Matthias Kretzler, MD
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research Professor
Computational Medicine and Bioinformatics
Medical School
[email protected]
Available to mentor
Matthias Kretzler, MD
Professor
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Qualifications
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PhDUniversity of Heidelberg, Heidelberg, Germany
1992 - 1993
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MDUniversity of Heidelberg, Heidelberg, Germany
1985 - 1992
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BaccalaureateSt. Paulusheim, Bruchsal, Germany
1976 - 1985
Center Memberships
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Center MemberAI and Digital Health Innovation
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Center MemberBiosciences Initiative
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Center MemberCenter for Global Health Equity
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Center MemberGlobal REACH
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Center MemberMM-PKUHSC Joint Institute
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberCaswell Diabetes Institute
Research Overview
- Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks
- Integrative systems biology of renal disease with a focus on glomerular diseases
- Molecular diagnostic and target identification of renal disease
Links
MiKTMC
Recent Publications
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Sandholm N, Cole JB, Nair V, Brennan E, Giardini E, Haukka JK, Ha E, Syreeni A, Dahlström EH, Salem RM, Fermin D, Mercader J, Smyth L, Hill C, Mychaleckyj J, McGurnaghan S, Miller RG, Costacou T, Snell-Bergeon J, Paterson AD, Verkauskiene R, Sokolovska J, Panduru NM, Zerbini G, Brismar K, Krolewski AS, Harjutsalo V, Rossing P, Hadjadj S, McKay G, McKnight AJ, Maxwell AP, Susztak K, Godson C, Kretzler M, Hirschhorn JN, Florez JC, Groop PH. Kidney International Reports, 2026 Jul 1; 11 (7):Journal ArticleResponse to the Letter to the Editor Entitled “A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics”
DOI:10.1016/j.ekir.2026.106572 -
Al Souz J, Wei Y, Cui C, Qu R, Choi JY, Wang F, Moioffer SJ, Barrett J, Chernova I, Nadella M, Siniscalco ER, Moeckel G, Joshi NS, Chen PM, Arazi A, Ho YC, Craft J, Anolik J, Apruzzese W, Arazi A, Barnas J, Belmont M, Berthier C, Brenner MB, Buyon J, Carlucci P, Clancy R, Connery S, Dall’Era M, Davidson A, DeJager W, Deonaraine K, Diamond B, Dunn PJ, Eisenhaure T, Fava A, Goff J, Goilav B, Grossman J, Guthridge J, Hacohen N, Hildeman D, Hodgin J, Hoover P, Hsu R, Ishigaki K, Ishimori M, Izmirly P, James J, Jones T, Kalunian K, Kamen DL, Korsunsky I, Kretzler M, Kustagi M, Lederer J, Li J, Lieb D, Macwana S, Maecker H, Mao R, McMahon M, Mears J, Menon R, Millard N, Morozov P, Nathan A, Payan-Schober F, Peters M, Petri M, Putterman C, Rao DA, Raychaudhuri S, Robinson B, Sakaue S, Suryawanshi H, Tuschl T, Utz PJ, Weinand K, Weisman M, Wofsy D, Woodle S, Xiao Q, Zhang F. Immunity, 2026 Jun 9; 59 (6): 1667 - 1687.e15.Journal ArticleOrgan injury in systemic autoimmunity is mediated by stem-like CD8+T cells arising from tissue-draining lymph nodes
DOI:10.1016/j.immuni.2026.03.022 PMID: 42013863 -
Ettou S, Greenberg A, Lee S, Rajesh A, Sun L, Tabibzadeh N, Oishi H, Konoe R, McCown PJ, Eddy S, Driscoll V, Miyoshi T, Hiratsuka K, Lam J, Srinivasan RS, Jung YL, Isaac B, Sun M, Taglienti ME, Keller K, Chen H, Kretzler M, Weins A, Morizane R, Rockowitz S, Schumacher VA, Lee D, Kreidberg JA. JCI Insight, 2026 Jun 8; 11 (11):Journal ArticleFOXC2 and WT1 regulate transcriptional reprogramming during the podocyte response to injury.
