Henry L Paulson, MD PhD
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About
Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.
Qualifications
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movement disorders and neurogeneticsUniversity of Pennsylvania Health System, Philadelphia, United States
1994 - 1997
Clinical Fellowship
Center Memberships
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Center MemberTaubman Institute
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Center MemberFrankel Institute for Heart and Brain Health
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Center MemberCenter for Cell Plasticity and Organ Design
Research Overview
Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.
Recent Publications
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Piras IS, Capuano AW, Maher AC, Schafer R, Bonfitto A, Song S, Taguinod F, Goldstein F, Roberts A, Okonkwo O, Martersteck A, El-Khoury J, Cardaio A, Ofori DO, Haller B, Tuncel Y, Aulakh N, Li J, Narayan E, Silveira C, Jesso S, Coleman K, Orange JB, Bartha R, Culum I, Finger E, Roberts AC, Uday V, Bruce M, Pandos A, Lose S, Doyle-Thomas K, Dunne C, Thai V, Beyer K, Van Ooteghem K, McIlroy B, Sturt Y, Warner K, Bhaumik A, Reader J, Bross J, Balog V, Wathen L, Paulson H, Lincoln GA, Rose E, Wang S, Capuano A, Hearns K, McCarthy M, Whitmore H, Moore S, Devine R, Timpo P, Engelmeyer J, Peirce H, Addison E, Zolliecoffer C, McDermott S, Kharitonova M, Seibert K, Swartz RH, Lim A, Mesulam M, Geula C, Ayala I, Stark B, Chung J, Ahmed H, Qui D, Saleh S, Ellison A, Harris G, Kaddoura L, Parker M, Trammell AR, Huentelman MJ, Rogalski E. Alzheimer S Research and Therapy, 2026 Dec 1; 18 (1):Journal ArticleSuperAging is not the inverse of common-variant Alzheimer’s risk: evidence across genetic ancestries
DOI:10.1186/s13195-026-02124-2 PMID: 42493810 -
Walker E, Rodríguez-Carmona Y, Wang X, Mukherjee B, Arboleda-Merino L, Hao W, Dodge H, Albin RL, Paulson HL, Park SK, Bakulski KM. J Alzheimers Dis, 2026 Sep 11; 13872877261487104Journal ArticleCadmium exposure and incidence of all-cause dementia and Alzheimer's disease in US adults.
DOI:10.1177/13872877261487104 PMID: 42725989 -
Soto C, Gorski D, Evans H, Pinho M, Rehan Z, Perkins M, Pinarbasi E, Reader J, Barmada S, Paulson H, Pritzkow S. 2026 Sep 6; Research Square,PreprintTandem Tau and α-Synuclein Seed Amplification Assays Reveal α-Synuclein Copathology Potentiates Tau Seeding in Alzheimer’s Disease
DOI:10.21203/rs.3.rs-10845149/v1 -
Chen C, Saloner R, Paolillo EW, Cadwallader CJ, VandeBunte AM, Lario Lago A, Rademakers R, Ramos EM, Considine CM, Weintraub S, Bayram E, Pantelyat A, Sullivan AC, Staffaroni AM, Kornak J, Tipton PW, Barmada S, Gendron T, Lapid MI, Kremers WK, Masdeu JC, Appleby BS, Bozoki AC, Clark DG, Darby RR, Dickerson BC, Domoto-Reilly K, Galasko D, Ghoshal N, Graff-Radford NR, Grant IM, Hales CM, Honig LS, Hsiung G-YR, Huey ED, Irwin DJ, Knopman DS, Kwan JY, Léger GC, Litvan I, Mackenzie IR, Mendez MF, Onyike CU, Pascual B, Roberson ED, Snyder A, Tartaglia MC, Wint D, Forsberg