Randy J Seeley
Surgery
2800 Plymouth Rd
Ann Arbor, MI 48109
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About
Dr. Randy Seeley is the Henry King Ransom Endowed Professor of Surgery, Internal Medicine, and Nutritional Sciences at the University of Michigan School of Medicine. He also serves as the director of the NIH-funded Michigan Nutrition Obesity Research Center (MNORC). Before that, Dr. Seeley was Professor of Medicine and held the Donald C. Harrison Endowed Chair at the University of Cincinnati College of Medicine. He also served as the Director of the Cincinnati Diabetes and Obesity Center (CDOC). His scientific work has focused on the brain-gut axis and its role in the regulation of energy balance and metabolism. He and his lab have worked to understand the actions of GLP-1 agonists and identify the molecular underpinnings of the potent effects of bariatric surgery on weight and metabolism.
Dr. Seeley received his B.A. from Grinnell College in 1989 and his Ph.D. from the University of Pennsylvania in 1993. He then spent two years as a fellow and two years on the faculty at the University of Washington before relocating to the University of Cincinnati in 1997 and then to the University of Michigan in 2014. He has published over 390 peer-reviewed articles including articles in Science, Nature, Nature Medicine, Nature Neuroscience, Science Translational Medicine, Cell Metabolism, The Journal of Clinical Investigation, and the New England Journal of Medicine. Collectively, this work has been cited more than 43,000 times and Dr. Seeley has a Scopus h-index of 103. He is the recipient of the 2003 Lilly Scientific Achievement Award from the Obesity Society given to the individual with the highest level of scientific achievement in obesity research in North America less than 15 years after their terminal degree. He is also the co-recipient of the 2008 Ernst Oppenheimer Award from the Endocrine Society. This Award is the premier award to an investigator under the age of 45 in recognition of meritorious accomplishment in the field of basic or clinical endocrinology. He also received the 2009 Outstanding Scientific Achievement Award from the American Diabetes Association. This award is presented to an individual medical researcher under age 45 who has made an outstanding contribution to diabetes research that demonstrates both originality and independence of thought.
Dr. Seeley has also served on numerous review panels for the NIH and was Chair of the Integrative Physiology of Obesity and Diabetes review panel. He served on the NIDDK Clinical Obesity Research Panel and on the Board of Reviewing Editors for Science. He currently serves as Senior Associate Editor for Diabetes.
Dr. Seeley has also been sought after by companies trying to bring new therapies for obesity and diabetes to patients. He has served as a consultant or member of a Scientific Advisory Board for venture capital, medical device, pharmaceutical, and biotech companies such as Procter & Gamble, Johnson & Johnson, Novartis, Novo Nordisk, Eli Lilly, Merck, Takeda, Amylin, Angiochem, Zealand, Boehringer Ingelheim, Eisai, Janssen, Novartis, Sanofi, Kallyope, Scohia, Ironwood Pharmaceuticals, Zafgen, Gilead, Kintai, Ionis, Rewind Health, and Calibrate. His laboratory has worked on numerous collaborative research projects with industry partners including Ethicon Endo-Surgery, Procter & Gamble, Pfizer, Novo Nordisk, Amylin, Roche, Merck, Zafgen, Zealand, Mannkind, Boehringer Ingelheim, Easai, Givaudan, AstraZeneca, Ablaris, Kintai, Energesis, Ionis, Fractyl, Amgen, Glyscend, Bullfrog AI and Eli Lilly. He has also been sought for numerous media interviews about obesity therapy including in the New York Times, Wall Street Journal, STAT News, and PBS’s Nova.
Links
Laboratory web site twitter
Qualifications
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NRSA Post-Doctoral FellowshipUniversity of Washington, Psychology, Seattle, United States
1995 - 1997
Postdoctoral Fellowship
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Ph.D.University of Pennsylvania, Philadelphia, USA
1989 - 1993
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BAGrinnell College, Grinnell, United States
1985 - 1989
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberSamuel and Jean Frankel Cardiovascular Center
Research Overview
His scientific work has focused on the brain-gut axis and its role in the regulation of energy balance and metabolism with a focus on new treatment strategies. He and his lab have worked to understand the actions of GLP-1 agonists and identify the molecular underpinnings of the potent effects of bariatric surgery on weight and metabolism.
