Randy J Seeley

seeley-randy
Henry King Ransom Professor of Surgery
Professor of Surgery
Professor of Internal Medicine
Medical School
Professor of Nutritional Sciences
School of Public Health
University of Michigan
Surgery
2800 Plymouth Rd
Ann Arbor, MI 48109
[email protected]
Available to mentor
Randy J Seeley
seeley-randy
Professor
  • About
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  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Dr. Randy Seeley is the Henry King Ransom Endowed Professor of Surgery, Internal Medicine, and Nutritional Sciences at the University of Michigan School of Medicine. He also serves as the director of the NIH-funded Michigan Nutrition Obesity Research Center (MNORC). Before that, Dr. Seeley was Professor of Medicine and held the Donald C. Harrison Endowed Chair at the University of Cincinnati College of Medicine. He also served as the Director of the Cincinnati Diabetes and Obesity Center (CDOC). His scientific work has focused on the brain-gut axis and its role in the regulation of energy balance and metabolism. He and his lab have worked to understand the actions of GLP-1 agonists and identify the molecular underpinnings of the potent effects of bariatric surgery on weight and metabolism.

    Dr. Seeley received his B.A. from Grinnell College in 1989 and his Ph.D. from the University of Pennsylvania in 1993. He then spent two years as a fellow and two years on the faculty at the University of Washington before relocating to the University of Cincinnati in 1997 and then to the University of Michigan in 2014. He has published over 390 peer-reviewed articles including articles in Science, Nature, Nature Medicine, Nature Neuroscience, Science Translational Medicine, Cell Metabolism, The Journal of Clinical Investigation, and the New England Journal of Medicine. Collectively, this work has been cited more than 43,000 times and Dr. Seeley has a Scopus h-index of 103. He is the recipient of the 2003 Lilly Scientific Achievement Award from the Obesity Society given to the individual with the highest level of scientific achievement in obesity research in North America less than 15 years after their terminal degree. He is also the co-recipient of the 2008 Ernst Oppenheimer Award from the Endocrine Society. This Award is the premier award to an investigator under the age of 45 in recognition of meritorious accomplishment in the field of basic or clinical endocrinology. He also received the 2009 Outstanding Scientific Achievement Award from the American Diabetes Association. This award is presented to an individual medical researcher under age 45 who has made an outstanding contribution to diabetes research that demonstrates both originality and independence of thought.

    Dr. Seeley has also served on numerous review panels for the NIH and was Chair of the Integrative Physiology of Obesity and Diabetes review panel. He served on the NIDDK Clinical Obesity Research Panel and on the Board of Reviewing Editors for Science. He currently serves as Senior Associate Editor for Diabetes.

    Dr. Seeley has also been sought after by companies trying to bring new therapies for obesity and diabetes to patients. He has served as a consultant or member of a Scientific Advisory Board for venture capital, medical device, pharmaceutical, and biotech companies such as Procter & Gamble, Johnson & Johnson, Novartis, Novo Nordisk, Eli Lilly, Merck, Takeda, Amylin, Angiochem, Zealand, Boehringer Ingelheim, Eisai, Janssen, Novartis, Sanofi, Kallyope, Scohia, Ironwood Pharmaceuticals, Zafgen, Gilead, Kintai, Ionis, Rewind Health, and Calibrate. His laboratory has worked on numerous collaborative research projects with industry partners including Ethicon Endo-Surgery, Procter & Gamble, Pfizer, Novo Nordisk, Amylin, Roche, Merck, Zafgen, Zealand, Mannkind, Boehringer Ingelheim, Easai, Givaudan, AstraZeneca, Ablaris, Kintai, Energesis, Ionis, Fractyl, Amgen, Glyscend, Bullfrog AI and Eli Lilly. He has also been sought for numerous media interviews about obesity therapy including in the New York Times, Wall Street Journal, STAT News, and PBS’s Nova.

    Links

    • Laboratory web site
    • twitter

    Qualifications

    • NRSA Post-Doctoral Fellowship
      University of Washington, Psychology, Seattle, United States
      1995 - 1997
      Postdoctoral Fellowship
    • Ph.D.
      University of Pennsylvania, Philadelphia, USA
      1989 - 1993
    • BA
      Grinnell College, Grinnell, United States
      1985 - 1989

    Center Memberships

    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center

    Research Overview

    His scientific work has focused on the brain-gut axis and its role in the regulation of energy balance and metabolism with a focus on new treatment strategies. He and his lab have worked to understand the actions of GLP-1 agonists and identify the molecular underpinnings of the potent effects of bariatric surgery on weight and metabolism.

