Thomas E Wilson, MD, PhD

HmGenFcltyHdsGrps21(045)
Legacy Professor of Pathology Research
Professor of Pathology
Professor of Human Genetics
Associate Medical Director, Molecular Diagnostics Laboratory and Program Assistant
MGP Fellowship Director
Medical School
Office:
University of Michigan
Pathology
109 Zina Pitcher Place, Room 2065
Ann Arbor, MI 48109
Email:
[email protected]
Phone:
Available to mentor
Thomas E Wilson, MD, PhD
HmGenFcltyHdsGrps21(045)
Professor
  • About
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  • Qualifications
  • Center Memberships
  • Recent Publications
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  • About

    Thomas E. Wilson, M.D. Ph.D., is a Professor of Pathology and Human Genetics at the University of Michigan Medical School.

    Dr. Wilson is a molecular genetic pathologist active in the clinic with related research interests that include basic studies of yeast double-strand break repair, mechanisms of mammalian chromosomal instability, genomic technologies in core facilities, and bioinformatics, including projects aimed at standardizing and sharing data analysis tools.

    Education and mentorship of diverse trainees is critical to our mission and Dr. Wilson directs classes and UROP and other research projects related to molecular genetics, translational research, and bioinformatics.

    Please visit https://wilsonte-umich.github.io/ learn more about Dr. Wilson's goals to advance understanding of the genetic processes that cause mutations associated with human diseases by detecting them in the clinical laboratory, exploring their mechanisms in the research laboratory, and developing resources to help students and other researchers do the same.

    Links

    • https://wilsonte-umich.github.io/

    Qualifications

    • Residency
      Washington University in St. Louis School of Medicine, Laboratory Medicine, St Louis, United States
      1994 - 1999
      Residency
    • Postdoctoral Fellow
      Washington University in St. Louis School of Medicine, St Louis, United States
      1995 - 1999
      Postdoctoral Fellowship
    • Chief Resident
      Washington University in St. Louis School of Medicine, St Louis, United States
      1998 - 1999
      Chief Resident

    Center Memberships

    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Computational Medicine and Bioinformatics

    Recent Publications

    See All Publications
    • Journal Article
      MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice.
      Lukaszewicz A, Wilson TE, Kim S, Keeney S, Jasin M. Genes Dev, 2026 Jul 31; DOI:10.1101/gad.353693.126
      PMID: 42538288
    • Journal Article
      X-chromosome inactivation draws L1 mutagenesis to the human X chromosome.
      de Los Rios Barreda J, Ferreiro ME, Jansz N, Bell CC, Botto JM, Nguyen TV, Pradhan B, Chen M, Colomer-Boronat A, Da Costa Guevara DJ, Flasch DA, Gericke S, Wilson TE, Ewing AD, Heras SR, Sanchez-Luque FJ, Lister R, Moran JV, Faulkner GJ. Science, 2026 Jul 30; 393 (6810): eadz8081 DOI:10.1126/science.adz8081
      PMID: 42531392
    • Journal Article
      A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis.
      Can G, Shyian M, Krishnamoorthy A, Ahmed S, Lim Y, Wu A, Pavani R, Zaher MS, Nussenzweig A, Räschle M, Wilson TE, Glover TW, Walter JC, Pellman D. Science, 2026 Jul 2; eaeh1834 DOI:10.1126/science.aeh1834
      PMID: 42391323
    • Preprint
      High-fidelity rare structural variant detection with HiFiRE3 reduced representation via restriction enzyme ends.
      Stewart JA, Mishler J, Ahmed S, Schwer B, Glover TW, Wilson TE. 2026 Jun 29; DOI:10.64898/2026.06.24.734375
      PMID: 42427526
    • Journal Article
      Isoform- and pathway-specific regulation of post-transcriptional RNA processing in human cells.
      Narayanan IV, Bedi K, Magnuson B, McShane A, Ashaka M, Paulsen M, Wilson TE, Ljungman M. Genome Res, 2026 Mar 26; DOI:10.1101/gr.280892.125
      PMID: 41887799
    • Preprint
      3D chromatin compartment of round spermatids encodes the spatiotemporal program of histone-to-protamine exchange in spermiogenesis.
      Rabbani M, Apell Z, Parnell TJ, Moritz L, Kim S, Srinivasan S, Agrawal R, Vargo A, Orchard P, Xie W, Freddolino L, Boyle AP, Li JZ, Lesch BJ, Cairns B, Kim M, Wilson TE, Hammoud SS. 2026 Mar 12; DOI:10.64898/2026.03.10.710708
      PMID: 41959395
    • Preprint
      MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice.
      Lukaszewicz A, Wilson TE, Kim S, Keeney S, Jasin M. 2026 Feb 15; DOI:10.64898/2026.02.11.705388
      PMID: 41726871
    • Journal Article
      Abstract PR003: KLIPP: Targeting fusion oncogenes with CRISPR
      Yang H, Hulbatte RS, Gratsch N, Urzynicok A, Sutter A, Cusnir M, Ashaka M, Narayanan IV, Paulsen M, Schwendeman A, Wilson TE, Newman E, Ljungman M. Cancer Research, 2026 Jan 15; 86 (1_Supplement): pr003 - pr003. DOI:10.1158/1538-7445.fusionpositive26-pr003

    Featured News & Stories

    Department News

    Highlighted Publications: August - December 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - November 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Congratulations to Lev Prasov, Tom Wilson, and Stephanie Moon on your newly awarded Research Scouts Grant!
    Department News

    Research Scouts grants awarded to Stephanie Moon, Lev Prasov, and Tom Wilson

    An agile, low-burden program which gives money to Research Scouts to invest in other scientists' bold ideas.