Malcolm J Low
Professor Emeritus of Molecular and Integrative Physiology
Professor Emeritus of Internal Medicine, Medical School
University of Michigan Medical School, Ann Arbor (UMMS)
Molecular & Integrative Physiology
2800 Plymouth Rd., North Campus Research Complex, Bldg 25, 25-3680
Ann Arbor, MI 48109
[email protected]
Molecular & Integrative Physiology
2800 Plymouth Rd., North Campus Research Complex, Bldg 25, 25-3680
Ann Arbor, MI 48109
Available to mentor
Malcolm J Low
Center Member
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About
Expert in the development and analysis of genetically engineered mutant mice and the hypothalamic regulation of pituitary function and metabolism.
Links
https://medicine.umich.edu/dept/molecular-integrative-physiology/malcolm-j-low-md-phd
Qualifications
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Fellow in NeuroendocrinologyTufts Medical Center, Endocrinology, Boston, United States
1982 - 1985
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Intern and Resident in Internal MedicineMichael Reese Hospital, University of Chicago, Internal Medicine, United States
1979 - 1982
Residency
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MDAlbany Medical College, Albany, United States
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PhDTufts Medical Center, Boston, United States
Center Memberships
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Center MemberCaswell Diabetes Institute
Research Overview
Neuroendocrinology, hypothalamic control of metabolism, hypothalamic and pituitary development, limbic dopamine systems, opioid peptide systems
Recent Publications
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Yu H, Chiang A, Rubinstein M, Low MJ. Mol Metab, 2024 Sep; 87: 101993Journal ArticleThe homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice.
DOI:10.1016/j.molmet.2024.101993 PMID: PMC11327434 -
Rojo D, Hael CE, Soria A, de Souza FSJ, Low MJ, Franchini LF, Rubinstein M. Proc Natl Acad Sci U S A, 2024 Apr 30; 121 (18): e2322692121Journal ArticleA mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight.
DOI:10.1073/pnas.2322692121 PMID: PMC11067048 -
Eliason NL, Martin L, Low MJ, Sharpe AL. Neuropeptides, 2022 Dec; 96: 102289Journal ArticleMelanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.
DOI:10.1016/j.npep.2022.102289 PMID: PMC10152796 -
Eliason N, Martin L, Low M, Sharpe A. 2022 Apr 15; bioRxiv,PreprintMelanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food
DOI:10.1101/2022.04.13.488209 -
Shakya M, Gahlot S, Martin NK, Arunagiri A, Martin MG, Arvan P, Low MJ, Lindberg I. Endocrinology, 2022 Mar 4; 163 (5):Journal ArticleThe G209R mutant mouse as a model for human PCSK1 polyendocrinopathy.
DOI:10.1210/endocr/bqac024 PMID: PMC9044177 -
Yu H, Rubinstein M, Low MJ. Elife, 2022 Jan 19; 11:Journal ArticleDevelopmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes.
DOI:10.7554/eLife.72883 PMID: PMC8806186 -
Surbhi , Wittmann G, Low MJ, Lechan RM. Mol Metab, 2021 Nov; 53: 101312Journal ArticleAdult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency.
DOI:10.1016/j.molmet.2021.101312 PMID: PMC8383116 -
Gupta A, Gullapalli S, Pan H, Ramos-Ortolaza DL, Hayward MD, Low MJ, Pintar JE, Devi LA, Gomes I. Cell Mol Neurobiol, 2021 Jul; 41 (5): 1103 - 1118.Journal ArticleRegulation of Opioid Receptors by Their Endogenous Opioid Peptides.
DOI:10.1007/s10571-020-01015-w PMID: PMC8277103
