Charles Francis Burant, MD, PhD
Internal Medicine
6309 Brehm Tower 1000 Wall St.
Ann Arbor, MI 48109
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About
Charles Burant is professor of Internal Medicine, Section of Metabolism, Endocrinology, and Diabetes. He holds the Robert C. and Veronica Atkins Professor of Metabolism endowed chair. His clinical interests are in the care of patients with obesity, type 2 diabetes, and related conditions. Burant is the Director of the Taubman Institute, leading its mission to support the careers of clinicians who are performing research as a primary focus of their academic activities as well as supporting a diverse number of muli-investigator translational research programs. He is the founding director of Director of the Michigan Metabolomics Core which provides the research community with access to cutting edge technology and informatics support to integrate metabolite profiling into their research program.
Qualifications
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EndocrinologyUniversity of Chicago, Chicago, United States
1989 - 1991
Clinical Fellowship
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Internal MedicineUniversity of California, San Francisco, San Francisco, United States
1987 - 1989
Residency
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PhDMedical University of South Carolina, Charleston, South Carolina, United States
1981 - 1987
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MDMedical University of South Carolina, Charleston, South Carolina, United States
1981 - 1987
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MSUniversity of Wisconsin, Madison, Wisconsin, United States
1979 - 1981
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BSUniversity of Wisconsin, Madison, Wisconsin, United States
1975 - 1979
Center Memberships
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberTaubman Institute
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberCaswell Diabetes Institute
Research Overview
Burant's personal research program centers on the interaction between genetically driven traits such as intrinsic oxidative capacity and environmental factors such as nutrients and exercise, in the development and treatment of insulin resistance, obesity and β-cell failure in both man and in animal models. Burant has a specific interest in intermediary metabolism and his laboratory combines genetics, epigenetics, metabolomics, and transcriptomics to understand the causes and phenotypic manifestation of cardiometabolic disease.
Recent Publications
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Smith GR, Zhao B, Lindholm ME, Raja A, Viggars M, Pincas H, Gay NR, Sun Y, Vangeti S, Ge Y, Nair VD, Sanford JA, Amper MAS, Vasoya M, Smith KS, Ramos I, Montgomery SB, Zaslavsky E, Bodine SC, Esser KA, Walsh MJ, Snyder MP, Sealfon SC, Zhen J, Zhang T, Zebarjadi N, Zaslavsky E, Zang C, Yu X, Yan Z, Xia A, Wu S, Williams JP, Wheeler MT, Walsh MJ, Walkup MP, Vornholt A, Volpi E, Vetr NG, Uppal K, Trappe TA, Trappe S, Tracy R, Tibshirani R, Thyfault J, Thalacker-Mercer A, Teng C, Stowe CL, Steep A, Sparks LM, Oliveira De Sousa LG, Soni T, Seenarine N, Schwartz RS, Schenk S, Schauer IE, Savage EM, Samdarshi M, Sagendorf TJ, Rushing S, Ruf-Zamojski F, Rubenstein AB, Rooney JL, Robbins JM, Rirak S, Richards CZT, Rejeski WJ, Rector RS, Ravussin E, Rasmussen BB, Raskind AS, Rankinen T, Ramaker ME, Ramachandran K, Raja AN, Radom-Aizik S, Qian WJ, Presby DM, Powers S, Piehowski PD, Petyuk VA, Pearce C, Pahor M, Ortlund EA, Nudelman G, Nigro P, Nicklas B, Nestor MD, Nair KS, Nair VD, Nachun D, Musi N, Mundorff CC, Moreau KL, Moore RJ, Moore SG, Montgomery SB, Monroe ME. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleMulti-omic identification of key transcriptional regulatory programs during endurance exercise training in rats
