Robert A Koeppe, PhD
Department of Radiology
2276 Medical Science Building ,1301 Catherine St
Ann Arbor, MI 48109
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Qualifications
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PhDUniversity of Wisconsin, Madison, WI, United States
1982 - 1984
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MSUniversity of Wisconsin, Madison, WI, United States
1980 - 1982
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MSUniversity of Missouri, Columbia, MO, United States
1978 - 1980
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BSUniversity of Missouri, Columbia, MO, United States
1973 - 1977
Research Overview
Robert Koeppe's research interests center around the quantitative aspects of positron emission tomography (PET). Specific research areas include the development and implementation of tracer kinetic models for new and existing positron labeled radiotracers, development of optimal techniques for estimation of physiological quantities, and development and implementation of automated image analysis routines for use with PET. Another specific area of research is the use of PET cerebral blood flow activation studies to examine various cognitive and neurological functions of the brain. Other research interests include the correlation and comparison of information obtained from PET studies to that obtained from corresponding anatomic imaging procedures such as magnetic resonance imaging.
Recent Publications
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Zhang W, Raghavan S, Tian J, Przybelski SA, Wiste HJ, Fought AJ, Senjem ML, Schwarz CG, Reid RI, Machulda MM, Petersen RC, Graff-Radford J, Jack CR, Lowe VJ, Silverberg N, Masterman D, Masliah E, Jackson J, Ho C, González H, Bernard M, Barnes L, Potter W, Carrillo M, Molchan S, Ryan L, Hsiao JK, Buckholtz N, Snyder PJ, Frank R, Kachaturian Z, Harkins K, Largent E, Grill J, Erickson C, Karlawish J, Shen L, Kaddurah-Daouk R, Lacy K, Potter Z, Faber K, Nudelman K, Apostolova LG, Craft H, Risacher SL, Jo T, Foroud TM, Neu S, Crawford K, Trojanowki JQ, Wan Y, Brylska M, Korecka M, Lee VMY, Franklin E, Morris J, LoPresti B, Villemagne V, Rabinovici G, Koeppe RA, Talavera S, Di Benedetto J, Ajayi A, Guzman V, Thomas L, Magana F, Weisensel T, Strong J, Germano KK, Hoang I, Glittenberg M, Ayo O, Parkins S, Thao MS, Amaza H, Hussen KA, Saito N, Jenkins C, Pizzola J, Mahboubi P, Adegoke O, Ogwang S, Smith S, Hergesheimer L, Webb C, Shaffer E, Clanton T, Walter S, Cabrera Y, Zimmerman C, Robison J, Boatwright V, Fidell A, Salazar J, Donohue M, Jimenez G, Raman R, Rafii M, Kormos A, Flenniken D. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleDivergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia
DOI:10.1038/s41467-026-70707-6 PMID: 41851083 -
Hernández D, Schlicht SM, Clarke JE, Daniszewski M, Karch CM, Goate AM, Pébay A, Adams S, Allegri R, Araki A, Barthelemy N, Bateman R, Bechara J, Benzinger T, Berman S, Bodge C, Brandon S, Bill Brooks W, Brosch J, Buck J, Buckles V, Carter K, Cash L, Chen C, Chhatwal J, Mendez PC, Chua J, Chui H, Courtney L, Cruchaga C, Day GS, DeLaCruz C, Denner D, Diffenbacher A, Dincer A, Donahue T, Douglas J, Duong D, Egido N, Esposito B, Fagan A, Farlow M, Feldman B, Fitzpatrick C, Flores S, Fox N, Franklin E, Joseph-Mathurin N, Fujii H, Gardener S, Ghetti B, Goate A, Goldberg S, Goldman J, Gonzalez A, Gordon B, Gräber-Sultan S, Graff-Radford N, Graham M, Gray J, Gremminger E, Grilo M, Groves A, Haass C, Häsler L, Hassenstab J, Hellm C, Herries E, Hoechst-Swisher L, Hofmann A, Hofmann A, Holtzman D, Hornbeck R, Igor Y, Ihara R, Ikeuchi T, Ikonomovic S, Ishii K, Jack C, Jerome G, Johnson E, Jucker M, Karch C, Käser S, Kasuga K, Keefe S, Klunk W, Koeppe R, Koudelis D, Kuder-Buletta E, Laske C, Levey A, Levin J, Li Y, Lopez O, Marsh J, Martins R, Mason NS, Masters C, Mawuenyega K. Stem Cell Research, 2026 Jun 1; 93:Journal ArticleRetraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying thePSEN1 H163Rmutation” [Stem Cell Res. 79 (2024) 103495]
