Available to mentor
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FellowshipMedical College of Wisconsin, Neuroproteomics of Alzheimer's, Kern Innovation Fellow, 2012
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FellowshipUniversity of Wisconsin–Milwaukee, Psychology, Cognitive Aging, 2009
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PhDNorthwestern University - Institue for Neuroscience, Evanston, IL, 2006
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BAUniversity of Wisconsin–Milwaukee, Milwaukee, WI, 2000
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N/AFront Range Community College, Westminster, CO, 1997
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberPrecision Health Initiative
My laboratory pioneers techniques to identify and validate genetic and cellular mechanisms that promote resilience to cognitive aging, Alzheimer's disease, and other age-related dementias. By combining mouse and human systems; genomic, anatomic, and behavioral approaches; and integrative analyses across multiple scales, data types, environmental factors, and species, we are accelerating discovery of the precise genetic mechanisms of cognitive resilience that could yield the next generation of targets and therapeutic strategies for promoting brain health. We are now uniquely poised to propel the field of personalized medicine forward using our genetically diverse, yet reproducible models of human neurodegenerative dementias, having already contributed conceptual and technical advances that revolutionized our ability to study complex diseases, specifically human AD dementia.
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Hurst CD, Dunn AR, Dammer EB, Duong DM, Seyfried NT, Kaczorowski CC, Johnson ECB. 2023 Jun 13;PreprintGenetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome.
DOI:10.1101/2023.06.12.544646 PMID: 37398142 -
Wells AE, Wilson JJ, Sears JD, Wei J, Heuer S, Pandey R, Costa MW, Kaczorowski CC, Roopenian DC, Chang C-H, Carter GW. bioRxiv, 2023 May 12;Journal ArticleTranscriptome Analysis Reveals Organ-Specific Effects of 2-Deoxyglucose Treatment in Healthy Mice.
DOI:10.1101/2023.04.24.537717 PMID: 37162857 -
Johnson GA, Tian Y, Ashbrook DG, Cofer GP, Cook JJ, Gee JC, Hall A, Hornburg K, Kaczorowski CC, Qi Y, Yeh F-C, Wang N, White LE, Williams RW. Proc Natl Acad Sci U S A, 2023 Apr 25; 120 (17): e2218617120Journal ArticleMerged magnetic resonance and light sheet microscopy of the whole mouse brain.
DOI:10.1073/pnas.2218617120 PMID: 37068254 -
Kaczorowski C. 2023 Mar 30;PresentationSystems Genetics Analysis of Alzheimer's Disease-Related Sleep Loss and the Transition to Dementia
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Kaczorowski C. 2023 Mar 24;PresentationCognitive resilience in AD: Modeling cell-cell interactions between hippocampal excitatory neurons microglia subtypes
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Korgan AC, Oliveira-Abreu K, Wei W, Martin SLA, Bridges ZJD, Leal-Cardoso JH, Kaczorowski CC, O'Connell KMS. Int J Obes (Lond), 2023 Mar; 47 (3): 224 - 235.Journal ArticleHigh sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight.
DOI:10.1038/s41366-023-01265-w PMID: 36725979 -
Gurdon B, Yates SC, Csucs G, Groeneboom NE, Hadad N, Telpoukhovskaia M, Ouellette A, Ouellette T, O'Connell K, Singh S, Murdy T, Merchant E, Bjerke I, Kleven H, Schlegel U, Leergaard TB, Puchades MA, Bjaalie JG, Kaczorowski CC. bioRxiv, 2023 Feb 28;Journal ArticleDetecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model.
DOI:10.1101/2023.02.27.530226 PMID: 36909528 -
Kaczorowski C. 2022 Nov 25;PresentationDeconstructing Alzheimer's disease complexity to identify resilience mechanisms
