Henry L Paulson, MD PhD
Lucile Groff Chair of Neurology for Alzheimers Disease
Research Professor, Michigan Neuroscience Institute
Professor of Neurology and Co-Division Chief Cognitive Disorders, Medical School
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[email protected]
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Henry L Paulson, MD PhD
Professor
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About
Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.
Qualifications
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movement disorders and neurogeneticsUniversity of Pennsylvania Health System, Philadelphia, United States
1994 - 1997
Clinical Fellowship
Center Memberships
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Center MemberTaubman Institute
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Center MemberFrankel Institute for Heart and Brain Health
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Center MemberCenter for Cell Plasticity and Organ Design
Research Overview
Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.
Recent Publications
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Piras IS, Capuano AW, Maher AC, Schafer R, Bonfitto A, Song S, Taguinod F, Goldstein F, Roberts A, Okonkwo O, Martersteck A, El-Khoury J, Cardaio A, Ofori DO, Haller B, Tuncel Y, Aulakh N, Li J, Narayan E, Silveira C, Jesso S, Coleman K, Orange JB, Bartha R, Culum I, Finger E, Roberts AC, Uday V, Bruce M, Pandos A, Lose S, Doyle-Thomas K, Dunne C, Thai V, Beyer K, Van Ooteghem K, McIlroy B, Sturt Y, Warner K, Bhaumik A, Reader J, Bross J, Balog V, Wathen L, Paulson H, Lincoln GA, Rose E, Wang S, Capuano A, Hearns K, McCarthy M, Whitmore H, Moore S, Devine R, Timpo P, Engelmeyer J, Peirce H, Addison E, Zolliecoffer C, McDermott S, Kharitonova M, Seibert K, Swartz RH, Lim A, Mesulam M, Geula C, Ayala I, Stark B, Chung J, Ahmed H, Qui D, Saleh S, Ellison A, Harris G, Kaddoura L, Parker M, Trammell AR, Huentelman MJ, Rogalski E. Alzheimer S Research and Therapy, 2026 Dec 1; 18 (1):Journal ArticleSuperAging is not the inverse of common-variant Alzheimer’s risk: evidence across genetic ancestries
DOI:10.1186/s13195-026-02124-2 PMID: 42493810 -
Rummey C, Subramony SH, Lynch DR, Corben LA, Delatycki MB, Schulz JB, Reetz K, Pandolfo M, Synofzik M, Zesiewicz T, Duquette A, Burns M, Vyhnálek M, Stovickova L, Murphy SM, Bogdanova-Mihaylova P, Kearney M, Walsh R, Roxburgh RH, Bushara K, Davis MY, Bertini ES, Vasco G, Sahni S, Faruq M, Srivastava AK, van de Warrenburg B, Indelicato E, Boesch S, Billnitzer A, Ashizawa T, Gupta AS, Yoon G, Koutsis G, Koniari C, Fleszar Z, Gomez CM, Martinuzzi A, Paparella G, Hamedani AG, Opal P, Akhtar RS, Mariotti C, Paulson H, Todd P, Srinivasan SR, Wilmot G, Schöls L, Perlman S, Schmahmann JD, Kuo S-H, Rosenthal LS, Shakkottai VG. Ann Clin Transl Neurol, 2026 Nov 4;Journal ArticleAxial Function Reflects Global Severity in Inherited Ataxias: The Upright Stability Score in Ambulatory Friedreich vs. Spinocerebellar Ataxia.
