Matthias Kretzler, MD

Kretzler
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research Professor
Computational Medicine and Bioinformatics
Medical School
[email protected]
Available to mentor
Matthias Kretzler, MD
Kretzler
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
  • Manage Your Profile

  • Qualifications

    • PhD
      University of Heidelberg, Heidelberg, Germany
      1992 - 1993
    • MD
      University of Heidelberg, Heidelberg, Germany
      1985 - 1992
    • Baccalaureate
      St. Paulusheim, Bruchsal, Germany
      1976 - 1985

    Center Memberships

    • Center Member
      AI and Digital Health Innovation
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Global Health Equity
    • Center Member
      Global REACH
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Caswell Diabetes Institute

    Research Overview

    - Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks
    - Integrative systems biology of renal disease with a focus on glomerular diseases
    - Molecular diagnostic and target identification of renal disease

    Links

    • MiKTMC

    Recent Publications

    See All Publications
    • Journal Article
      Response to the Letter to the Editor Entitled “A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics”
      Sandholm N, Cole JB, Nair V, Brennan E, Giardini E, Haukka JK, Ha E, Syreeni A, Dahlström EH, Salem RM, Fermin D, Mercader J, Smyth L, Hill C, Mychaleckyj J, McGurnaghan S, Miller RG, Costacou T, Snell-Bergeon J, Paterson AD, Verkauskiene R, Sokolovska J, Panduru NM, Zerbini G, Brismar K, Krolewski AS, Harjutsalo V, Rossing P, Hadjadj S, McKay G, McKnight AJ, Maxwell AP, Susztak K, Godson C, Kretzler M, Hirschhorn JN, Florez JC, Groop PH. Kidney International Reports, 2026 Jul 1; 11 (7): DOI:10.1016/j.ekir.2026.106572
    • Journal Article
      Organ injury in systemic autoimmunity is mediated by stem-like CD8+T cells arising from tissue-draining lymph nodes
      Al Souz J, Wei Y, Cui C, Qu R, Choi JY, Wang F, Moioffer SJ, Barrett J, Chernova I, Nadella M, Siniscalco ER, Moeckel G, Joshi NS, Chen PM, Arazi A, Ho YC, Craft J, Anolik J, Apruzzese W, Arazi A, Barnas J, Belmont M, Berthier C, Brenner MB, Buyon J, Carlucci P, Clancy R, Connery S, Dall’Era M, Davidson A, DeJager W, Deonaraine K, Diamond B, Dunn PJ, Eisenhaure T, Fava A, Goff J, Goilav B, Grossman J, Guthridge J, Hacohen N, Hildeman D, Hodgin J, Hoover P, Hsu R, Ishigaki K, Ishimori M, Izmirly P, James J, Jones T, Kalunian K, Kamen DL, Korsunsky I, Kretzler M, Kustagi M, Lederer J, Li J, Lieb D, Macwana S, Maecker H, Mao R, McMahon M, Mears J, Menon R, Millard N, Morozov P, Nathan A, Payan-Schober F, Peters M, Petri M, Putterman C, Rao DA, Raychaudhuri S, Robinson B, Sakaue S, Suryawanshi H, Tuschl T, Utz PJ, Weinand K, Weisman M, Wofsy D, Woodle S, Xiao Q, Zhang F. Immunity, 2026 Jun 9; 59 (6): 1667 - 1687.e15. DOI:10.1016/j.immuni.2026.03.022
      PMID: 42013863
    • Journal Article
      FOXC2 and WT1 regulate transcriptional reprogramming during the podocyte response to injury.
      Ettou S, Greenberg A, Lee S, Rajesh A, Sun L, Tabibzadeh N, Oishi H, Konoe R, McCown PJ, Eddy S, Driscoll V, Miyoshi T, Hiratsuka K, Lam J, Srinivasan RS, Jung YL, Isaac B, Sun M, Taglienti ME, Keller K, Chen H, Kretzler M, Weins A, Morizane R, Rockowitz S, Schumacher VA, Lee D, Kreidberg JA. JCI Insight, 2026 Jun 8; 11 (11): DOI:10.1172/jci.insight.190175
      PMID: 42258752
    • Journal Article
      Not all reference samples are equal in single-cell transcriptomics of human kidney tissue.
      Menon R, Kimmel PL, Otto EA, Subramanian L, O'Connor CL, Godfrey B, Smith C, Alakwaa F, Berthier CC, Sarwal MM, Woodle ES, Pyle L, Choi YJ, Ladd P, Sedor JR, Rosas SE, Waikar SS, Naik AS, Melo Ferreira R, Eadon MT, Bitzer M, Bjornstad P, Hodgin JB, Kretzler M. JCI Insight, 2026 May 19; DOI:10.1172/jci.insight.204385
      PMID: 42160485
    • Journal Article
      A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease.
      Ferreira RM, Gisch DL, Phillips CL, Cheng Y-H, Lucarelli N, Yennapureddy S, Asthana M, Lake BB, Bowen WS, Fang F, Asghari M, Sabo A, Barwinska D, Ferkowicz MJ, Toto RD, Sedor JR, Rosas SE, Bjornstad P, Hodgin JB, Alpers CE, Sarder P, Himmelfarb J, Schaub JA, Nair V, Winfree S, Sutton TA, Kelly KJ, Kidney Precision Medicine Project , Kretzler M, Jain S, El-Achkar TM, Dagher PC, Eadon MT. Kidney Int, 2026 Apr 27; DOI:10.1016/j.kint.2026.03.020
      PMID: 42055320
    • Journal Article
      Hypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition.
      Nair V, Minakawa A, Smith C, Berthier CC, Hartman J, Menon R, Fermin D, Otto EA, Gisch DL, Eadon MT, Jain S, Choi YJ, Pyle L, Eichinger F, Alakwaa FM, Rose MP, Subramanian L, El Saghir J, Beamish JA, Hodgin JB, Brosius FC, Bjornstad P, Nelson PJ, Harder JL, Werner T, Kretzler M, Schaub JA. Signal Transduct Target Ther, 2026 Apr 21; 11 (1): DOI:10.1038/s41392-026-02653-0
      PMID: 42009641
    • Journal Article
      Association of Urinary Epidermal Growth Factor with Kidney Outcomes and Effects of Sodium-Glucose Cotransporter 2 Inhibition.
      Moedt E, Koshino A, Jongs N, Ju W, Nair V, Kretzler M, Hansen MK, Arnott CG, Wheeler DC, Rossing P, Coca SG, Hammarstedt A, Greasley PJ, Bjornstad P, Bakker SJL, Heerspink HJL. J Am Soc Nephrol, 2026 Apr 2; DOI:10.1681/ASN.0000001086
      PMID: 41926219
    • Proceeding / Abstract / Poster
      WCN26-2200 INHIBITION OF NNMT, A KIDNEY FAILURE-ASSOCIATED GENE INDENTIFIED BY TRANSCRIPTOMIC ANALYSIS, BLOCKS PROGRESSION OF DKD IN MICE
      Ju W, Strömstedt M, Huang Y, Johansson A, Löfgren L, Rosengren B, Nair V, Eddy S, O'Connor C, Chaki S, Bitzer M, Reznichenko A, Hansen PB, Fjellström O, Kretzler M. Kidney International Reports, 2026 Mar 26; 11 (4): 104423 DOI:10.1016/j.ekir.2026.104423

