Robert A Koeppe, PhD

Portrait of Robert Koeppe
Professor of Radiology
Medical School
Office:
University of Michigan
Department of Radiology
2276 Medical Science Building ,1301 Catherine St
Ann Arbor, MI 48109
Email:
[email protected]
Phone:
Available to mentor
Robert A Koeppe, PhD
Portrait of Robert Koeppe
Professor
  • Qualifications
  • Research Overview
  • Recent Publications
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  • Qualifications

    • PhD
      University of Wisconsin, Madison, WI, United States
      1982 - 1984
    • MS
      University of Wisconsin, Madison, WI, United States
      1980 - 1982
    • MS
      University of Missouri, Columbia, MO, United States
      1978 - 1980
    • BS
      University of Missouri, Columbia, MO, United States
      1973 - 1977

    Research Overview

    Robert Koeppe's research interests center around the quantitative aspects of positron emission tomography (PET). Specific research areas include the development and implementation of tracer kinetic models for new and existing positron labeled radiotracers, development of optimal techniques for estimation of physiological quantities, and development and implementation of automated image analysis routines for use with PET. Another specific area of research is the use of PET cerebral blood flow activation studies to examine various cognitive and neurological functions of the brain. Other research interests include the correlation and comparison of information obtained from PET studies to that obtained from corresponding anatomic imaging procedures such as magnetic resonance imaging.

