Matthias Kretzler, MD
Professor
Email:
[email protected]
Available to mentor
Matthias Kretzler, MD
Professor
Manage Your Profile
Qualifications
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PhDUniversity of Heidelberg, Heidelberg, Germany
1992 - 1993
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MDUniversity of Heidelberg, Heidelberg, Germany
1985 - 1992
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BaccalaureateSt. Paulusheim, Bruchsal, Germany
1976 - 1985
Center Memberships
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Center MemberAI and Digital Health Innovation
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Center MemberBiosciences Initiative
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Center MemberCenter for Global Health Equity
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Center MemberGlobal REACH
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Center MemberMM-PKUHSC Joint Institute
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberCaswell Diabetes Institute
Research Overview
- Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks
- Integrative systems biology of renal disease with a focus on glomerular diseases
- Molecular diagnostic and target identification of renal disease
Links
MiKTMC
Recent Publications
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Troost JP, Kshirsagar AV, Smoyer WE, Klein J, Merchant ML, Helmuth M, Mariani LH, Kretzler M, Smith AR, Lacey F, Engel LS, Trachtman H, O’Lenick CR. Environmental Health A Global Access Science Source, 2026 Dec 1; 25 (1):Journal ArticleAir pollution and disease progression among patients with primary glomerular disease: an expanded study with extended follow-up
DOI:10.1186/s12940-026-01312-9 PMID: 42243965 -
Nair V, Minakawa A, Smith C, Berthier CC, Hartman J, Menon R, Fermin D, Otto EA, Gisch DL, Eadon MT, Jain S, Choi YJ, Pyle L, Eichinger F, Alakwaa FM, Rose MP, Subramanian L, El Saghir J, Beamish JA, Hodgin JB, Brosius FC, Bjornstad P, Nelson PJ, Harder JL, Werner T, Kretzler M, Schaub JA. Signal Transduction and Targeted Therapy, 2026 Dec 1; 11 (1):Journal ArticleHypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition
DOI:10.1038/s41392-026-02653-0 PMID: 42009641 -
Acera-Mateos M, Adiconis X, Li JK, Marchese D, Caratù G, Hon CC, Tiwari P, Kojima M, Vieth B, Murphy MA, Simmons SK, Lefevre T, Claes I, O’Connor CL, Menon R, Otto EA, Ando Y, Vandereyken K, Kretzler M, Bitzer M, Fraenkel E, Voet T, Enard W, Carninci P, Heyn H, Levin JZ, Mereu E. Genome Biology, 2026 Dec 1; 27 (1):Journal ArticleSystematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues
DOI:10.1186/s13059-026-04002-4 PMID: 41821037 -
Ju W, Nair V, Vart P, Smeijer JD, Hudkins KL, Moedt E, Larkina M, Perco P, Burdet F, Shedden K, Hwang M, Lee E, O’Connor C, Hartman J, Subramanian L, Bitzer M, Ibberson M, Duffin KL, Gomez MF, Alpers CE, Kretzler M, Heerspink HJL. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleUrinary clusterin as a biomarker of human kidney disease progression and response to the endothelin receptor antagonist atrasentan: An exploratory analysis from the SONAR trial
DOI:10.1038/s41467-026-68973-5 PMID: 41654492 -
Mariani LH, Eddy S, AlAkwaa FM, McCown PJ, Harder JL, Nair V, Eichinger F, Martini S, Ademola AD, Boima V, Reich HN, El Saghir J, Godfrey B, Ju W, Tanner EC, Vega-Warner V, Wys NL, Adler SG, Appel GB, Athavale A, Atkinson MA, Bagnasco SM, Barisoni L, Brown E, Cattran DC, Coppock GM, Dell KM, Derebail VK, Fervenza FC, Fornoni A, Gadegbeku CA, Gibson KL, Greenbaum LA, Hingorani SR, Hladunewich MA, Hodgin JB, Hogan MC, Holzman LB, Jefferson JA, Kaskel FJ, Kopp JB, Lafayette RA, Lemley KV, Lieske JC, Lin J-J, Menon R, Meyers KE, Nachman PH, Nast CC, O'Shaughnessy MM, Otto EA, Reidy KJ, Sambandam KK, Sedor JR, Sethna CB, Singer P, Srivastava T, Tran CL, Tuttle KR, Vento SM, Wang C-S, Ojo AO, Adu D, Gipson DS, Trachtman H, Kretzler M. Kidney Int, 2026 Nov; 110 (5): 1325 - 1326.Journal ArticleCorrigendum to "Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis." Kidney International 2023;103,565-579.
