Gary J Fisher, PhD

portrait of Gary Fisher
Harry Helfman Professor of Molecular Dermatology and Professor of Dermatology
Medical School
[email protected]
Available to mentor
Gary J Fisher, PhD
portrait of Gary Fisher
Professor
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  • About

    Gary Fisher is the Harry Helfman Professor of Molecular Dermatology in the Department of Dermatology at the University of Michigan in Ann Arbor and Director of the Photoaging and Aging Research Program. He received his PhD from Cornell University in 1980 and received his postdoctoral training at Washington University in the Departments of Biological Chemistry and Laboratory Medicine.

    Dr. Fisher is mentor to junior faculty in translational research and to post-doctoral fellows, medical (at all levels) and diversity students in laboratory science. Also Dr. Fisher directs the basic science core curriculum course, which is taught to all residents in the Dermatology Department. Dr. Fisher has been a guest lecturer at NIH workshops and continuing education conferences for medical students and nurses alike.

    Dr. Fisher has received recognition as an inventor and by the dean for achievements in clinical and basic science research. He is associate editor for the Journal for Investigative Dermatology and Journal of Dermatological Science. In addition, he is a reviewer for several scholarly journals and is an invited speaker at major scientific meetings in the United States, Europe and Asia. Dr. Fisher is the author of over a hundred published papers.

    Dr. Fisher's research studies the molecular mechanisms of sun-induced premature skin aging and the molecular mechanisms of chronological skin aging focusing on four major areas: procollagen biosynthesis, collagen degradation, signal transduction, and inflammation. Dr. Fisher's laboratory works with the Clinical Research Unit (CRU), Cosmetic Laser Surgery Unit and Cutaneous Surgery and Oncology Unit. His additional current interests include mechanisms of protein phosphatases and stem cells in aging human skin.

    Center Memberships

    • Center Member
      Rogel Cancer Center

    Recent Publications

    See All Publications
    • Preprint
      Fibroblast-specific Deletion of Yap/Taz Impairs Mouse Postnatal Dermal Development by Suppressing Collagen Production and Deposition.
      Alexandre , Kim AJ, Hansen KC, McCabe M, Kim JY, Qin Z, Zhang Z, He T, Guo C, Voorhees JJ, Fisher GJ, Quan T. 2026 Jan 22; DOI:10.64898/2026.01.19.700422
      PMID: 41648482
    • Proceeding / Abstract / Poster
      239 A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease
      Marella S, Bogle R, Fox J, Tsoi L, Xing X, Zhang H, Dey P, Gu Y, Kirma J, Sarkar M, van Drongelen V, Klein B, Fisher G, Kozlow J, Harms P, Gallagher K, Naik S, Rebecca V, Andersen B, Nakamura M, Kahlenberg JM, Modlin R, Billi A, Gudjonsson J. Journal of Investigative Dermatology, 2025 Nov 11; 145 (11): e68 DOI:10.1016/j.jid.2025.09.243
    • Journal Article
      Integrin α11β1 as a Key Collagen Receptor in Human Skin Dermis: Insight into Fibroblast Function and Skin Dermal Aging
      Quan T, Qin Z, He T, Fisher GJ. Journal of Investigative Dermatology, 2025 Oct 1; 145 (10): 2449 - 2463. DOI:10.1016/j.jid.2025.03.006
      PMID: 40139564
    • Journal Article
      CCN2 functions as a modulator of cell cycle regulation in human dermal fibroblasts
      Quan T, Shao Y, Purohit T, Jiang Y, Qin Z, Fisher GJ, Lents NH, Baldassare JJ. Journal of Cell Communication and Signaling, 2025 Mar 1; 19 (1): DOI:10.1002/ccs3.70003
    • Journal Article
      Fibroblast-Specific Deletion of Tgfbr2 in Mouse Skin Recapitulates Human Skin Dermal Aging by Suppressing Collagen Production
      He T, Bergin IL, Kim JY, Guo C, Chu CQ, Fisher GJ, Voorhees JJ, Quan T. Journal of Investigative Dermatology, 2025 Jan 1; DOI:10.1016/j.jid.2025.10.541
      PMID: 41130513
    • Chapter
      Skin Ageing
      Pedersen EA, Fisher GJ, Voorhees JJ, Sachs DL. 2024 Jun 17; Rook's Textbook of Dermatology, DOI:10.1002/9781119709268.rook156
    • Journal Article
      Implications for cumulative and prolonged clinical improvement induced by cross-linked hyaluronic acid: An in vivo biochemical/microscopic study in humans.
      Wang F, Do TT, Smith N, Orringer JS, Kang S, Voorhees JJ, Fisher GJ. Exp Dermatol, 2024 Aug 26; 33 (1): e14998 - e14998. DOI:10.1111/exd.14998
    • Journal Article
      Age-related changes in dermal collagen physical properties in human skin
      He T, Fisher GJ, Kim AJ, Quan T. Plos One, 2023 Dec 1; 18 (12 December): DOI:10.1371/journal.pone.0292791
      PMID: 38064445