Xinjun Zhang

ZHANG_Jun4x5.jpg
Assistant Professor of Human Genetics, Medical School
Assistant Professor of Ecology and Evolutionary Biology, College of Literature, Science, and the Arts
[email protected]
Available to mentor
Xinjun Zhang
ZHANG_Jun4x5.jpg
Assistant Professor
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  • About

    In the Zhang lab, we synthesize evolutionary, genomic, and computational approaches to study a fundamental question in population genetics, which is, how have evolutionary processes such as admixture and natural selection shaped human genetic diversity and health?

    Our research is currently funded by NIH/NIGMS (R35). Ongoing projects include:
    1) Inferring a comprehensive genomic atlas of archaic introgression in modern humans;
    2) Modeling dynamic admixture and natural selection processes using Drosophila and nonhuman primates;
    3) Inferring non-additive selective effects on the human genome for accurate estimation of complex trait phenotypes;
    4) Studying the impact of recent admixture on the genetic architecture of complex traits in modern human populations.

    Center Memberships

    • Center Member
      Center for Computational Medicine and Bioinformatics

    Recent Publications

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    • Journal Article
      Parameter Scaling in Population Genetics Simulations may Introduce Unintended Background Selection: Considerations for Scaled Simulation Design
      Ferrari T, Feng S, Zhang X, Mooney J. Genome Biology and Evolution, 2025 Jun 1; 17 (6): DOI:10.1093/gbe/evaf097
      PMID: 40405504
    • Preprint
      Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations.
      Zhang X, Yang J, Zhu L, Sachdev N, Mooney J, Sankararaman S, Lohmueller KE. 2025 May 7; DOI:10.1101/2025.05.07.652751
      PMID: 40654668
    • Journal Article
      Determining the driving factors shaping genetic architecture of complex traits in recently admixed populations
      Kim M, Durvasula A, Zhang X. bioRxiv, 2026 Jan 5; 2025.12.15.694350 DOI:10.64898/2025.12.15.694350
    • Journal Article
      Ethics and Best Practices of Studying Contemporary Human Populations
      Adegboyega M, Zhang X. Human Biology, 2023 Mar 1; 94 (2): 89 - 92. DOI:10.1353/hub.2023.a933266
    • Journal Article
      MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations
      Zhang X, Kim B, Singh A, Sankararaman S, Durvasula A, Lohmueller KE. Molecular Biology and Evolution, 2023 Jan 1; 40 (1): DOI:10.1093/molbev/msad001
      PMID: 36617238
    • Journal Article
      Denisovans and Homo sapiens on the Tibetan Plateau: dispersals and adaptations
      Zhang P, Zhang X, Zhang X, Gao X, Huerta-Sanchez E, Zwyns N. Trends in Ecology and Evolution, 2022 Mar 1; 37 (3): 257 - 267. DOI:10.1016/j.tree.2021.11.004
      PMID: 34863581
    • Journal Article
      Apportioning archaic variants among modern populations
      Witt KE, Villanea F, Loughran E, Zhang X, Huerta-Sanchez E. Philosophical Transactions of the Royal Society B Biological Sciences, 2022 Jan 1; 377 (1852): DOI:10.1098/rstb.2020.0411
      PMID: 35430882
    • Journal Article
      A signature of Neanderthal introgression on molecular mechanisms of environmental responses
      Findley AS, Zhang X, Boye C, Lin YL, Kalita CA, Barreiro L, Lohmueller KE, Pique-Regi R, Luca F. Plos Genetics, 2021 Sep 27; 17 (9): DOI:10.1371/JOURNAL.PGEN.1009493
      PMID: 34570765