E Gifford and Love Barnett Upjohn Professor of Internal Medicine and Oncology
Professor of Internal Medicine
Research Professor
Life Sciences Institute
Life Sciences Institute
210 Washtenaw
Ann Arbor, Mi 48109
[email protected]
210 Washtenaw
Ann Arbor, Mi 48109
Available to mentor
Stephen J Weiss
Research Professor
I hold the Upjohn Chair in Medicine & Oncology at the University. I am a member of the Life Sciences Institute and have previously served as the Chief of Molecular Medicine in the Dept of Int Med, the interim Director of the Life Sciences Institute and the Assoc Director of Basic Science Research at the Rogel Cancer Center. I have no clinical or formal teaching responsibilities and confine all of my efforts to the my research program.
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FellowUniversity of Michigan, Internal Medicine, 1980
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Intern/ResidentWashington University in St. Louis School of Medicine, Pathology, 1978
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MDOhio State University, United States of America, 1977
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Center MemberCaswell Diabetes Institute
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Center MemberRogel Cancer Center
Research interests focus on interactions between mesenchymal/skeletal stems as well as adipocytes and the surrounding extracellular matrix both in vitro and in vivo with particular emphasis on the role of mechanotransduction-linked pathways impacting nuclear transcription.
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Fu J, Li S, Ma H, Yang J, Pagnotti GM, Brown LM, Weiss SJ, Mapara MY, Lentzsch S. Nat Commun, 2023 Jul 17; 14 (1): 4271Journal ArticleThe checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease.
DOI:10.1038/s41467-023-39769-8 PMID: 37460553 -
Pagani CA, Bancroft AC, Tower RJ, Livingston N, Sun Y, Hong JY, Nanes BA, Kent RN, Dean K, Franceschi R, Baker BM, Weiss SJ, Levi B. Plastic & Reconstructive Surgery Global Open, 11 (5S): 7 - 8.Journal Article11. Mesenchymal Lineage Discoidin Domain Receptor 2 Affects Heterotopic Ossification Formation and Extracellular Matrix Organization
DOI:10.1097/01.gox.0000937640.56138.fb -
Zhu L, Tang Y, Li X-Y, Kerk SA, Lyssiotis CA, Feng W, Sun X, Hespe GE, Wang Z, Stemmler MP, Brabletz S, Brabletz T, Keller ET, Ma J, Cho J-S, Yang J, Weiss SJ. EMBO J, 2023 Apr 3; 42 (7): e111148Journal ArticleA Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.
DOI:10.15252/embj.2022111148 PMID: 36843552 -
Zhu L, Tang Y, Li X-Y, Kerk SA, Lyssiotis CA, Sun X, Wang Z, Cho J-S, Ma J, Weiss SJ. J Cell Biol, 2023 Apr 3; 222 (4):Journal ArticleProteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.
DOI:10.1083/jcb.202206121 PMID: 36880731 -
Pagani CA, Bancroft AC, Tower RJ, Livingston N, Sun Y, Hong JY, Kent RN, Strong AL, Nunez JH, Medrano JMR, Patel N, Nanes BA, Dean KM, Li Z, Ge C, Baker BM, James AW, Weiss SJ, Franceschi RT, Levi B. Sci Adv, 2022 Dec 21; 8 (51): eabq6152Journal ArticleDiscoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization.
DOI:10.1126/sciadv.abq6152 PMID: 36542719 -
Bahr JC, Li X-Y, Feinberg TY, Jiang L, Weiss SJ. Nat Commun, 2022 Oct 27; 13 (1): 6409Journal ArticleDivergent regulation of basement membrane trafficking by human macrophages and cancer cells.
DOI:10.1038/s41467-022-34087-x PMID: 36302921 -
Fu J, Li S, Ma H, Yang J, Brown LM, Pagnotti GM, Weiss SJ, Mapara MY, Lentzsch S. Blood, 2022 Nov 15; 140 (Supplement 1): 9930 - 9932.Journal ArticleThe Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Cytoskeleton Regulation and Multiple Myeloma Bone Disease
DOI:10.1182/blood-2022-169921 -
Fu J, Li S, Ma H, Yang J, Brown L, Pagnotti G, Weiss S, Mapara M, Lentzsch S. Clinical Lymphoma Myeloma & Leukemia, 2022 Aug; 22: s15Journal ArticleOAB-025: The role of checkpoint inhibitor PD-1H/VISTA in osteoclast activation and bone disease in multiple myeloma
DOI:10.1016/s2152-2650(22)00298-1
