Timothy L Frankel, MD

Timothy Frankel
Maud T Lane Professor of Surgical Oncology
Professor of Surgery and Co-Director of the Rogel and Blondy Center for Pancreatic Cancer
Rogel Cancer Center
Medical School
Email:
[email protected]
Phone:
Available to mentor
Timothy L Frankel, MD
Timothy Frankel
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Dr. Timothy L. Frankel is a faculty member within the Section of General Surgery at the University of Michigan. He graduated Magna Cum Laude from Connecticut College in 2000 with a B.A. in Physics and was elected into Phi Beta Kappa. He earned his medical degree from George Washington University in 2004 and was inducted into the Alpha Omega Alpha Honor Medical Society. He completed a residency in General Surgery at the University of Michigan in 2011 during which time he spent two years at the National Cancer Institute studying tumor immunology and genetic engineering. He developed techniques to genetically modify peripheral blood lymphocytes allowing them to more effectively target tumors for destruction. His work resulted in multiple publications and awards including the James Crudup Surgical Research Award. After completion of residency, he completed a two-year surgical oncology fellowship at Memorial Sloan-Kettering Cancer Center in New York.

    Clinical Interests
    • His clinical interests are in the treatment of gastrointestinal malignancies including cancers of the liver, pancreas and stomach. He has published multiple clinical papers on techniques in liver resection for colorectal metastases. He is the surgical lead for the liver tumor program at the Ann Arbor VA and has doubled the volume of liver surgery since joining. He is also establishing multidisciplinary cancer clinics to accelerate work-up and treatment of veterans with cancer. He serves as the Chair of the Commission on Cancer certified Cancer Program and was recently named Director of Comprehensive Cancer Care at the Ann Arbor VA. This role is tasked with monitoring the quality of cancer care provided at the institution and shaping policy related to the treatment of cancer patients. He has formed a cancer care navigation program staffed with providers who facilitate care of patients with newly diagnosed or suspicious tumors guiding them through evaluation and treatment.

    Links

    • https://medresearch.umich.edu/labs-departments/labs/frankel-lab
    • twitter

    Qualifications

    • Fellow
      Memorial Sloan Kettering Cancer Center, Surgery, New York, United States
      2011 - 2013
      Clinical Fellowship
    • Resident
      University of Michigan Medical School, Surgery, Ann Arbor, United States
      2004 - 2011
      Residency
    • Research Fellow, Surgical Oncology
      National Cancer Institute, Surgery, Bethesda, United States
      2007 - 2009
      Postdoctoral Fellowship

    Center Memberships

    • Center Member
      e-Health and Artificial Intelligence Initiative
    • Center Member
      Rogel Cancer Center

    Research Overview

    • Inflammation induced pancreatic cancer
    • Understanding spatial relationships of immune cells in the tumor microenvironment
    • Understanding the role of adipose derived progenitor cells in promoting pancreatic cancer formation in diabetics

    Recent Publications

    See All Publications
    • Journal Article
      Informed spatially aware patterns for multiplexed immunofluorescence data
      Bhadury S, Peruzzi M, Acharyya S, Eliason J, Di Magliano MP, Frankel TL, Ravikumar V, Krishnan S, Rao A. Scientific Reports, 2026 Dec 1; 16 (1): DOI:10.1038/s41598-026-35341-8
      PMID: 41521220
    • Additional Scholarship
      Clinical Trial Protocol1 from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
      Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15; DOI:10.1158/1078-0432.34519891
    • Additional Scholarship
      Data from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
      Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15; DOI:10.1158/1078-0432.c.8775241
    • Additional Scholarship
      Supplementary Figures and Table1 from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
      Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15; DOI:10.1158/1078-0432.34519885
    • Journal Article
      Abstract A034: Spatial multi-omics defines cancer-like precursor lesions in human pancreas
      Okoye JO, Carr R, Espinoza C, Zhang Y, Columbe P, Frankel T, Pasca di Magliano M. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): a034 - a034. DOI:10.1158/1538-7445.pancreatic26-a034
    • Journal Article
      Abstract A090: Quantitative evaluation of changes to healthy pancreatic microanatomy across the human lifespan
      Matos-Romero V, Lombardo K, Higuera-Garrido D, Gensbigler P, Habib S, Wang J, Dequiedt L, Chen W-C, Attaa A, Forjaz A, Muñoz-Barrutia A, Hruban RH, Wirtz D, Frankel TL, Pasca di Magliano M, Wood LD, Kiemen AL. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): a090 - a090. DOI:10.1158/1538-7445.pancreatic26-a090
    • Proceeding / Abstract / Poster
      Abstract B003: Developing an all-human model of perineural invasion in pancreatic cancer
      Casimiro-Núñez RA, Willey S, Hiraki H, Henstridge AZ, Azorsa PA, Goldwasser M, Koenig F, Sahai V, Peterson N, Machicado JD, Kwon R, Schulman AR, Wamsteker E, Philips G, Menees SB, Xia JY, Rao A, Shi J, Saadeh Y, Szerlip N, Biesterveld B, Frankel TL, Bednar F, Pasca di Magliano M, Callaghan B, Todd PK, Carpenter ES. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): b003 - b003. DOI:10.1158/1538-7445.pancreatic26-b003
    • Journal Article
      Abstract B012: Pan-RAS Inhibition Reprograms T Cell Immunity within the Pancreatic Adaptive Immune Microenvironment
      Kumar RJ, Lasse-Opsahl E, Gerbereux L, Espinoza CE, Wang J, Okoye JO, Frankel TL, Pasca di Magliano M. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): b012 - b012. DOI:10.1158/1538-7445.pancreatic26-b012

    Featured News & Stories

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    Health Lab

    Study sheds light on how early pancreas lesions become cancerous

    Why many precursor lesions never develop into pancreatic cancer, according to findings from Michigan Medicine.
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    News Release

    Ribbon-cutting for new pancreatic cancer program

    The Rogel and Blondy Center for Pancreatic Cancer was officially launched with a special ribbon-cutting ceremony on the sixth floor of the Rogel Cancer Center.
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    Study shows how smoking drives pancreatic cancer

    Why smokers have a higher chance of developing pancreatic cancer and why they tend to have worse outcomes than nonsmokers, according to a new study by University of Michigan Health Rogel Cancer Center.
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    Health Lab

    Avoiding recovery delays with hospitalized pancreatitis

    Acute pancreatitis is among the most common gastrointestinal conditions requiring inpatient hospital care in the United States. Balancing the signaling of the interleukin-22 protein and interleukin-22 binding protein is crucial to recovery from acute and chronic pancreatitis.
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    Donor pancreas tissue helps define ‘new normal’ in pancreatic cancer research

    A research partnership between Michigan Medicine and Gift of Life Michigan has revealed a new pathway to understanding the progression of pancreatic cancer.