Matthias Kretzler, MD

Kretzler
Professor
Email:
[email protected]
Available to mentor
Matthias Kretzler, MD
Kretzler
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
  • Manage Your Profile

  • Qualifications

    • PhD
      University of Heidelberg, Heidelberg, Germany
      1992 - 1993
    • MD
      University of Heidelberg, Heidelberg, Germany
      1985 - 1992
    • Baccalaureate
      St. Paulusheim, Bruchsal, Germany
      1976 - 1985

    Center Memberships

    • Center Member
      AI and Digital Health Innovation
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Global Health Equity
    • Center Member
      Global REACH
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Caswell Diabetes Institute

    Research Overview

    - Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks
    - Integrative systems biology of renal disease with a focus on glomerular diseases
    - Molecular diagnostic and target identification of renal disease

    Links

    • MiKTMC

    Recent Publications

    See All Publications
    • Journal Article
      Air pollution and disease progression among patients with primary glomerular disease: an expanded study with extended follow-up
      Troost JP, Kshirsagar AV, Smoyer WE, Klein J, Merchant ML, Helmuth M, Mariani LH, Kretzler M, Smith AR, Lacey F, Engel LS, Trachtman H, O’Lenick CR. Environmental Health A Global Access Science Source, 2026 Dec 1; 25 (1): DOI:10.1186/s12940-026-01312-9
      PMID: 42243965
    • Journal Article
      Hypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition
      Nair V, Minakawa A, Smith C, Berthier CC, Hartman J, Menon R, Fermin D, Otto EA, Gisch DL, Eadon MT, Jain S, Choi YJ, Pyle L, Eichinger F, Alakwaa FM, Rose MP, Subramanian L, El Saghir J, Beamish JA, Hodgin JB, Brosius FC, Bjornstad P, Nelson PJ, Harder JL, Werner T, Kretzler M, Schaub JA. Signal Transduction and Targeted Therapy, 2026 Dec 1; 11 (1): DOI:10.1038/s41392-026-02653-0
      PMID: 42009641
    • Journal Article
      Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues
      Acera-Mateos M, Adiconis X, Li JK, Marchese D, Caratù G, Hon CC, Tiwari P, Kojima M, Vieth B, Murphy MA, Simmons SK, Lefevre T, Claes I, O’Connor CL, Menon R, Otto EA, Ando Y, Vandereyken K, Kretzler M, Bitzer M, Fraenkel E, Voet T, Enard W, Carninci P, Heyn H, Levin JZ, Mereu E. Genome Biology, 2026 Dec 1; 27 (1): DOI:10.1186/s13059-026-04002-4
      PMID: 41821037
    • Journal Article
      Urinary clusterin as a biomarker of human kidney disease progression and response to the endothelin receptor antagonist atrasentan: An exploratory analysis from the SONAR trial
      Ju W, Nair V, Vart P, Smeijer JD, Hudkins KL, Moedt E, Larkina M, Perco P, Burdet F, Shedden K, Hwang M, Lee E, O’Connor C, Hartman J, Subramanian L, Bitzer M, Ibberson M, Duffin KL, Gomez MF, Alpers CE, Kretzler M, Heerspink HJL. Nature Communications, 2026 Dec 1; 17 (1): DOI:10.1038/s41467-026-68973-5
      PMID: 41654492
    • Journal Article
      Corrigendum to "Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis." Kidney International 2023;103,565-579.
      Mariani LH, Eddy S, AlAkwaa FM, McCown PJ, Harder JL, Nair V, Eichinger F, Martini S, Ademola AD, Boima V, Reich HN, El Saghir J, Godfrey B, Ju W, Tanner EC, Vega-Warner V, Wys NL, Adler SG, Appel GB, Athavale A, Atkinson MA, Bagnasco SM, Barisoni L, Brown E, Cattran DC, Coppock GM, Dell KM, Derebail VK, Fervenza FC, Fornoni A, Gadegbeku CA, Gibson KL, Greenbaum LA, Hingorani SR, Hladunewich MA, Hodgin JB, Hogan MC, Holzman LB, Jefferson JA, Kaskel FJ, Kopp JB, Lafayette RA, Lemley KV, Lieske JC, Lin J-J, Menon R, Meyers KE, Nachman PH, Nast CC, O'Shaughnessy MM, Otto EA, Reidy KJ, Sambandam KK, Sedor JR, Sethna CB, Singer P, Srivastava T, Tran CL, Tuttle KR, Vento SM, Wang C-S, Ojo AO, Adu D, Gipson DS, Trachtman H, Kretzler M. Kidney Int, 2026 Nov; 110 (5): 1325 - 1326. DOI:10.1016/j.kint.2026.08.001
      PMID: 42901693
    • Journal Article
      Association of Urinary EGF with Kidney Outcomes and Effects of Sodium-Glucose Cotransporter 2 Inhibition
      Moedt E, Koshino A, Jongs N, Ju W, Nair V, Kretzler M, Hansen MK, Arnott CG, Wheeler DC, Rossing P, Coca SG, Hammarstedt A, Greasley PJ, Bjornstad P, Bakker SJL, Heerspink HJL. Journal of the American Society of Nephrology, 2026 Oct 1; 37 (10): DOI:10.1681/ASN.0000001086
      PMID: 41926219
    • Journal Article
      Length of Follow-Up Time Needed for Stable eGFR Slope Estimation in Glomerular Disease
      Liu Q, Chen A, Mariani LH, Janowczyk A, Lafata K, Hodgin J, Barisoni L, Holzman LB, Zee J. Kidney360, 2026 Sep 1; 7 (9): 2056 - 2065. DOI:10.34067/KID.0000001235
      PMID: 42189610
    • Journal Article
      Sparsentan as first-line treatment in IgA nephropathy from SPARTAN
      Cheung CK, Barratt WA, Chaki S, Chinnakotla S, Dhaun N, Graham-Brown MPM, Griffin S, Hendry B, Howson A, Jama AAA, Ju W, Khan I, Komers R, Kretzler M, Mercer A, Moody S, Nair V, Nawaz N, Parke K, Roberts ISD, Sayer M, Sinha S, Szklarzewicz J, Willcocks L, Barratt J. Kidney International Reports, 2026 Sep 25; 107105 DOI:10.1016/j.ekir.2026.107105

