Nicolaas Bohnen, MD
Radiology
24 Frank Lloyd Wright Dr., Lobby B, Rm 100
Ann Arbor, Michigan 48105
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About
Dr. Bohnen is professor of Radiology and Neurology at the University of Michigan. He attended medical school in the Netherlands and completed a PhD in neuropsychology. He completed residency training in neurology (Mayo Clinic, Rochester, MN) and nuclear medicine (University of Michigan, Ann Arbor, MI). He was a fellow in movement disorders at the University of Michigan Medical Center. He holds clinical appointments in the Departments of Radiology (Division of Nuclear Medicine), Neurology at the University of Michigan, and the Ann Arbor VA (movement and cognitive disorders clinic). Dr. Bohnen’s research interests include the use of PET and MRI in the study of neurodegenerative disorders and normal aging. He is the director of the UM Functional Neuroimaging, Cognitive and Mobility Laboratory where his clinical research has a focus on neurobiological correlates of cognition, vestibular and multisensory processing during gait and postural control, olfaction and mobility in normal aging and in Parkinson disease.
Links
Functional Neuroimaging, Cognitive and Mobility Laboratory (FNICOMO Lab)
Qualifications
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ResidencyUniversity of Michigan Health, Nuclear Medicine, United States
1996 - 1998
Residency
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ResidencyMayo Clinic, Neurology, United States
1992 - 1996
Residency
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EpidemiologyMayo Clinic, Rochester, United States
1991 - 1992
Postdoctoral Fellowship
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PhDUniversity of Limburg, Maastricht, Maastricht, Netherlands
1987 - 1991
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MDRabdoud University Nijmegen Medical Centre, Nijmegen, Netherlands
1979 - 1987
Center Memberships
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Center MemberFrankel Institute for Heart and Brain Health
Research Overview
The Functional Neuroimaging, Cognitive, and Mobility (FNiCoMo) Laboratory is part of the Departments of Radiology and Neurology at the University of Michigan. The mission of this lab is to gain a better understanding of how the architecture of the brain and functional processes in the brain (obtained with functional neuroimaging) determine cognitive functioning and mobility both in patients with neurodegenerative diseases (such as Parkinson's Disease) and in normal aging.
Recent Publications
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Carli G, Brown T, Michalakis F, Biddix A, Roytman S, Vangel R, Van Hout A, Kanel P, Scott P, Albin RL, Bohnen NI. Brain, 2026 May 12;Journal ArticleWhite matter lesions disrupt cholinergic pathways important for cognition in Parkinson's disease.
DOI:10.1093/brain/awag172 PMID: 42117428 -
Rosano C, Bohnen NI, Lopresti B, Chahine LM, Barnes HN, Studenski SL, Glynn NW, Newman AB, Marcinek DJ, Hepple RT, Coen PM. Journals of Gerontology Series A Biological Sciences and Medical Sciences, 2026 Apr 1; 81 (4):Journal ArticleStriatal dopamine and skeletal muscle energy metabolism in older adults
DOI:10.1093/gerona/glag039 PMID: 41691472 -
Craig C, Kanel P, Ray N, Bohnen N. European Journal of Neuroscience, 2026 Mar 1; 63 (6):Journal ArticleAsymmetric Cholinergic Basal Forebrain Atrophy Marks Freezing of Gait in Parkinson's Disease
DOI:10.1111/ejn.70467 PMID: 41866810 -
Kanel P, Carli G, Roytman S, van der Zee S, Vangel R, Barr J, Brown T, Spears CC, Narkis A, Slingerland S, Meles S, van Laar T, Scott PJH, Albin RL, Bohnen NI. 2026 Feb 4;PreprintCholinergic substrates of gait and postural impairments in Progressive Supranuclear Palsy.
DOI:10.21203/rs.3.rs-8778777/v1 PMID: 41674844 -
Song Y, Rosano C, Chahine LM, Rosso AL, Ambrosio F, Bohnen N, Kim S. 2026 Jan 25; medRxiv,PreprintA Bayesian Network Analysis of Gait Speed Change Upon Transition to Uneven Surfaces in Older Adults
DOI:10.64898/2026.01.22.26344627 -
Brown T, Carli G, Kanel P, Roytman S, Barr J, Bohnen NI, Albin RL. Annals of Clinical and Translational Neurology, 2026 Jan 1;Journal ArticleBaseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease
DOI:10.1002/acn3.70335 -
Bohnen JLB, Roytman S, Wigstrom TP, Vangel RK, Barr JE, Carli G, Parks SM, Mittal H, Martino C, Kanel P, Albin RL, Bohnen NI. Neurotherapeutics, 2026 Jan 1; 23 (1):Journal ArticleDietary tributyrin supplementation in Parkinson’s disease: An open-label target engagement study
DOI:10.1016/j.neurot.2025.e00791 PMID: 41271518 -
Step K, Hernández CF, Khani M, Eltaraifee E, Hernández-Medrano AJ, Kung PJ, Ostrožovičová M, Zirra A, Pérez-Palma E, Mencacci NE, Keller Sarmiento IJ, Morris HR, Mata IF, Acosta-Uribe J, Fang ZH, Bandres-Ciga S, Mecheri Y, Sofiane BM, Traki B, Gatto EM, Kauffman M, Capparelli F, Muller MV, Tela MS, Adamec DS, Avila C, Khachatryan S, Tavadyan Z, Isayan M, Shepherd C, Kumar K, Ellis M, Rentería M, Koks S, Rowel S, Yeow D, Sue C, Ocampo V, Wools C, Weiss KA, Siow SF, Davis R, Willis A, He S, Wilcox RA, Howting D, Price JD, Cheong PL, Tchan M, Young MA, Mclean C, Martin N, Briceño HM, Kimber T, Wu K, O'Sullivan J, Singleton L, Rudaks LI, García-Marín L, Zimprich A, Jafarov K, Ceferov K, Sarker I, Crosiers D, Schumacher-Schuh A, Rieder C, Awad P, Tumas V, Camargos S, Costa L, Neto P, Monchi O, Fon E, Thibault R, Gan-Or Z, Teferra M, Lang A, Senkevich K, Miranda M, Bustamante M, Nuñez J, Lucero B, Colombo A, Personal MT, Palma E, Chana-Cuevas P, Cortes ABM, Pinto MEC, Canals F, Galleguillos B, Aguilera PAO, Fernandez-Toledo E, Tang B, Shang H, Guo J, Chan P, Luo W, Liu Z, Chan G. Movement Disorders, 2026 Jan 1;Journal ArticleGenome-Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology
DOI:10.1002/mds.70182 PMID: 41808632
