Matthew K Iyer, MD, PhD

 Matthew K. Iyer profile photo
Clinical Assistant Professor of Surgery
Clinical Assistant Professor of Pathology
Medical School
University of Michigan–Ann Arbor
Rogel Cancer Center
5303 Rogel Cancer Center
Ann Arbor, MI 48109-5940
Available to mentor
Matthew K Iyer, MD, PhD
Matthew K. Iyer profile photo
Clinical Assistant Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

  • Manage Your Profile

    • About

    I am a Clinical Assistant Professor of Surgery and Pathology at the University of Michigan, and I care for patients at the University of Michigan hospital as well as the Ann Arbor VA Healthcare System. I conduct research in the areas of computational biology, bioinformatics, and data science. My long-term goal is to learn how we can use high-throughput molecular data such as DNA and RNA sequencing to improve our care of patients with cancer.

    Qualifications
    • Fellow, Complex General Surgical Oncology
      Duke University Health System, Surgery, Durham, United States
      2021 - 2023
      Other
    • Fellow, HPB Surgery
      Duke University Health System, Surgery, Durham, United States
      2021 - 2023
      Other
    • Resident, General Surgery
      Weill Cornell Medicine, Surgery, New York, United States
      2016 - 2021
      Residency
    • PhD
      University of Michigan–Ann Arbor, Ann Arbor, United States
      2007 - 2016
    • MD
      University of Michigan Medical School, Ann Arbor, United States
      2007 - 2016
    • MS Electrical Engineering
      University of Colorado Boulder, Boulder, United States
      2004 - 2006
    • BA Music
      University of Colorado Boulder, Boulder, United States
      1999 - 2003
    • BS Electrical and Computer Engineering
      University of Colorado Boulder, Boulder, United States
      1999 - 2003

    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Computational Medicine and Bioinformatics

    Research Overview

    - Development of blood, urine and other biofluid tests to detect and monitor cancer
    - Investigating tumor biology using RNA-Seq, single-cell RNA-Seq, spatial transcriptomics datasets
    - Curation of a compendium of over 100,000 RNA-Seq datasets for general use in cancer research

    Recent Publications

     See All Publications
    • Additional Scholarship
      Supplementary Figures S1-S15 from Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms Reveals Divergent Indolent and Malignant States
      Iyer MK, Fletcher AA, Okoye JO, Shi C, Chen F, Kanu EN, Eckhoff AM, Bao M, Pasca di Magliano M, Frankel TL, Chinnaiyan AM, Nussbaum DP, Allen PJ. 2026 Jun 17; DOI:10.1158/1078-0432.32709068
    • Additional Scholarship
      Supplementary Tables S1-S9 from Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms Reveals Divergent Indolent and Malignant States
      Iyer MK, Fletcher AA, Okoye JO, Shi C, Chen F, Kanu EN, Eckhoff AM, Bao M, Pasca di Magliano M, Frankel TL, Chinnaiyan AM, Nussbaum DP, Allen PJ. 2026 Jun 17; DOI:10.1158/1078-0432.32709065
    • Journal Article
      Abstract 4146: Melanocytic transcriptional state is an independent marker of survival in metastatic melanoma
      Huang Z, Rhodin KE, Al-Rohil R, Geron V, Chinnaiyan AM, O'Connor MH, Angeles CV, Nair SK, Beasley GM, Iyer MK. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 4146 - 4146. DOI:10.1158/1538-7445.am2026-4146
    • Additional Scholarship
      Data from Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization
      Griffith BD, Kadiyala P, McGue J, Sun L, Kumar A, Espinoza CE, Donahue KL, Iyer MK, Speyer C, Nelson S, Spiteri A, Elhossiny AM, Brown K, Attebury H, Bednar F, Carpenter ES, Kryczek I, Zhang Y, Zou W, Pasca di Magliano M, Frankel TL. 2026 Jan 12; DOI:10.1158/2159-8290.c.8239507
    • Additional Scholarship
      Figure S1 from Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization
      Griffith BD, Kadiyala P, McGue J, Sun L, Kumar A, Espinoza CE, Donahue KL, Iyer MK, Speyer C, Nelson S, Spiteri A, Elhossiny AM, Brown K, Attebury H, Bednar F, Carpenter ES, Kryczek I, Zhang Y, Zou W, Pasca di Magliano M, Frankel TL. 2026 Jan 12; DOI:10.1158/2159-8290.31047022
    • Additional Scholarship
      Figure S2 from Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization
      Griffith BD, Kadiyala P, McGue J, Sun L, Kumar A, Espinoza CE, Donahue KL, Iyer MK, Speyer C, Nelson S, Spiteri A, Elhossiny AM, Brown K, Attebury H, Bednar F, Carpenter ES, Kryczek I, Zhang Y, Zou W, Pasca di Magliano M, Frankel TL. 2026 Jan 12; DOI:10.1158/2159-8290.31047019
    • Additional Scholarship
      Figure S3 from Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization
      Griffith BD, Kadiyala P, McGue J, Sun L, Kumar A, Espinoza CE, Donahue KL, Iyer MK, Speyer C, Nelson S, Spiteri A, Elhossiny AM, Brown K, Attebury H, Bednar F, Carpenter ES, Kryczek I, Zhang Y, Zou W, Pasca di Magliano M, Frankel TL. 2026 Jan 12; DOI:10.1158/2159-8290.31047016
    • Additional Scholarship
      Figure S4 from Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization
      Griffith BD, Kadiyala P, McGue J, Sun L, Kumar A, Espinoza CE, Donahue KL, Iyer MK, Speyer C, Nelson S, Spiteri A, Elhossiny AM, Brown K, Attebury H, Bednar F, Carpenter ES, Kryczek I, Zhang Y, Zou W, Pasca di Magliano M, Frankel TL. 2026 Jan 12; DOI:10.1158/2159-8290.31047013