Recent Publications
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Sood A, Peterson J, Jena J, Challa V, Washburn C, Seeley RJ, Pereira RO. Journal of Molecular Medicine, 2026 Dec 1; 104 (1):Journal ArticleGFRAL is required to mediate changes in systemic metabolism in response to mitochondrial stress in brown adipose tissue
DOI:10.1007/s00109-026-02671-z PMID: 41974995 -
Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell JE, Candela P, Castelino RL, Coupland C, Culot M, Dodson WS, Douros JD, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao X-B, Gosselet F, Grandl G, Gutgesell RM, Haas DT, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach AC, Keuper M, Kusminski CM, Leander DC, Liskiewicz A, Liu X, Maity-Kumar G, Martinez SM, Mowery SA, Nogueiras R, Paisley M, Perez-Tilve D, Petersen PSS, Pfluger PT, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath TL, Scherer PE, Seeley RJ, DiMarchi RD, Tschöp MH, Krahmer N, Knerr PJ, Müller TD. Nature, 2026 May 18;Journal ArticlePublisher Correction: GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.
DOI:10.1038/s41586-026-10619-z PMID: 42151694 -
Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell JE, Candela P, Castelino RL, Coupland C, Culot M, Dodson WS, Douros JD, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao X-B, Gosselet F, Grandl G, Gutgesell RM, Haas DT, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach AC, Keuper M, Kusminski CM, Leander DC, Liskiewicz A, Liu X, Maity-Kumar G, Martinez SM, Mowery SA, Nogueiras R, Paisley M, Perez-Tilve D, Petersen PSS, Pfluger PT, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath TL, Scherer PE, Seeley RJ, DiMarchi RD, Tschöp MH, Krahmer N, Knerr PJ, Müller TD. Nature, 2026 Apr 29;Journal ArticleGLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.
DOI:10.1038/s41586-026-10427-5 PMID: 42056522 -
Yang Loureiro Z, Westcott GP, Gulko A, Essene A, Zhou Z, Liang W, Jacobs C, Nagesh S, Bozadjieva-Kramer N, Seeley RJ, Gourash W, Loureiro JJ, Jennings LL, Gerszten RE, Courcoulas A, Tsai LT, Emont MP, Rosen ED. 2026 Apr 16; openRxiv,PreprintRapid Remodeling of Human White Adipose Tissue Following Bariatric Surgery
DOI:10.64898/2026.04.09.717542 -
Bozadjieva-Kramer N, McMahon G, Li Z, Wean J, Shin JH, Myronovych A, O'Rourke RW, MacDougald OA, Seeley RJ. Diabetes, 2026 Apr 1;Journal ArticleGut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss.
DOI:10.2337/db25-0466 PMID: 41920187 -
Sonner JK, Kahn A, Binkle-Ladisch L, Engler JB, Haack B, Zeiler C, Unger L, Bauer S, Fischbach F, Almanzar G, Walkenhorst M, Mayer C, Kolakowska A, Graute S, Ramien C, Winschel I, Rothammer N, Heine M, Horneffer-van der Sluis V, Thiemann V, Vieira V, Meurs N, Renné T, Prelog M, Jørgensen SB, Seeley RJ, Diemert A, Arck PC, Gold SM, Heeren J, Wischhusen J, Friese MA. Nature Immunology, 2026 Mar 1; 27 (3): 503 - 515.Journal ArticleA GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation
DOI:10.1038/s41590-025-02406-1 PMID: 41540266 -
Carlson TL, Fineman M, Kernodle S, Hutch CR, Bryant C, Colbert K, Seeley RJ, Nimgaonkar A. Molecular Metabolism, 2026 Jan 1; 103:Journal ArticleAdditive effects of GLY-200 (oral pharmacologic duodenal exclusion therapy) and GLP-1R agonist in obesity management
DOI:10.1016/j.molmet.2025.102287 PMID: 41270831 -
Greiner TU, Seeley RJ, Bäckhed F. American Journal of Physiology Endocrinology and Metabolism, 2026 Jan 1; 330 (1): E106 - E113.Journal ArticleGLP-1 from the distal gut is dispensable for body weight and glucose regulation but slows small intestinal transit in female mice
DOI:10.1152/ajpendo.00158.2025 PMID: 41369590
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