Matthias Kretzler, MD

Kretzler
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research
Professor, Computational Medicine and Bioinformatics
Medical School
Email:
[email protected]
Available to mentor
Matthias Kretzler, MD
Kretzler
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
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  • Qualifications

    • PhD
      University of Heidelberg, Heidelberg, Germany
      1992 - 1993
    • MD
      University of Heidelberg, Heidelberg, Germany
      1985 - 1992
    • Baccalaureate
      St. Paulusheim, Bruchsal, Germany
      1976 - 1985

    Center Memberships

    • Center Member
      AI and Digital Health Innovation
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Global Health Equity
    • Center Member
      Global REACH
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Caswell Diabetes Institute

    Research Overview

    - Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks
    - Integrative systems biology of renal disease with a focus on glomerular diseases
    - Molecular diagnostic and target identification of renal disease

    Links

    • MiKTMC

    Recent Publications

    See All Publications
    • Journal Article
      Air pollution and disease progression among patients with primary glomerular disease: an expanded study with extended follow-up
      Troost JP, Kshirsagar AV, Smoyer WE, Klein J, Merchant ML, Helmuth M, Mariani LH, Kretzler M, Smith AR, Lacey F, Engel LS, Trachtman H, O’Lenick CR. Environmental Health A Global Access Science Source, 2026 Dec 1; 25 (1): DOI:10.1186/s12940-026-01312-9
      PMID: 42243965
    • Journal Article
      Hypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition
      Nair V, Minakawa A, Smith C, Berthier CC, Hartman J, Menon R, Fermin D, Otto EA, Gisch DL, Eadon MT, Jain S, Choi YJ, Pyle L, Eichinger F, Alakwaa FM, Rose MP, Subramanian L, El Saghir J, Beamish JA, Hodgin JB, Brosius FC, Bjornstad P, Nelson PJ, Harder JL, Werner T, Kretzler M, Schaub JA. Signal Transduction and Targeted Therapy, 2026 Dec 1; 11 (1): DOI:10.1038/s41392-026-02653-0
      PMID: 42009641
    • Journal Article
      Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues
      Acera-Mateos M, Adiconis X, Li JK, Marchese D, Caratù G, Hon CC, Tiwari P, Kojima M, Vieth B, Murphy MA, Simmons SK, Lefevre T, Claes I, O’Connor CL, Menon R, Otto EA, Ando Y, Vandereyken K, Kretzler M, Bitzer M, Fraenkel E, Voet T, Enard W, Carninci P, Heyn H, Levin JZ, Mereu E. Genome Biology, 2026 Dec 1; 27 (1): DOI:10.1186/s13059-026-04002-4
      PMID: 41821037
    • Journal Article
      Urinary clusterin as a biomarker of human kidney disease progression and response to the endothelin receptor antagonist atrasentan: An exploratory analysis from the SONAR trial
      Ju W, Nair V, Vart P, Smeijer JD, Hudkins KL, Moedt E, Larkina M, Perco P, Burdet F, Shedden K, Hwang M, Lee E, O’Connor C, Hartman J, Subramanian L, Bitzer M, Ibberson M, Duffin KL, Gomez MF, Alpers CE, Kretzler M, Heerspink HJL. Nature Communications, 2026 Dec 1; 17 (1): DOI:10.1038/s41467-026-68973-5
      PMID: 41654492
    • Journal Article
      Novel protein biomarkers for risk stratification and personalized medicine
      Moedt E, Ju W, Nair V, Bjornstad P, Kretzler M, Heerspink HJL. Nephrology Dialysis Transplantation Official Publication of the European Dialysis and Transplant Association European Renal Association, 2026 Aug 25; 41 (2): ii50 - ii58. DOI:10.1093/ndt/gfag068
      PMID: 41874429
    • Preprint
      An Integrated Atlas of the Human Kidney Spanning Health and Diseases
      Stasinos K, Wang H, Predeus AV, Richoz N, Menon R, Thokadiwala M, Zhu Y, Tian R, Zhou W, Chatzigeorgiou A, Yordanova G, Zucchi I, Laszik Z, Mueller MF, Subramanian A, Greka A, Regev A, Kretzler M, Marioni J, Luecken MD, Clatworthy M, Teichmann SA, He P. 2026 Aug 18; bioRxiv, DOI:10.64898/2026.08.12.744548
    • Preprint
      A Principled Statistical Framework for Analyzing Spatial Patterns in Spatially Resolved Multi-Omics
      Li J, Raina M, Wang Y, Zeng S, Yu Y, Yu X, Jin X, Chang Y, Feliciano D, Himmelfarb J, Ricardo AC, Nachman PH, Vazquez M, Caramori ML, Barisoni L, Kretzler M, Jain S, Dagher PC, El-Achkar TM, Eadon MT, Program HBA, Project KPM, Ferreira RM, Ma Q, Wang J, Xu D. 2026 Aug 13; bioRxiv, DOI:10.64898/2026.08.04.742894
    • Journal Article
      Acute tubular injury versus acute interstitial nephritis in the kidney precision medicine project
      Schaub JA, Menon R, Melo Ferreira R, Kiernan E, Schmidt IM, Limonte CP, Yennapureddy S, Cheng YH, Herlitz L, Rosenberg AZ, Henderson JM, Smith KD, Hodgin JB, Otto E, Moeckel GW, Cantley LG, Setty S, Balis UG, Demeke D, Fogo AB, Bomback AS, D'Agati VD, Stillman IE, Torrealba JR, Hendricks AR, Bracamonte E, Moreno V, Bhatraju P, Mottl AK, Brosius FC, Thajudeen B, Coca SG, Palevsky PM, Randhawa PS, Murugan R, Barisoni L, Alpers CE, Menez S, Wilson FP, Moledina DG, Eadon MT, Kretzler M, Himmelfarb J, Parikh CR. Jci Insight, 2026 Aug 10; 11 (15): DOI:10.1172/jci.insight.204127
      PMID: 42579799

