Gilbert S Omenn, MD, PhD
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About
Gil Omenn is Harold T. Shapiro Distinguished University Professor of the Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, Internal Medicine, Human Genetics, and Public Health at the University of Michigan, Ann Arbor, USA. He served as Executive Vice President for Medical Affairs and as Chief Executive Officer of the University of Michigan Health System from 1997 to 2002. He was Dean of the School of Public Health, and Professor of Medicine and Environmental Health, University of Washington, Seattle, 1982-1997. He is the leader of the global Human Proteome Project (HPP) of the Human Proteome Organization (HUPO). His current research is focused on proteogenomics of alternative splicing in cancers. Splice variants are a major source of protein diversity in multi-cellular organisms with multi-exonic genes. Splice isoforms are good candidates for more specific biomarkers and therapeutic targets. He is author of 700 publications. Omenn has visited China 12 times since 1976. He is an honorary faculty of Peking Union Medical College, affiliate faculty of the Institute for Systems Biology in Seattle, member of the U.S. National Academy of Medicine, past president of the American Association for the Advancement of Science, board member of the Weizmann Institute of Science in Israel, and a director of several biotech companies. He served as a White House Fellow at the U.S. Atomic Energy Commission and as associate director of the White House Office of Science & Technology Policy and Office of Management & Budget. He earned the B.A. from Princeton University, M.D. from Harvard Medical School, and PhD in genetics from University of Washington. He is a musician and tennis player.
Center Memberships
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Center MemberRogel Cancer Center
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberInstitute for Healthcare Policy and Innovation
Research Overview
Dr. Omenn's research focuses on proteo-genomics of cancers and proteomics informatics. He long chaired and remains active in the Human Proteome Organization (HUPO) global Human Proteome Project (www.thehpp.org). There are datasets for application of analytical tools, and there are research teams eager to engage in collaborative studies in the Chromosome-centric HPP and Biology and Disease-driven HPP initiatives. He is a co-founder of the Consortium for Clinical Characterization of Covid-19 using Electronic Health Records (4CE) organized by the i2b2tranSMART Foundation and Harvard colleagues. He has long-standing interests in mechanisms of genetic predispositions to risks from environmental and occupational exposures (eco-genetics) and science-based risk analyses.
Recent Publications
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Song Y, Zhang C, Omenn GS, O’Meara MJ, Welch JD. Genome Biology, 2025 Dec 1; 26 (1):Journal ArticlePredicting the structural impact of human alternative splicing
DOI:10.1186/s13059-025-03744-x PMID: 40963109 -
Hutch MR, Son J, Le TT, Hong C, Wang X, Shakeri Hossein Abad Z, Morris M, Gutiérrez-Sacristán A, Klann JG, Spiridou A, Batugo A, Bellazzi R, Benoit V, Bonzel CL, Bryant WA, Chiudinelli L, Cho K, Das P, González González T, Hanauer DA, Henderson DW, Ho YL, Loh NHW, Makoudjou A, Makwana S, Malovini A, Moal B, Mowery DL, Neuraz A, Samayamuthu MJ, Sanz Vidorreta FJ, Schriver ER, Schubert P, Talbert J, Tan ALM, Tan BWL, Tan BWQ, Tibollo V, Tippman P, Verdy G, Yuan W, Avillach P, Gehlenborg N, Omenn GS, Visweswaran S, Cai T, Luo Y, Xia Z. Plos Digital Health, 2025 Jul 1; 4 (7 July):Journal ArticleCorrection: Neurological diagnoses in hospitalized COVID-19 patients associated with adverse outcomes: A multinational cohort study (PLOS Digit Health (2024) 3:4 (e0000484) DOI: 10.1371/journal.pdig.0000484)
DOI:10.1371/journal.pdig.0000957 -
