Lynn McCain

Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer.

Dr. Rohit Mehra, professor and member of the Michigan Center for Translational Pathology (MCTP), and his international team of collaborators were recently recognized by the Asian Journal of Urology for the best paper published in their journal in 2023.

Dr. Lakshmi Priya Kunju is the newly installed A. James French Professor of Anatomic Pathology.

A study from the University of Michigan Health Rogel Cancer Center furthers research that suggests the potential of developing new cancer treatments to target oncogenic transcription factors by indirectly affecting their ability to access enhancer DNA in chromatin.

There are times in many people’s lives that can be called defining moments. Moments when their lives suddenly take a turn, and the entire trajectory of their lives change. This was true for Matthew Iyer, MD, PhD, Assistant Professor of Surgery and Pathology.

With 20 subtypes of Renal Cell Carcinoma (RCC) listed by the World Health Organization in 2022, determining the specific type of RCC and the correct treatment protocol for patients can be daunting. Only seven of the 20 subtypes had been defined by specific molecular changes and the 20% of RCCs that are classified as non-clear cell RCCs (non-ccRCC), were primarily identified only by histopathologic features.

In a manuscript published this week in JAMA Oncology, senior author Dr. Arul Chinnaiyan and members of the EDRN-PCA3 Study Group reported on their development and validation of a new 18-gene urine-based test for diagnosis of high-grade prostate cancer, MPS2. This test was initially developed in the Department of Pathology.

Russell Ryan, MD, and his team’s discovery appears to address longstanding mysteries about mutations found in B-cell acute lymphoblastic leukemia