Maureen Sartor, PhD

 Maureen Sartor
Co-Director
Bioinformatics Graduate Program
Professor of Computational Medicine and Bioinformatics
Medical School
Professor of Biostatistics
School of Public Health
[email protected]
Available to mentor
Maureen Sartor, PhD
Maureen Sartor
Professor
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  • Research Overview
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    • Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      AI and Digital Health Innovation

    Research Overview

    The Sartor laboratory has both methodological and biomedical areas of focus. Their methodological focus is bioinformatics methods and tools for the analysis of genome-wide regulatory and epigenomics data, and for assessing the biological/clinical significance of results. For instance, Dr. Sartor is a member of the Impact of Genomic Variants on Function (IGVF) NIH Consortium, for which she is developing a coupled tensor-matrix completion method to prioritize disease-specific variant-gene target pairs. The Sartor Lab also focuses on multi-omics approaches for biomarker and treatment-target discovery in disease, focusing specifically on Amyotrophic Lateral Sclerosis (ALS) and head and neck squamous cell carcinomas (HNSCC). Dr. Sartor is PI of an R01 studying downstream consequences of HPV integration in HPV-associated HNSCC, and Co-PI of a Transformative R01 linking environmental exposures with multi-omics in ALS. Being formally trained in biostatistics, Dr. Sartor uses machine learning and statistical approaches to make advances in the above areas.

    Links
    • Sartor Lab

    Recent Publications

     See All Publications
    • Journal Article
      The importance of HPV testing in oropharyngeal cancer in two US populations.
      Lawas MM, Hsieh M, Patil S, Mohebbi E, Zhang R, Ahn J, Benjamin W, Chinn SB, Witek M, Mabvakure B, Duttargi A, Cruz LM, Garb B, Li S, D'Silva NJ, Sartor MA, Rozek LS. Neoplasia, 2026 Jul 2; 79: 101323 DOI:10.1016/j.neo.2026.101323
      PMID: 42391786
    • Preprint
      Race and Socioeconomic Status Impact Survival from Early and Late-Onset Colorectal Cancer.
      Purrington K, Hsieh M-C, Patil S, Mabvakure B, Ahn J, Zhang R, Ruterbusch JJ, Samdani R, Lee G, Wenzlaff A, Latif S, Dash C, Sartor M, Schwartz AG, Stoffel EM, Rozek LS. 2026 Jun 29; DOI:10.64898/2026.06.24.26356439
      PMID: 42428080
    • Preprint
      Somatic Mutation Profiles in Colorectal Cancers Differ by Population.
      Mabvakure BM, Promprasert P, Martinez Cruz L, Patil S, Barros J, Hayhurst M, Mohebbi E, de la Caridad Delgado Herrera D, Lee G, Latif S, Williams F, Samdani R, Duttargi A, Berhane B, Besufikad E, Tadesse S, Jibril Suleiman A, Lefante C, Hsieh M-C, Purrington K, Adjei E, Qin T, Sartor M, Stoffel EM, Rozek LS. 2026 Jun 29; DOI:10.64898/2026.06.24.26356431
      PMID: 42428056
    • Journal Article
      Correction: SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.
      Chen X-W, Wang H, Bajaj K, Zhang P, Ma D, Bai Y, Liu H-H, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D. Elife, 2026 Jun 24; 15: DOI:10.7554/eLife.112375
      PMID: 42339786
    • Journal Article
      Abstract 3943: Morphology-derived spindle-cell gene signature in HPV+ HNSCC is linked to pEMT, molecular subtype, HPV integration, and recurrence-free survival.
      Xia S, Lim YX, Liu M, Grab B, Patil S, Li S, Rozek L, D'silva NJ, Sartor MA. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 3943 - 3943. DOI:10.1158/1538-7445.am2026-3943
    • Journal Article
      Identification of isoform switching events linked with esophageal adenocarcinoma patient survival informs novel prognostic and therapeutic targets, In Revision
      Zhang Y, Ntsiful DA, Israel R, Vandenburg B, Barnett S, Riethoven J-J, Clarke J, Lagisetty K, Lin J, Reddy RM, Chang A, Odell D, DiFeo A, Sartor MA, Kresty LA. Cell Death and Disease, 2025 May 29;
    • Preprint
      TFBSpedia: a comprehensive human and mouse transcription factor binding sites database
      Li S, Chou E, Wang K, Boyle AP, Sartor MA. 2026 Mar 8; bioRxiv, DOI:10.64898/2026.03.04.709638
    • Journal Article
      HPV Integration in Head and Neck Cancer: Downstream Splicing Events and Expression Ratios Linked with Poor Outcomes
      Li S, Xia S, Lawas M, Kulshreshtha A, Garb BF, Soppe SE, Perera C, Li C, Liu M, Lim YX, Qin T, Welch JD, D’silva NJ, Rozek LS, Sartor MA. Clinical Cancer Research, 2026 Feb 1; 32 (3): 581 - 595. DOI:10.1158/1078-0432.CCR-25-0645
      PMID: 41269209

    Featured News & Stories

         Elysia Chou
    Department News

    Elysia Chou receives Rackham Predoctoral Fellowship

    Elysia Chou, graduate student in the Sartor lab in the Department of Computational Medicine & Bioinformatics, is a recipient of this year’s Rackham Predoctoral Fellowship.
         blood vial blue gloves blurred background
    Health Lab

    Researchers develop models to help diagnose ALS earlier through blood biomarkers

    New machine learning models by Michigan Medicine may help diagnose amyotrophic lateral sclerosis, or ALS, earlier on through a blood sample.
         Mahnoor Gondal sitting on a sandy beach
    Points of Blue

    Mahnoor Gondal, PhD candidate: Advancing cancer immunology and fostering career skills in others

    Mahnoor Gondal is a PhD Candidate in Bioinformatics.
    Department News

    Congratulations to Dr. Kai Wang for your K99/R00 grant

    Congratulations to Dr. Kai Wang, who was awarded a K99/R00 grant starting August 2023 from the NIEHS titled “Improving chemical exposome target prediction by application of Coupled Matrix/Tensor-Matrix Completion algorithms.”