Henry L Paulson, MD PhD

Henry Paulson
Professor
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[email protected]
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Available to mentor
Henry L Paulson, MD PhD
Henry Paulson
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.

    Qualifications

    • movement disorders and neurogenetics
      University of Pennsylvania Health System, Philadelphia, United States
      1994 - 1997
      Clinical Fellowship

    Center Memberships

    • Center Member
      Taubman Institute
    • Center Member
      Frankel Institute for Heart and Brain Health
    • Center Member
      Center for Cell Plasticity and Organ Design

    Research Overview

    Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.

    Recent Publications

    See All Publications
    • Journal Article
      SuperAging is not the inverse of common-variant Alzheimer’s risk: evidence across genetic ancestries
      Piras IS, Capuano AW, Maher AC, Schafer R, Bonfitto A, Song S, Taguinod F, Goldstein F, Roberts A, Okonkwo O, Martersteck A, El-Khoury J, Cardaio A, Ofori DO, Haller B, Tuncel Y, Aulakh N, Li J, Narayan E, Silveira C, Jesso S, Coleman K, Orange JB, Bartha R, Culum I, Finger E, Roberts AC, Uday V, Bruce M, Pandos A, Lose S, Doyle-Thomas K, Dunne C, Thai V, Beyer K, Van Ooteghem K, McIlroy B, Sturt Y, Warner K, Bhaumik A, Reader J, Bross J, Balog V, Wathen L, Paulson H, Lincoln GA, Rose E, Wang S, Capuano A, Hearns K, McCarthy M, Whitmore H, Moore S, Devine R, Timpo P, Engelmeyer J, Peirce H, Addison E, Zolliecoffer C, McDermott S, Kharitonova M, Seibert K, Swartz RH, Lim A, Mesulam M, Geula C, Ayala I, Stark B, Chung J, Ahmed H, Qui D, Saleh S, Ellison A, Harris G, Kaddoura L, Parker M, Trammell AR, Huentelman MJ, Rogalski E. Alzheimer S Research and Therapy, 2026 Dec 1; 18 (1): DOI:10.1186/s13195-026-02124-2
      PMID: 42493810
    • Journal Article
      Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing
      Soto I, Bonomo M, Nelthrope BS, Carr BD, Palmer E, Sierra M, Erturk I, Peppercorn D, Cox E, Vasconcellos TK, Paulson HL, Shorrock HK, Srinivasan SR. Annals of Neurology, 2026 Oct 1; 100 (4): 850 - 866. DOI:10.1002/ana.78282
      PMID: 42310491
    • Journal Article
      Cadmium exposure and incidence of all-cause dementia and Alzheimer's disease in US adults.
      Walker E, Rodríguez-Carmona Y, Wang X, Mukherjee B, Arboleda-Merino L, Hao W, Dodge H, Albin RL, Paulson HL, Park SK, Bakulski KM. J Alzheimers Dis, 2026 Sep 11; 13872877261487104 DOI:10.1177/13872877261487104
      PMID: 42725989
    • Preprint
      Tandem Tau and α-Synuclein Seed Amplification Assays Reveal α-Synuclein Copathology Potentiates Tau Seeding in Alzheimer’s Disease
      Soto C, Gorski D, Evans H, Pinho M, Rehan Z, Perkins M, Pinarbasi E, Reader J, Barmada S, Paulson H, Pritzkow S. 2026 Sep 6; Research Square, DOI:10.21203/rs.3.rs-10845149/v1
    • Journal Article
      Associations of Plasma GDF15, CRP, and IL-6 With Cognitive Trajectories in Patients With Frontotemporal Lobar Degeneration
      Chen C, Saloner R, Paolillo EW, Cadwallader CJ, VandeBunte AM, Lario Lago A, Rademakers R, Ramos EM, Considine CM, Weintraub S, Bayram E, Pantelyat A, Sullivan AC, Staffaroni AM, Kornak J, Tipton PW, Barmada S, Gendron T, Lapid MI, Kremers WK, Masdeu JC, Appleby BS, Bozoki AC, Clark DG, Darby RR, Dickerson BC, Domoto-Reilly K, Galasko D, Ghoshal N, Graff-Radford NR, Grant IM, Hales CM, Honig LS, Hsiung G-YR, Huey ED, Irwin DJ, Knopman DS, Kwan JY, Léger GC, Litvan I, Mackenzie IR, Mendez MF, Onyike CU, Pascual B, Roberson ED, Snyder A, Tartaglia MC, Wint D, Forsberg LK, Heuer HW, Boeve BF, Rosen HJ, Rojas JC, Boxer AL, Casaletto KB, Abdullah M, Apostolova L, Botha H, Brushaber D, Day GS, Dickson D, Dwosh E, Faber K, Fields JA, Fong JC, Foroud T, Gavrilova R, Geschwind DH, Goldman J, Graff-Radford J, Jones DT, Kantarci K, Kolander T, Lee S, Ljubenkov P, Lucente D, Massimo L, McGinnis S, McMillan CT, Mester C, Miyagawa T, Molden J, Paulson H, Petrucelli L, Ramanan V, Rankin KP, Rascovsky K, Rhoads KW, Savica R, Seeley W, Syrjanen J, Taylor J, Vandebergh M, Wong B, Yokoyama J. Neurology Open Access, 2026 Aug 31; 2 (3): DOI:10.1212/wn9.0000000000000142
    • Journal Article
      Clinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia
      Olzinski M, Downer J, Cobigo Y, Rajbanshi B, Li J, Loureiro J, Worringer KA, Heuer H, Ljubenkov P, Vandevrede L, Staffaroni A, Lario-Lago A, Leichter D, Wolf A, Wise A, Sanderson-Cimino M, Barragan E, Spina S, Grinberg LT, Seeley WW, Casaletto KB, Kramer J, Ramos EM, Geschwind D, Cook C, Petrucelli L, Forsberg LK, Gendron T, Boeve BF, Perneel J, Rademakers R, Rosen HJ, Saloner R, Boxer AL, Rojas JC. JAMA Neurology, 2026 Aug 10; 83 (8): 778 - 787. DOI:10.1001/jamaneurol.2026.1927
      PMID: 42329632
    • Preprint
      Ficd loss rescues motor impairments and reverses oligodendrocyte maturation deficits in a mouse model of spinocerebellar ataxia type 3.
      Van Pelt KM, Deng Y, Nesvizhskii AI, Paulson HL, Costa MDC, Truttmann MC. 2026 Aug 10; DOI:10.64898/2026.08.07.743629
      PMID: 42845343
    • Journal Article
      A Severity-Agnostic Atrophy Pattern in Spinocerebellar Ataxia Type 3: Volumetrics from ENIGMA-Ataxia
      Robertson JW, Adanyeguh I, Arpin DJ, Ashizawa T, Bender B, Cendes F, Chen X, Coarelli G, Coutinho L, Deistung A, Dogan I, Durr A, Faber J, Fernandez-Ruiz J, Ferreira M, França MC, Göricke SL, Han S, Klockgether T, Liu C, Luo J, Martinez ARM, Ono SE, Onyike CU, Öz G, Paulson H, Prince JL, Reetz K, Rezende TJR, Synofzik M, Ghizoni Teive HA, Thomopoulos SI, Thompson PM, Timmann D, Vaillancourt D, van de Warrenburg B, van Gaalen J, Wang X, Wegner P, Ying SH, Harding IH, Hernandez-Castillo CR. Movement Disorders, 2026 Aug 1; 41 (8): 2143 - 2154. DOI:10.1002/mds.70349
      PMID: 42108727

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