Elizabeth K Speliotes, MD, PhD, MPH
Keith S Henley M.D. Legacy Professor of Gastroenterology
Professor of Internal Medicine
Professor of Computational Medicine and Bioinformatics
Associate Director
Medical Scientist Training Program (MSTP)
Program Director
Precision Medicine Program
Medical School
[email protected]
Available to mentor
Elizabeth K Speliotes, MD, PhD, MPH
Professor
Manage Your Profile
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberMM-PKUHSC Joint Institute
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Center MemberAI and Digital Health Innovation
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Center MemberFrankel Institute for Heart and Brain Health
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Center MemberGlobal REACH
Recent Publications
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Bjarnadottir H, Jonmundsson T, Ingvarsdottir HK, Frick EA, Finkel N, Loureiro JJ, Launer LJ, Aspelund T, Chen Y, Speliotes EK, Orth AP, Smith AV, Emilsson V, Gudnason V, Gudmundsdottir V. bioRxiv, 2026 Mar 18;Journal ArticleThe impact of low-frequency genetic variants on serum protein levels.
DOI:10.64898/2026.03.17.712047 PMID: PMC13015512 -
Hussain R, Raut C, Prabhu P, Irshaid A, Hegde Y, Chen Y, Pant A, Oliveri A, Wei X, Yin L, Russell TL, Halligan B, Semenkovich CF, Speliotes EK. J Lipid Res, 2026 Mar 3; 101013Journal ArticleLYPLAL1 Rare Loss-of-Function Variants in Humans and Deletion in Human Hepatoma Cells Protect Against MASLD.
DOI:10.1016/j.jlr.2026.101013 PMID: 41786251 -
Alyousifi Y, Raut C, Chen VL, Oliveri A, Chen Y, Speliotes EK. Liver International, 2026 Feb 1; 46 (2):Journal ArticleGenetic Information Enhances a Novel Non-Invasive Steatosis Index and Outperforms Existing Steatosis Indices
DOI:10.1111/liv.70410 PMID: 41521699 -
Tincopa MA, Speliotes EK, Valenti L, Loomba R. Annual Review of Medicine, 2026 Jan 1; 77 (1): 103 - 115.Journal ArticleMetabolic Dysfunction–Associated Steatotic Liver Disease and Metabolic Dysfunction–Associated Steatohepatitis–Related Fibrosis: Therapeutic Options and Approaches to Treatment
DOI:10.1146/annurev-med-050324-124753 PMID: 41592926 -
Vujkovic M, Kaplan DE, Ghouse J, Loza B-L, Brancale J, Lewis A, Zhang DY, Levin MG, Veatch OJ, Johnson JP, Schneider CV, Verma A, Wangensteen KJ, Scorletti E, Gill D, Konkwo C, Garófalo AM, Guare LA, Schwantes-An T-W, Abreu MV, Gellert-Kristensen H, Pedersen OB, Erikstrup C, Bundgaard JS, Sørensen E, Ostrowski SR, Bundgaard H, Lee KM, Shaked A, Olthoff KM, Hoteit MA, Speliotes EK, Chen Y, Oliveri A, Yin L, Valenti LV, Malvestiti F, Marchelli D, Miano L, Anstee QM, Daly AK, Cordell HJ, Darlay R, Verweij N, Hindy G, Locke A, Matsuura K, Asrani SK, Testa G, Lotta LA, Jones MB, Dochtermann DR, Norden-Krichmar TM, Teerlink CC, Devineni P, Pyarajan S, Rader DJ, Tanaka Y, Voight BF, Vilarinho S, Bastarache LA, Stender S, Tsao PS, Penn Medicine Biobank , DBDS Genomic Consortium , BioVU Biobank , Michigan Genomics Initiative , Regeneron Genetics Center , Indiana Biobank , All Of Us Research Program , Milano Biobank , LITMUS Consortium , VA Million Veteran Program , Morgan TR, Lynch JA, Chang K-M. 2025 Sep 18;PreprintGermline Variants Influence Chronic Liver Disease Progression through Distinct Pathways.
DOI:10.1101/2025.09.16.25335186 PMID: 41001506 -
Yeo YH, Zhu Y, Gao J, Liu S, Ni W, Rui F, Bai X, Geng N, Jin R, Speliotes EK, Wu C, Shi J, Qi X, Chen VL, Newsome PN, Li J. Alimentary Pharmacology and Therapeutics, 2025 Jul 1; 62 (2): 168 - 179.Journal ArticleAnthropometric Measures and Mortality Risk in Individuals With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Population-Based Cohort Study
DOI:10.1111/apt.70174 PMID: 40366297 -
Chen VL, Oliveri A, Raut C, Chen Y, Cushing-Damm KC, Speliotes EK. American Journal of Gastroenterology, 2025 Jul 1; 120 (7): 1538 - 1547.Journal ArticleTM6SF2-rs58542926 Genotype Has Opposing Effects on Incidence of Hepatic and Cardiac Events in a Community Cohort
DOI:10.14309/ajg.0000000000003169 PMID: 39471479 -
Yeo YH, Zhu Y, Gao J, Liu S, Ni W, Rui F, Bai X, Geng N, Jin R, Speliotes EK, Wu C, Shi J, Qi X, Chen VL, Newsome P, Li J. Gastroenterology, 2025 Jul 4; 169 (1): s-1713-s-1714Journal ArticleSa1589: ANTHROPOMETRIC MEASURES AND MORTALITY RISK IN INDIVIDUALS WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD): A POPULATION-BASED COHORT STUDY
DOI:10.1016/s0016-5085(25)04809-7
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