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Recent Publicatons
Explore the latest publications from our lab.
- Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.
Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour SA, Satin LS, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Protein Sci. 2024 Apr;33(4):e4949. doi: 10.1002/pro.4949 - Structural features of thyroglobulin linked to protein trafficking.
Citterio CE, Kim K, Rajesh B, Pena K, Clarke OB, Arvan P. Protein Sci. 2023 Nov;32(11):e4784. doi: 10.1002/pro.4784. PMID: 37717261 - Nutrient-dependent regulation of β-cell proinsulin content.
Xu X, Arunagiri A, Alam M, Haataja L, Evans CR, Zhao I, Castro-Gutierrez R, Russ HA, Demangel C, Qi L, Tsai B, Liu M, Arvan P. J Biol Chem. 2023 Jul;299(7):104836. doi: 10.1016/j.jbc.2023.104836. Epub 2023 May 19. PMID: 37209827 - Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland.
Zhang X, Young C, Liao XH, Refetoff S, Torres M, Tomer Y, Stefan-Lifshitz M, Zhang H, Larkin D, Fang D, Qi L, Arvan P. JCI Insight. 2023 Jun 22;8(12):e169937. doi: 10.1172/jci.insight.169937. PMID: 37345654 - Integration of ER protein quality control mechanisms defines β cell function and ER architecture.
Shrestha N, Torres M, Zhang J, Lu Y, Haataja L, Reinert RB, Knupp J, Chen YJ, Parlakgul G, Arruda AP, Tsai B, Arvan P, Qi L. J Clin Invest. 2023 Jan 3;133(1):e163584. doi: 10.1172/JCI163584. PMID: 36346671 - IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of β cells.
Yang J, Zhen J, Feng W, Fan Z, Ding L, Yang X, Huang Y, Shu H, Xie J, Li X, Qiao J, Fan Y, Sun J, Li N, Liu T, Wang S, Zhang X, Arvan P, Liu M. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2204443119. doi: 10.1073/pnas.2204443119. Epub 2022 Nov 2. PMID: 36322741 - Defective Thyroglobulin: Cell Biology of Disease.
Zhang X, Young C, Morishita Y, Kim K, Kabil OO, Clarke OB, Di Jeso B, Arvan P. Int J Mol Sci. 2022 Nov 6;23(21):13605. doi: 10.3390/ijms232113605. PMID: 36362390 - Proteasomal degradation of WT proinsulin in pancreatic beta cells.
Xu X, Arunagiri A, Haataja L, Alam M, Ji S, Qi L, Tsai B, Liu M, Arvan P. J Biol Chem. 2022 Oct;298(10):102406. doi: 10.1016/j.jbc.2022.102406. Epub 2022 Aug 19. PMID: 35988641 - Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
Zhang X, Malik B, Young C, Zhang H, Larkin D, Liao XH, Refetoff S, Liu M, Arvan P. J Biol Chem. 2022 Jul;298(7):102066. doi: 10.1016/j.jbc.2022.102066. Epub 2022 May 23. PMID: 35618019 - The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum.
Xu X, Huang Y, Li X, Arvan P, Liu M. Diabetes. 2022 Mar 1;71(3):440-452. doi: 10.2337/db21-0638. PMID: 34857543