LK, Heuer HW, Boeve BF, Rosen HJ, Rojas JC, Boxer AL, Casaletto KB, Abdullah M, Apostolova L, Botha H, Brushaber D, Day GS, Dickson D, Dwosh E, Faber K, Fields JA, Fong JC, Foroud T, Gavrilova R, Geschwind DH, Goldman J, Graff-Radford J, Jones DT, Kantarci K, Kolander T, Lee S, Ljubenkov P, Lucente D, Massimo L, McGinnis S, McMillan CT, Mester C, Miyagawa T, Molden J, Paulson H, Petrucelli L, Ramanan V, Rankin KP, Rascovsky K, Rhoads KW, Savica R, Seeley W, Syrjanen J, Taylor J, Vandebergh M, Wong B, Yokoyama J. Neurology Open Access, 2026 Aug 31; 2 (3):Journal ArticleAssociations of Plasma GDF15, CRP, and IL-6 With Cognitive Trajectories in Patients With Frontotemporal Lobar Degeneration
DOI:10.1212/wn9.0000000000000142 -
Van Pelt KM, Deng Y, Nesvizhskii AI, Paulson HL, Costa MDC, Truttmann MC. 2026 Aug 12; openRxiv,Preprint<i>Ficd</i> loss rescues motor impairments and reverses oligodendrocyte maturation deficits in a mouse model of spinocerebellar ataxia type 3
DOI:10.64898/2026.08.07.743629 -
Lambert JC, Ramirez A, Ruiz A, Andreassen O, Sims R, Hiltunen M, Ingelsson M, Sleegers K, Sánchez-Juan P, Ghidoni R, Frikke-Schmidt R, van Duijn C, Tsolaki M, Kehoe PG, Fernandez MV, Mather K, Holstege H, Jessen F, Rossi G, Masullo C, Bossù P, Daniele A, Rainero I, Seripa D, Spallazzi M, Nacmias B, Wagner M, Borroni B, Tremolizzo L, Squassina A, Parnetti L, Solfrizzi V, Mecocci P, Arosio B, Galimberti D, Popp J, Grünblatt E, Debette S, Hanon O, Pasquier F, Dufouil C, Nicolas G, Deleuze JF, Boland A, Amouyel P, Nicolas A, Palmal S, Le Borgne J, Holmans P, Williams J, Kilander L, Löwenmark M, Giedraitis V, Papenberg G, Ullgren A, Thonberg H, Graff C, Biessels GJ, Hulsman M, Papma J, Ramakers I, Seelaar H, van der Flier W, Pijnenburg YAL, Thomassen JQ, Luo J, Sandau N, Vyhnalek M, Hort J, Mehrabian S, de Mendonça A, Soininen H, Rodriguez-Rodriguez E, García-Alberca JM, Piñol-Ripoll G, Real LM, Mir P, Puerta R, García-González P, Boada M, Álvarez V, Sánchez-Valle R, Pastor P, Bullido MJ, Pérez-Tur J, Moreno F, Dols-Icardo O, Scarmeas N, Tegos T, Schmid M, Moebus S, Heilmann-Heimbach S, Wiltfang J, Grimmer T, Düzel E, Molina-Porcel L, Hausner L, Riedel-Heller S, Deckert J, Scherbaum N. Nature Genetics, 2026 Jun 1; 58 (6): 1214 - 1225.Journal ArticleConsensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias
DOI:10.1038/s41588-026-02583-1 PMID: 42237039 -
Mahajan A, Dwivedi AK, Galvin JE, Maixner SM, Paulson HL, Manning CA, Fields JA, Boeve BF, Mills KA, Morrow C, Pontone GM, Armstrong MJ. Neurology, 2026 Apr 15; 106 (9):Journal ArticleCognitive Fluctuations, Neuropsychiatric Burden, and Quality of Life in Moderate-Advanced Dementia With Lewy Bodies
DOI:10.1212/wnl.0000000000214934 -
Dunietz GL, Lyu X, Paulson H, Chervin R, Shedden K, Braley T. Sleep, 2026 May 10; 49 (Supplement_1): a509 - a509.Journal Article1142 Obstructive Sleep Apnea, Use of Positive Airway Pressure Therapy, and Dementia Incidence: A Longitudinal Study of Medicare Beneficiaries
DOI:10.1093/sleep/zsag091.1141
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