Viji Nair
Nephrology
W Medical Center Drive Ann Arbor MI 48109-5948
Ann Arbor, Michigan 48109
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About
Dr. Nair has more than 17 years of experience in bioinformatics and computational biology research in nephrology. Her research focuses on translational science, integrating multi-omic data from patients with various kidney disease etiologies. The goal is to identify key therapeutic targets for disease initiation and progression. Her approaches range from classic mathematical models to more complex AI/ML algorithms. These are used to integrate transcriptomic and proteomics profiles with clinical and structural endophenotypes, identifying biomarkers that predict disease progression and facilitate patient stratification. Dr. Nair's domain knowledge and expertise plays an integral role in identifying gene signatures that predict disease progression, linking these to non-invasive biomarkers, and interpreting their relevance to the underlying pathophysiology of the mechanisms under study. She has extensive experience in combining animal models with patient population data, which serves as critical validation tools in the preclinical space. She is also leading the bioinformatic/computational efforts in several of our academic and industry collaborative projects nationally and internationally.
Links
linkedin
Center Memberships
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberAI and Digital Health Innovation
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Center MemberData Analysts and Statisticians Cohort
Research Overview
Translational Science, bioinformatics and computational biology, Data Integration
Application of Bioinformatic/Computational Methods to Identify and Characterize Regulatory Mechanism Linked to Diabetic Kidney Disease /Chronic Kidney Disease
Precision Medicine in Kidney Diseases using Translational Research.
Patient Stratification and Risk modelling
Non-Invasive Biomarker and Target Discovery using Bioinformatic/Statistical/Machine learning approaches.
Recent Publications
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Melo Ferreira R, Gisch DL, Phillips CL, Cheng YH, Lucarelli N, Yennapureddy S, Asthana M, Lake BB, Bowen WS, Fang F, Asghari M, Sabo A, Barwinska D, Ferkowicz MJ, Toto RD, Sedor JR, Rosas SE, Bjornstad P, Hodgin JB, Alpers CE, Sarder P, Himmelfarb J, Schaub JA, Nair V, Winfree S, Sutton TA, Kelly KJ, Kretzler M, Jain S, El-Achkar TM, Dagher PC, Eadon MT. Kidney International, 2026 Jul 1; 110 (1): 227 - 244.Journal ArticleA MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease
DOI:10.1016/j.kint.2026.03.020 PMID: 42055320 -
Sandholm N, Cole JB, Nair V, Brennan E, Giardini E, Haukka JK, Ha E, Syreeni A, Dahlström EH, Salem RM, Fermin D, Mercader J, Smyth L, Hill C, Mychaleckyj J, McGurnaghan S, Miller RG, Costacou T, Snell-Bergeon J, Paterson AD, Verkauskiene R, Sokolovska J, Panduru NM, Zerbini G, Brismar K, Krolewski AS, Harjutsalo V, Rossing P, Hadjadj S, McKay G, McKnight AJ, Maxwell AP, Susztak K, Godson C, Kretzler M, Hirschhorn JN, Florez JC, Groop PH. Kidney International Reports, 2026 Jul 1; 11 (7):Journal ArticleResponse to the Letter to the Editor Entitled “A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics”
DOI:10.1016/j.ekir.2026.106572 -
Nair V, Minakawa A, Smith C, Berthier CC, Hartman J, Menon R, Fermin D, Otto EA, Gisch DL, Eadon MT, Jain S, Choi YJ, Pyle L, Eichinger F, Alakwaa FM, Rose MP, Subramanian L, El Saghir J, Beamish JA, Hodgin JB, Brosius FC, Bjornstad P, Nelson PJ, Harder JL, Werner T, Kretzler M, Schaub JA. Signal Transduction and Targeted Therapy, 2026 Apr 21; 11 (1):Journal ArticleHypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition
DOI:10.1038/s41392-026-02653-0 PMID: 42009641 -
Moedt E, Koshino A, Jongs N, Ju W, Nair V, Kretzler M, Hansen MK, Arnott CG, Wheeler DC, Rossing P, Coca SG, Hammarstedt A, Greasley PJ, Bjornstad P, Bakker SJL, Heerspink HJL. J Am Soc Nephrol, 2026 Apr 2;Journal ArticleAssociation of Urinary Epidermal Growth Factor with Kidney Outcomes and Effects of Sodium-Glucose Cotransporter 2 Inhibition.
DOI:10.1681/ASN.0000001086 PMID: 41926219 -
Ju W, Strömstedt M, Huang Y, Johansson A, Löfgren L, Rosengren B, Nair V, Eddy S, O'Connor C, Chaki S, Bitzer M, Reznichenko A, Hansen PB, Fjellström O, Kretzler M. Kidney International Reports, 2026 Mar 26; 11 (4): 104423Proceeding / Abstract / PosterWCN26-2200 INHIBITION OF NNMT, A KIDNEY FAILURE-ASSOCIATED GENE INDENTIFIED BY TRANSCRIPTOMIC ANALYSIS, BLOCKS PROGRESSION OF DKD IN MICE
DOI:10.1016/j.ekir.2026.104423 -
Nair V, Hodgin J, Fermin D, Lee E, Chaki S, Gong A, Barisoni L, Kretzler M, Ju W. Kidney International Reports, 2026 Mar 26; 11 (4): 104446Proceeding / Abstract / PosterWCN26-3669 AN INTEGRATIVE APPROACH IDENTIFIES A URINARY BIOMARKER PANEL FOR PREDICTING INTERSTITIAL FIBROSIS IN PATIENTS WITH GLOMERULAR DISEASE
DOI:10.1016/j.ekir.2026.104446 -
Moedt E, Ju W, Nair V, Bjornstad P, Kretzler M, Heerspink HJL. Nephrol Dial Transplant, 2026 Mar 24;Journal ArticleNovel protein biomarkers for risk stratification and personalized medicine.
DOI:10.1093/ndt/gfag068 PMID: 41874429 -
Ju W, Nair V, Vart P, Smeijer JD, Hudkins KL, Moedt E, Larkina M, Perco P, Burdet F, Shedden K, Hwang M, Lee E, O'Connor C, Hartman J, Subramanian L, Bitzer M, Ibberson M, Duffin KL, Gomez MF, Alpers CE, Kretzler M, Heerspink HJL. Nat Commun, 2026 Feb 7;Journal ArticleUrinary clusterin as a biomarker of human kidney disease progression and response to the endothelin receptor antagonist atrasentan: An exploratory analysis from the SONAR trial.
DOI:10.1038/s41467-026-68973-5 PMID: 41654492