Robert A Koeppe, PhD
Department of Radiology
2276 Medical Science Building ,1301 Catherine St
Ann Arbor, MI 48109
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Qualifications
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PhDUniversity of Wisconsin, Madison, WI, United States
1982 - 1984
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MSUniversity of Wisconsin, Madison, WI, United States
1980 - 1982
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MSUniversity of Missouri, Columbia, MO, United States
1978 - 1980
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BSUniversity of Missouri, Columbia, MO, United States
1973 - 1977
Research Overview
Robert Koeppe's research interests center around the quantitative aspects of positron emission tomography (PET). Specific research areas include the development and implementation of tracer kinetic models for new and existing positron labeled radiotracers, development of optimal techniques for estimation of physiological quantities, and development and implementation of automated image analysis routines for use with PET. Another specific area of research is the use of PET cerebral blood flow activation studies to examine various cognitive and neurological functions of the brain. Other research interests include the correlation and comparison of information obtained from PET studies to that obtained from corresponding anatomic imaging procedures such as magnetic resonance imaging.
Recent Publications
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Zhang W, Raghavan S, Tian J, Przybelski SA, Wiste HJ, Fought AJ, Senjem ML, Schwarz CG, Reid RI, Machulda MM, Petersen RC, Graff-Radford J, Jack CR, Lowe VJ, Silverberg N, Masterman D, Masliah E, Jackson J, Ho C, González H, Bernard M, Barnes L, Potter W, Carrillo M, Molchan S, Ryan L, Hsiao JK, Buckholtz N, Snyder PJ, Frank R, Kachaturian Z, Harkins K, Largent E, Grill J, Erickson C, Karlawish J, Shen L, Kaddurah-Daouk R, Lacy K, Potter Z, Faber K, Nudelman K, Apostolova LG, Craft H, Risacher SL, Jo T, Foroud TM, Neu S, Crawford K, Trojanowki JQ, Wan Y, Brylska M, Korecka M, Lee VMY, Franklin E, Morris J, LoPresti B, Villemagne V, Rabinovici G, Koeppe RA, Talavera S, Di Benedetto J, Ajayi A, Guzman V, Thomas L, Magana F, Weisensel T, Strong J, Germano KK, Hoang I, Glittenberg M, Ayo O, Parkins S, Thao MS, Amaza H, Hussen KA, Saito N, Jenkins C, Pizzola J, Mahboubi P, Adegoke O, Ogwang S, Smith S, Hergesheimer L, Webb C, Shaffer E, Clanton T, Walter S, Cabrera Y, Zimmerman C, Robison J, Boatwright V, Fidell A, Salazar J, Donohue M, Jimenez G, Raman R, Rafii M, Kormos A, Flenniken D. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleDivergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia
DOI:10.1038/s41467-026-70707-6 PMID: 41851083 -
Touroutoglou A, Katsumi Y, Hensel J, Schindler SE, Ibanez L, Brickhouse M, Eloyan A, Eckbo R, Zaitsev A, La Joie R, Thangarajah M, Taurone A, Vemuri P, Jack CR, Hammers DB, Foroud T, Aisen P, Beckett L, Koeppe R, Kukull WA, Toga A, Atri A, Clark D, Day GS, Duara R, Graff-Radford NR, Grant IM, Honig LS, Johnson ECB, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha S, Turner RS, Wingo TS, Wolk DA, Womack K, Carrillo MC, Rabinovici GD, Apostolova LG, Dage JL, Dickerson BC, Eldaief MC. Alzheimer S and Dementia, 2026 Jul 1; 22 (7):Journal ArticleRelationships of CSF biomarkers to cortical atrophy in early-onset Alzheimer's disease
DOI:10.1002/alz.71479 PMID: 42477860 -
