Buchakjian Lab Publications

Wenzel PA, Van Meeteren SL, Pagedar NA, Buchakjian MR.Perineural Invasion and Lymph Node Ratio Quartile Are Associated With Extranodal Extension in Oral Cavity Squamous Cell Carcinoma.J Oral Maxillofac Surg. 2025 Jun;83(6):768-775. doi: 10.1016/j.joms.2025.02.012. Epub 2025 Mar 5. PubMed PMID: 40120633.

Smith JD, Gensterblum-Miller E, Forner DWA, Yalamanchi P, Buchakjian MR, Chinn SB, Shuman AG, Casper KA, Malloy KM, Stucken CL, Mclean SA, Mierzwa ML, Shah J, Swiecicki PL, Worden FP, Prince MEP, Spector ME, Brenner JC, Heft Neal ME.Tumor Hypoxia andCD8(+) T-Cell Infiltration in Patients With Advanced Laryngeal Cancer.Otolaryngol Head Neck Surg. 2025 May 5;. doi: 10.1002/ohn.1291. [Epub ahead of print] PubMed PMID: 40323140.

Li X, Wang Z, Oakley GG, Wang L, Lanzel EA, Buchakjian MR, Peng A.Targeting Aurora A to Overcome Cisplatin Resistance in Head and Neck Cancer.J Dent Res. 2025 May;104(5):531-540. doi: 10.1177/00220345241309624. Epub 2025 Feb 27. PubMed PMID: 40017056; PubMed Central PMCID: PMC12000625.

Wenzel PA, Van Meeteren SL, Pagedar NA, Buchakjian MR.Correlation of Lymph Node Characteristics and Extranodal Extension in Oral Cavity Squamous Cell Carcinoma.OTO Open. 2024 Oct-Dec;8(4):e70032. doi: 10.1002/oto2.70032. eCollection 2024 Oct-Dec. PubMed PMID: 39430065; PubMed Central PMCID: PMC11487070.

Isaac H, Arnold MA, Pagedar NA, Buchakjian MR, Arnold KE.Is Preoperative Chemoprophylaxis Safe for Venous Thromboembolism Prevention in Patients With Head and Neck Cancer?.Otolaryngol Head Neck Surg. 2024 Oct;171(4):1097-1105. doi: 10.1002/ohn.875. Epub 2024 Jun 29. PubMed PMID: 38943444.

Prince ADP, Heft Neal ME, Buchakjian MR, Chinn SB, Stucken CL, Casper KA, Malloy KM, Prince MEP, Rosko AJ, McHugh JB, Spector ME.Pharyngeal Mucosal Margin Vessel Counts Predict Pharyngocutaneous Fistula in Salvage Laryngectomy.Otolaryngol Head Neck Surg. 2024 Sep;171(3):785-790. doi: 10.1002/ohn.865. Epub 2024 Jun 17. PubMed PMID: 38881401.

Wongpattaraworakul W, Choi A, Buchakjian MR, Lanzel EA, Kd AR, Simons AL.Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma.BMC Cancer. 2024 Jun 26;24(1):766. doi: 10.1186/s12885-024-12539-5. PubMed PMID: 38926643; PubMed Central PMCID: PMC11201865.

Witt E, Leach AJ, Bi J, Hatfield S, Cotoia AT, McGovern MK, Cafi AB, Rhodes AC, Cook AN, Uaroon S, Parajuli B, Kim J, Feig V, Scheiflinger A, Nwosu I, Jimenez M, Coleman MC, Buchakjian MR, Bosch DE, Tift MS, Traverso G, Otterbein LE, Byrne JD.Modulation of diabetic wound healing using carbon monoxide gas-entrapping materials.Device. 2024 May 17;2(5). doi: 10.1016/j.device.2024.100320. Epub 2024 Mar 12. PubMed PMID: 38911126; PubMed Central PMCID: PMC11192243.

Moore AE, Alvi SA, Tarabichi O, Zhu VL, Buchakjian MR.Role of Lymphovascular Invasion in Oral Cavity Squamous Cell Carcinoma Regional Metastasis and Prognosis.Ann Otol Rhinol Laryngol. 2024 Mar;133(3):300-306. doi: 10.1177/00034894231211116. Epub 2023 Nov 5. PubMed PMID: 37927046; PubMed Central PMCID: PMC11578272.

Ding QJ, Remy MT, Upara C, Hu J, Mora Mata AV, Haes AJ, Lanzel E, Sun H, Buchakjian MR, Hong L.CaCO(3) Nanoparticles Delivering MicroRNA-200c Suppress Oral Squamous Cell Carcinoma.J Dent Res. 2024 Feb;103(2):147-155. doi: 10.1177/00220345231216110. Epub 2023 Dec 27. PubMed PMID: 38149503; PubMed Central PMCID: PMC10915176.

