Stephen J Weiss
E Gifford and Love Barnett Upjohn Professor of Internal Medicine and Oncology
Professor of Internal Medicine
Medical School and Research Professor
Life Sciences Institute
University of Michigan
Life Sciences Institute
210 Washtenaw
Ann Arbor, Mi 48109
[email protected]
Life Sciences Institute
210 Washtenaw
Ann Arbor, Mi 48109
Available to mentor
Stephen J Weiss
Research Professor
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About
I hold the Upjohn Chair in Medicine & Oncology at the University. I am a member of the Life Sciences Institute and have previously served as the Chief of Molecular Medicine in the Dept of Int Med, the interim Director of the Life Sciences Institute and the Assoc Director of Basic Science Research at the Rogel Cancer Center. I have no clinical or formal teaching responsibilities and confine all of my efforts to the my research program.
Qualifications
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FellowUniversity of Michigan, Internal Medicine, Ann Arbor, United States
1978 - 1980
Postdoctoral Fellowship
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Intern/ResidentWashington University in St. Louis School of Medicine, Pathology, St Louis, United States
1977 - 1978
Residency
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MDOhio State University, United States of America
1977
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberRogel Cancer Center
Research Overview
Research interests focus on interactions between mesenchymal/skeletal stems as well as adipocytes and the surrounding extracellular matrix both in vitro and in vivo with particular emphasis on the role of mechanotransduction-linked pathways impacting nuclear transcription.
Recent Publications
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Olson AW, Li J, Li X-Y, King L, Jiang L, Banerjee K, McCoy AJ, Gondal MN, Chinnaiyan AM, El-Ashry D, Keller ET, Putnam AJ, Weiss SJ. Proc Natl Acad Sci U S A, 2026 Apr 14; 123 (15): e2520717123Journal ArticleAmoeboid-mesenchymal transition and the proteolytic control of cancer invasion plasticity.
DOI:10.1073/pnas.2520717123 PMID: 41961858 -
Zhang M, Zhu X, Cui M, Guan Y, Zhang Y, Weiss SJ, Chen J, Yao Y, Fu R, Wu Z. Chinese Journal of Natural Medicines, 2026 Apr 1; 24 (4): 414 - 426.Journal ArticleTargeting of MARK2, but not other MARKs, suppresses TNBC progression by inhibition of the mutant p53-driven signaling pathway
DOI:10.1016/S1875-5364(26)61172-7 PMID: 42019995 -
Olson AW, Li J, Li X-Y, King L, Banerjee K, McCoy AJ, Gondal MN, Chinnaiyan AM, El-Ashry D, Keller ET, Putnam AJ, Weiss SJ. 2025 Oct 24;PreprintAmoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity.
DOI:10.1101/2025.10.24.684403 PMID: 41278919 -
Ren BX, Zeng ZL, Deng L, Hu JM, Chen MZ, Jiang HW, Zang CZ, Fang ST, Weiss SJ, Liu J, Fu R, Wu ZQ. Acta Pharmacologica Sinica, 2025 Jan 1;Journal ArticleGenetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation
DOI:10.1038/s41401-025-01519-5 -
Sun X, Wang Z, Tang Y, Weiss SJ, Zhu L. Bio-protocol, 2024 Nov 5; 14 (21):Journal ArticleAn In Vitro Model of Murine Osteoclast-Mediated Bone Resorption
DOI:10.21769/BioProtoc.5100 -
Sabeh F, Li XY, Olson AW, Botvinick E, Kurup A, Gimenez LE, Cho JS, Weiss SJ. Journal of Cell Biology, 2024 Sep 2; 223 (9):Journal ArticleMmp14-dependent remodeling of the pericellular–dermal collagen interface governs fibroblast survival
DOI:10.1083/jcb.202312091 PMID: 38990714 -
Liu X, Li B, Wang S, Zhang E, Schultz M, Touma M, Da Rocha AM, Evans SM, Eichmann A, Herron T, Chen R, Xiong D, Jaworski A, Weiss S, Si MS. Circulation Research, 2024 Mar 29; 134 (7): 913 - 930.Journal ArticleStromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy
DOI:10.1161/CIRCRESAHA.122.321292 PMID: 38414132 -
Fu J, Li S, Ma H, Yang J, Pagnotti GM, Brown LM, Weiss SJ, Mapara MY, Lentzsch S. Nature Communications, 2023 Dec 1; 14 (1):Journal ArticleThe checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease
DOI:10.1038/s41467-023-39769-8 PMID: 37460553
