Ilona Kryczek, PhD

 Kryczek, Ilona
Associate Research Scientist
Surgery
Medical School
Office:
University of Michigan Medical School
Surgery
109 Zina Pitcher Pl
Ann Arbor, Michigan 48109
Email:
[email protected]
Available to mentor
Ilona Kryczek, PhD
Kryczek, Ilona
Associate Research Scientist
  • About
  • Links
  • Qualifications
  • Research Overview
  • Recent Publications

  • Manage Your Profile

    • About

    Dr. Ilona Kryczek is an Associate Research Scientist in the Department of Surgery at the University of Michigan Medical School. An internationally recognized immunologist, Dr. Kryczek’s research focuses on the interplay between the immune system and cancer, with special emphasis on the development of novel immunotherapies for advanced cancers. Her pioneering work explores how immune cells and the tumor microenvironment affect cancer progression, metastasis, and resistance to treatment. Dr. Kryczek’s work has led to over 120 publications in high-impact journals, with more than 34,000 citations, underscoring its substantial influence and recognition within the scientific community. Dr. Kryczek is deeply involved in mentoring the next generation of scientists and is widely sought after as a reviewer and program advisor for leading international funding agencies and journals. Her contributions have been recognized with numerous awards.

    Links
    • https://scholar.google.com/citations?hl=en&user=Rhdk_K4AAAAJ

    Qualifications
    • Post-Doctoral Fellow
      Tulane School of Medicine, New Orleans, United States
      2004 - 2006
      Postdoctoral Fellowship
    • Research Fellow
      Inserm, Paris, France
      2002 - 2003
      Postdoctoral Fellowship
    • PhD
      L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
      1995 - 2000
    • MS
      University of Wroclaw, Wroclaw, Poland
      1990 - 1994

    Research Overview

    Tumor immunology; regulatory T cells and immune evasion; Th17/Treg balance; stem-like memory T cells; cytokine regulation of cancer stemness; IL-17/IL-22 signaling; tumor immunometabolism; immune checkpoint biology; antigen-presenting cell function; ferroptosis and metabolic regulation of anti-tumor immunity; mechanisms of resistance to cancer immunotherapy; translational immuno-oncology; biomarker discovery and personalized immunotherapy.

    Recent Publications

     See All Publications
    • Journal Article
      Durvalumab and guadecitabine in advanced clear cell renal cell carcinoma: results from the phase Ib/II study BTCRC-GU16-043
      Zakharia Y, Singer EA, Acharyya S, Garje R, Joshi M, Peace D, Baladandayuthapani V, Majumdar A, Li X, Lalancette C, Kryczek I, Zou W, Alva A. Nature Communications, 2026 Jun 3; 15 (1): DOI:10.1038/s41467-024-45216-z
    • Journal Article
      PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages
      Pitter MR, Kryczek I, Zhang H, Nagarsheth N, Xia H, Wu Z, Tian Y, Okla K, Liao P, Wang W, Zhou J, Li G, Lin H, Vatan L, Grove S, Wei S, Li Y, Zou W. Cell Reports, 2024 Mar 26; 43 (3): DOI:10.1016/j.celrep.2024.113942
      PMID: 38489266
    • Journal Article
      Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade–associated colitis via Fcg receptors
      Lo BC, Kryczek I, Yu J, Vatan L, Caruso R, Matsumoto M, Sato Y, Shaw MH, Inohara N, Xie Y, Lei YL, Zou W, Núñez G. Science, 2024 Jan 1; 383 (6678): 62 - 70. DOI:10.1126/science.adh8342
      PMID: 38175892
    • Journal Article
      Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
      Li G, Choi JE, Kryczek I, Sun Y, Liao P, Li S, Wei S, Grove S, Vatan L, Nelson R, Schaefer G, Allen SG, Sankar K, Fecher LA, Mendiratta-Lala M, Frankel TL, Qin A, Waninger JJ, Tezel A, Alva A, Lao CD, Ramnath N, Cieslik M, Harms PW, Green MD, Chinnaiyan AM, Zou W. Cancer Cell, 2023 Feb 13; 41 (2): 304 - 322.e7. DOI:10.1016/j.ccell.2022.12.008
      PMID: 36638784
    • Journal Article
      Transcriptional and post-translational regulation of B7-H4 2258098
      Yu J, Yan Y, Li S, Kryczek I, Chen L, Zou W. The Journal of Immunology, 2026 Jul 29; 215 (Supplement_1): vkag141.539 DOI:10.1093/jimmun/vkag141.539
    • Journal Article
      B7-H4 in Cancer Immune Evasion and Immunotherapy
      Xiao R, Yu J, Yan Y, Kryczek I, Zou W. Clinical Cancer Research, 2026 Jul 15; 32 (14): 2806 - 2813. DOI:10.1158/1078-0432.CCR-25-2442
      PMID: 42189671
    • Additional Scholarship
      Supplementary Figure S1 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
      Bao Y, Cruz G, Zhang Y, Qiao Y, Mannan R, Hu J, Yang F, Gondal M, Shahine M, Kang S, Mahapatra S, Chu A, Choi JE, Yu J, Lin H, Miner SJ, Robinson DR, Wu Y-M, Zheng Y, Cao X, Su F, Wang R, Hosseini N, Cieslik M, Kryczek I, Vaishampayan U, Zou W, Chinnaiyan AM. 2026 Jun 17; DOI:10.1158/2159-8290.32700772
    • Additional Scholarship
      Supplementary Figure S10 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
      Bao Y, Cruz G, Zhang Y, Qiao Y, Mannan R, Hu J, Yang F, Gondal M, Shahine M, Kang S, Mahapatra S, Chu A, Choi JE, Yu J, Lin H, Miner SJ, Robinson DR, Wu Y-M, Zheng Y, Cao X, Su F, Wang R, Hosseini N, Cieslik M, Kryczek I, Vaishampayan U, Zou W, Chinnaiyan AM. 2026 Jun 17; DOI:10.1158/2159-8290.32700769