Mary O'Riordan, PhD
Frederick C Neidhardt Collegiate Professor
Professor of Microbiology and Immunology
PhD Program Director & Graduate Studies Chair
Microbiology & Immunology
Microbiology & Immunology
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-5620
[email protected]

Available to mentor

Mary O'Riordan, PhD
Professor
  • About
  • Links
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    Our laboratory explores the interaction of bacterial pathogens with host cells, focusing on how mammalian cellular stress signaling sculpts transcriptional, spatial and metabolic reprogramming during the innate immune response.

    Links
    • O'Riordan Lab
    Qualifications
    • Postdoctoral Fellow
      University of California, Berkeley, Molecular and Cell Biology, 2003
    • PhD
      University of California, San Francisco, 1999
    • MA
      Princeton University, Princeton, 1994
    • BS
      University of Washington, Seattle, 1990
    Research Overview

    Innate immune signaling and inflammation are foundations for effective host defense against microbial infection. Dysregulation of these responses can drive pathological immune responses that lead to autoimmunity and chronic inflammatory disease. Cellular perturbation by infection or other kinds of stress elicit specific signaling pathways, termed cellular stress responses, triggered by sensors of endoplasmic reticulum unfolded proteins (unfolded protein response; UPR), nutrient stress (integrated stress response; ISR) and mitochondrial stress. We study mechanisms by which these stress response pathways synergize with innate immune signaling to regulate specific inflammatory responses. Using different bacterial pathogens, including methicillin-resistant Staphylococcus aureus, Listeria monocytogenes and Salmonella enterica, we are investigating how macrophages, neutrophils and epithelial cells alter subcellular structure and organization to enable robust inflammatory responses, anti-microbial defenses, metabolic remodeling, survival, and differentiation.

    Recent Publications See All Publications
    • Journal Article
      Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection.
      Reynolds MB, Klein B, McFadden MJ, Judge NK, Navarrete HE, Michmerhuizen BC, Awad D, Schultz TL, Harms PW, Zhang L, O'Meara TR, Sexton JZ, Lyssiotis CA, Kahlenberg JM, O'Riordan MX. Cell Rep, 2024 Aug 27; 43 (8): 114607 DOI:10.1016/j.celrep.2024.114607
      PMID: 39126652
    • Journal Article
      Non-canonical activation of IRE1α during Candida albicans infection enhances macrophage fungicidal activity.
      McFadden MJ, Reynolds MB, Michmerhuizen BC, Ólafsson EB, Anderson FM, Schultz TL, O'Riordan MXD, O'Meara TR. bioRxiv, 2024 May 2; DOI:10.1101/2023.10.02.560560
      PMID: 37873171
    • Preprint
      Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity.
      Klein B, Reynolds MB, Xu B, Gharaee-Kermani M, Gao Y, Berthier CC, Henning S, Loftus SN, McNeely KE, Victory AM, Dobry C, Hile GA, Ma F, Turnier JL, Gudjonsson JE, O'Riordan MX, Kahlenberg JM. 2024 Jan 26; DOI:10.1101/2024.01.23.576771
      PMID: 38328232
    • Journal Article
      Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation.
      Reynolds MB, Hong HS, Michmerhuizen BC, Lawrence A-LE, Zhang L, Knight JS, Lyssiotis CA, Abuaita BH, O'Riordan MX. Sci Adv, 2023 Feb 3; 9 (5): eade8701 DOI:10.1126/sciadv.ade8701
      PMID: 36735777
    • Journal Article
      Human neutrophil IL1β directs intestinal epithelial cell extrusion during Salmonella infection.
      Lawrence A-LE, Berger RP, Hill DR, Huang S, Yadagiri VK, Bons B, Fields C, Sule GJ, Knight JS, Wobus CE, Spence JR, Young VB, O'Riordan MX, Abuaita BH. PLoS Pathog, 2022 Oct; 18 (10): e1010855 DOI:10.1371/journal.ppat.1010855
      PMID: 36191054
    • Journal Article
      IFN-κ is critical for normal wound repair and is decreased in diabetic wounds.
      Wolf SJ, Audu CO, Joshi A, denDekker A, Melvin WJ, Davis FM, Xing X, Wasikowski R, Tsoi LC, Kunkel SL, Gudjonsson JE, O'Riordan MX, Kahlenberg JM, Gallagher KA. JCI Insight, 2022 May 9; 7 (9): DOI:10.1172/jci.insight.152765
      PMID: 35358091
    • Journal Article
      Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids.
      Abuaita BH, Lawrence A-LE, Berger RP, Hill DR, Huang S, Yadagiri VK, Bons B, Fields C, Wobus CE, Spence JR, Young VB, O'Riordan MX. PLoS Pathog, 2021 Oct; 17 (10): e1009987 DOI:10.1371/journal.ppat.1009987
      PMID: 34669717
    • Journal Article
      The IRE1α Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function.
      Abuaita BH, Sule GJ, Schultz TL, Gao F, Knight JS, O'Riordan MX. J Immunol, 2021 Jul 1; 207 (1): 210 - 220. DOI:10.4049/jimmunol.2001321
      PMID: 34145058
    Featured News & Stories Professor Mary O'Riordan (left) and Dr. Anna-Lisa Lawrence hold the MacNeal Award plaque
    Department News
    Dr. Anna-Lisa Lawrence receives the 2023 MacNeal Distinguished Dissertation Award.
    This M&I award recognizes outstanding dissertations.