    Recent Publications

    See All Publications
    • Journal Article
      GFRAL is required to mediate changes in systemic metabolism in response to mitochondrial stress in brown adipose tissue
      Sood A, Peterson J, Jena J, Challa V, Washburn C, Seeley RJ, Pereira RO. Journal of Molecular Medicine, 2026 Dec 1; 104 (1): DOI:10.1007/s00109-026-02671-z
      PMID: 41974995
    • Journal Article
      Publisher Correction: GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.
      Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell JE, Candela P, Castelino RL, Coupland C, Culot M, Dodson WS, Douros JD, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao X-B, Gosselet F, Grandl G, Gutgesell RM, Haas DT, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach AC, Keuper M, Kusminski CM, Leander DC, Liskiewicz A, Liu X, Maity-Kumar G, Martinez SM, Mowery SA, Nogueiras R, Paisley M, Perez-Tilve D, Petersen PSS, Pfluger PT, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath TL, Scherer PE, Seeley RJ, DiMarchi RD, Tschöp MH, Krahmer N, Knerr PJ, Müller TD. Nature, 2026 May 18; DOI:10.1038/s41586-026-10619-z
      PMID: 42151694
    • Journal Article
      GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.
      Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell JE, Candela P, Castelino RL, Coupland C, Culot M, Dodson WS, Douros JD, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao X-B, Gosselet F, Grandl G, Gutgesell RM, Haas DT, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach AC, Keuper M, Kusminski CM, Leander DC, Liskiewicz A, Liu X, Maity-Kumar G, Martinez SM, Mowery SA, Nogueiras R, Paisley M, Perez-Tilve D, Petersen PSS, Pfluger PT, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath TL, Scherer PE, Seeley RJ, DiMarchi RD, Tschöp MH, Krahmer N, Knerr PJ, Müller TD. Nature, 2026 Apr 29; DOI:10.1038/s41586-026-10427-5
      PMID: 42056522
    • Preprint
      Rapid Remodeling of Human White Adipose Tissue Following Bariatric Surgery
      Yang Loureiro Z, Westcott GP, Gulko A, Essene A, Zhou Z, Liang W, Jacobs C, Nagesh S, Bozadjieva-Kramer N, Seeley RJ, Gourash W, Loureiro JJ, Jennings LL, Gerszten RE, Courcoulas A, Tsai LT, Emont MP, Rosen ED. 2026 Apr 16; openRxiv, DOI:10.64898/2026.04.09.717542
    • Journal Article
      Gut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss.
      Bozadjieva-Kramer N, McMahon G, Li Z, Wean J, Shin JH, Myronovych A, O'Rourke RW, MacDougald OA, Seeley RJ. Diabetes, 2026 Apr 1; DOI:10.2337/db25-0466
      PMID: 41920187
    • Journal Article
      A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation
      Sonner JK, Kahn A, Binkle-Ladisch L, Engler JB, Haack B, Zeiler C, Unger L, Bauer S, Fischbach F, Almanzar G, Walkenhorst M, Mayer C, Kolakowska A, Graute S, Ramien C, Winschel I, Rothammer N, Heine M, Horneffer-van der Sluis V, Thiemann V, Vieira V, Meurs N, Renné T, Prelog M, Jørgensen SB, Seeley RJ, Diemert A, Arck PC, Gold SM, Heeren J, Wischhusen J, Friese MA. Nature Immunology, 2026 Mar 1; 27 (3): 503 - 515. DOI:10.1038/s41590-025-02406-1
      PMID: 41540266
    • Journal Article
      Additive effects of GLY-200 (oral pharmacologic duodenal exclusion therapy) and GLP-1R agonist in obesity management
      Carlson TL, Fineman M, Kernodle S, Hutch CR, Bryant C, Colbert K, Seeley RJ, Nimgaonkar A. Molecular Metabolism, 2026 Jan 1; 103: DOI:10.1016/j.molmet.2025.102287
      PMID: 41270831
    • Journal Article
      GLP-1 from the distal gut is dispensable for body weight and glucose regulation but slows small intestinal transit in female mice
      Greiner TU, Seeley RJ, Bäckhed F. American Journal of Physiology Endocrinology and Metabolism, 2026 Jan 1; 330 (1): E106 - E113. DOI:10.1152/ajpendo.00158.2025
      PMID: 41369590

    Featured News & Stories

    2025 Dean's Lecture and Bold Science Symposium
    Medical School News

    2025 Dean’s Lecturer: GLP-1 therapies saving, improving lives of many patients

    Lives are being saved, and many others are being changed dramatically, by current GLP-1 therapies like tirzepatide, which has helped many patients treat type 2 diabetes and sleep apnea, and also lose weight. It has been a long road from bench research to clinical trials to the health care market, but patients are now benefitting more than ever, according to a leading scientist who served as the keynote speaker for the second annual Dean’s Lecture and Bold Science Symposium, “Metabolism Research from Bench to Bedside.” Daniel Skovronsky, M.D., Ph.D., chief scientific officer and executive vice president of science and technology at Eli Lilly and Company and president of Research Laboratories and Lilly Immunology, was the Dean’s Lecturer on April 14 at the North Campus Research Complex Dining Hall.
    man standing smiling in hallway
    Health Lab

    Randy Seeley gets a lot of questions about GLP-1s. Here’s why

    A Michigan Medicine Ph.D. researcher dissected bariatric surgery to understand how it actually works, contributing to obesity therapies that have given rise to drugs like Ozempic and Wegovy.
    man standing smiling in hallway
    Research News

    Obesity Expert & CDI Faculty, Randy Seeley PhD, featured in Health Lab

    CDI Faculty member Randy Seeley, PhD, has been studying communication between the gut and brain and how it translates into obesity and diabetes therapies for more than 30 years.
    Smiling tall white man in glasses and a dark blue suit.
    Department News

    Randy Seeley gets a lot of questions about GLP-1s. Here’s why.

    Learn more about Randy Seeley, PhD, and why his research has so many people turning to him for answers about weight-loss drugs.
    Illustrated graphic of a person working in a lab
    Department News

    Why does bariatric surgery work? A peptide holds one more clue

    A recent paper published in Cell Metabolism described one more key to understand how the surgery works: The triggering of an increase of an antimicrobial peptide called Regenerating Islet-Derived Protein 3 Gamma (Reg3g).