Antiphospholipid Syndrome Research Labs

Our team is working to advance the understanding of Antiphospholipid Syndrome (APS) and identifying new, personalized and proactive treatments.

Learn About Our Research

Learn more about the APS Research Lab’s work and impact.

News & Achievements

Find out the latest news in the APS Research Labs.


Explore the latest publications from our labs.


Watch lectures presented by our team members.


Get to know the team behind the APS Research Labs.

Support Our Work

Find out ways to support our research.

Antiphospholipid Syndrome Research Labs

Antiphospholipid syndrome (APS) is an unpredictable, chronic autoimmune disease that can cause dangerous clots to form in the body's blood vessels. An estimated 200,000 people in the United States have this condition that leads to serious and sometimes life-threatening complications including stroke, heart attack, and pregnancy-related problems such as miscarriage or premature birth.

Our team, along with many collaborators across Michigan Medicine, are working to advance the understanding of the disease process and identify new, sophisticated approaches to the treatment of APS that are both personalized and proactive. We are also taking what we learn about blood clotting in APS and applying that knowledge to other diseases including lupus, diabetes, and COVID-19.

Patient Inquiries

Please visit the Antiphospholipid Syndrome Program section on to learn about APS and how to make an appointment at our clinic. In this section, you will also find APS 101, a recurring feature that provides facts and key information to help patients better understand the disease.

lab leadership
Jason S. Knight, MD, PhD

Marvin and Betty Danto Research Professor of Connective Tissue Research
Associate Professor, Division of Rheumatology

Michigan Medicine Profile
Google Scholar Profile
Email: [email protected]
Twitter: @jasonsknight

Yu (Ray) Zuo, MD, MSCS

Edward T. and Ellen K. Dryer Early Career Professor of Rheumatology
Assistant Professor, Division of Rheumatology

Michigan Medicine Profile
Google Scholar Profile
Email: [email protected]
Twitter: @RayZuoMD

The patients in our APS clinic help to accelerate our research and are our most important partners in our fight against APS. Patients seen in our clinic are given the opportunity to be a part of our ANSWERS study, a prospective cohort study in which we regularly sample blood in pursuit of deep molecular phenotyping. Blood samples are taken to our labs, where we study the process of how antiphospholipid antibodies accelerate blood clotting. We believe this study will eventually allow us to treat patients before their first blood clot even happens.

Clinical Trails & Research Studies

Our team is involved in numerous clinical trials and research studies focused on understanding APS.

Learn More

Dr. Jason Knight and Dr. Yu (Ray) Zuo give a virtual tour of their labs and discuss their research work on APS and COVID-19.

Join Our Email List

If you are interested in receiving updates on our patient care and research efforts, please join our APS Program email list

Read the APS Program February 2024 Update.

Support Our Work

New research holds exceptional promise for finally treating APS at its source. Donor funding makes a significant, measurable difference to researchers. Read Support Our Work to learn about the impact donor generosity can have on our research.

Support Our Work
Basic Research
Sri Yalavarthi, MS
Michigan Medicine
1150 West Medical Center Drive
5504 MSRB 1
Ann Arbor, MI 48109

Phone: 734-615-1880

Clinical Research
Cyrus Sarosh, MSA
Michigan Medicine
1150 West Medical Center Drive
5504 MSRB 1
Ann Arbor, MI 48109

Phone: 734-647-5644