He F, Aebersold R, Baker MS, Bian X, Bo X, Chan DW, Chang C, Chen L, Chen X, Chen YJ, Cheng H, Collins BC, Corrales F, Cox J, E W, Van Eyk JE, Fan J, Faridi P, Figeys D, Gao GF, Gao W, Gao ZH, Goda K, Goh WWB, Gu D, Guo C, Guo T, He Y, Heck AJR, Hermjakob H, Hunter T, Iyer NG, Jiang Y, Jimenez CR, Joshi L, Kelleher NL, Li M, Li Y, Lin Q, Liu CH, Liu F, Liu GH, Liu Y, Liu Z, Low TY, Lu B, Mann M, Meng A, Moritz RL, Nice E, Ning G, Omenn GS, Overall CM, Palmisano G, Peng Y, Pineau C, Poon TCW, Purcell AW, Qiao J, Reddel RR, Robinson PJ, Roncada P, Sander C, Sha J, Song E, Srivastava S, Sun A, Sze SK, Tang C, Tang L, Tian R, Vizcaíno JA, Wang C, Wang C, Wang X, Wang X, Wang Y, Weiss T, Wilhelm M, Winkler R, Wollscheid B, Wong L, Xie L, Xie W, Xu T, Xu T, Yan L, Yang J, Yang X, Yates J, Yun T, Zhai Q, Zhang B, Zhang H, Zhang L, Zhang L, Zhang P, Zhang Y, Zheng YZ, Zhong Q. Nature, 2025 Jan 16; 637 (8046): E22Journal ArticleCorrection to: π-HuB: the proteomic navigator of the human body (Nature, (2024), 636, 8042, (322-331), 10.1038/s41586-024-08280-5)
DOI:10.1038/s41586-024-08555-x PMID: 39715925 -
Rajaei F, Minoccheri C, Wittrup E, Wilson RC, Athey BD, Omenn GS, Najarian K. IEEE Transactions on Computational Biology and Bioinformatics, 2025 Jan 1; 22 (1): 97 - 115.Journal ArticleAI-Based Computational Methods in Early Drug Discovery and Post Market Drug Assessment: A Survey
DOI:10.1109/TCBB.2024.3492708 -
Menezes MCS, Hoffmann AF, Tan ALM, Nalbandyan M, Omenn GS, Mazzotti DR, Hernández-Arango A, Visweswaran S, Venkatesh S, Mandl KD, Bourgeois FT, Lee JWK, Makmur A, Hanauer DA, Semanik MG, Kerivan LT, Hill T, Forero J, Restrepo C, Vigna M, Ceriana P, Abu-el-rub N, Avillach P, Bellazzi R, Callaci T, Gutiérrez-Sacristán A, Malovini A, Mathew JP, Morris M, Murthy VL, Buonocore TM, Parimbelli E, Patel LP, Sáez C, Samayamuthu MJ, Thompson JA, Tibollo V, Xia Z, Kohane IS. Lancet Digital Health, 2025 Jan 1; 7 (1): e35 - e43.Journal ArticleThe potential of Generative Pre-trained Transformer 4 (GPT-4) to analyse medical notes in three different languages: a retrospective model-evaluation study
DOI:10.1016/S2589-7500(24)00246-2 PMID: 39722251 -
He F, Aebersold R, Baker MS, Bian X, Bo X, Chan DW, Chang C, Chen L, Chen X, Chen YJ, Cheng H, Collins BC, Corrales F, Cox J, E W, Van Eyk JE, Fan J, Faridi P, Figeys D, Gao GF, Gao W, Gao ZH, Goda K, Goh WWB, Gu D, Guo C, Guo T, He Y, Heck AJR, Hermjakob H, Hunter T, Iyer NG, Jiang Y, Jimenez CR, Joshi L, Kelleher NL, Li M, Li Y, Lin Q, Liu CH, Liu F, Liu GH, Liu Y, Liu Z, Low TY, Lu B, Mann M, Meng A, Moritz RL, Nice E, Ning G, Omenn GS, Overall CM, Palmisano G, Peng Y, Pineau C, Poon TCW, Purcell AW, Qiao J, Reddel RR, Robinson PJ, Roncada P, Sander C, Sha J, Song E, Srivastava S, Sun A, Sze SK, Tang C, Tang L, Tian R, Vizcaíno JA, Wang C, Wang C, Wang X, Wang X, Wang Y, Weiss T, Wilhelm M, Winkler R, Wollscheid B, Wong L, Xie L, Xie W, Xu T, Xu T, Yan L, Yang J, Yang X, Yates J, Yun T, Zhai Q, Zhang B, Zhang H, Zhang L, Zhang L, Zhang P, Zhang Y, Zheng YZ, Zhong Q. Nature, 2024 Dec 12; 636 (8042): 322 - 331.Journal Articleπ-HuB: the proteomic navigator of the human body
DOI:10.1038/s41586-024-08280-5 PMID: 39663494 -
Omenn GS, Orchard S, Lane L, Lindskog C, Pineau C, Overall CM, Budnik B, Mudge JM, Packer NH, Weintraub ST, Roehrl MHA, Nice E, Guo T, Van Eyk JE, Völker U, Zhang G, Bandeira N, Aebersold R, Moritz RL, Deutsch EW. Journal of Proteome Research, 2024 Dec 6; 23 (12): 5296 - 5311.Journal ArticleThe 2024 Report on the Human Proteome from the HUPO Human Proteome Project
DOI:10.1021/acs.jproteome.4c00776 PMID: 39514846 -
Geyer PE, Hornburg D, Pernemalm M, Hauck SM, Palaniappan KK, Albrecht V, Dagley LF, Moritz RL, Yu X, Edfors F, Vandenbrouck Y, Mueller-Reif JB, Sun Z, Brun V, Ahadi S, Omenn GS, Deutsch EW, Schwenk JM. Journal of Proteome Research, 2024 Dec 6; 23 (12): 5279 - 5295.Journal ArticleThe Circulating Proteome─Technological Developments, Current Challenges, and Future Trends
DOI:10.1021/acs.jproteome.4c00586 PMID: 39479990
Featured News & Stories
Highlighted Publications: January - May 2026
Omenn Lecture explores how AI is transforming medicine
Mark your calendars: Aviv Regev to give Omenn lecture March 25
Gil Omenn, M.D., Ph.D. Receives the prestigious AAAS Philip Hauge Abelson Prize
Highlighted Publications - January 2025
