Max S Wicha, MD

 Max Wicha, MD
Madeline and Sidney Forbes Professor of Oncology
Professor of Internal Medicine
Medical School
Email:
[email protected]
Available to mentor
Max S Wicha, MD
Max Wicha, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

  • Manage Your Profile

    • Qualifications
    • Biology Degree
      State University of NY at Stony Brook, United States
      1966 - 1970

    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Taubman Institute
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Biointerfaces Institute
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Global REACH

    Research Overview

    Mammary cell biology
    * Regulation of mammary growth, differentiation and apoptosis
    * Stem cells in normal mammary development and breast cancer
    * Cancer stem cell therapeutics

    Recent Publications

     See All Publications
    • Journal Article
      CD6-Directed Immunotherapy Targets Breast Cancer Stem Cell Function and Enhances Immune-Mediated Cytotoxicity in Triple-Negative Breast Cancer
      Gurrea-Rubio M, Sloan S, Chada A, Amarista CI, Maeda K, Campbell PL, Tsou P-S, Cooney LA, Wicha MS, Fox DA. Biomolecules, 2026 Aug 19; 16 (8): 1202 DOI:10.3390/biom16081202
    • Preprint
      S100A9-Dependent CXCR2hi Neutrophils Mediate Systemic Immune Suppression and Checkpoint Resistance in Metastatic TNBC
      Koksalar Alkan F, Caglayan AB, Alkan HK, Lee E, Piranlioglu R, Jones C, Alimadadi M, Brown E, Arnold A, Langer Gramer A, Vogl T, Dyson G, Chadli A, Kasimir-Bauer S, Assad H, Boerner J, Al Achkar M, Azmi AS, Neamati N, Ozturk G, Bollag R, Hedrick CC, Korkaya H, Wicha M, Shi H. 2026 Jun 14; bioRxiv, DOI:10.64898/2026.06.09.731132
    • Journal Article
      Abstract 184: TNF-alpha plays pleiotropic role in innate immune activation and blood-brain barrier disruption driving brain metastasis.
      Celiker N, Alkan FK, Alkan HK, Caglayan A, Lawal A, Al Achkar M, Max WS, Korkaya H. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 184 - 184. DOI:10.1158/1538-7445.am2026-184
    • Journal Article
      Abstract 2375: Stress-responsive immune microenvironment in triple-negative breast cancer among African American women
      Lawal AM, Alkan FK, Alkan HK, Caglayan AB, Celiker N, Temby B, WICHA M, Al Achkar M, Purrington K, Korkaya H. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 2375 - 2375. DOI:10.1158/1538-7445.am2026-2375
    • Journal Article
      Abstract 3431: Neutrophil-like monocytes (NeuMos) with high levels of CXCL2 expression orchestrate systemic granulopoiesis and drive immunotherapy resistance in TNBC
      Alkan F, Alkan HK, Caglayan A, Caglayan A, Lawal A, Celiker N, Shi H, Vogl T, Neamati N, Max W, Korkaya H. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 3431 - 3431. DOI:10.1158/1538-7445.am2026-3431
    • Journal Article
      Abstract 6110: Systemic inflammation induced by calprotectin (S100A8/S100A9 complex) triggers reactivation of dormant cells in mouse models of breast cancer
      Caglayan AB, Xin Y, Caglayan A, Nagaraja S, Sharma D, Hager C, Koksalar-Alkan F, Alkan HK, Burness M, Korkaya H, Wicha MS. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 6110 - 6110. DOI:10.1158/1538-7445.am2026-6110
    • Journal Article
      Author Correction: Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology.
      Fujiwara H, Seike K, Brooks MD, Mathew AV, Kovalenko I, Pal A, Lee H-J, Peltier D, Kim S, Liu C, Oravecz-Wilson K, Li L, Sun Y, Byun J, Maeda Y, Wicha MS, Saunders TL, Rehemtulla A, Lyssiotis CA, Pennathur S, Reddy P. Nat Immunol, 2026 Mar 24; DOI:10.1038/s41590-026-02504-8
      PMID: 41876720
    • Preprint
      Exploring the Influence of Chemical Exposures in Breast Cancer Disparities: High-Throughput Transcriptomic Analysis in Normal Breast Cells from Diverse Donors
      Zhao N, Zhao P, Tapaswi A, Polemi K, Thong T, Sexton J, Charles S, Wicha MS, Svoboda L, Zhou X, Colacino JA. 2026 Feb 26; bioRxiv, DOI:10.64898/2026.02.23.707203

    Featured News & Stories
    News Release

    Max Wicha set to retire after 46 years

    After 46 years of service, Max S. Wicha, MD, founding director of the University of Michigan Rogel Cancer Center, will retire from the University of Michigan and move to emeritus status.
         Max Wicha, M.D. and Sunitha Nagrath, Ph.D. Photo credit: Leisa Thompson
    Illuminate

    Nurturing High-Risk, High-Reward Ideas

    The Forbes Institute fosters cross-disciplinary collaboration, encouraging partnerships among faculty from various disciplines across the University of Michigan campus. Learn more about their research into tumor dormancy.