Stephen J Weiss
Research Professor
Office:
University of Michigan
Life Sciences Institute
210 Washtenaw
Ann Arbor, Mi 48109
Life Sciences Institute
210 Washtenaw
Ann Arbor, Mi 48109
Email:
[email protected]
Available to mentor
Stephen J Weiss
Research Professor
Manage Your Profile
About
I hold the Upjohn Chair in Medicine & Oncology at the University. I am a member of the Life Sciences Institute and have previously served as the Chief of Molecular Medicine in the Dept of Int Med, the interim Director of the Life Sciences Institute and the Assoc Director of Basic Science Research at the Rogel Cancer Center. I have no clinical or formal teaching responsibilities and confine all of my efforts to the my research program.
Qualifications
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FellowUniversity of Michigan, Internal Medicine, Ann Arbor, United States
1978 - 1980
Postdoctoral Fellowship
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Intern/ResidentWashington University in St. Louis School of Medicine, Pathology, St Louis, United States
1977 - 1978
Residency
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MDOhio State University, United States of America
1977
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberRogel Cancer Center
Research Overview
Research interests focus on interactions between mesenchymal/skeletal stems as well as adipocytes and the surrounding extracellular matrix both in vitro and in vivo with particular emphasis on the role of mechanotransduction-linked pathways impacting nuclear transcription.
Recent Publications
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Zhao H, Sun X, Zhou S, Chang Z, Yang J, Yu J, Wang Z, Tang Y, Lin C, Wang L, Weiss SJ, Zhu L. Journal of Biological Chemistry, 2026 Aug 1; 302 (8):Journal ArticleMyeloid-specific interferon regulatory factor 5 promotes bone formation via orchestration of osteoclast lineage-osteoblast coupling
DOI:10.1016/j.jbc.2026.113279 PMID: 42331106 -
Olson AW, Li J, Li XY, King L, Jiang L, Banerjee K, McCoy AJ, Gondal MN, Chinnaiyan AM, El-Ashry D, Keller ET, Putnam AJ, Weiss SJ. Proceedings of the National Academy of Sciences of the United States of America, 2026 Apr 14; 123 (15):Journal ArticleAmoeboid–mesenchymal transition and the proteolytic control of cancer invasion plasticity
DOI:10.1073/pnas.2520717123 PMID: 41961858 -
Zhang M, Zhu X, Cui M, Guan Y, Zhang Y, Weiss SJ, Chen J, Yao Y, Fu R, Wu Z. Chinese Journal of Natural Medicines, 2026 Apr 1; 24 (4): 414 - 426.Journal ArticleTargeting of MARK2, but not other MARKs, suppresses TNBC progression by inhibition of the mutant p53-driven signaling pathway
DOI:10.1016/S1875-5364(26)61172-7 PMID: 42019995 -
Chen Z, Zhang HJ, Chang Z, Tang Y, Weiss SJ, Zhu L. Protein and Cell, 2025 Nov 1; 16 (11): 928 - 931.Journal ArticlePeriosteal reaction: a natural extracellular matrix barrier to prevent cancer-bone invasion
DOI:10.1093/procel/pwaf050 -
Olson AW, Li J, Li X-Y, King L, Banerjee K, McCoy AJ, Gondal MN, Chinnaiyan AM, El-Ashry D, Keller ET, Putnam AJ, Weiss SJ. 2025 Oct 24;PreprintAmoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity.
DOI:10.1101/2025.10.24.684403 PMID: 41278919 -
Ren BX, Zeng ZL, Deng L, Hu JM, Chen MZ, Jiang HW, Zang CZ, Fang ST, Weiss SJ, Liu J, Fu R, Wu ZQ. Acta Pharmacologica Sinica, 2025 Aug 1; 46 (8): 2196 - 2212.Journal ArticleGenetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation
DOI:10.1038/s41401-025-01519-5 PMID: 40133628 -
Sun X, Wang Z, Tang Y, Weiss SJ, Zhu L. Bio Protocol, 2024 Nov 5; 14 (21):Journal ArticleAn In Vitro Model of Murine Osteoclast-Mediated Bone Resorption
DOI:10.21769/BioProtoc.5100 -
Sabeh F, Li XY, Olson AW, Botvinick E, Kurup A, Gimenez LE, Cho JS, Weiss SJ. Journal of Cell Biology, 2024 Sep 2; 223 (9):Journal ArticleMmp14-dependent remodeling of the pericellular–dermal collagen interface governs fibroblast survival
DOI:10.1083/jcb.202312091 PMID: 38990714
