Marina Pasca di Magliano, PhD

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Marina Pasca di Magliano, PhD
Maud T Lane Professor of Surgical Immunology
Professor of Surgery
Professor of Cell and Developmental Biology
Co-Leader Signaling and Tumor Microenvironment Program
Co-Director of the Rogel and Blondy Center for Pancreatic Cancer
Rogel Cancer Center
Medical School
[email protected]
Available to mentor
Marina Pasca di Magliano, PhD
pascadimagliano_marina4x5
Professor
  • Qualifications
  • Center Memberships
  • Recent Publications

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    • Qualifications
    • Embryonic signaling pathways in pancreatic cancer
      University of California, San Francisco, San Francisco, United States
      2002 - 2008
      Postdoctoral Fellowship

    Center Memberships
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Rogel Cancer Center

    Recent Publications

     See All Publications
    • Additional Scholarship
      Supplementary Figures S1-S15 from Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms Reveals Divergent Indolent and Malignant States
      Iyer MK, Fletcher AA, Okoye JO, Shi C, Chen F, Kanu EN, Eckhoff AM, Bao M, Pasca di Magliano M, Frankel TL, Chinnaiyan AM, Nussbaum DP, Allen PJ. 2026 Jun 17; DOI:10.1158/1078-0432.32709068
    • Additional Scholarship
      Supplementary Tables S1-S9 from Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms Reveals Divergent Indolent and Malignant States
      Iyer MK, Fletcher AA, Okoye JO, Shi C, Chen F, Kanu EN, Eckhoff AM, Bao M, Pasca di Magliano M, Frankel TL, Chinnaiyan AM, Nussbaum DP, Allen PJ. 2026 Jun 17; DOI:10.1158/1078-0432.32709065
    • Journal Article
      Targeting CCR1 remodels the tumor microenvironment and relieves immune suppression in pancreatic cancer.
      Zhang Y, Kadiyala P, Yan W, Brown K, Avritt FR, Donahue KL, Procario MC, Okoye JO, Giridharan T, Elhossiny AM, Espinoza CE, Awad D, Lasse Opsahl EL, Medina-Cabrera PI, Velez-Delgado A, Menjivar RE, Yang OA, Yang S, He X, Gupta S, Tariq R, Brandt AR, Wang X, denDekker A, Nwosu ZC, Carpenter ES, Courtney AH, Bednar F, Frankel TL, Lyssiotis CA, Zheng B, Kryczek I, Pasca di Magliano M. Cancer Immunol Res, 2026 May 28; DOI:10.1158/2326-6066.CIR-25-1300
      PMID: 42207977
    • Journal Article
      Asynchronous evolution of epithelium and stroma differentiates precursor lesions from pancreatic cancer.
      Elhossiny AM, Kadiyala P, Okoye JO, Hiraki HL, Procario MC, Giridharan T, Watkoske HR, Tannus Ruckert M, Wang J, Griffith BD, Bray AW, Mills JN, Espinoza CE, Zeller J, Peterson N, Bednar F, Zhang Y, Rao A, Lyssiotis CA, Szczepanski JM, Shi J, Deshpande A, Maitra A, Fertig EJ, Carpenter ES, Frankel TL, Pasca di Magliano M. Cancer Discov, 2026 May 21; DOI:10.1158/2159-8290.CD-25-2001
      PMID: 42165710
    • Journal Article
      Hypoxia Impairs CD8+ T Cell Fitness and Is Associated with a Dysfunctional CD8+ T Cell State in Pancreatic Cancer
      Mello AM, Pasca di Magliano M, Lee KE. Cancers, 2026 May 13; 18 (10): 1508 - 1508. DOI:10.3390/cancers18101508
    • Journal Article
      Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition.
      Reyes J, Del Priore I, Chaikovsky AC, Pasnuri N, Elhossiny AM, Park J, Weiler P, Krause T, Moorman A, Snopkowski C, Takizawa M, Burdziak C, Ratnayeke N, Masilionis I, Ho Y-J, Chaligné R, Romesser PB, Filliol A, Nawy T, Morris JP, Zhao Z, Pasca Di Magliano M, Alonso-Curbelo D, Pe'er D, Lowe SW. Cell, 2026 Apr 15; DOI:10.1016/j.cell.2026.03.032
      PMID: 41990751
    • Journal Article
      Hypoxia-Induced Fibroblast IL-6 Promotes Immunosuppressive Macrophage Phenotypes in Pancreatic Cancer
      Hannifin S, Mello AM, Ngodup T, Kim NH, Pasca di Magliano M, Lee KE. Cells, 2026 Apr 15; 15 (8): 683 - 683. DOI:10.3390/cells15080683
    • Journal Article
      Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer.
      Mbah NE, Sutton D, Hong HS, Singhal R, Menjivar RE, Perricone MD, Giza H, Sajjakulnukit P, Myers AL, Nwosu ZC, Alektiar JM, Lin J, Long D, Andren AC, Zhang L, Crawford HC, Frankel TL, Pasca di Magliano M, Franchi L, Shah YM, Lyssiotis CA. Cancer Metab, 2026 Apr 4; 14 (1): DOI:10.1186/s40170-026-00428-3
      PMID: PMC13072669

    Featured News & Stories

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    Health Lab

    Study sheds light on how early pancreas lesions become cancerous

    Why many precursor lesions never develop into pancreatic cancer, according to findings from Michigan Medicine.
         Susan and Richard Rogel stand with Dr. Eric Fearon the director of the Rogel Cancer Center as well as the leaders of the new Rogel and Blondy Center for Pancreatic Cancer Research
    News Release

    Ribbon-cutting for new pancreatic cancer program

    The Rogel and Blondy Center for Pancreatic Cancer was officially launched with a special ribbon-cutting ceremony on the sixth floor of the Rogel Cancer Center.
         A scientific diagram of immunofluoresence
    Department News

    Donor pancreas tissue helps define ‘new normal’ in pancreatic cancer research

    A research partnership between Michigan Medicine and Gift of Life Michigan has revealed a new pathway to understanding the progression of pancreatic cancer.
    Department News

    Congratulations to Marina Pasca di Magliano

    Marina has been inducted as a 2022 Fellow of the American Association for the Advancement of Science (AAAS).