    Featured News & Stories

    Kretzler
    Department News

    Dr. Matthias Kretzler Receives ASN's Prestigious 2026 Homer W. Smith Award

    Dr. Matthias Kretzler has been selected as the recipient of the 2026 Homer W. Smith Award, one of the highest honors in nephrology, presented by the American Society of Nephrology (ASN). He will be formally recognized at ASN Kidney Week 2026 in Denver this October.
    Dr. Kretzler and lab member looking at a sample in the lab
    Great Minds, Greater Discoveries Stories

    Matthias Kretzler, MD: Studying the onset and progression of kidney diseases

    Learn more about the innovative work of research investigators at the University of Michigan Medical School.
    Rare Kidney Disease
    Department News

    University of Michigan Faculty Members Join Rare Kidney Disease Advocates for Capitol Hill Day

    Faculty members from the University of Michigan, Division of Nephrology, joined patients, caregivers, and advocates from across the country for Capitol Hill Day, hosted by the American Kidney Fund (AKF) and the IgA Nephropathy Foundation.
    kidneys blue yellow
    Health Lab

    New technology called PathoPlex maps the location of proteins inside cells

    Abnormal changes in protein levels and patterns can result in diseases. Understanding protein organization can improve treatments and minimize disease symptoms. A team of researchers developed a new technology called pathology-oriented multiplexing, or PathoPlex, to map more than 140 different proteins across 40 tissue samples.