    Featured News & Stories

    Department News

    CDI members lead one of 37 projects set to receive Strategic Initiative Funds

    The Michigan Initiative to Reprogram Cells for Diabetes (MIRC-D), involving the work of several CDI members, is set to receive $40 million in Strategic Initiative Funding.
    Department News

    Dr. Matthias Kretzler Receives Prestigious Honor from the American Society of Nephrology (ASN)

    CDI congratulates Dr. Matthias Kretzler on receiving the 2026 Homer W. Smith Award from the American Society of Nephrology.
    Kretzler
    Department News

    Dr. Matthias Kretzler Receives ASN's Prestigious 2026 Homer W. Smith Award

    Dr. Matthias Kretzler has been selected as the recipient of the 2026 Homer W. Smith Award, one of the highest honors in nephrology, presented by the American Society of Nephrology (ASN). He will be formally recognized at ASN Kidney Week 2026 in Denver this October.
    Dr. Kretzler and lab member looking at a sample in the lab
    Great Minds, Greater Discoveries Stories

    Matthias Kretzler, MD: Studying the onset and progression of kidney diseases

    Learn more about the innovative work of research investigators at the University of Michigan Medical School.
    Rare Kidney Disease
    Department News

    University of Michigan Faculty Members Join Rare Kidney Disease Advocates for Capitol Hill Day

    Faculty members from the University of Michigan, Division of Nephrology, joined patients, caregivers, and advocates from across the country for Capitol Hill Day, hosted by the American Kidney Fund (AKF) and the IgA Nephropathy Foundation.
    kidneys blue yellow
    Health Lab

    New technology called PathoPlex maps the location of proteins inside cells

    Abnormal changes in protein levels and patterns can result in diseases. Understanding protein organization can improve treatments and minimize disease symptoms. A team of researchers developed a new technology called pathology-oriented multiplexing, or PathoPlex, to map more than 140 different proteins across 40 tissue samples.