Daniel A Lawrence
Frederick G L Huetwell Legacy Professor of Basic Research in Cardiovascular Medicine
Professor of Internal Medicine
Professor of Molecular and Integrative Physiology
Medical School
[email protected]
Available to mentor
Daniel A Lawrence
Professor
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Center Memberships
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberWeil Institute for Critical Care Research
Recent Publications
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Gan Y, Liang W, Liu C, Yalavarthi S, Warnock M, Sabb K, Sarosh C, Schaefer JK, Tambralli A, Madison JA, Emal CD, Tsou PS, Shi H, Zuo Y, Lawrence DA, Knight JS. Journal of Autoimmunity, 2026 Jun 1; 161:Journal ArticleEndothelial cell-derived plasminogen activator inhibitor-1 potentiates thrombosis in antiphospholipid syndrome
DOI:10.1016/j.jaut.2026.103563 -
Zuchelkowski BE, Inman KW, Nouraie SM, Beru N, Naqvi A, Qin S, Yeh CH, Zhang Y, Shah FA, Sharma L, Dela Cruz CS, Zhang L, McVerry BJ, Morris A, Neal MD, Seheult J, Kitsios GD, Mellors JW, Lawrence DA, Kim PY, Jacobs JL, Bain WG. J Am Heart Assoc, 2026 May 6; e047693Journal ArticleSoluble Thrombomodulin Links Viremia and Mortality During COVID-19: Results From the ACTIV-4a Trial.
DOI:10.1161/JAHA.125.047693 PMID: 42089155 -
Ngodup T, Elson B, Mello AM, Hannifin S, Liu M, Zhang Y, Shi J, Shah YM, Lawrence DA, di Magliano MP, Lee KE. Sci Adv, 2026 Apr 3; 12 (14): eaea6734Journal ArticleA stromal PAI1-tPA axis orchestrates immunosuppression in pancreatic cancer.
DOI:10.1126/sciadv.aea6734 PMID: 41931610 -
Zhai T, Zhang W, Ma C, Ni L, Paulus YM, Su EJ, Murphy GG, Lawrence DA, Wang X. Photoacoustics, 2026 Apr 1; 48:Journal ArticleMulti-parametric longitudinal imaging of cerebral biomarkers in a rodent model of Alzheimer's disease
DOI:10.1016/j.pacs.2026.100808 -
Su EJ, Tsou P-S, Warnock M, Subbotina N, Mann K, Vichaikul S, Rosek A, Leung L, Xing X, Xing E, Plazyo O, Bogle R, Tsoi LC, Emal CD, Khanna D, Varga J, Sisson TH, Gudjonsson JE, Lawrence DA. JCI Insight, 2026 Feb 17;Journal ArticleA potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.
DOI:10.1172/jci.insight.195005 PMID: 41701900 -
Shaydakov ME, Emal CD, Rainey JP, Lawrence DA, Diaz JA. Phlebology, 2026 Jan 1;Journal ArticlePAI-1 Inhibition in experimental venous thrombosis
DOI:10.1177/02683555261421027 -
Shifman SG, O’Connor JL, Radin DP, Sharma A, Infante L, Ferraresso F, Kastrup CJ, Lawrence DA, Tsirka SE. Journal of Experimental and Clinical Cancer Research, 2025 Dec 1; 44 (1):Journal ArticleTargeting autophagy and plasminogen activator inhibitor-1 increases survival and remodels the tumor microenvironment in glioblastoma
DOI:10.1186/s13046-025-03473-w PMID: 40684232 -
Torrente D, Su EJ, Citalán-Madrid AF, Schielke GP, Magaoay D, Warnock M, Stevenson T, Mann K, Lesept F, Delétage N, Blanc M, Norris EH, Vivien D, Lawrence DA. Journal of Neuroinflammation, 2025 Dec 1; 22 (1):Journal ArticleThe interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity
DOI:10.1186/s12974-025-03336-3 PMID: 39810216
