L Michel M Espinoza-Fonseca
Associate Professor of Internal Medicine
[email protected]

Available to mentor
L Michel M Espinoza-Fonseca
Associate Professor
  • About
  • Center Memberships
  • Recent Publications
    • About

    The goal of the Espinoza-Fonseca group is to understand the fundamental molecular motions and interactions that are responsible for regulating calcium transport in muscle cells, and to design effective molecular therapies to treat human diseases associated with dysregulation of calcium transport in heart failure. We approach these multidisciplinary problems with a combination of computational methods and experimental techniques.

    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Recent Publications See All Publications
    • Journal Article
      Missense variants in phospholamban and cardiac myosin binding protein identified in patients with a family history and clinical diagnosis of dilated cardiomyopathy.
      Armanious GP, Lemieux MJ, Espinoza-Fonseca LM, Young HS. Biochim Biophys Acta Mol Cell Res, 2024 Feb 22; 1871 (4): 119699 DOI:10.1016/j.bbamcr.2024.119699
      PMID: 38387507
    • Presentation
      Development and mechanisms of calcium pump activators for heart failure therapy
      Espinoza-Fonseca LM. 2024 Feb 26;
    • Journal Article
      Mechanisms for cardiac calcium pump activation by its substrate and a synthetic allosteric modulator using fluorescence lifetime imaging.
      Šeflová J, Cruz-Cortés C, Guerrero-Serna G, Robia SL, Espinoza-Fonseca LM. PNAS Nexus, 2024 Jan; 3 (1): pgad453 DOI:10.1093/pnasnexus/pgad453
      PMID: 38222469
    • Journal Article
      Replacement of Lys27 by asparagine in the SERCA regulator myoregulin: A Ca2+ affinity modulator or a catalytic activity switch?
      Rathod N, Guerrero-Serna G, Young HS, Espinoza-Fonseca LM. Biochim Biophys Acta Mol Cell Res, 2024 Jan; 1871 (1): 119613 DOI:10.1016/j.bbamcr.2023.119613
      PMID: 37918638
    • Journal Article
      A novel machine learning-based screening identifies statins as inhibitors of the calcium pump SERCA.
      Cruz-Cortés C, Velasco-Saavedra MA, Fernández-de Gortari E, Guerrero-Serna G, Aguayo-Ortiz R, Espinoza-Fonseca LM. J Biol Chem, 2023 May; 299 (5): 104681 DOI:10.1016/j.jbc.2023.104681
      PMID: 37030504
    • Journal Article
      Functional Role of an Unusual Transmembrane Acidic Residue in the Calcium Pump Regulator Myoregulin.
      Liu AY, Rathod N, Guerrero-Serna G, Young HS, Espinoza-Fonseca LM. Biochemistry, 2023 Apr 18; 62 (8): 1331 - 1336. DOI:10.1021/acs.biochem.3c00026
      PMID: 37014032
    • Journal Article
      Primitive Phospholamban- and Sarcolipin-like Peptides Inhibit the Sarcoplasmic Reticulum Calcium Pump SERCA.
      Bak JJ, Aguayo-Ortiz R, Rathod N, Primeau JO, Khan MB, Robia SL, Lemieux MJ, Espinoza-Fonseca LM, Young HS. Biochemistry, 2022 Jul 19; 61 (14): 1419 - 1430. DOI:10.1021/acs.biochem.2c00246
      PMID: 35771007
    • Journal Article
      Fluorescence lifetime imaging microscopy reveals sodium pump dimers in live cells.
      Seflova J, Habibi NR, Yap JQ, Cleary SR, Fang X, Kekenes-Huskey PM, Espinoza-Fonseca LM, Bossuyt JB, Robia SL. J Biol Chem, 2022 May; 298 (5): 101865 DOI:10.1016/j.jbc.2022.101865
      PMID: 35339486