Liangyou Rui
Louis G D'Alecy Legacy Professor of Molecular and Integrative Physiology
Professor of Molecular and Integrative Physiology
Professor of Internal Medicine
Medical School
University of Michigan Medical School
Molecular and Integrative Physiology
2800 Plymouth Road
Ann Arbor, MI 48109
[email protected]
Molecular and Integrative Physiology
2800 Plymouth Road
Ann Arbor, MI 48109
Available to mentor
Liangyou Rui
Professor
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Qualifications
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Postdoctoral fellowHarvard Medical School, Joslin Diabetes Center, Boston, United States
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PhDUniversity of Michigan Medical School, Ann Arbor, United States
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberRogel Cancer Center
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Center MemberBiosciences Initiative
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberGlobal REACH
Research Overview
Epigenetics, Epitranscriptomics, m6A, SH2B1, NIK, TRAF2, TRAF3, Hypothalamic Energy Balance Circuits, Obesity, Type 2 Diabetes, MASH, Alcohol-related Liver Disease
Links
https://sites.google.com/a/umich.edu/liangyouruilab/
Recent Publications
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Zhang X, Huang S, Chen P, Zhang Z, Cai J, Yu T, Xia Z, Yuan S, Chen Y, Gao M, Wu Z, He J, Liao Y, Fu Q, Yang Q, Yin T, Liu J, Song K, Duan SZ, Yang T, Rui L, Zeng YA, Meng ZX, Liu J, Liu Y. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleEndothelial IRE1α promotes thrombospondin-1 mRNA decay and supports metabolic stress adaptation of pancreatic islets
DOI:10.1038/s41467-025-68276-1 PMID: 41513664 -
Li Y, Kim M-H, Ren D, Rui L. Nat Commun, 2026 Apr 15;Journal ArticlePOMC neuron METTL14/m6A/YTHDC1/YTHDF2 pathways safeguard energy balance, body weight, and metabolism.
DOI:10.1038/s41467-026-71672-w PMID: 41986358 -
Zhang Q, Zhang Z, Rui L. Am J Physiol Gastrointest Liver Physiol, 2026 Feb 12;Journal ArticleBrown Adipose Tissue Inactivation Exacerbates Alcohol-Induced Liver Steatosis, Inflammation, and Fibrosis.
DOI:10.1152/ajpgi.00336.2025 PMID: 41677414 -
Wang Y, Nikooie R, Kang Q, Rui L. FASEB Journal, 2025 Dec 15; 39 (23):Journal ArticleBiliary NF-κB-Inducing Kinase Promotes Ductular Reaction, Inflammation, and Fibrosis and Impedes Liver Disease Resolution
DOI:10.1096/fj.202502014RRR PMID: 41348430 -
Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, Colacino JA, Nunez G, Rui L, Shah YM. Nature Communications, 2025 Dec 1; 16 (1):Journal ArticleCorrection to: Intestinal non-canonical NFκB signaling shapes the local and systemic immune response (Nature Communications, (2019), 10, 1, (660), 10.1038/s41467-019-08581-8)
DOI:10.1038/s41467-025-61581-9 PMID: 40628801 -
Zhou R, Ju L, Kang Q, Zheng Q, Ren D, Rui L. Cell Reports, 2025 Oct 28; 44 (10):Journal ArticleAdipose m6A reader YTHDF2 promotes obesity, insulin resistance, and liver steatosis by suppressing β-adrenergic signaling and lipolysis
DOI:10.1016/j.celrep.2025.116445 PMID: 41100256 -
Zhang J, Zhao Y, Pulivendala G, Zhang Q, Rui L, Gao J, Wang H, Zhang G, Nuotio-Antar A, Tong X, Yin L. Advanced Science, 2025 Aug 7; 12 (29):Journal ArticleThe Non-Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF-β-E2F1 Axis
DOI:10.1002/advs.202415032 PMID: 40548862 -
WANG Y, RUI L. Diabetes, 2025 Jun 16; 74 (Supplement_1):Journal Article1646-P: Tumor Cell–Intrinsic NIK Shapes Metabolic Cross Talk between Tumors and Brown Adipose Tissue
DOI:10.2337/db25-1646-p
Featured News & Stories
Health Lab
New study reveals a missing step in a weight control pathway that could be targeted for obesity treatment
New research led by Liangyou Rui, Ph.D., of the Department of Molecular & Integrative Physiology at the University of Michigan Medical School outlines a missing step in one of these alternative pathways, an important discovery in the fight against obesity.