Zhu VL, Rand DR, Arnold KE, Pagedar NA, Bayon R, Buchakjian MR.Association of Core Biopsy With Extranodal Extension in Surgically Treated Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma.JAMA Otolaryngol Head Neck Surg. 2023 Nov 1;149(11):955-960. doi: 10.1001/jamaoto.2023.1897. PubMed PMID: 37433026; PubMed Central PMCID: PMC10336708.

Ding QJ, Remy MT, Upara C, Hu J, Mata AVM, Haes AJ, Lanzel E, Sun H, Buchakjian MR, Hong L.CaCO (3) Nanoparticles Delivering MicroRNA-200c Suppress Oral Squamous Cell Carcinoma.bioRxiv. 2023 Oct 5;. doi: 10.1101/2023.10.05.561110. PubMed PMID: 37873146; PubMed Central PMCID: PMC10592969.

Holcomb AJ, Farrokhian N, Tolan C, Whiteford E, Villwock M, Kakarala K, Shnayder Y, Sykes K, Lominska C, Gan G, Buchakjian MR, Harding B, Dooley L, Shinn J, Burton Wood C, Rohde S, Khaja S, Abt NB, Varvares M, Bur AM.Adjuvant radiotherapy mitigates impact of perineural invasion on oncologic outcomes in early-stage oral cavity squamous cell carcinoma. A multi-institutional analysis of 557 patients.Oral Oncol. 2023 Jul;142:106420. doi: 10.1016/j.oraloncology.2023.106420. Epub 2023 May 12. PubMed PMID: 37182430; PubMed Central PMCID: PMC10575471.

Buchakjian MR.Response to Letter to the Editor: Can Red Blood Cell Distribution Width Predict Laryngectomy Complications and Survival Outcomes?.Ann Otol Rhinol Laryngol. 2023 Feb;132(2):236. doi: 10.1177/00034894221089405. Epub 2022 Mar 26. PubMed PMID: 35341347.

Al-Qurayshi Z, Zhu VL, Bayon R, Buchakjian MR.Presentation and outcomes of patients with clinically T1-2, N0 oropharynx squamous cell carcinoma: The interplay of primary treatment modality and human papillomavirus status.Head Neck. 2023 Jan;45(1):64-74. doi: 10.1002/hed.27211. Epub 2022 Oct 7. PubMed PMID: 36205359.

Marcus K, Sullivan CB, Al-Qurayshi Z, Buchakjian MR.Can Red Blood Cell Distribution Width Predict Laryngectomy Complications or Survival Outcomes?.Ann Otol Rhinol Laryngol. 2022 Oct;131(10):1102-1108. doi: 10.1177/00034894211056117. Epub 2021 Oct 29. PubMed PMID: 34715735.

Al-Qurayshi Z, Sullivan CB, Allison DB, Buchakjian MR.Presentation and outcomes of patients with clinically T1-2, N0 parotid mucoepidermoid carcinoma: The roles of elective neck dissection and adjuvant radiotherapy.Head Neck. 2022 Oct;44(10):2151-2161. doi: 10.1002/hed.27128. Epub 2022 Jun 22. PubMed PMID: 35731030; PubMed Central PMCID: PMC9544346.

Farrokhian N, Holcomb AJ, Dimon E, Karadaghy O, Ward C, Whiteford E, Tolan C, Hanly EK, Buchakjian MR, Harding B, Dooley L, Shinn J, Wood CB, Rohde S, Khaja S, Parikh A, Bulbul MG, Penn J, Goodwin S, Bur AM.Assessing Prognostic Value of Quantitative Neck Dissection Quality Measures in Patients With Clinically Node-Negative Oral Cavity Squamous Cell Carcinoma.JAMA Otolaryngol Head Neck Surg. 2022 Oct 1;148(10):947-955. doi: 10.1001/jamaoto.2022.2312. PubMed PMID: 36074415; PubMed Central PMCID: PMC9459899.

Remy MT, Ding Q, Krongbaramee T, Hu J, Mora Mata AV, Haes AJ, Amendt BA, Sun H, Buchakjian MR, Hong L.Plasmid encoding miRNA-200c delivered by CaCO(3)-based nanoparticles enhances rat alveolar bone formation.Nanomedicine (Lond). 2022 Aug;17(19):1339-1354. doi: 10.2217/nnm-2022-0151. Epub 2022 Sep 20. PubMed PMID: 36125080; PubMed Central PMCID: PMC9706369.

Wongpattaraworakul W, Gibson-Corley KN, Choi A, Buchakjian MR, Lanzel EA, Rajan Kd A, Simons AL.Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma.Front Oncol. 2022;12:885236. doi: 10.3389/fonc.2022.885236. eCollection 2022. PubMed PMID: 35957892; PubMed Central PMCID: PMC9357911.

Ngouajio A, Buchakjian M.A Rare and Unusual Cause of Tenth Cranial Nerve Palsy Leading to Dysphagia.Dysphagia. 2022 Jun;37(3):686-688. doi: 10.1007/s00455-021-10298-0. Epub 2021 Apr 3. PubMed PMID: 33811519.

