Antiphospholipid Syndrome Research Labs

Our team is working to advance the understanding of antiphospholipid syndrome and to identify new treatments that are more personalized and proactive.

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APS Research Labs
Research

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News & Achievements

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Publications

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Lectures

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People

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Antiphospholipid Syndrome Research Labs

Antiphospholipid syndrome (APS) is an unpredictable, chronic autoimmune disease that can cause dangerous clots to form in the body's blood vessels. An estimated 200,000 people in the United States have this condition that leads to serious and sometimes life-threatening complications including stroke, heart attack, and pregnancy-related problems such as miscarriage or premature birth.

Our team, along with many collaborators across Michigan Medicine, are working to advance the understanding of the disease process and identify new, sophisticated approaches to the treatment of APS that are both personalized and proactive. We are also taking what we learn about blood clotting in APS and applying that knowledge to other diseases including lupus, diabetes, and COVID-19.

Patient Inquiries

Please visit the Antiphospholipid Syndrome Program section on UofMHealth.org to learn about APS and how to make an appointment at our clinic. In this section, you will also find APS 101, a recurring feature that provides facts and key information to help patients better understand the disease.

lab leadership
Jason Knight, MD, PhD White Coat Headshot
Jason S. Knight, MD, PhD

Marvin and Betty Danto Research Professor of Connective Tissue Research
Associate Professor, Division of Rheumatology

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Google Scholar Profile
Email: [email protected]
Twitter: @jasonsknight

intmedrheumresearchknightlabzuo350x450
Yu (Ray) Zuo, MD, MSCS

Edward T. and Ellen K. Dryer Early Career Professor of Rheumatology
Assistant Professor, Division of Rheumatology

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Email: [email protected]
Twitter: @RayZuoMD


The patients in our APS clinic help to accelerate our research and are our most important partners in our fight against APS. Patients seen in our clinic are given the opportunity to be a part of our ANSWERS study, a prospective cohort study in which we regularly sample blood in pursuit of deep molecular phenotyping. Blood samples are taken to our labs, where we study the process of how antiphospholipid antibodies accelerate blood clotting. We believe this study will eventually allow us to treat patients before their first blood clot even happens.

Clinical Trials & Research Studies

Our team is involved in numerous clinical trials and research studies focused on understanding APS.

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Support Our Work

New research holds exceptional promise for finally treating APS at its source. Donor funding makes a significant, measurable difference to researchers. Read Support Our Work to learn about the impact donor generosity can have on our research.

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Join Our Email List

If you are interested in receiving updates on our patient care and research efforts, please join our APS Program email list

Read the APS Program October 2024 Update.

contact
Basic Research
Sri Yalavarthi, MS
Michigan Medicine
1150 West Medical Center Drive
5504 MSRB 1
Ann Arbor, MI 48109

Phone: 734-615-1880

Clinical Research
Cyrus Sarosh, MSA, CCRP
Michigan Medicine
1150 West Medical Center Drive
5504 MSRB 1
Ann Arbor, MI 48109

Phone: 734-647-5644