James Rae, PhD

 James Rae
Thomas H Simpson Legacy Professor of Cancer Research
Associate Professor of Internal Medicine
Associate Professor of Pharmacology
Medical School
[email protected]
Available to mentor
James Rae, PhD
James Rae
Associate Professor
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    • Center Memberships
    • Center Member
      Rogel Cancer Center

    Recent Publications

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    • Proceeding / Abstract / Poster
      Abstract 5290: Investigating the intrinsic epigenetic dependencies of estrogen receptor positive and ESR1 mutant breast cancer
      Coleski A, Young E, Das S, Cao X, VanAken S, Su F, Cao Y, Wang R, Rae JM, Parolia A, Qiao Y, Xiao L, Chinnaiyan AM. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 5290 - 5290. DOI:10.1158/1538-7445.am2026-5290
    • Journal Article
      Abstract 6604: Aurora kinase B inhibition enhances radiation response and activates type 1 interferon signaling in triple-negative breast cancer.
      Endraws MA, Jungles KM, Bishop C, Wilson C, Rana PS, Hauk B, Diedrich C, Markovic V, Hochmuth E, McBean BN, Liu M, Pierce L, Rae JM, Speers CW. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 6604 - 6604. DOI:10.1158/1538-7445.am2026-6604
    • Journal Article
      Abstract PS2-07-22: Serial, multi-omic, multi-analyte, liquid biopsy monitoring of metastatic lobular breast cancer to detect clinically-relevant heterogeneity and evolution
      Cani AK, Dolce EM, Darga EP, Hu K, Liu C, Robinson D, Wu Y, Paoletti C, Luker GD, Tomlins SA, Udager AM, Henderson NC, Thomas DG, Rae JM, Arul CM, Cobain EF, Hayes DF. Clinical Cancer Research, 2026 Feb 23; 32 (4_Supplement): ps2-07-22-ps2-07-22 DOI:10.1158/1557-3265.sabcs25-ps2-07-22
    • Preprint
      Generative AI Enables Breast Cancer Genomic Subtype Prediction from Histology Images
      Simon BG, Weiss CL, Chan D, Mangiante L, Ma Z, Smith NH, Meisner A, Rae JM, Speers CW, Albain KS, Karakas C, Bean GR, Mouron S, Quintela-Fandino M, Curtis C. 2026 Jan 2; bioRxiv, DOI:10.64898/2025.12.29.692457
    • Journal Article
      Optimal Treatment Sequence for CDK4/6 Inhibitors and Radiation Combination Therapy in Triple Negative and Estrogen Receptor Positive Breast Cancer
      Pisano CE, Zeidane RA, Hochmuth E, Hauk B, Lichtman-Mikol S, Rana P, Tao M, Mercer V, McBean B, Pesch A, Hirsh N, Rae J, Pierce LJ, Cobain E, Lyons J, Speers C. International Journal of Radiation Oncology • Biology • Physics, 2025 Sep 28; 123 (1): e504 - e505. DOI:10.1016/j.ijrobp.2025.06.2654
    • Journal Article
      Targeting monopolar spindle kinase I (Mps1 or TTK) induces radiosensitization in syngeneic models of triple negative breast cancer (TNBC) and potentiates type I interferon (T1IFN) signaling
      Jungles KM, Bishop CR, Wilson CM, Liu M, Jungles KR, Wilder-Romans K, Speers CW, Pierce LJ, Rae JM. Neoplasia United States, 2025 Aug 1; 66: DOI:10.1016/j.neo.2025.101190
      PMID: 40499340
    • Journal Article
      A real-world analysis of cancer prevention measures among individuals with hereditary breast and ovarian cancer (HBOC) syndromes and no personal history of malignancy
      Hadley A, Buning G, Henderson NC, Milliron KJ, Hulswit BB, Hipp LE, Pleasant VA, Rae JM, Pilewskie ML, Hayes DF, Henry NL, Merajver SD, Cobain EF. Clinical Cancer Research, 2025 Oct 7; 31 (12_Supplement): p1-05-15-p1-05-15 - p1-05-15-p1-05-15. DOI:10.1158/1557-3265.sabcs24-p1-05-15
    • Journal Article
      Assessment of ctDNA somatic homologous recombination deficiency (HRD) in triple-negative breast cancer (TNBC) from SWOG S1416 trial.
      Stecklein SR, Barlow WE, Tsai J, Yablonovitch A, Rodler E, Kuhn P, Hicks J, Pathak HB, Hayes DF, Rae JM, Hortobagyi GN, Thompson AM, Godwin AK, Pusztai L, Sharma P. Journal of Clinical Oncology, 2025 May 30; 43 (16_suppl): 1012 - 1012. DOI:10.1200/jco.2025.43.16_suppl.1012