    Featured News & Stories

    Department News

    CDI members lead one of 37 projects set to receive Strategic Initiative Funds

    The Michigan Initiative to Reprogram Cells for Diabetes (MIRC-D), involving the work of several CDI members, is set to receive $40 million in Strategic Initiative Funding.
    Department News

    Dr. Matthias Kretzler Receives Prestigious Honor from the American Society of Nephrology (ASN)

    CDI congratulates Dr. Matthias Kretzler on receiving the 2026 Homer W. Smith Award from the American Society of Nephrology.
    Kretzler
    Department News

    Dr. Matthias Kretzler Receives ASN's Prestigious 2026 Homer W. Smith Award

    Dr. Matthias Kretzler has been selected as the recipient of the 2026 Homer W. Smith Award, one of the highest honors in nephrology, presented by the American Society of Nephrology (ASN). He will be formally recognized at ASN Kidney Week 2026 in Denver this October.
    Dr. Kretzler and lab member looking at a sample in the lab
    Great Minds, Greater Discoveries Stories

    Matthias Kretzler, MD: Studying the onset and progression of kidney diseases

    Learn more about the innovative work of research investigators at the University of Michigan Medical School.
    Rare Kidney Disease
    Department News

    University of Michigan Faculty Members Join Rare Kidney Disease Advocates for Capitol Hill Day

    Faculty members from the University of Michigan, Division of Nephrology, joined patients, caregivers, and advocates from across the country for Capitol Hill Day, hosted by the American Kidney Fund (AKF) and the IgA Nephropathy Foundation.
    kidneys blue yellow
    Health Lab

    New technology called PathoPlex maps the location of proteins inside cells

    Abnormal changes in protein levels and patterns can result in diseases. Understanding protein organization can improve treatments and minimize disease symptoms. A team of researchers developed a new technology called pathology-oriented multiplexing, or PathoPlex, to map more than 140 different proteins across 40 tissue samples.