Research Scouts
Funding Bold Ideas
An agile, low-burden program which gives money to Research Scouts to invest in other scientists' bold ideas.
The Research Scouts program catalyzes new, exciting lines of investigation by making bold, creative ideas possible. Who better to identify great scientific ideas than our own world-class scientists! The Medical School Office of Research, as part of the Bold Science strategy of the research strategic plan, Great Minds, Greater Discoveries, created Research Scouts as an agile, low-burden program for Medical School faculty to invest in their colleagues’ bold scientific ideas. Research Scouts aim to:
- Spark new scientific conversations and connections
- Unleash the creativity of our faculty
- Test bold ideas that may otherwise go unexplored
- Have fun while facilitating new lines of investigation
In its inaugural year, the program brought together 24 faculty scouts who funded 46 projects from 51 U-M researchers, with a total investment of $3.2 million.
Research Scouts Spotlights
Ultra-High-Speed Imaging for Advancing Ultrasound-Based Theranostics
Mitra Aliabouzar, Ph.D.
Gene-Editing Therapeutics for Hereditary Eye Diseases
Shahzad Mian, M.D., Lev Prasov, M.D., Ph.D., and Yan Zhang, Ph.D.
Computational Modeling of Cell-Paired Morphological and Gene Expression Data
Joshua Welch, Ph.D.
Bold Ideas & Scholars Funded in 2025
AI-Guided Engineering of Transcription Factors for High-Efficiency Cellular Reprogramming
Liu Liu, Ph.D.
Outside the Bottle: Redefining Human Lactation Through Mechanically Tunable 3D Mammary Organoid Systems
Brigid Gregg, M.D.
Bridging the Gap in Spinal Cord Injury: Using Polyethylene Glycol Microporous Annealed Particle Tubes to Stimulate Neuroregeneration Through Spinal Cord Injury Sites
Noojan Kazemi, M.D.
Seeing Endogenous RNA in Action: Single-Molecule Spatiotemporal Transcriptomics from Cells to Brains
Swathi Yadlapalli, Ph.D. and Nils Walter, Ph.D.
Point-of-Care Urine-Based Human Papillomavirus (HPV) Screening to Reduce Cervical Cancer
Dhanu Thiyag, M.D., M.P.H.
Investigate Whether Inhibition of Glycolysis or Glutaminolysis of the Host Limits Norovirus Infection In Vivo
Christiane Wobus, Ph.D., M.S.
Novel Enterocyte Iron-Shuttling Molecules as a Transformative Therapy for Refractory Anemias
Nupus Das, M.D., Ph.D.
Development of a Novel Preclinical Model for Targeting Resistance in Lethal High Grade Gliomas
Wajd Al-Holou, M.D.
Patient Centered Urine Collection for Cervical Cancer Screening by Primary HPV Testing
Diane Harper, M.D., M.P.H., M.S. & Chandan Bhambhani, Ph.D. & Muneesh Tewari, M.D., Ph.D.
AI Matchmaking for Chronic Condition Management
Susan Murphy, ScD, OTR & Nirali Shah
A Platform for Automated Assessment of Rare Disease Patients’ Eligibility for Customized Therapies
Geoffrey Siwo, Ph.D., Catherine Keegan, M.D., Ph.D., and Elizabeth Ames, M.D., Ph.D.
Visualizing Cellular Dynamics in Tissue with Light
Changyang Linghu, Ph.D.
Automated Clinical Case Review for Enhanced Medical Education
Florian Schmitzberger, M.D., M.S., and Alexander Janke, M.D., M.H.S.
Aging and Regeneration in Leopard Geckos
Longhua Guo, Ph.D.
CRISPR-Map: Unifying Phenotype and Transcriptome in CRISPR–Cas9 Screens
Jonathan Sexton, Ph.D.
Developing a Novel Gene Agnostic Therapy for Treating Retinal Degeneration Via Targeted Epigenetic Silencing
Thanh Hoang, Ph.D.
How Do Weight Loss Drugs (GLP-1 Receptor Agonists) Affect Behavior?
Shelly Flagel, Ph.D.
Eye Exams for Children Using Robotic Characters
Nita Valikodath, M.D., M.S.
Inhibition of Fibrocyte Induced Scarring to Treat Corneal Blindness
Vinay Aakalu, M.D., M.P.H.
