Our lab works to examine molecular mechanisms involved in the folding, trafficking, and targeting of newly-synthesized endocrine secretory proteins.
William K. and Delores S. Brehm Professor of Type 1 Diabetes Research
Professor of Internal Medicine and Molecular and Integrative Physiology
Michigan Medicine Brehm Center for Diabetes Research
Brehm Center for Diabetes Research
1000 Wall Street, 5th floor Brehm Tower
Ann Arbor, MI 48105
Campus Address: Suite 5100 Brehm Tower, SPC 5714
Peter Arvan, MD, PhD
[email protected]
Emily Fullerton, Administrative Assistant
phone: (734) 615-9497
fax: (734) 936-6684
[email protected]
Michigan Medicine Affiliations
Department of Internal Medicine Division of Metabolism, Endocrinology & Diabetes
Department of Molecular & Integrative Physiology
Our projects currently concentrate on two cell types relevant to issues of health and disease:
1) Pancreatic beta cells that store insulin in secretory granules for release to the bloodstream in response to an increase in blood glucose or other secretagogues.
2) Thyroid epithelial cells that use thyroglobulin (Tg) as a precursor for iodination in the synthesis of thyroid hormone. In these cell types, the lab is particularly interested in protein interactions that allow the secretory pathway [comprising the endoplasmic reticulum (ER), Golgi complex, secretory vesicles, as well as organelles of the endosome-lysosome-autophagosome system] to optimize production of polypeptide-derived hormones.