Harrison TM, Harvey DJ, Chadwick T, Chao Y, Taggett J, Maillard P, Lovato L, Farias ST, Papp KV, Lockhart SN, Toga AW, Koeppe RA, Jung Y, Jagust WJ, Whitmer RA, Snyder HM, Carrillo MC, Baker LD, Espeland MA, Vemuri P, Decarli C, Landau SM. JAMA Neurology, 2026 Jun 8; 83 (6): 521 - 529.Journal ArticleBrain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study
DOI:10.1001/jamaneurol.2026.0832 PMID: 42008251 -
Hernández D, Schlicht SM, Clarke JE, Daniszewski M, Karch CM, Goate AM, Pébay A, Adams S, Allegri R, Araki A, Barthelemy N, Bateman R, Bechara J, Benzinger T, Berman S, Bodge C, Brandon S, Bill Brooks W, Brosch J, Buck J, Buckles V, Carter K, Cash L, Chen C, Chhatwal J, Mendez PC, Chua J, Chui H, Courtney L, Cruchaga C, Day GS, DeLaCruz C, Denner D, Diffenbacher A, Dincer A, Donahue T, Douglas J, Duong D, Egido N, Esposito B, Fagan A, Farlow M, Feldman B, Fitzpatrick C, Flores S, Fox N, Franklin E, Joseph-Mathurin N, Fujii H, Gardener S, Ghetti B, Goate A, Goldberg S, Goldman J, Gonzalez A, Gordon B, Gräber-Sultan S, Graff-Radford N, Graham M, Gray J, Gremminger E, Grilo M, Groves A, Haass C, Häsler L, Hassenstab J, Hellm C, Herries E, Hoechst-Swisher L, Hofmann A, Hofmann A, Holtzman D, Hornbeck R, Igor Y, Ihara R, Ikeuchi T, Ikonomovic S, Ishii K, Jack C, Jerome G, Johnson E, Jucker M, Karch C, Käser S, Kasuga K, Keefe S, Klunk W, Koeppe R, Koudelis D, Kuder-Buletta E, Laske C, Levey A, Levin J, Li Y, Lopez O, Marsh J, Martins R, Mason NS, Masters C, Mawuenyega K. Stem Cell Research, 2026 Jun 1; 93:Journal ArticleRetraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying thePSEN1 H163Rmutation” [Stem Cell Res. 79 (2024) 103495]
DOI:10.1016/j.scr.2026.103956 PMID: 41861779 -
Kim DJ, Saberi M, Kaur T, Shao X, Koeppe RA, Scott PJH, Porreca F, DaSilva AF. J Headache Pain, 2026 May 25;Journal ArticleKappa opioid receptor availability correlates with depressive symptom burden in chronic migraine: a preliminary investigation.
DOI:10.1186/s10194-026-02398-9 PMID: 42185954 -
Landau SM, Liu P, Harrison TM, Taggett J, Ward TJ, Murphy A, Lockhart SN, Lovato LC, Koeppe R, Farias ST, Papp KV, Snyder HM, Harvey DJ, Espeland M, Maillard P, DeCarli C, Vemuri P, Weiner M, Baker LD, Jagust WJ, Weiner MW, Trojanowski JQ, Shaw L, Beckett L, Aisen P, Petersen R, Saykin AJ, Toga AW, Jack C, Morris JC, Jagust W, Baker LD, Espeland MA, Vemuri P, DeCarli C, Harrison TM, Koeppe RA, Jagust WJ, Maillard P, Jung Y, Lovato L, Harvey DJ, Toga AW, Zamora E, Cleveland J, DeCarli C, Whitmer R, Aggarwal N, Tangney C, Gitelman D, Masdeu J, Pavlik V, Yu M, Oh H, Huey E, Salloway S, Wing R. Alzheimer S and Dementia, 2026 May 1; 22 (5):Journal ArticleElevated AD biomarkers do not explain cognitive performance in a community-recruited clinical trial cohort
DOI:10.1002/alz.71472 PMID: 42151735 -
Kim D, Saberi M, Kaur T, Shao X, Koeppe R, Scott P, Frank P, Dasilva A. The Journal of Headache and Pain, 2026 Jan 24; 27: 27 - xx.Journal ArticleKappa opioid receptor availability correlates with depressive symptom severity in chronic migraine
DOI:10.1186/s10194-026-02398-9 -
La Joie R, Blazhenets G, Maiti P, Chiotis K, Eloyan A, Kirby K, Hammers D, Koeppe RA, Ackley SF, Robison J, Soleimani-Meigooni DN, Carrillo MC, Dickerson BC, Apostolova LG, Rabinovici GD. Alzheimer S and Dementia Diagnosis Assessment and Disease Monitoring, 2026 Apr 1; 18 (2):Journal ArticleIdentification of patients receiving amyloid-targeting therapies in observational studies using amyloid PET trajectories: Insights from LEADS
DOI:10.1002/dad2.70408