Robert A Koeppe, PhD

Portrait of Robert Koeppe
Professor of Radiology
Medical School
University of Michigan
Department of Radiology
2276 Medical Science Building ,1301 Catherine St
Ann Arbor, MI 48109
[email protected]
Available to mentor
Robert A Koeppe, PhD
Portrait of Robert Koeppe
Professor
  • Qualifications
  • Research Overview
  • Recent Publications
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  • Qualifications

    • PhD
      University of Wisconsin, Madison, WI, United States
      1982 - 1984
    • MS
      University of Wisconsin, Madison, WI, United States
      1980 - 1982
    • MS
      University of Missouri, Columbia, MO, United States
      1978 - 1980
    • BS
      University of Missouri, Columbia, MO, United States
      1973 - 1977

    Research Overview

    Robert Koeppe's research interests center around the quantitative aspects of positron emission tomography (PET). Specific research areas include the development and implementation of tracer kinetic models for new and existing positron labeled radiotracers, development of optimal techniques for estimation of physiological quantities, and development and implementation of automated image analysis routines for use with PET. Another specific area of research is the use of PET cerebral blood flow activation studies to examine various cognitive and neurological functions of the brain. Other research interests include the correlation and comparison of information obtained from PET studies to that obtained from corresponding anatomic imaging procedures such as magnetic resonance imaging.