MAK2-Guided Antibiotic Susceptibility Testing: Rapid PCR-Based Growth Curve Analysis for Precision Diagnostics
Vishwaratn Asthana, M.D., Ph.D.
Genomic Justice
Versha Pleasant, M.D., M.P.H.
Elucidating the Airway Microbiome's Capacity to Metabolize Inhaled Drugs
Yvonne Huang, M.D.
Whole-Organ Scale 3D Spatial Multi-Omics with Single-Molecule Resolution
Dawen Cai, Ph.D.
In addition to these new projects, eight 2023 Research Scout Scholars have been awarded competitive renewal funds:
Metabolic Adaptations in Spiny Mouse Cardiomyocytes: A Model for Cardiac Regeneration
Ahmed Abdel-Latif, M.D., Ph.D.
Real-Time In Vivo Imaging and Ultrasound Theranostics: A Novel Approach with Ultrasound Responsive Droplets
Mitra Aliabouzar, Ph.D.
Investigating the Role of Cancer Associated Fibroblasts in Pancreatic Tumor Cell Fitness and Perineural Invasion
Eileen Carpenter, M.D., Ph.D.
Engineered Enzyme Filaments for the Combinatorial Biosynthesis of New-to-Nature Antimicrobial Peptides
Tobias Giessen, Ph.D.
Primma: A Multimodal AI Model for Neuroimaging
Todd Hollon, M.D.
Neurotransmitter Switching: An Epilepsy Pathomechanism Hiding in Plain Sight?
Joanna Mattis, M.D., Ph.D.
Pathogen Emergence Through Genomic Flexibility
Teresa O’Meara, Ph.D.
High-Throughput Measurement of Gene Expression, Morphology, and Temporal Phenotypes in the Same Cell
Joshua Welch, Ph.D.
Frequently Asked Questions
Harnessing the momentum of the Research Scouts 2023 Program, up to 20 Research Scouts are selected and given 12 months to make a single award of $150,000 or two awards of $75,000 to Medical School scientists with compelling, new ideas. These awardees are known as "Scout Scholars."
In addition, Research Scouts in 2025 may opt to combine funds to support projects with especially transformative potential and require a larger sum than one individual scout can contribute.
There is no formal RFP or grant application process. Instead, the Research Scouts leverage an online questionnaire to review ideas submitted by medical school faculty, attend Office of Research-sponsored pitch events, and/or actively seek out and identify early-stage ideas for funding through attendance at department meetings, seminars, word-of-mouth, and other avenues of their choice.
Research Scouts receive modest discretionary funds to facilitate faculty connections and identify opportunities.
Research Scout positions are voluntary. Department chairs and administrators are notified of their faculty members who have accepted the role of Research Scout.
The Research Scouts program does not issue RFPs or formal grant application processes. Instead, the Research Scouts leverage an online questionnaire to review ideas submitted by Medical School faculty. To prepare for the questionnaire, consider the following:
- What are you trying to do or what problem are you trying to solve?
- Why should this project be considered bold or transformative?
- Who or what would this project benefit? What is the potential significance and impact of the project?
- Why is this project important to you?
In addition to the questionnaire, Scouts will attend Office of Research-sponsored pitch events and/or actively seek out and identify early-stage ideas for funding through attendance at department meetings, seminars, word-of-mouth, and other avenues of their choice.
The Office of Research plans to host pitch events in a Shark Tank-like format, where medical school faculty can promote their ideas to a larger audience at once. Advance notice of these pitch events will be provided. Be sure to check for announcements in the Research News email newsletters. Pitch events are necessarily limited in timing and number of presenters. Therefore, those interested in becoming Scouts Scholars are strongly encouraged to submit ideas through the portal to ensure they are seen.
Scouts cannot entertain unsolicited requests or proposals, and any faculty member who approaches a Scout directly for funding will be deemed ineligible.
A Scout Scholar is a faculty member with a primary appointment in the medical school selected by a Research Scout to receive funding for their bold idea. Research Scouts are directed to keep awards at “arm’s length”:
- Scouts cannot make awards to faculty with whom they have directly collaborated on a grant proposal (submitted or awarded) within the last five years.
- Research Scouts are discouraged from funding faculty whose research interests overlap with their own.
- Research Scouts should avoid funding members of their department (division for large departments).
In addition, the Research Scouts will not entertain unsolicited requests directly from a faculty, and any faculty who approaches a Scout for funding will be deemed ineligible.