DOI:10.1038/s41467-026-70397-0 PMID: 41862462 -
Kelty TJ, Franczak E, Gay NR, Many GM, Sagendorf TJ, Sanford JA, Hou Z, Gaul DA, Fernández FM, Rekowski M, Burant CF, Hevener AL, Adkins JN, Bodine S, Lindholm ME, Ortlund EA, Schenk S, Thyfault JP, Rector RS, Albertson BG, Amper MAS, Asef C, Babcock M, Bae D, Bamman MM, Bergman BC, Bessesen DH, Buford TW, Carr S, Chen CY, Clayton ZS, Cutter GR, Ge Y, Goodyear LJ, Guevara K, Gulbin X, Hirshman MF, Jankowski CM, Jean Beltran PM, Keshishian H, Kohrt WM, Lessard SJ, Lester B, Lira AK, Makarewicz NS, Maner-Smith KM, Marjanovic N, Melanson EL, Miller ME, Moore SG, Moreau KL, Mundorff CC, Nair VD, Nudelman G, Okwara NL, Piehowski PD, Qian WJ, Rasmussen BB, Rirak S, Schauer IE, Seenarine N, Stowe CL, Sun Y, Trappe S, Trappe TA, Vasoya M, Vornholt A, Walkup MP, Xia A, Yu X. Cell Reports, 2026 Jun 23; 45 (6):Journal ArticleEndurance exercise elicits temporal and sexual dimorphic multi-omics remodeling of liver metabolism revealed by MoTrPAC
DOI:10.1016/j.celrep.2026.117416 -
Burant C, Weitzel AM, Orchard P, Evans C, Li J, Parker S. Journal of Biological Chemistry, 2026 May 22; 302 (5): 112409Journal ArticleAbstract 3915 Selection for epigenomic domains regulating skeletal muscle mitochondrial gene expression and angiogenesis underlies enhanced fatty acid metabolism in a model of cardiorespiratory fitness
DOI:10.1016/j.jbc.2026.112409 -
Peng R, Liu L, Chu X, Xia Z, Fu Q, Silva LF, Ji X, Hu X, Liang Y, Li J, Ryan B, Bose D, Stringham HM, Morrison J, Wen X, Scott LJ, Burant CF, Fauman E, Yang T, Boehnke M, Laakso M, Yin X. Diabetologia, 2026 Mar 18;Journal ArticlePlasma metabolite association profiles for type 2 diabetes genetic clusters in Finnish men.
DOI:10.1007/s00125-026-06710-9 PMID: 41848902 -
Keshishian H, Many GM, Smith G, Clark NM, Iyer G, Hart P, Lindholm ME, Montalvo S, Zhang Z, Jin C, Sanford JA, Carr SA, Adkins JN, Mani DR, Bodine SC, Trappe S, Houmard JA, Musi N, Huffman KM, Kraus WE, Sparks LM, Thalacker-Mercer AE, Sealfon SC, Xia AY, Katz DH, Newgard CB, Burant CF, Coen PM, Goodpaster BH. 2026 Mar 10; openRxiv,PreprintIntegrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)
DOI:10.64898/2026.03.04.705181 -
Robbins JM, Katz DH, Many G, Rao P, Smith GR, Tiwari G, Spielmann G, Montalvo S, Iyer G, Amar D, Leach DT, Coyne BJ, Lindholm ME, Goodpaster BH, Walsh MJ, Clish CB, Burant CF, Gerszten RE. 2026 Mar 5; openRxiv,PreprintBlood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)
DOI:10.64898/2026.03.02.704798 -
Zhang Z, Nudelman G, Pincas H, Iyer G, Smith GR, Keshishian H, Jin CA, Trappe S, Katz DH, Burant CF, Nair VD, Zaslavsky E, Sealfon SC. 2026 Mar 5; openRxiv,PreprintExercise modulation of the alternative splicing landscape in human tissues
DOI:10.64898/2026.03.03.704460 -
Katz DH, Jin CA, Many GM, Smith GR, Keshishian H, Clark NM, Iyer G, Ahn C, Lindholm ME, Sagendorf TJ, Amar D, Barber JL, Brandt AR, Coen PM, Ge Y, Hart P, Hsu F-C, Jaeger BC, Jimenez-Morales D, Leach DT, Mani DR, Montalvo S, Pincas H, Rao P, Sanford JA, Smith KS, Vetr NG, Adkins JN, Ashley EA, Carr SA, Miller ME, Montgomery SB, Nair VD, Robbins JM, Snyder MP, Sparks LM, Tracy R, Walsh MJ, Wheeler MT, Xia AY, Burant CF, Goodpaster BH, Sealfon SC, Gerszten RE, Trappe S. 2026 Mar 13; bioRxiv,PreprintMulti-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium
DOI:10.64898/2026.02.27.702183
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