Thomas E Wilson, MD, PhD
Pathology
109 Zina Pitcher Place, Room 2065
Ann Arbor, MI 48109
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About
Thomas E. Wilson, M.D. Ph.D., is a Professor of Pathology and Human Genetics at the University of Michigan Medical School.
Dr. Wilson is a molecular genetic pathologist active in the clinic with related research interests that include basic studies of yeast double-strand break repair, mechanisms of mammalian chromosomal instability, genomic technologies in core facilities, and bioinformatics, including projects aimed at standardizing and sharing data analysis tools.
Education and mentorship of diverse trainees is critical to our mission and Dr. Wilson directs classes and UROP and other research projects related to molecular genetics, translational research, and bioinformatics.
Please visit https://wilsonte-umich.github.io/ learn more about Dr. Wilson's goals to advance understanding of the genetic processes that cause mutations associated with human diseases by detecting them in the clinical laboratory, exploring their mechanisms in the research laboratory, and developing resources to help students and other researchers do the same.
Links
https://wilsonte-umich.github.io/
Qualifications
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ResidencyWashington University in St. Louis School of Medicine, Laboratory Medicine, St Louis, United States
1994 - 1999
Residency
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Postdoctoral FellowWashington University in St. Louis School of Medicine, St Louis, United States
1995 - 1999
Postdoctoral Fellowship
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Chief ResidentWashington University in St. Louis School of Medicine, St Louis, United States
1998 - 1999
Chief Resident
Center Memberships
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Center MemberRogel Cancer Center
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Center MemberCenter for Computational Medicine and Bioinformatics
Recent Publications
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Lukaszewicz A, Wilson TE, Kim S, Keeney S, Jasin M. Genes Dev, 2026 Jul 31;Journal ArticleMRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice.
DOI:10.1101/gad.353693.126 PMID: 42538288 -
de Los Rios Barreda J, Ferreiro ME, Jansz N, Bell CC, Botto JM, Nguyen TV, Pradhan B, Chen M, Colomer-Boronat A, Da Costa Guevara DJ, Flasch DA, Gericke S, Wilson TE, Ewing AD, Heras SR, Sanchez-Luque FJ, Lister R, Moran JV, Faulkner GJ. Science, 2026 Jul 30; 393 (6810): eadz8081Journal ArticleX-chromosome inactivation draws L1 mutagenesis to the human X chromosome.
DOI:10.1126/science.adz8081 PMID: 42531392 -
Can G, Shyian M, Krishnamoorthy A, Ahmed S, Lim Y, Wu A, Pavani R, Zaher MS, Nussenzweig A, Räschle M, Wilson TE, Glover TW, Walter JC, Pellman D. Science, 2026 Jul 2; eaeh1834Journal ArticleA CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis.
DOI:10.1126/science.aeh1834 PMID: 42391323 -
Stewart JA, Mishler J, Ahmed S, Schwer B, Glover TW, Wilson TE. 2026 Jun 29;PreprintHigh-fidelity rare structural variant detection with HiFiRE3 reduced representation via restriction enzyme ends.
DOI:10.64898/2026.06.24.734375 PMID: 42427526 -
Narayanan IV, Bedi K, Magnuson B, McShane A, Ashaka M, Paulsen M, Wilson TE, Ljungman M. Genome Res, 2026 Mar 26;Journal ArticleIsoform- and pathway-specific regulation of post-transcriptional RNA processing in human cells.
DOI:10.1101/gr.280892.125 PMID: 41887799 -
Rabbani M, Apell Z, Parnell TJ, Moritz L, Kim S, Srinivasan S, Agrawal R, Vargo A, Orchard P, Xie W, Freddolino L, Boyle AP, Li JZ, Lesch BJ, Cairns B, Kim M, Wilson TE, Hammoud SS. 2026 Mar 12;Preprint3D chromatin compartment of round spermatids encodes the spatiotemporal program of histone-to-protamine exchange in spermiogenesis.
DOI:10.64898/2026.03.10.710708 PMID: 41959395 -
Lukaszewicz A, Wilson TE, Kim S, Keeney S, Jasin M. 2026 Feb 15;PreprintMRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice.
DOI:10.64898/2026.02.11.705388 PMID: 41726871 -
Yang H, Hulbatte RS, Gratsch N, Urzynicok A, Sutter A, Cusnir M, Ashaka M, Narayanan IV, Paulsen M, Schwendeman A, Wilson TE, Newman E, Ljungman M. Cancer Research, 2026 Jan 15; 86 (1_Supplement): pr003 - pr003.Journal ArticleAbstract PR003: KLIPP: Targeting fusion oncogenes with CRISPR
DOI:10.1158/1538-7445.fusionpositive26-pr003
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Highlighted Publications: August - December 2025
Highlighted Publications - November 2024