Malini Raghavan, PhD

 Malini Raghavan
Nancy Walls Research Professor of Microbiology and Immunology
Professor of Microbiology and Immunology, Medical School
University of Michigan Medical School
Department of Microbiology and Immunology
5724A Medical Science Building II
Ann Arbor, Michigan 48109
[email protected]
Available to mentor
Malini Raghavan, PhD
Malini Raghavan
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications

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    • Qualifications
    • Postdoctoral Fellowship
      California Institute of Technology, Pasadena, United States
      1991 - 1996
    • PhD
      Princeton University, Princeton, New Jersey, United States
      1985 - 1991
    • MS
      Indian Institute of Technology, Kanpur, India
      1983 - 1985
    • BSc
      Women's Christian College, Madras, India
      1980 - 1983

    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Global REACH
    • Center Member
      Center for Global Health Equity

    Research Overview

    Human Leukocyte Antigen (HLA) class I Polymorphisms & their Influences on Immunity
    Cell Transformation and Immunity in Myleoproliferative Neoplasms

    Links
    • Raghavan Lab

    Recent Publications

     See All Publications
    • Preprint
      Molecular and Functional Analysis of Calcium Binding by a Cancer-linked Calreticulin Mutant
      Tagoe INA, Kaur A, Quaye O, Tagoe EA, Koropatkin N, Satin LS, Raghavan M. 2026 Jan 27; eLife Sciences Publications, Ltd, DOI:10.7554/elife.109647
    • Preprint
      Molecular and Functional Analysis of Calcium Binding by a Cancer-linked Calreticulin Mutant.
      Tagoe INA, Kaur A, Quaye O, Tagoe EA, Koropatkin N, Satin LS, Raghavan M. 2025 Nov 5; DOI:10.1101/2025.06.25.661618
      PMID: 40667107
    • Journal Article
      Effects of calreticulin mutations on HLA class I expression in myeloproliferative neoplasms 3478
      Kaur A, Pagnucco G, Desikan H, Kandarpa M, Talpaz M, Raghavan M. The Journal of Immunology, 2025 Nov 23; 214 (Supplement_1): DOI:10.1093/jimmun/vkaf283.1278
    • Journal Article
      Misfolded HLA class I accumulation in the endoplasmic reticulum induces the cell surface expression of high mannose glycoforms via a Golgi-mediated secretory route 3608
      Owoicho O, Quaye O, Raghavan M. The Journal of Immunology, 2025 Nov 23; 214 (Supplement_1): DOI:10.1093/jimmun/vkaf283.1388
    • Journal Article
      Functional Diversifications of HLA Class I Molecules Through Assembly Variations
      Brener M, Raghavan M. ASHI Quarterly, 2026 Jan 31; Third Quarter (49): 14 - 17.
    • Preprint
      Effects of Calreticulin Mutations on HLA Class I Expression in Myeloproliferative Neoplasms.
      Kaur A, Desikan H, Pagnucco G, Kandarpa M, Talpaz M, Raghavan M. 2025 Jun 27; DOI:10.1101/2025.06.24.661416
      PMID: 40667261
    • Journal Article
      Class II HLA-DRB4 is a predictive biomarker for survival following immunotherapy in metastatic non-small cell lung cancer
      Jiang CY, Zhao L, Green MD, Ravishankar S, Towlerton AMH, Scott AJ, Raghavan M, Cusick MF, Warren EH, Ramnath N. Scientific Reports, 2024 Dec 1; 14 (1): DOI:10.1038/s41598-023-48546-y
      PMID: 38172168
    • Journal Article
      Lysosomal degradation targets mutant calreticulin and the thrombopoietin receptor in myeloproliferative neoplasms
      Kaur A, Venkatesan A, Kandarpa M, Talpaz M, Raghavan M. Blood Advances, 2024 Jul 9; 8 (13): 3372 - 3387. DOI:10.1182/bloodadvances.2023011432
      PMID: 38640435

    Featured News & Stories
    Department News

    Congratulations to Our Immunology T32 Awardees!

    Our learners have been selected for support through the prestigious Immunology T32 Training Grant for the 2025–2026 academic year.
         Microscopic view of lung cells: The lungs are patrolled by specialized adaptive immune cells called CD4+ T cells that constantly interact with distinct lung epithelial cells to ensure our lungs are protected from pathogens.
    Department News

    What do we do in M&I? "Adaptive Immunology"

    In M&I, we study adaptive immunology, also known as acquired immunology. The adaptive system is highly specific in that it distinguishes between different agents, recognizes a previously encountered agent, and adapts its response accordingly. When that agent is a pathogen, the adaptive response can help to clear that infection. A key feature of adaptive immunity is the development of immunological memory. This is the biology behind vaccines.
         Nicole wearing a lab coat standing in a laboratory
    Points of Blue

    Nicole Jerome, PhD candidate: Evolving from patient to cutting-edge cancer biologist

    Nicole Jerome is a PhD Candidate in Cancer Biology.
         Malini Raghavan, Ph.D., and members of her laboratory
    Medical School News

    Medical School faculty embrace honor, history and future tied to named professorships

    There are many intriguing aspects to the honor of a faculty member holding a named professorship in the University of Michigan Medical School: the excitement of receiving one of the highest honors the U-M can bestow on a faculty member; an understanding of the rich history of the person(s) for whom their professorship is named; and the flexibility of what the professorship allows the holders to do during their career. On April 1, the Medical School hosted a celebration of faculty who were appointed to named professorships in 2023.
    Department News

    Dr. Malini Raghavan named the Nancy Williams Walls Research Professor

    Dr. Malini Raghavan named the Nancy Williams Walls Research Professor