Yoichi Osawa
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Pharmacology and Associate Chair for Innovation and Wellness
Department of Pharmacology, Medical School
[email protected]
Available to mentor
Yoichi Osawa
Professor
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Recent Publications
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Sun Y, Huang X, Zhang J, Osawa Y, Chen YE, Zhang H. ACS Synthetic Biology, 2026 Mar 20; 15 (3): 1082 - 1089.Journal ArticleComputational Design of CYP102A1 Variants for Biosynthesis of a Next-Generation Antiplatelet Drug DT-678
DOI:10.1021/acssynbio.5c00768 PMID: 41791881 -
Garcia AM, Davis AK, Martinez-Ramos C, Morishima Y, Lau M, Xu E, Sunil A, Zhang H, Alt A, Lieberman AP, Osawa Y. Molecular Pharmacology, 2025 Feb 1; 107 (2):Journal ArticleHigh-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase
DOI:10.1016/j.molpha.2024.100008 PMID: 40023517 -
Sun Y, Osawa Y, Zhang H. Archives of Biochemistry and Biophysics, 2024 Dec 1; 762:Journal ArticleBacterial expression, purification, and characterization of human cytochrome P450 3A4 without N-terminal modifications
DOI:10.1016/j.abb.2024.110208 PMID: 39522857 -
Sun Y, Martinez-Ramos C, Chen E, Osawa Y, Zhang H. Biomedicines, 2024 Aug 1; 12 (8):Journal ArticleA General Method to Screen Nanobodies for Cytochrome P450 Enzymes from a Yeast Surface Display Library
DOI:10.3390/biomedicines12081863 -
Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth DR, Osawa Y. Journal of Biological Chemistry, 2024 Jan 1; 300 (1):Journal ArticleMapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry
DOI:10.1016/j.jbc.2023.105464 PMID: 37979917 -
Huang X, Sun Y, Osawa Y, Chen YE, Zhang H. Journal of Biological Chemistry, 2023 Aug 1; 299 (8):Journal ArticleComputational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign
DOI:10.1016/j.jbc.2023.105050 PMID: 37451479 -
Sun Y, Huang X, Osawa Y, Chen YE, Zhang H. Molecules, 2023 Jul 1; 28 (14):Journal ArticleThe Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering
DOI:10.3390/molecules28145353 PMID: 37513226 -
Morishima Y, Lau M, Pratt WB, Osawa Y. Journal of Biological Chemistry, 2023 Feb 1; 299 (2):Journal ArticleDynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase
DOI:10.1016/j.jbc.2022.102856 PMID: 36596358
