, EB, Booz, GW, Zouein, FA, J Cardiovasc Pharmacol, 2023 Oct; DOI:10.1097/FJC.0000000000001455
PMID: 37539950
Gene Expression Signatures in Inflammatory and Sclerotic Morphea Skin and Sera Distinguish Morphea from Systemic Sclerosis
Chen, HW, Zhu, JL, Martyanov, V, Tsoi, LC, Johnson, ME, Barber, G, Popovich, D, O'Brien, JC, Coias, J, Cyrus, N, Malviya, N, Florez-Pollack, S, Kunzler, E, Hosler, GA, Gudjonsson, JE, Khanna, D, Whitfield, M, Jacobe, HT, J Invest Dermatol, 2023 Oct; DOI:10.1016/j.jid.2023.02.036
PMID: 37028702
Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury
Rhee, J, Freeman, R, Roh, K, Lyons, M, Xiao, C, Zlotoff, D, Yeri, A, Li, H, Guerra, J, Guseh, JS, Kuznetsov, A, Houstis, N, Roh, J, Damilano, F, Liu, X, Silverman, M, Kwong, R, Das, S, Rosenzweig, A, Circ Res, 2023 Sep; DOI:10.1161/CIRCRESAHA.123.322640
PMID: 37638415
Inhibition of SIRT2 promotes death of human cytomegalovirus-infected peripheral blood monocytes via apoptosis and necroptosis
Cheung, J, Remiszewski, S, Chiang, LW, Ahmad, E, Pal, M, Rahman, SA, Nikolovska-Coleska, Z, Chan, GC, Antiviral Res, 2023 Sep; DOI:10.1016/j.antiviral.2023.105698
PMID: 37562606
microscopic red tissues lines and lab note badge image
Health Lab
High fat diet activates early inflammation in mouse brains, supports link to neurologic disease
The findings may support the immune pathway as a bridge between diet and neurologic disease
arm with tape around it and cast and picture of field with kids playing and one kid sitting on bench
Health Lab
Properly treating, and recovering, from pediatric sports injuries
A kid's orthopaedic surgeon and sports medicine specialist gives parents tips to make sure their children get the care they need when injured and have an effective recovery.