    Recent Publications

    See All Publications
    • Journal Article
      Divergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia
      Zhang W, Raghavan S, Tian J, Przybelski SA, Wiste HJ, Fought AJ, Senjem ML, Schwarz CG, Reid RI, Machulda MM, Petersen RC, Graff-Radford J, Jack CR, Lowe VJ, Silverberg N, Masterman D, Masliah E, Jackson J, Ho C, González H, Bernard M, Barnes L, Potter W, Carrillo M, Molchan S, Ryan L, Hsiao JK, Buckholtz N, Snyder PJ, Frank R, Kachaturian Z, Harkins K, Largent E, Grill J, Erickson C, Karlawish J, Shen L, Kaddurah-Daouk R, Lacy K, Potter Z, Faber K, Nudelman K, Apostolova LG, Craft H, Risacher SL, Jo T, Foroud TM, Neu S, Crawford K, Trojanowki JQ, Wan Y, Brylska M, Korecka M, Lee VMY, Franklin E, Morris J, LoPresti B, Villemagne V, Rabinovici G, Koeppe RA, Talavera S, Di Benedetto J, Ajayi A, Guzman V, Thomas L, Magana F, Weisensel T, Strong J, Germano KK, Hoang I, Glittenberg M, Ayo O, Parkins S, Thao MS, Amaza H, Hussen KA, Saito N, Jenkins C, Pizzola J, Mahboubi P, Adegoke O, Ogwang S, Smith S, Hergesheimer L, Webb C, Shaffer E, Clanton T, Walter S, Cabrera Y, Zimmerman C, Robison J, Boatwright V, Fidell A, Salazar J, Donohue M, Jimenez G, Raman R, Rafii M, Kormos A, Flenniken D. Nature Communications, 2026 Dec 1; 17 (1): DOI:10.1038/s41467-026-70707-6
      PMID: 41851083
    • Journal Article
      Relationships of CSF biomarkers to cortical atrophy in early-onset Alzheimer's disease
      Touroutoglou A, Katsumi Y, Hensel J, Schindler SE, Ibanez L, Brickhouse M, Eloyan A, Eckbo R, Zaitsev A, La Joie R, Thangarajah M, Taurone A, Vemuri P, Jack CR, Hammers DB, Foroud T, Aisen P, Beckett L, Koeppe R, Kukull WA, Toga A, Atri A, Clark D, Day GS, Duara R, Graff-Radford NR, Grant IM, Honig LS, Johnson ECB, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha S, Turner RS, Wingo TS, Wolk DA, Womack K, Carrillo MC, Rabinovici GD, Apostolova LG, Dage JL, Dickerson BC, Eldaief MC. Alzheimer S and Dementia, 2026 Jul 1; 22 (7): DOI:10.1002/alz.71479
      PMID: 42477860
    • Journal Article
      Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study
      Harrison TM, Harvey DJ, Chadwick T, Chao Y, Taggett J, Maillard P, Lovato L, Farias ST, Papp KV, Lockhart SN, Toga AW, Koeppe RA, Jung Y, Jagust WJ, Whitmer RA, Snyder HM, Carrillo MC, Baker LD, Espeland MA, Vemuri P, Decarli C, Landau SM. JAMA Neurology, 2026 Jun 8; 83 (6): 521 - 529. DOI:10.1001/jamaneurol.2026.0832
      PMID: 42008251
    • Journal Article
      Retraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying thePSEN1 H163Rmutation” [Stem Cell Res. 79 (2024) 103495]
      Hernández D, Schlicht SM, Clarke JE, Daniszewski M, Karch CM, Goate AM, Pébay A, Adams S, Allegri R, Araki A, Barthelemy N, Bateman R, Bechara J, Benzinger T, Berman S, Bodge C, Brandon S, Bill Brooks W, Brosch J, Buck J, Buckles V, Carter K, Cash L, Chen C, Chhatwal J, Mendez PC, Chua J, Chui H, Courtney L, Cruchaga C, Day GS, DeLaCruz C, Denner D, Diffenbacher A, Dincer A, Donahue T, Douglas J, Duong D, Egido N, Esposito B, Fagan A, Farlow M, Feldman B, Fitzpatrick C, Flores S, Fox N, Franklin E, Joseph-Mathurin N, Fujii H, Gardener S, Ghetti B, Goate A, Goldberg S, Goldman J, Gonzalez A, Gordon B, Gräber-Sultan S, Graff-Radford N, Graham M, Gray J, Gremminger E, Grilo M, Groves A, Haass C, Häsler L, Hassenstab J, Hellm C, Herries E, Hoechst-Swisher L, Hofmann A, Hofmann A, Holtzman D, Hornbeck R, Igor Y, Ihara R, Ikeuchi T, Ikonomovic S, Ishii K, Jack C, Jerome G, Johnson E, Jucker M, Karch C, Käser S, Kasuga K, Keefe S, Klunk W, Koeppe R, Koudelis D, Kuder-Buletta E, Laske C, Levey A, Levin J, Li Y, Lopez O, Marsh J, Martins R, Mason NS, Masters C, Mawuenyega K. Stem Cell Research, 2026 Jun 1; 93: DOI:10.1016/j.scr.2026.103956
      PMID: 41861779
    • Journal Article
      Kappa opioid receptor availability correlates with depressive symptom burden in chronic migraine: a preliminary investigation.
      Kim DJ, Saberi M, Kaur T, Shao X, Koeppe RA, Scott PJH, Porreca F, DaSilva AF. J Headache Pain, 2026 May 25; DOI:10.1186/s10194-026-02398-9
      PMID: 42185954
    • Journal Article
      Elevated AD biomarkers do not explain cognitive performance in a community-recruited clinical trial cohort
      Landau SM, Liu P, Harrison TM, Taggett J, Ward TJ, Murphy A, Lockhart SN, Lovato LC, Koeppe R, Farias ST, Papp KV, Snyder HM, Harvey DJ, Espeland M, Maillard P, DeCarli C, Vemuri P, Weiner M, Baker LD, Jagust WJ, Weiner MW, Trojanowski JQ, Shaw L, Beckett L, Aisen P, Petersen R, Saykin AJ, Toga AW, Jack C, Morris JC, Jagust W, Baker LD, Espeland MA, Vemuri P, DeCarli C, Harrison TM, Koeppe RA, Jagust WJ, Maillard P, Jung Y, Lovato L, Harvey DJ, Toga AW, Zamora E, Cleveland J, DeCarli C, Whitmer R, Aggarwal N, Tangney C, Gitelman D, Masdeu J, Pavlik V, Yu M, Oh H, Huey E, Salloway S, Wing R. Alzheimer S and Dementia, 2026 May 1; 22 (5): DOI:10.1002/alz.71472
      PMID: 42151735
    • Journal Article
      Kappa opioid receptor availability correlates with depressive symptom severity in chronic migraine
      Kim D, Saberi M, Kaur T, Shao X, Koeppe R, Scott P, Frank P, Dasilva A. The Journal of Headache and Pain, 2026 Jan 24; 27: 27 - xx. DOI:10.1186/s10194-026-02398-9
    • Journal Article
      Identification of patients receiving amyloid-targeting therapies in observational studies using amyloid PET trajectories: Insights from LEADS
      La Joie R, Blazhenets G, Maiti P, Chiotis K, Eloyan A, Kirby K, Hammers D, Koeppe RA, Ackley SF, Robison J, Soleimani-Meigooni DN, Carrillo MC, Dickerson BC, Apostolova LG, Rabinovici GD. Alzheimer S and Dementia Diagnosis Assessment and Disease Monitoring, 2026 Apr 1; 18 (2): DOI:10.1002/dad2.70408