Brigid Ellen Gregg, MD
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About
The focus of the Gregg lab is to understand how early life nutrient stressors can program offspring risk for obesity, diabetes and metabolic syndrome. We use both animal models and a human mother-infant cohort to understand the molecular events that set the stage for lifelong metabolic health. Our previous work helped establish the importance of early life for pancreatic beta-cell expansion. We are now studying the impact of nutrient stressors during the lactation period on the function of key tissues responsible for a coordinated response to glucose: the pancreatic islets, adipose tissue, and the liver. We also study the impact of maternal metabolic disease on lactation physiology.
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberInstitute for Research on Women And Gender
Research Overview
Perinatal programming of adult metabolic disease
Nutritional alterations during the lactation period and lactational programming of metabolic disease
Impact of maternal metabolic health on lactation
Neonatal/childhood determinants of pancreatic beta-cell mass
Stimulus to burst of postnatal beta-cell replication
Recent Publications
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Wardell JR, Shaska N, Ahmed Z, Gregg B, Singer K, Lee JE, Hirschfeld E, Garrity A, Woolford S, Peterson KE, Bragg-Gresham J, Orringer K, Oshman L, Gabison J, Mohammed L, Yoon E, Bilhartz J, Burns B, Lee JM. BMC Medical Informatics and Decision Making, 2026 Dec 1; 26 (1):Journal ArticleLeveraging clinical decision support system tools for childhood overweight/obesity management
DOI:10.1186/s12911-025-03293-0 PMID: 41388408 -
Zhao AY, Sun H, Yan L, Shiyanbola O, Bridges D, Gregg B. Molecular Nutrition and Food Research, 2026 Apr 27; 70 (8):Journal ArticleLactational Western-Style Fat Exposure in Mice Programs Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Male Offspring
DOI:10.1002/mnfr.70468 PMID: 41994919 -
Josefson JL, Gregg B, Sen S, Rajakumar K, McGowan EC, Andrei AC, Arend AB, Rick AM, Marshall E, Caal K, Robinson DT. BMJ Open, 2026 Apr 24; 16 (4): e116936Journal ArticleGlycemia Range and Offspring Weight and adiposity in response To Human milk (GROWTH) study: protocol for an observational cohort designed to study lactational programming
DOI:10.1136/bmjopen-2026-116936 PMID: 42031491 -
Bruder A, Ellsworth L, Sturza J, Gregg B, Miller AL, Lumeng JC. Nutrients, 2026 Apr 12; 18 (8): 1203Journal ArticleThe Association of Human Milk Appetite-Regulating Hormones with Infant Growth and Eating Behaviors to Age Six Months
DOI:10.3390/nu18081203 -
Zhu W, Pan L, Cui X, Russo AC, Ray R, Pederson B, Wei X, Lin LL, Torres M, Hafner H, Gregg B, Shrestha N, Liu C, Naji A, Arvan P, Sandoval DA, Lindberg I, Qi L, Reinert RB. Nature Communications, 2026 Feb 25; 17 (1):Journal ArticleSEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells
DOI:10.1038/s41467-026-69928-6 PMID: 41741474 -
Li E, Yuan Y, Sun H, Patel K, Zhang N, Nagesh S, Aristizabal-Henao JJ, Kiebish M, Jacobs C, Bridges D, Gregg B, Rosen ED. Cell Metabolism, 2026 Jan 1;Journal ArticleOxytocin signaling in adipocytes is required for normal milk fat production
DOI:10.1016/j.cmet.2026.03.013 -
Yalagala PCR, Sugasini D, Chantapim S, Caal K, Sun H, Nicastro S, Sargis RM, Gregg B, Subbaiah PV. Nutrients, 2025 May 29; 17 (11):Journal ArticleEfficient Enrichment of Docosahexaenoic Acid (DHA) in Mother's Milk and in the Brain and Retina of the Offspring by Lysophosphatidylcholine (LPC)-DHA in the Maternal Diet.
DOI:10.3390/nu17111864 PMID: 40507133 -
Mehdi AZ, Deng L, Chase CL, Foss-Freitas MC, Gregg B, Naylor RN, Oral EA, Herman WH, Krishnamurthy M, Broome DT. BMJ Open Diabetes Res Care, 2025 Apr 23; 13 (2):Journal ArticleGLP-1 RA and dual GIP/GLP-1 RA treatment in MODY: a descriptive case series.
DOI:10.1136/bmjdrc-2024-004885 PMID: PMC12020758
