Henry L Paulson, MD PhD
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About
Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.
Qualifications
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movement disorders and neurogeneticsUniversity of Pennsylvania Health System, Philadelphia, United States
1994 - 1997
Clinical Fellowship
Center Memberships
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Center MemberTaubman Institute
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Center MemberFrankel Institute for Heart and Brain Health
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Center MemberCenter for Cell Plasticity and Organ Design
Research Overview
Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.
Recent Publications
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Piras IS, Capuano AW, Maher AC, Schafer R, Bonfitto A, Song S, Taguinod F, Goldstein F, Roberts A, Okonkwo O, Martersteck A, El-Khoury J, Cardaio A, Ofori DO, Haller B, Tuncel Y, Aulakh N, Li J, Narayan E, Silveira C, Jesso S, Coleman K, Orange JB, Bartha R, Culum I, Finger E, Roberts AC, Uday V, Bruce M, Pandos A, Lose S, Doyle-Thomas K, Dunne C, Thai V, Beyer K, Van Ooteghem K, McIlroy B, Sturt Y, Warner K, Bhaumik A, Reader J, Bross J, Balog V, Wathen L, Paulson H, Lincoln GA, Rose E, Wang S, Capuano A, Hearns K, McCarthy M, Whitmore H, Moore S, Devine R, Timpo P, Engelmeyer J, Peirce H, Addison E, Zolliecoffer C, McDermott S, Kharitonova M, Seibert K, Swartz RH, Lim A, Mesulam M, Geula C, Ayala I, Stark B, Chung J, Ahmed H, Qui D, Saleh S, Ellison A, Harris G, Kaddoura L, Parker M, Trammell AR, Huentelman MJ, Rogalski E. Alzheimer S Research and Therapy, 2026 Dec 1; 18 (1):Journal ArticleSuperAging is not the inverse of common-variant Alzheimer’s risk: evidence across genetic ancestries
DOI:10.1186/s13195-026-02124-2 PMID: 42493810 -
Soto I, Bonomo M, Nelthrope BS, Carr BD, Palmer E, Sierra M, Erturk I, Peppercorn D, Cox E, Vasconcellos TK, Paulson HL, Shorrock HK, Srinivasan SR. Annals of Neurology, 2026 Oct 1; 100 (4): 850 - 866.Journal ArticleCardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing
DOI:10.1002/ana.78282 PMID: 42310491 -
Walker E, Rodríguez-Carmona Y, Wang X, Mukherjee B, Arboleda-Merino L, Hao W, Dodge H, Albin RL, Paulson HL, Park SK, Bakulski KM. J Alzheimers Dis, 2026 Sep 11; 13872877261487104Journal ArticleCadmium exposure and incidence of all-cause dementia and Alzheimer's disease in US adults.
DOI:10.1177/13872877261487104 PMID: 42725989 -
Soto C, Gorski D, Evans H, Pinho M, Rehan Z, Perkins M, Pinarbasi E, Reader J, Barmada S, Paulson H, Pritzkow S. 2026 Sep 6; Research Square,PreprintTandem Tau and α-Synuclein Seed Amplification Assays Reveal α-Synuclein Copathology Potentiates Tau Seeding in Alzheimer’s Disease
DOI:10.21203/rs.3.rs-10845149/v1 -
Chen C, Saloner R, Paolillo EW, Cadwallader CJ, VandeBunte AM, Lario Lago A, Rademakers R, Ramos EM, Considine CM, Weintraub S, Bayram E, Pantelyat A, Sullivan AC, Staffaroni AM, Kornak J, Tipton PW, Barmada S, Gendron T, Lapid MI, Kremers WK, Masdeu JC, Appleby BS, Bozoki AC, Clark DG, Darby RR, Dickerson BC, Domoto-Reilly K, Galasko D, Ghoshal N, Graff-Radford NR, Grant IM, Hales CM, Honig LS, Hsiung G-YR, Huey ED, Irwin DJ, Knopman DS, Kwan JY, Léger GC, Litvan I, Mackenzie IR, Mendez MF, Onyike CU, Pascual B, Roberson ED, Snyder A, Tartaglia MC, Wint D, Forsberg LK, Heuer HW, Boeve BF, Rosen HJ, Rojas JC, Boxer AL, Casaletto KB, Abdullah M, Apostolova L, Botha H, Brushaber D, Day GS, Dickson D, Dwosh E, Faber K, Fields JA, Fong JC, Foroud T, Gavrilova R, Geschwind DH, Goldman J, Graff-Radford J, Jones DT, Kantarci K, Kolander T, Lee S, Ljubenkov P, Lucente D, Massimo L, McGinnis S, McMillan CT, Mester C, Miyagawa T, Molden J, Paulson H, Petrucelli L, Ramanan V, Rankin KP, Rascovsky K, Rhoads KW, Savica R, Seeley W, Syrjanen J, Taylor J, Vandebergh M, Wong B, Yokoyama J. Neurology Open Access, 2026 Aug 31; 2 (3):Journal ArticleAssociations of Plasma GDF15, CRP, and IL-6 With Cognitive Trajectories in Patients With Frontotemporal Lobar Degeneration
DOI:10.1212/wn9.0000000000000142 -
Olzinski M, Downer J, Cobigo Y, Rajbanshi B, Li J, Loureiro J, Worringer KA, Heuer H, Ljubenkov P, Vandevrede L, Staffaroni A, Lario-Lago A, Leichter D, Wolf A, Wise A, Sanderson-Cimino M, Barragan E, Spina S, Grinberg LT, Seeley WW, Casaletto KB, Kramer J, Ramos EM, Geschwind D, Cook C, Petrucelli L, Forsberg LK, Gendron T, Boeve BF, Perneel J, Rademakers R, Rosen HJ, Saloner R, Boxer AL, Rojas JC. JAMA Neurology, 2026 Aug 10; 83 (8): 778 - 787.Journal ArticleClinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia
DOI:10.1001/jamaneurol.2026.1927 PMID: 42329632 -
Van Pelt KM, Deng Y, Nesvizhskii AI, Paulson HL, Costa MDC, Truttmann MC. 2026 Aug 10;PreprintFicd loss rescues motor impairments and reverses oligodendrocyte maturation deficits in a mouse model of spinocerebellar ataxia type 3.
DOI:10.64898/2026.08.07.743629 PMID: 42845343 -
Robertson JW, Adanyeguh I, Arpin DJ, Ashizawa T, Bender B, Cendes F, Chen X, Coarelli G, Coutinho L, Deistung A, Dogan I, Durr A, Faber J, Fernandez-Ruiz J, Ferreira M, França MC, Göricke SL, Han S, Klockgether T, Liu C, Luo J, Martinez ARM, Ono SE, Onyike CU, Öz G, Paulson H, Prince JL, Reetz K, Rezende TJR, Synofzik M, Ghizoni Teive HA, Thomopoulos SI, Thompson PM, Timmann D, Vaillancourt D, van de Warrenburg B, van Gaalen J, Wang X, Wegner P, Ying SH, Harding IH, Hernandez-Castillo CR. Movement Disorders, 2026 Aug 1; 41 (8): 2143 - 2154.Journal ArticleA Severity-Agnostic Atrophy Pattern in Spinocerebellar Ataxia Type 3: Volumetrics from ENIGMA-Ataxia
DOI:10.1002/mds.70349 PMID: 42108727
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