Julien Sebag
Associate Professor of Pharmacology
Medical School
[email protected]
Available to mentor
Julien Sebag
Associate Professor
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About
Our laboratory focuses on identifying new pathways involved in the control of energy and glucose homeostasis and discovering novel targets for the treatment of obesity and diabetes. Our main focus is understanding the role and mechanism of GPCR regulation by the Melanocortin Receptor Accessory Protein 2 (MRAP2). MRAP2 is a critical protein for the maintenance of proper energy and glucose balance. Deletion of MRAP2 causes obesity and insulin resistance, however, the mechanisms involved are poorly understood. We are also studying new regulators of insulin-stimulated GLUT4 translocation using high throughput screening and structural biology.
Links
Lab Website
Qualifications
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PhDUniversity of Rochester Medical Center, Rochester, United States
Center Memberships
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Center MemberCaswell Diabetes Institute
Recent Publications
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Buscaglia P, Bowman KR, Lawler K, Hernandez CC, Scotucci J, Bounds R, Keogh JM, Henning E, Cone RD, Farooqi IS, Sebag JA. 2026 Jan 19; medRxiv,PreprintAttractin-Like Protein 1 (ATRNL1): An Essential Partner of MC4R to Regulate Body Weight
DOI:10.64898/2026.01.12.26343722 -
Mittal A, Buscaglia P, Srivastava D, Artemyev NO, Sebag JA. Molecular Metabolism, 2025 Oct 1; 100:Journal ArticleInhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue
DOI:10.1016/j.molmet.2025.102230 PMID: 40754229 -
Yin TC, Van Vranken JG, Srivastava D, Mittal A, Buscaglia P, Moore AE, Verdinez JA, Graham AE, Walsh SA, Acevedo MA, Kerns RJ, Artemyev NO, Gygi SP, Sebag JA. Cell Chemical Biology, 2023 Aug 17; 30 (8): 933 - 942.e6.Journal ArticleInsulin sensitization by small molecules enhancing GLUT4 translocation
DOI:10.1016/j.chembiol.2023.06.012 PMID: 37453421 -
Yin TC, Mittal A, Buscaglia P, Li W, Sebag JA. Journal of Biological Chemistry, 2023 Jan 1; 299 (1):Journal ArticleActivation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2
DOI:10.1016/j.jbc.2022.102814 PMID: 36539034 -
Rouault AAJ, Buscaglia P, Sebag JA. Journal of Biological Chemistry, 2022 Jun 1; 298 (6):Journal ArticleMRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation
DOI:10.1016/j.jbc.2022.102057 PMID: 35605660 -
Li M, Shao F, Qian Q, Yu W, Zhang Z, Chen B, Su D, Guo Y, Phan AV, Song LS, Stephens SB, Sebag J, Imai Y, Yang L, Cao H. Molecular Therapy Nucleic Acids, 2021 Dec 3; 26: 307 - 320.Journal ArticleA putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells
DOI:10.1016/j.omtn.2021.06.027 -
Verdinez JA, Sebag JA. Frontiers in Neuroscience, 2021 Aug 13; 15:Journal ArticleRole of N-Linked Glycosylation in PKR2 Trafficking and Signaling
DOI:10.3389/fnins.2021.730417 -
Bui TM, Butin-Israeli V, Wiesolek HL, Zhou M, Rehring JF, Wiesmüller L, Wu JD, Yang GY, Hanauer SB, Sebag JA, Sumagin R. Gastroenterology, 2021 Jul 1; 161 (1): 225 - 238.e15.Journal ArticleNeutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer
DOI:10.1053/j.gastro.2021.03.027 PMID: 33753103
