Shaomeng Wang, PhD
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine
Professor of Pharmacology
Professor of Medicinal Chemistry
College of Pharmacy
[email protected]

Available to mentor
Shaomeng Wang, PhD
Professor
  • Center Memberships
  • Recent Publications
    • Center Memberships
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Rogel Cancer Center
    Recent Publications See All Publications
    • Journal Article
      Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis.
      Wei X, Lu Y, Lin LL, Zhang C, Chen X, Wang S, Wu SA, Li ZJ, Quan Y, Sun S, Qi L. Nat Commun, 2024 Jan 22; 15 (1): 659 DOI:10.1038/s41467-024-44948-2
      PMID: 38253565
    • Journal Article
      Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?
      Sun D, Macedonia C, Chen Z, Chandrasekaran S, Najarian K, Zhou S, Cernak T, Ellingrod VL, Jagadish HV, Marini B, Pai M, Violi A, Rech JC, Wang S, Li Y, Athey B, Omenn GS. J Med Chem, 2024 Sep 26; 67 (18): 16035 - 16055. DOI:10.1021/acs.jmedchem.4c01684
      PMID: 39253942
    • Journal Article
      SHP2 ablation mitigates osteoarthritic cartilage degeneration by promoting chondrocyte anabolism through SOX9.
      Wang L, Yang H, Wang C, Wang M, Huang J, Nyunt T, Osorio C, Sun S-Y, Pacifici M, Lefebvre V, Moore DC, Wang S, Yang W. FASEB J, 2024 Sep 15; 38 (17): e70013 DOI:10.1096/fj.202400642R
      PMID: 39225365
    • Journal Article
      Corrigendum to "Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma" [Neoplasia, Volume 21, Issue 3 (2019) 322-330].
      Choi JE, Verhaegen ME, Yazdani S, Malik R, Harms PW, Mangelberger D, Tien J, Cao X, Wang Y, Cieślik M, Gurkan J, Yazdani M, Jing X, Juckette K, Su F, Wang R, Zhou B, Apel IJ, Wang S, Dlugosz AA, Chinnaiyan AM. Neoplasia, 2024 Sep; 55: 101019 DOI:10.1016/j.neo.2024.101019
      PMID: 38943995
    • Journal Article
      IL-4-STAT6 axis amplifies histamine-induced vascular endothelial dysfunction and hypovolemic shock.
      Krempski J, Yamani A, Thota LNR, Marella S, Ganesan V, Sharma A, Kaneshige A, Bai L, Zhou H, Foster PS, Wang S, Obi AT, Hogan SP. J Allergy Clin Immunol, 2024 Sep; 154 (3): 719 - 734. DOI:10.1016/j.jaci.2024.05.009
      PMID: 38777155
    • Journal Article
      Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9.
      Wang C, Wang M, Wang Y, Rej RK, Aguilar A, Xu T, Bai L, Tošović J, McEachern D, Li Q, Sarkari F, Wen B, Sun D, Wang S. J Med Chem, 2024 Aug 22; 67 (16): 14125 - 14154. DOI:10.1021/acs.jmedchem.4c00971
      PMID: 39132814
    • Journal Article
      3D reconstruction of the mouse cochlea from scRNA-seq data suggests morphogen-based principles in apex-to-base specification.
      Wang S, Chakraborty S, Fu Y, Lee MP, Liu J, Waldhaus J. Dev Cell, 2024 Jun 17; 59 (12): 1538 - 1552.e6. DOI:10.1016/j.devcel.2024.03.028
      PMID: 38593801
    • Preprint
      p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer.
      Luo J, Chen Z, Qiao Y, Tien JC-Y, Young E, Mannan R, Mahapatra S, He T, Eyunni S, Zhang Y, Zheng Y, Su F, Cao X, Wang R, Cheng Y, Seri R, George J, Shahine M, Miner SJ, Vaishampayan U, Wang M, Wang S, Parolia A, Chinnaiyan AM. 2024 May 23; DOI:10.1101/2024.03.29.587346
      PMID: 38586029