Henry L Paulson, MD PhD
Lucile Groff Chair of Neurology for Alzheimer's Disease
Research Professor
Michigan Neuroscience Institute
Professor of Neurology
Co-Division Chief Cognitive Disorders
Medical School
Email:
[email protected]
Phone:
Available to mentor
Henry L Paulson, MD PhD
Professor
Manage Your Profile
About
Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.
Qualifications
-
movement disorders and neurogeneticsUniversity of Pennsylvania Health System, Philadelphia, United States
1994 - 1997
Clinical Fellowship
Center Memberships
-
Center MemberTaubman Institute
-
Center MemberFrankel Institute for Heart and Brain Health
-
Center MemberCenter for Cell Plasticity and Organ Design
Research Overview
Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.
Recent Publications
-
Piras IS, Capuano AW, Maher AC, Schafer R, Bonfitto A, Song S, Taguinod F, Goldstein F, Roberts A, Okonkwo O, Martersteck A, El-Khoury J, Cardaio A, Ofori DO, Haller B, Tuncel Y, Aulakh N, Li J, Narayan E, Silveira C, Jesso S, Coleman K, Orange JB, Bartha R, Culum I, Finger E, Roberts AC, Uday V, Bruce M, Pandos A, Lose S, Doyle-Thomas K, Dunne C, Thai V, Beyer K, Van Ooteghem K, McIlroy B, Sturt Y, Warner K, Bhaumik A, Reader J, Bross J, Balog V, Wathen L, Paulson H, Lincoln GA, Rose E, Wang S, Capuano A, Hearns K, McCarthy M, Whitmore H, Moore S, Devine R, Timpo P, Engelmeyer J, Peirce H, Addison E, Zolliecoffer C, McDermott S, Kharitonova M, Seibert K, Swartz RH, Lim A, Mesulam M, Geula C, Ayala I, Stark B, Chung J, Ahmed H, Qui D, Saleh S, Ellison A, Harris G, Kaddoura L, Parker M, Trammell AR, Huentelman MJ, Rogalski E. Alzheimer S Research and Therapy, 2026 Dec 1; 18 (1):Journal ArticleSuperAging is not the inverse of common-variant Alzheimer’s risk: evidence across genetic ancestries
DOI:10.1186/s13195-026-02124-2 PMID: 42493810 -
Van Pelt KM, Deng Y, Nesvizhskii AI, Paulson HL, Costa MDC, Truttmann MC. 2026 Aug 12; openRxiv,Preprint<i>Ficd</i> loss rescues motor impairments and reverses oligodendrocyte maturation deficits in a mouse model of spinocerebellar ataxia type 3
DOI:10.64898/2026.08.07.743629 -
Lambert JC, Ramirez A, Ruiz A, Andreassen O, Sims R, Hiltunen M, Ingelsson M, Sleegers K, Sánchez-Juan P, Ghidoni R, Frikke-Schmidt R, van Duijn C, Tsolaki M, Kehoe PG, Fernandez MV, Mather K, Holstege H, Jessen F, Rossi G, Masullo C, Bossù P, Daniele A, Rainero I, Seripa D, Spallazzi M, Nacmias B, Wagner M, Borroni B, Tremolizzo L, Squassina A, Parnetti L, Solfrizzi V, Mecocci P, Arosio B, Galimberti D, Popp J, Grünblatt E, Debette S, Hanon O, Pasquier F, Dufouil C, Nicolas G, Deleuze JF, Boland A, Amouyel P, Nicolas A, Palmal S, Le Borgne J, Holmans P, Williams J, Kilander L, Löwenmark M, Giedraitis V, Papenberg G, Ullgren A, Thonberg H, Graff C, Biessels GJ, Hulsman M, Papma J, Ramakers I, Seelaar H, van der Flier W, Pijnenburg YAL, Thomassen JQ, Luo J, Sandau N, Vyhnalek M, Hort J, Mehrabian S, de Mendonça A, Soininen H, Rodriguez-Rodriguez E, García-Alberca JM, Piñol-Ripoll G, Real LM, Mir P, Puerta R, García-González P, Boada M, Álvarez V, Sánchez-Valle R, Pastor P, Bullido MJ, Pérez-Tur J, Moreno F, Dols-Icardo O, Scarmeas N, Tegos T, Schmid M, Moebus S, Heilmann-Heimbach S, Wiltfang J, Grimmer T, Düzel E, Molina-Porcel L, Hausner L, Riedel-Heller S, Deckert J, Scherbaum N. Nature Genetics, 2026 Jun 1; 58 (6): 1214 - 1225.Journal ArticleConsensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias
DOI:10.1038/s41588-026-02583-1 PMID: 42237039 -
Mahajan A, Dwivedi AK, Galvin JE, Maixner SM, Paulson HL, Manning CA, Fields JA, Boeve BF, Mills KA, Morrow C, Pontone GM, Armstrong MJ. Neurology, 2026 Apr 15; 106 (9):Journal ArticleCognitive Fluctuations, Neuropsychiatric Burden, and Quality of Life in Moderate-Advanced Dementia With Lewy Bodies
DOI:10.1212/wnl.0000000000214934 -
Dunietz GL, Lyu X, Paulson H, Chervin R, Shedden K, Braley T. Sleep, 2026 May 10; 49 (Supplement_1): a509 - a509.Journal Article1142 Obstructive Sleep Apnea, Use of Positive Airway Pressure Therapy, and Dementia Incidence: A Longitudinal Study of Medicare Beneficiaries
DOI:10.1093/sleep/zsag091.1141 -
Irfan B, Pal S, Reader J, Bakulski KM, Paulson H, Giordani B. Medicine, 2026 Feb 20; 105 (8): e47717Journal ArticleLinking sleep apnea and arthritis in the National Alzheimer Coordinating Center Cohort: A cross-sectional analysis
DOI:10.1097/MD.0000000000047717 PMID: 41731796 -
Wang X, Bakulski KM, Walker E, Mukherjee B, Dodge H, Albin RL, Paulson HL, Park SK. Alzheimer S and Dementia, 2026 Feb 1; 22 (2):Journal ArticleExposure to lead and incidence of Alzheimer's disease and all-cause dementia in the United States
DOI:10.1002/alz.71075 -
Walker E, Rodríguez-Carmona Y, Wang X, Mukherjee B, Arboleda-Merino L, Hao W, Dodge H, Albin RL, Paulson HL, Park SK, Bakulski KM. 2026 Jan 21; medRxiv,PreprintCadmium Exposure and Incidence of All-Cause Dementia and Alzheimer’s Disease in US Adults
DOI:10.64898/2026.01.16.26344271
Featured News & Stories
Research News
Delaying dementia diagnosis wastes precious time, Michigan experts warn
Published in Bridge Michigan by Robin Erb
Department News
Delaying dementia diagnosis wastes precious time, Michigan experts warn
“If I can give a person and their family more precise knowledge about what the future is going to hold for them, that is important," said Dr. Henry Paulson.
Health Lab
Is everything you know about Alzheimer's wrong?
Amyloid’s role in Alzheimer’s disease and other forms of dementia doesn’t tell the whole story; other molecules and prevention via cardiovascular, social and cognitive.
Health Lab
How virus-like proteins shape a cell’s stress response
Researchers from University of Michigan have identified pivotal roles for a pair of virus-like proteins and their effect on how cells self-regulate and respond to stress. These proteins are implicated in several cancers and neurodegenerative diseases
Philanthropy News
Benjamin M. Hampstead Named Philip B. and Myrna R. Fischer Research Professor of Neurology
Benjamin Hampstead, Ph.D., the Philip B. and Myrna R. Fischer Research Professor of Neurology at U-M, advances Alzheimer's disease research.
Department News
Dr. Benjamin Hampstead named the Fischer Research Professor in Neurology
Dr. Benjamin Hampstead has been named the Philip B. and Myrna R. Fischer Research Professor of Neurology at U-M, advancing Alzheimer’s research and care.