Ideally, the types of ideas that may be funded don’t fit or are too early for traditional funding criteria and, if an idea does come to fruition, it may…
• challenge common dogma
• be potentially paradigm shifting
• transform our current understanding of or approach to a scientific concept or field
• be wildly new and visionary
Ideas should be at an early stage. Preliminary data is not required. This investment mechanism is not intended to advance research with a funding track record; it aims to spark new lines of investigation. Funding is intended to support remarkable ideas and enable our faculty the full intellectual creativity and exploration that is often hindered by traditional funding sources.
We recognize that pushing boundaries and placing bets on bold, novel ideas increases the likelihood of unexpected or negative findings. Knowledge comes in all forms, both from positive and negative results.
Research Scouts use their curiosity and ability to see exciting opportunities where others don’t to identify research ideas/projects that excite them. After discussing and conducting due diligence, the Scout may invite a faculty member, a “Prospect,” to flesh out their idea.
Projects should be scoped realistically. A Prospect, if funded, should be able to deploy the dollars quickly, and meaningful progress in testing the hypothesis should be achievable within the funding level and 18-24 months. If the Scout and Prospect mutually agree on the progress that can be made within an appropriate budget and timeline, the Scout may elect to invest in the project. If so, the Scout and Prospect will complete the short Research Scout Investment Agreement form and submit it to the Medical School Office of Research. The form includes information about the Prospect Scout Scholar, a brief description of the idea, key milestone(s)/deliverable(s) to be achieved with the investment, award amount, and attestation that the Scout and Prospect are not current or recent collaborators. The Scout Scholar, or a team member, agrees to participate in future events (lightning talks, symposia) showcasing the Scout Scholars and ideas in which the Research Scouts invested.
Research Scouts are directed to keep awards at “arm’s length”:
- Scouts cannot make awards to faculty with whom they have directly collaborated on a grant proposal (submitted or awarded) within the last five years.
- Research Scouts are discouraged from funding faculty whose research interests overlap with their own.
- Research Scouts should avoid funding members of their department (division for large departments).
- Research Scouts funding may not be used to support faculty effort.
In addition, the Research Scouts will not entertain unsolicited requests directly from a faculty, and any faculty who approaches a Scout for funding will be deemed ineligible.
Research Scouts are outstanding scientists from diverse backgrounds and various career stages who demonstrate immense curiosity, creativity, and calculated risk-taking. Scouts have an innate tendency to support the success of others.
Nominations for Research Scouts 2025 are now closed.
Faculty who accept the nomination to be considered for a Research Scout are invited to submit a video* recording, 3 minutes or less, describing why she/he/they would make a great Research Scout. The video should showcase or provide examples demonstrating the characteristics of a Research Scout, such as intellectual curiosity, creativity, and calculated risk-taking. If a video exceeds 3 minutes, only the first 3 minutes will be viewed.
*Any medium, such as phone, Zoom, webcam, etc. can be used for the video. Videos are not expected to be professional and are intended to get to know you in a way that a paper CV does not convey.
Submit the video and a current CV to [email protected] by 11:59 PM on Friday, November 1, 2024.
Submissions are evaluated by a review panel composed of medical school faculty and staff. Applicants are assessed on their curiosity, creativity, and risk-taking, as well as their scholarly work, mentorship, service, and diversity. Diversity includes scientific interests, disciplines, departments, career stages, gender, and racial/cultural backgrounds. Research Scouts are featured on the Office of Research website.
Faculty with a primary appointment in the Medical School. Research Scouts and Scout Scholars from 2023 can also apply to be Research Scouts in the 2025 program.
Additional questions about the Research Scouts program should be directed to [email protected].
Research Scouts 2025
J. Brian Byrd, MD
Lara Coughlin, PhD
Oliver He, DVM, PhD
Allison Janda, MD
Catherine Kaczorowski, PhD
Claire Kalpakjian, PhD, MS
Tom K. W. Kerppola, PhD
Rishindra Reddy, MD, MBA
Rachel Richesson, PhD, MPH, MS, FACMI
Gurjit Sandhu, PhD
Udit Singhal, MD
Joanna Spencer-Segal, MD, PhD
Sharan Srinivasan, MD, PhD
Hakam Tiba, MD
Matthew Willsey, MD, PhD
Bing Ye, PhD
Wenxi Yu, PhD
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University of Michigan Medical School
Ann Arbor, Michigan