Farrokhian N, Holcomb AJ, Dimon E, Karadaghy O, Ward C, Whiteford E, Tolan C, Hanly EK, Buchakjian MR, Harding B, Dooley L, Shinn J, Wood CB, Rohde SL, Khaja S, Parikh A, Bulbul MG, Penn J, Goodwin S, Bur AM.Development and Validation of Machine Learning Models for Predicting Occult Nodal Metastasis in Early-Stage Oral Cavity Squamous Cell Carcinoma.JAMA Netw Open. 2022 Apr 1;5(4):e227226. doi: 10.1001/jamanetworkopen.2022.7226. PubMed PMID: 35416990; PubMed Central PMCID: PMC9008495.

Al-Qurayshi Z, Ngouajio AL, Buchakjian MR.Presentation and outcomes of patients with clinically T1-2, N0 supraglottic squamous cell carcinoma: The role of definitive radiotherapy compared to primary partial laryngectomy.Head Neck. 2022 Mar;44(3):735-744. doi: 10.1002/hed.26966. Epub 2021 Dec 29. PubMed PMID: 34964526.

Spielbauer KK, Sunde J, Buchakjian M, Casper KA, Malloy KM, Stucken CL, Prince ME, Rosko AJ, Schechtman S, Chinn SB, Kumar SS, Spector ME.Use of rotational thromboelastometry (ROTEM®) to predict thrombotic complications of microvascular head and neck reconstruction.Oral Oncol. 2022 Jan;124:105515. doi: 10.1016/j.oraloncology.2021.105515. Epub 2021 Sep 2. PubMed PMID: 34481704.

Buchakjian MR, Ginader T, Tasche KK, Pagedar NA, Smith BJ, Sperry SM.Independent Predictors of Prognosis Based on Oral Cavity Squamous Cell Carcinoma Surgical Margins.Otolaryngol Head Neck Surg. 2018 Oct;159(4):675-682. doi: 10.1177/0194599818773070. Epub 2018 May 8. PubMed PMID: 29737907; PubMed Central PMCID: PMC6341475.

Tasche KK, Buchakjian MR, Pagedar NA, Sperry SM.Definition of "Close Margin" in Oral Cancer Surgery and Association of Margin Distance With Local Recurrence Rate.JAMA Otolaryngol Head Neck Surg. 2017 Dec 1;143(12):1166-1172. doi: 10.1001/jamaoto.2017.0548. PubMed PMID: 28445581; PubMed Central PMCID: PMC5824301.

Buchakjian MR, Davis AB, Sciegienka SJ, Pagedar NA, Sperry SM.Longitudinal Perioperative Pain Assessment in Head and Neck Cancer Surgery.Ann Otol Rhinol Laryngol. 2017 Sep;126(9):646-653. doi: 10.1177/0003489417723034. Epub 2017 Aug 3. PubMed PMID: 28770621.

Buchakjian MR, Merritt NM, Moose DL, Dupuy AJ, Tanas MR, Henry MD.A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging.PLoS One. 2017;12(8):e0183469. doi: 10.1371/journal.pone.0183469. eCollection 2017. PubMed PMID: 28841687; PubMed Central PMCID: PMC5571905.

Buchakjian MR, Tasche KK, Robinson RA, Pagedar NA, Sperry SM.Association of Main Specimen and Tumor Bed Margin Status With Local Recurrence and Survival in Oral Cancer Surgery.JAMA Otolaryngol Head Neck Surg. 2016 Dec 1;142(12):1191-1198. doi 10.1001/jamaoto.2016.2329. PubMed PMID: 27423460.

Buchakjian MR, Kornbluth S.The engine driving the ship: metabolic steering of cell proliferation and death.Nat Rev Mol Cell Biol. 2010 Oct;11(10):715-27. doi: 10.1038/nrm2972. Review. PubMed PMID: 20861880.

Andersen JL, Johnson CE, Freel CD, Parrish AB, Day JL, Buchakjian MR, Nutt LK, Thompson JW, Moseley MA, Kornbluth S.Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.EMBO J. 2009 Oct 21;28(20):3216-27. doi: 10.1038/emboj.2009.253. Epub 2009 Sep 3. PubMed PMID: 19730412; PubMed Central PMCID: PMC2771089.

Nutt LK, Buchakjian MR, Gan E, Darbandi R, Yoon SY, Wu JQ, Miyamoto YJ, Gibbons JA, Andersen JL, Freel CD, Tang W, He C, Kurokawa M, Wang Y, Margolis SS, Fissore RA, Kornbluth S.Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.Dev Cell. 2009 Jun;16(6):856-66. doi: 10.1016/j.devcel.2009.04.005. PubMed PMID: 19531356; PubMed Central PMCID: PMC2698816.

Joseph SM, Buchakjian MR, Dubyak GR.Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes.J Biol Chem. 2003 Jun 27;278(26):23331-42. doi: 10.1074/jbc.M302680200. Epub 2003 Apr 8. PubMed PMID: 12684505.