DOI:10.1016/j.scr.2026.103956 PMID: 41861779 -
Landau SM, Liu P, Harrison TM, Taggett J, Ward TJ, Murphy A, Lockhart SN, Lovato LC, Koeppe R, Farias ST, Papp KV, Snyder HM, Harvey DJ, Espeland M, Maillard P, DeCarli C, Vemuri P, Weiner M, Baker LD, Jagust WJ, Weiner MW, Trojanowski JQ, Shaw L, Beckett L, Aisen P, Petersen R, Saykin AJ, Toga AW, Jack C, Morris JC, Jagust W, Baker LD, Espeland MA, Vemuri P, DeCarli C, Harrison TM, Koeppe RA, Jagust WJ, Maillard P, Jung Y, Lovato L, Harvey DJ, Toga AW, Zamora E, Cleveland J, DeCarli C, Whitmer R, Aggarwal N, Tangney C, Gitelman D, Masdeu J, Pavlik V, Yu M, Oh H, Huey E, Salloway S, Wing R. Alzheimer S Dementia the Journal of the Alzheimer S Association, 2026 May 1; 22 (5): e71472Journal ArticleElevated AD biomarkers do not explain cognitive performance in a community-recruited clinical trial cohort
DOI:10.1002/alz.71472 PMID: 42151735 -
Harrison TM, Harvey DJ, Chadwick T, Chao Y, Taggett J, Maillard P, Lovato L, Farias ST, Papp KV, Lockhart SN, Toga AW, Koeppe RA, Jung Y, Jagust WJ, Whitmer RA, Snyder HM, Carrillo MC, Baker LD, Espeland MA, Vemuri P, DeCarli C, Landau SM. JAMA Neurol, 2026 Apr 20;Journal ArticleBrain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study.
DOI:10.1001/jamaneurol.2026.0832 PMID: PMC13097035 -
Bourgeat P, Fripp J, Lebrat L, Xia Y, Feizpour A, Cox T, Zisis G, Gillman A, Goyal MS, Tosun D, Benzinger TLS, LaMontagne P, Breakspear M, Lupton MK, Short C, Adam R, Robertson JS, Sperling R, O'Bryant SE, Johnson SC, Jr CRJ, Schwarz CG, Barkhof F, Farrar G, Bollack A, Collij LE, Landau S, Koeppe R, Morris JC, Weiner MW, Villemagne VL, Masters CL, Rowe CC, Dore V. Alzheimer S and Dementia, 2026 Feb 1; 22 (2):Journal ArticleAI-enhanced Centiloid quantification of amyloid PET images
DOI:10.1002/alz.71162 PMID: 41670187 -
Lockhart SN, Sutphen CL, Tanley J, Gonzalez-Ortiz F, Kac PR, Habes M, Heckbert SR, Ashton NJ, Mielke MM, Koeppe R, Rudolph MD, Sai KKS, Whitlow CT, Hiatt KD, Craft S, Register TC, Hayden KM, Rapp SR, Sachs BC, Zetterberg H, Blennow K, Karikari TK, Hughes TM. Alzheimer S and Dementia, 2026 Feb 1; 22 (2):Journal ArticlePlasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA
DOI:10.1002/alz.71131 PMID: 41630612 -
Pentchev JV, Jackson T, Khan N, Rosewood TJ, Huang YN, Nho K, Saykin AJ, Eloyan A, Taurone A, Thangarajah M, Riddle M, Salloway S, Atri A, Honig LS, Johnson ECB, Turner RS, Masdeu JC, Foroud TM, Clark D, Hammers DB, Dage JL, Kirby K, Ghetti B, Newell K, Onyike CU, Day GS, Graff-Radford NR, Murray ME, Jones DT, Jack CR, Vemuri P, Touroutoglou A, Duara R, Grant I, Sha S, Wingo TS, Beckett LA, Rogalski E, Mendez MF, Kramer J, La Joie R, Blazhenets G, Grinberg LT, Koeppe R, Wolk DA, Aisen P, Raman R, Toga A, Kukull WA, Musiek E, Womack KB, Carrillo MC, Rabinovici GD, Dickerson BC, Apostolova LG, Nudelman KNH. Alzheimer S Dementia the Journal of the Alzheimer S Association, 2026 Jan 1; 22 (1): e71066Journal ArticleAlzheimer's disease polygenic risk in early- and late-onset Alzheimer's disease
DOI:10.1002/alz.71066 PMID: 41532810 -
Bao J, Wen J, Chang C, Mu S, Chen J, Shivakumar M, Cui Y, Erus G, Yang Z, Yang S, Wen Z, Alzheimer’s Disease Neuroimaging Initiative , Zhao Y, Kim D, Duong-Tran D, Saykin AJ, Zhao B, Davatzikos C, Long Q, Shen L. Nat Commun, 2025 Apr 14; 16 (1): 3524Journal ArticleA genetically informed brain atlas for enhancing brain imaging genomics.
DOI:10.1038/s41467-025-57636-6 PMID: PMC11997130