Timothy L Frankel, MD
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About
Dr. Timothy L. Frankel is a faculty member within the Section of General Surgery at the University of Michigan. He graduated Magna Cum Laude from Connecticut College in 2000 with a B.A. in Physics and was elected into Phi Beta Kappa. He earned his medical degree from George Washington University in 2004 and was inducted into the Alpha Omega Alpha Honor Medical Society. He completed a residency in General Surgery at the University of Michigan in 2011 during which time he spent two years at the National Cancer Institute studying tumor immunology and genetic engineering. He developed techniques to genetically modify peripheral blood lymphocytes allowing them to more effectively target tumors for destruction. His work resulted in multiple publications and awards including the James Crudup Surgical Research Award. After completion of residency, he completed a two-year surgical oncology fellowship at Memorial Sloan-Kettering Cancer Center in New York.
Clinical Interests
• His clinical interests are in the treatment of gastrointestinal malignancies including cancers of the liver, pancreas and stomach. He has published multiple clinical papers on techniques in liver resection for colorectal metastases. He is the surgical lead for the liver tumor program at the Ann Arbor VA and has doubled the volume of liver surgery since joining. He is also establishing multidisciplinary cancer clinics to accelerate work-up and treatment of veterans with cancer. He serves as the Chair of the Commission on Cancer certified Cancer Program and was recently named Director of Comprehensive Cancer Care at the Ann Arbor VA. This role is tasked with monitoring the quality of cancer care provided at the institution and shaping policy related to the treatment of cancer patients. He has formed a cancer care navigation program staffed with providers who facilitate care of patients with newly diagnosed or suspicious tumors guiding them through evaluation and treatment.
Links
https://medresearch.umich.edu/labs-departments/labs/frankel-lab twitter
Qualifications
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FellowMemorial Sloan Kettering Cancer Center, Surgery, New York, United States
2011 - 2013
Clinical Fellowship
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ResidentUniversity of Michigan Medical School, Surgery, Ann Arbor, United States
2004 - 2011
Residency
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Research Fellow, Surgical OncologyNational Cancer Institute, Surgery, Bethesda, United States
2007 - 2009
Postdoctoral Fellowship
Center Memberships
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Center Membere-Health and Artificial Intelligence Initiative
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Center MemberRogel Cancer Center
Research Overview
• Inflammation induced pancreatic cancer
• Understanding spatial relationships of immune cells in the tumor microenvironment
• Understanding the role of adipose derived progenitor cells in promoting pancreatic cancer formation in diabetics
Recent Publications
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Bhadury S, Peruzzi M, Acharyya S, Eliason J, Di Magliano MP, Frankel TL, Ravikumar V, Krishnan S, Rao A. Scientific Reports, 2026 Dec 1; 16 (1):Journal ArticleInformed spatially aware patterns for multiplexed immunofluorescence data
DOI:10.1038/s41598-026-35341-8 PMID: 41521220 -
Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15;Additional ScholarshipClinical Trial Protocol1 from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
DOI:10.1158/1078-0432.34519891 -
Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15;Additional ScholarshipData from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
DOI:10.1158/1078-0432.c.8775241 -
Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15;Additional ScholarshipSupplementary Figures and Table1 from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
DOI:10.1158/1078-0432.34519885 -
Okoye JO, Carr R, Espinoza C, Zhang Y, Columbe P, Frankel T, Pasca di Magliano M. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): a034 - a034.Journal ArticleAbstract A034: Spatial multi-omics defines cancer-like precursor lesions in human pancreas
DOI:10.1158/1538-7445.pancreatic26-a034 -
Matos-Romero V, Lombardo K, Higuera-Garrido D, Gensbigler P, Habib S, Wang J, Dequiedt L, Chen W-C, Attaa A, Forjaz A, Muñoz-Barrutia A, Hruban RH, Wirtz D, Frankel TL, Pasca di Magliano M, Wood LD, Kiemen AL. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): a090 - a090.Journal ArticleAbstract A090: Quantitative evaluation of changes to healthy pancreatic microanatomy across the human lifespan
DOI:10.1158/1538-7445.pancreatic26-a090 -
Casimiro-Núñez RA, Willey S, Hiraki H, Henstridge AZ, Azorsa PA, Goldwasser M, Koenig F, Sahai V, Peterson N, Machicado JD, Kwon R, Schulman AR, Wamsteker E, Philips G, Menees SB, Xia JY, Rao A, Shi J, Saadeh Y, Szerlip N, Biesterveld B, Frankel TL, Bednar F, Pasca di Magliano M, Callaghan B, Todd PK, Carpenter ES. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): b003 - b003.Proceeding / Abstract / PosterAbstract B003: Developing an all-human model of perineural invasion in pancreatic cancer
DOI:10.1158/1538-7445.pancreatic26-b003 -
Kumar RJ, Lasse-Opsahl E, Gerbereux L, Espinoza CE, Wang J, Okoye JO, Frankel TL, Pasca di Magliano M. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): b012 - b012.Journal ArticleAbstract B012: Pan-RAS Inhibition Reprograms T Cell Immunity within the Pancreatic Adaptive Immune Microenvironment
DOI:10.1158/1538-7445.pancreatic26-b012
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