Evan T Keller, DVM, PhD

Evan T. Keller, DVM, PhD is a Professor of Urology and Pathology, School of Medicine, University of Michigan. He is Director of the Single Cell Spatial Analysis Program; Associate Director for Shared Resource for the University of Michigan Comprehensive Rogel Cancer Center; Directs an NIH-funded Program Project on Prostate Cancer Bone Metastasis; and Co-Director of the Single Cell Analysis Core. Dr. Keller obtained Doctor of Veterinary Medicine (DVM) and Master of Preventive Veterinary Medicine (MPVM) degrees at University of California and attained American College of Veterinary Internal Medicine certification in Oncology and a PhD in Developmental Biology at the University of Wisconsin, Madison. His areas of research include (1) prostate cancer metastasis research, with a special emphasis on bone metastasis and the tumor microenvironment and (2) single cell and spatial analytic methods. Key research accomplishments include (1) defining importance of osteoclastic activity and targeting it in prostate cancer leading to clinical use of RANKL inhibitor (Denosumab); (2) identification of raf kinase inhibitor protein (RKIP) as a novel metastasis suppressor gene; (3) determining the importance of the Wnt pathway in bone metastasis; and (4) defining interleukin-6 as a contributor to castration resistant prostate cancer.

Research interests include (1) prostate cancer metastasis research, with a special emphasis on bone metastasis and the tumor microenvironment; (2) single cell analytic methods; (3) drug resistance; (4) spatial analytics.