DOI:10.1172/jci.insight.190175 PMID: 42258752 -
Menon R, Kimmel PL, Otto EA, Subramanian L, O'Connor CL, Godfrey B, Smith C, Alakwaa F, Berthier CC, Sarwal MM, Woodle ES, Pyle L, Choi YJ, Ladd P, Sedor JR, Rosas SE, Waikar SS, Naik AS, Melo Ferreira R, Eadon MT, Bitzer M, Bjornstad P, Hodgin JB, Kretzler M. JCI Insight, 2026 May 19;Journal ArticleNot all reference samples are equal in single-cell transcriptomics of human kidney tissue.
DOI:10.1172/jci.insight.204385 PMID: 42160485 -
Ferreira RM, Gisch DL, Phillips CL, Cheng Y-H, Lucarelli N, Yennapureddy S, Asthana M, Lake BB, Bowen WS, Fang F, Asghari M, Sabo A, Barwinska D, Ferkowicz MJ, Toto RD, Sedor JR, Rosas SE, Bjornstad P, Hodgin JB, Alpers CE, Sarder P, Himmelfarb J, Schaub JA, Nair V, Winfree S, Sutton TA, Kelly KJ, Kidney Precision Medicine Project , Kretzler M, Jain S, El-Achkar TM, Dagher PC, Eadon MT. Kidney Int, 2026 Apr 27;Journal ArticleA MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease.
DOI:10.1016/j.kint.2026.03.020 PMID: 42055320 -
Nair V, Minakawa A, Smith C, Berthier CC, Hartman J, Menon R, Fermin D, Otto EA, Gisch DL, Eadon MT, Jain S, Choi YJ, Pyle L, Eichinger F, Alakwaa FM, Rose MP, Subramanian L, El Saghir J, Beamish JA, Hodgin JB, Brosius FC, Bjornstad P, Nelson PJ, Harder JL, Werner T, Kretzler M, Schaub JA. Signal Transduct Target Ther, 2026 Apr 21; 11 (1):Journal ArticleHypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition.
DOI:10.1038/s41392-026-02653-0 PMID: 42009641 -
Moedt E, Koshino A, Jongs N, Ju W, Nair V, Kretzler M, Hansen MK, Arnott CG, Wheeler DC, Rossing P, Coca SG, Hammarstedt A, Greasley PJ, Bjornstad P, Bakker SJL, Heerspink HJL. J Am Soc Nephrol, 2026 Apr 2;Journal ArticleAssociation of Urinary Epidermal Growth Factor with Kidney Outcomes and Effects of Sodium-Glucose Cotransporter 2 Inhibition.
DOI:10.1681/ASN.0000001086 PMID: 41926219 -
Ju W, Strömstedt M, Huang Y, Johansson A, Löfgren L, Rosengren B, Nair V, Eddy S, O'Connor C, Chaki S, Bitzer M, Reznichenko A, Hansen PB, Fjellström O, Kretzler M. Kidney International Reports, 2026 Mar 26; 11 (4): 104423Proceeding / Abstract / PosterWCN26-2200 INHIBITION OF NNMT, A KIDNEY FAILURE-ASSOCIATED GENE INDENTIFIED BY TRANSCRIPTOMIC ANALYSIS, BLOCKS PROGRESSION OF DKD IN MICE
DOI:10.1016/j.ekir.2026.104423
Featured News & Stories
Department News
Dr. Matthias Kretzler Receives ASN's Prestigious 2026 Homer W. Smith Award
Dr. Matthias Kretzler has been selected as the recipient of the 2026 Homer W. Smith Award, one of the highest honors in nephrology, presented by the American Society of Nephrology (ASN). He will be formally recognized at ASN Kidney Week 2026 in Denver this October.
Great Minds, Greater Discoveries Stories
Matthias Kretzler, MD: Studying the onset and progression of kidney diseases
Learn more about the innovative work of research investigators at the University of Michigan Medical School.
Department News
University of Michigan Faculty Members Join Rare Kidney Disease Advocates for Capitol Hill Day
Faculty members from the University of Michigan, Division of Nephrology, joined patients, caregivers, and advocates from across the country for Capitol Hill Day, hosted by the American Kidney Fund (AKF) and the IgA Nephropathy Foundation.
Health Lab
New technology called PathoPlex maps the location of proteins inside cells
Abnormal changes in protein levels and patterns can result in diseases. Understanding protein organization can improve treatments and minimize disease symptoms. A team of researchers developed a new technology called pathology-oriented multiplexing, or PathoPlex, to map more than 140 different proteins across 40 tissue samples.