The Stanley and Judith Frankel Institute for Heart and Brain Health

Enhancing the Michigan Medicine Research Community

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Clinical and epidemiological studies demonstrate a strong link between diseases of the heart and the brain. Many within the U-M research community are at the forefront of research examining the connection between these two critical organs.

The Stanley and Judith Frankel Institute for Heart and Brain Health (Frankel IHBH) brings together current and new U-M researchers to unravel the biological mechanisms that the heart and brain have in common, as well as how these organs signal to each other and impact clinical outcomes.

Research

Learn more about our research and impact.

People

Get to know our diverse team.

Membership

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Our Mission

Discovering the root causes of heart and brain disease, determining how these organs communicate with each other, and developing the treatments of tomorrow.

Our Vision

Our discoveries will propel life-changing new approaches to the prevention and treatment of heart and brain diseases.

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Collaboration and engagement with the clinical and scientific community at the University of Michigan is essential to the success of Frankel IHBH, we are actively developing initiatives and events to facilitate such interactions for our members.

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Michigan Medicine part of research group awarded $15 million to study inflammation's impact on heart, brain health

The American Heart Association funds scientists at University of Michigan, Northwestern University and University of Pittsburgh for studies focused on closing knowledge gaps about inflammation’s role in cardiac and brain dysfunction.

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Faculty Featured Research: Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition

Skeletal muscle plasticity and remodeling are critical for adapting tissue function to use, disuse, and regeneration. The aim of this study was to identify genes and molecular pathways that regulate the transition from atrophy to compensatory hypertrophy or recovery from injury. Here, we have used a mouse model of hindlimb unloading and reloading, which causes skeletal muscle atrophy, and compensatory regeneration and hypertrophy, respectively.

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News
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Research News
2024 Frankel IHBH Innovative Multidisciplinary Research Pilot Award Recipients
2024 recipients of the Innovative Multidisciplinary Research Pilot Award
jorge
Research News
Jorge Ruas, PhD recruited to the Department of Pharmacology and Frankel IHBH
Jorge Ruas, Ph.D. Recruited to the Department of Pharmacology and the Institute for Heart and Brain Health
Anthony Rosenzweig, M.D.
Research News
Medical School establishes Frankel IHBH; Anthony Rosenzweig, MD, is inaugural director.
The mission for the institute is to become the world’s premier research institute discovering the root causes of heart and brain disease, determining how these organs communicate with each other, and developing the treatments of tomorrow.
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Research News
Welcoming Meng Wang, PhD to Frankel IHBH and DCMB
The Department of Computational Medicine and Bioinformatics (DCMB) and the Stanley and Judith Frankel Institute for Heart and Brain Health (Frankel IHBH) at the University of Michigan Medical School are pleased to welcome Meng Wang, Ph.D., as a new Assistant Professor as of September 1, 2023.
AI generated heart and brains
Research News
Frankel IHBH and M-BoCA Present: Innovative Multidisciplinary Research Pilot Award 2025
The Frankel IHBH is partnering with M-BoCA for the FY 25 Multidisciplinary Pilot Award.
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University of Michigan Medical School

North Campus Research Complex
NCRC B25-2791
Ann Arbor, MI 48105

Email: Frankel-IHBH@umich.edu