    Recent Publications

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    • Journal Article
      Divergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia
      Zhang W, Raghavan S, Tian J, Przybelski SA, Wiste HJ, Fought AJ, Senjem ML, Schwarz CG, Reid RI, Machulda MM, Petersen RC, Graff-Radford J, Jack CR, Lowe VJ, Silverberg N, Masterman D, Masliah E, Jackson J, Ho C, González H, Bernard M, Barnes L, Potter W, Carrillo M, Molchan S, Ryan L, Hsiao JK, Buckholtz N, Snyder PJ, Frank R, Kachaturian Z, Harkins K, Largent E, Grill J, Erickson C, Karlawish J, Shen L, Kaddurah-Daouk R, Lacy K, Potter Z, Faber K, Nudelman K, Apostolova LG, Craft H, Risacher SL, Jo T, Foroud TM, Neu S, Crawford K, Trojanowki JQ, Wan Y, Brylska M, Korecka M, Lee VMY, Franklin E, Morris J, LoPresti B, Villemagne V, Rabinovici G, Koeppe RA, Talavera S, Di Benedetto J, Ajayi A, Guzman V, Thomas L, Magana F, Weisensel T, Strong J, Germano KK, Hoang I, Glittenberg M, Ayo O, Parkins S, Thao MS, Amaza H, Hussen KA, Saito N, Jenkins C, Pizzola J, Mahboubi P, Adegoke O, Ogwang S, Smith S, Hergesheimer L, Webb C, Shaffer E, Clanton T, Walter S, Cabrera Y, Zimmerman C, Robison J, Boatwright V, Fidell A, Salazar J, Donohue M, Jimenez G, Raman R, Rafii M, Kormos A, Flenniken D. Nature Communications, 2026 Dec 1; 17 (1): DOI:10.1038/s41467-026-70707-6
      PMID: 41851083
    • Journal Article
      Retraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying thePSEN1 H163Rmutation” [Stem Cell Res. 79 (2024) 103495]
      Hernández D, Schlicht SM, Clarke JE, Daniszewski M, Karch CM, Goate AM, Pébay A, Adams S, Allegri R, Araki A, Barthelemy N, Bateman R, Bechara J, Benzinger T, Berman S, Bodge C, Brandon S, Bill Brooks W, Brosch J, Buck J, Buckles V, Carter K, Cash L, Chen C, Chhatwal J, Mendez PC, Chua J, Chui H, Courtney L, Cruchaga C, Day GS, DeLaCruz C, Denner D, Diffenbacher A, Dincer A, Donahue T, Douglas J, Duong D, Egido N, Esposito B, Fagan A, Farlow M, Feldman B, Fitzpatrick C, Flores S, Fox N, Franklin E, Joseph-Mathurin N, Fujii H, Gardener S, Ghetti B, Goate A, Goldberg S, Goldman J, Gonzalez A, Gordon B, Gräber-Sultan S, Graff-Radford N, Graham M, Gray J, Gremminger E, Grilo M, Groves A, Haass C, Häsler L, Hassenstab J, Hellm C, Herries E, Hoechst-Swisher L, Hofmann A, Hofmann A, Holtzman D, Hornbeck R, Igor Y, Ihara R, Ikeuchi T, Ikonomovic S, Ishii K, Jack C, Jerome G, Johnson E, Jucker M, Karch C, Käser S, Kasuga K, Keefe S, Klunk W, Koeppe R, Koudelis D, Kuder-Buletta E, Laske C, Levey A, Levin J, Li Y, Lopez O, Marsh J, Martins R, Mason NS, Masters C, Mawuenyega K. Stem Cell Research, 2026 Jun 1; 93: DOI:10.1016/j.scr.2026.103956
      PMID: 41861779
    • Journal Article
      Elevated AD biomarkers do not explain cognitive performance in a community-recruited clinical trial cohort
      Landau SM, Liu P, Harrison TM, Taggett J, Ward TJ, Murphy A, Lockhart SN, Lovato LC, Koeppe R, Farias ST, Papp KV, Snyder HM, Harvey DJ, Espeland M, Maillard P, DeCarli C, Vemuri P, Weiner M, Baker LD, Jagust WJ, Weiner MW, Trojanowski JQ, Shaw L, Beckett L, Aisen P, Petersen R, Saykin AJ, Toga AW, Jack C, Morris JC, Jagust W, Baker LD, Espeland MA, Vemuri P, DeCarli C, Harrison TM, Koeppe RA, Jagust WJ, Maillard P, Jung Y, Lovato L, Harvey DJ, Toga AW, Zamora E, Cleveland J, DeCarli C, Whitmer R, Aggarwal N, Tangney C, Gitelman D, Masdeu J, Pavlik V, Yu M, Oh H, Huey E, Salloway S, Wing R. Alzheimer S Dementia the Journal of the Alzheimer S Association, 2026 May 1; 22 (5): e71472 DOI:10.1002/alz.71472
      PMID: 42151735
    • Journal Article
      Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study.
      Harrison TM, Harvey DJ, Chadwick T, Chao Y, Taggett J, Maillard P, Lovato L, Farias ST, Papp KV, Lockhart SN, Toga AW, Koeppe RA, Jung Y, Jagust WJ, Whitmer RA, Snyder HM, Carrillo MC, Baker LD, Espeland MA, Vemuri P, DeCarli C, Landau SM. JAMA Neurol, 2026 Apr 20; DOI:10.1001/jamaneurol.2026.0832
      PMID: PMC13097035
    • Journal Article
      AI-enhanced Centiloid quantification of amyloid PET images
      Bourgeat P, Fripp J, Lebrat L, Xia Y, Feizpour A, Cox T, Zisis G, Gillman A, Goyal MS, Tosun D, Benzinger TLS, LaMontagne P, Breakspear M, Lupton MK, Short C, Adam R, Robertson JS, Sperling R, O'Bryant SE, Johnson SC, Jr CRJ, Schwarz CG, Barkhof F, Farrar G, Bollack A, Collij LE, Landau S, Koeppe R, Morris JC, Weiner MW, Villemagne VL, Masters CL, Rowe CC, Dore V. Alzheimer S and Dementia, 2026 Feb 1; 22 (2): DOI:10.1002/alz.71162
      PMID: 41670187
    • Journal Article
      Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA
      Lockhart SN, Sutphen CL, Tanley J, Gonzalez-Ortiz F, Kac PR, Habes M, Heckbert SR, Ashton NJ, Mielke MM, Koeppe R, Rudolph MD, Sai KKS, Whitlow CT, Hiatt KD, Craft S, Register TC, Hayden KM, Rapp SR, Sachs BC, Zetterberg H, Blennow K, Karikari TK, Hughes TM. Alzheimer S and Dementia, 2026 Feb 1; 22 (2): DOI:10.1002/alz.71131
      PMID: 41630612
    • Journal Article
      Alzheimer's disease polygenic risk in early- and late-onset Alzheimer's disease
      Pentchev JV, Jackson T, Khan N, Rosewood TJ, Huang YN, Nho K, Saykin AJ, Eloyan A, Taurone A, Thangarajah M, Riddle M, Salloway S, Atri A, Honig LS, Johnson ECB, Turner RS, Masdeu JC, Foroud TM, Clark D, Hammers DB, Dage JL, Kirby K, Ghetti B, Newell K, Onyike CU, Day GS, Graff-Radford NR, Murray ME, Jones DT, Jack CR, Vemuri P, Touroutoglou A, Duara R, Grant I, Sha S, Wingo TS, Beckett LA, Rogalski E, Mendez MF, Kramer J, La Joie R, Blazhenets G, Grinberg LT, Koeppe R, Wolk DA, Aisen P, Raman R, Toga A, Kukull WA, Musiek E, Womack KB, Carrillo MC, Rabinovici GD, Dickerson BC, Apostolova LG, Nudelman KNH. Alzheimer S Dementia the Journal of the Alzheimer S Association, 2026 Jan 1; 22 (1): e71066 DOI:10.1002/alz.71066
      PMID: 41532810
    • Journal Article
      A genetically informed brain atlas for enhancing brain imaging genomics.
      Bao J, Wen J, Chang C, Mu S, Chen J, Shivakumar M, Cui Y, Erus G, Yang Z, Yang S, Wen Z, Alzheimer’s Disease Neuroimaging Initiative , Zhao Y, Kim D, Duong-Tran D, Saykin AJ, Zhao B, Davatzikos C, Long Q, Shen L. Nat Commun, 2025 Apr 14; 16 (1): 3524 DOI:10.1038/s41467-025-57636-6
      PMID: PMC11997130