DOI:10.1016/j.kint.2026.08.001 PMID: 42901693 -
Moedt E, Koshino A, Jongs N, Ju W, Nair V, Kretzler M, Hansen MK, Arnott CG, Wheeler DC, Rossing P, Coca SG, Hammarstedt A, Greasley PJ, Bjornstad P, Bakker SJL, Heerspink HJL. Journal of the American Society of Nephrology, 2026 Oct 1; 37 (10):Journal ArticleAssociation of Urinary EGF with Kidney Outcomes and Effects of Sodium-Glucose Cotransporter 2 Inhibition
DOI:10.1681/ASN.0000001086 PMID: 41926219 -
Liu Q, Chen A, Mariani LH, Janowczyk A, Lafata K, Hodgin J, Barisoni L, Holzman LB, Zee J. Kidney360, 2026 Sep 1; 7 (9): 2056 - 2065.Journal ArticleLength of Follow-Up Time Needed for Stable eGFR Slope Estimation in Glomerular Disease
DOI:10.34067/KID.0000001235 PMID: 42189610 -
Cheung CK, Barratt WA, Chaki S, Chinnakotla S, Dhaun N, Graham-Brown MPM, Griffin S, Hendry B, Howson A, Jama AAA, Ju W, Khan I, Komers R, Kretzler M, Mercer A, Moody S, Nair V, Nawaz N, Parke K, Roberts ISD, Sayer M, Sinha S, Szklarzewicz J, Willcocks L, Barratt J. Kidney International Reports, 2026 Sep 25; 107105Journal ArticleSparsentan as first-line treatment in IgA nephropathy from SPARTAN
DOI:10.1016/j.ekir.2026.107105
Featured News & Stories
Department News
CDI members lead one of 37 projects set to receive Strategic Initiative Funds
The Michigan Initiative to Reprogram Cells for Diabetes (MIRC-D), involving the work of several CDI members, is set to receive $40 million in Strategic Initiative Funding.
Department News
Dr. Matthias Kretzler Receives Prestigious Honor from the American Society of Nephrology (ASN)
CDI congratulates Dr. Matthias Kretzler on receiving the 2026 Homer W. Smith Award from the American Society of Nephrology.
Department News
Dr. Matthias Kretzler Receives ASN's Prestigious 2026 Homer W. Smith Award
Dr. Matthias Kretzler has been selected as the recipient of the 2026 Homer W. Smith Award, one of the highest honors in nephrology, presented by the American Society of Nephrology (ASN). He will be formally recognized at ASN Kidney Week 2026 in Denver this October.
Great Minds, Greater Discoveries Stories
Matthias Kretzler, MD: Studying the onset and progression of kidney diseases
Learn more about the innovative work of research investigators at the University of Michigan Medical School.
Department News
University of Michigan Faculty Members Join Rare Kidney Disease Advocates for Capitol Hill Day
Faculty members from the University of Michigan, Division of Nephrology, joined patients, caregivers, and advocates from across the country for Capitol Hill Day, hosted by the American Kidney Fund (AKF) and the IgA Nephropathy Foundation.
Health Lab
New technology called PathoPlex maps the location of proteins inside cells
Abnormal changes in protein levels and patterns can result in diseases. Understanding protein organization can improve treatments and minimize disease symptoms. A team of researchers developed a new technology called pathology-oriented multiplexing, or PathoPlex, to map more than 140 different proteins across 40 tissue samples.