DOI:10.1002/acn3.70563 PMID: PMC13736190 -
Walker E, Rodríguez-Carmona Y, Wang X, Mukherjee B, Arboleda-Merino L, Hao W, Dodge H, Albin RL, Paulson HL, Park SK, Bakulski KM. Journal of Alzheimer S Disease, 2026 Nov 1; 114 (1): 183 - 197.Journal ArticleCadmium exposure and incidence of all-cause dementia and Alzheimer's disease in US adults
DOI:10.1177/13872877261487104 PMID: 42725989 -
Walker* E, Rodriguez-Carmona Y, Wang X, Mukherjee B, Arboleda-Merino L, Hao W, Dodge H, Albin RL, Paulson HL, Park SK, Bakulski KM. Epidemiology, 2026 Oct 14; 37 (S2):Journal ArticleCadmium Exposure and Incidence of All-Cause Dementia and Alzheimer’s Disease in US Adults
DOI:10.1097/01.ede.0001281380.90914.8c -
Soto I, Bonomo M, Nelthrope BS, Carr BD, Palmer E, Sierra M, Erturk I, Peppercorn D, Cox E, Vasconcellos TK, Paulson HL, Shorrock HK, Srinivasan SR. Annals of Neurology, 2026 Oct 1; 100 (4): 850 - 866.Journal ArticleCardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing
DOI:10.1002/ana.78282 PMID: 42310491 -
Bartfield J, Milanowski L, Jansen-West KR, Hanna Al-Shaikh R, Chmiela T, Gendron TF, Dunmore JA, Gorcenco S, Puschmann A, Lemos J, Januário C, LeDoux MS, Friedman JH, Onodera O, Aiba I, Pfeiffer RF, Paulson HL, McLoughlin HS, Dulski J, Slawek J, Teive HAG, Soto-Piña AE, Uitti RJ, Strongosky A, Petrucelli L, Prudencio M, Wszolek ZK. Movement Disorders, 2026 Oct 1; 41 (10): 2662 - 2667.Journal ArticleLongitudinal Dynamics of Polyglutamine-Expanded ATXN3 in Biofluids of Spinocerebellar Ataxia Type 3
DOI:10.1002/mds.70411 PMID: 42381263 -
Gorski D, Evans H, Pinho M, Rehan Z, Perkins M, Pinarbasi E, Reader J, Barmada S, Paulson H, Pritzkow S, Soto C. 2026 Sep 4;PreprintTandem Tau and α-Synuclein Seed Amplification Assays Reveal α-Synuclein Copathology Potentiates Tau Seeding in Alzheimer's Disease.
DOI:10.21203/rs.3.rs-10845149/v1 PMID: 42922684 -
Chen C, Saloner R, Paolillo EW, Cadwallader CJ, VandeBunte AM, Lario Lago A, Rademakers R, Ramos EM, Considine CM, Weintraub S, Bayram E, Pantelyat A, Sullivan AC, Staffaroni AM, Kornak J, Tipton PW, Barmada S, Gendron T, Lapid MI, Kremers WK, Masdeu JC, Appleby BS, Bozoki AC, Clark DG, Darby RR, Dickerson BC, Domoto-Reilly K, Galasko D, Ghoshal N, Graff-Radford NR, Grant IM, Hales CM, Honig LS, Hsiung G-YR, Huey ED, Irwin DJ, Knopman DS, Kwan JY, Léger GC, Litvan I, Mackenzie IR, Mendez MF, Onyike CU, Pascual B, Roberson ED, Snyder A, Tartaglia MC, Wint D, Forsberg LK, Heuer HW, Boeve BF, Rosen HJ, Rojas JC, Boxer AL, Casaletto KB, Abdullah M, Apostolova L, Botha H, Brushaber D, Day GS, Dickson D, Dwosh E, Faber K, Fields JA, Fong JC, Foroud T, Gavrilova R, Geschwind DH, Goldman J, Graff-Radford J, Jones DT, Kantarci K, Kolander T, Lee S, Ljubenkov P, Lucente D, Massimo L, McGinnis S, McMillan CT, Mester C, Miyagawa T, Molden J, Paulson H, Petrucelli L, Ramanan V, Rankin KP, Rascovsky K, Rhoads KW, Savica R, Seeley W, Syrjanen J, Taylor J, Vandebergh M, Wong B, Yokoyama J. Neurology Open Access, 2026 Aug 31; 2 (3):Journal ArticleAssociations of Plasma GDF15, CRP, and IL-6 With Cognitive Trajectories in Patients With Frontotemporal Lobar Degeneration
DOI:10.1212/wn9.0000000000000142
Featured News & Stories
Research News
Henry Paulson Receives the Distinguished Faculty Achievement Award
Dr. Henry Paulson received the Distinguished Faculty Achievement Award.
News Release
Michigan Alzheimer's Disease Research Center receives $22M to advance efforts statewide
NIH renews $22M for Michigan Alzheimer's Disease Research Center, supporting a first-of-its-kind statewide partnership and dementia research.
Research News
Michigan ADRC Receives $22M Award to Continue Efforts to Advance Alzheimer’s Disease Research Statewide
NIH awards a center at U-M $22M to continue efforts to advance Alzheimer’s disease research statewide
Research News
Delaying dementia diagnosis wastes precious time, Michigan experts warn
Published in Bridge Michigan by Robin Erb
Department News
Delaying dementia diagnosis wastes precious time, Michigan experts warn
“If I can give a person and their family more precise knowledge about what the future is going to hold for them, that is important," said Dr. Henry Paulson.
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Is everything you know about Alzheimer's wrong?
Amyloid’s role in Alzheimer’s disease and other forms of dementia doesn’t tell the whole story; other molecules and prevention via cardiovascular, social and cognitive.
