Jason Scott Knight, MD, PhD
Marvin and Betty Danto Research Professor of Connective Tissue Research
Professor of Internal Medicine
Department of Internal Medicine, Rheumatology
5560D MSRB2, 1150 W. Medical Center Drive
Ann Arbor, MI 48109-5678
jsknight@umich.edu

Available to mentor

Jason Scott Knight, MD, PhD
Professor
  • About
  • Links
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Knight received his M.D. and Ph.D. degrees from the University of Michigan and completed his molecular biology Ph.D. research in the laboratory of Dr. Erle Robertson at the University of Pennsylvania. His fellowship in rheumatology was at the University of Michigan, where he pursued postdoctoral research in the laboratory of Dr. Mariana Kaplan. During fellowship, he received the prestigious American College of Rheumatology Distinguished Fellow Award, as well as a Rheumatology Research Foundation Scientist Development Award.

    As a faculty member, he has been awarded the Jerome W. Conn Award for Excellence in Research by the Department of Internal Medicine. He has also received the Edmund L. Dubois Award for young lupus researchers from the American College of Rheumatology and the Mary Betty Stevens Young Investigator Prize from the Lupus Foundation of America. He is a member of the American Society for Clinical Investigation.

    His NIH-funded research laboratory has also received financial support from the Burroughs Wellcome Fund, Department of Defense, Lupus Research Alliance, and Rheumatology Research Foundation, His research group is working to better understand the triggers and effectors of autoimmunity in lupus and the related antiphospholipid syndrome (APS). His group is also interested in other diseases characterized by excessive neutrophil-mediated inflammation including diabetes and COVID-19.

    Dr. Knight is an international leader in the clinical care of APS patients and the role of inflammation in APS. Contact Dr. Knight if you are interested in participating in APS research studies.

    Links
    • http://michmed.org/knight-lab
    • https://scholar.google.com/citations?user=CMmo3wsAAAAJ&hl=en
    • twitter
    • http://michmed.org/aps-research-labs
    Center Memberships
    • Center Member
      Global REACH
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Interplay between the immune system and thrombosis.
    Role of neutrophils and neutrophil extracellular traps (NETs) in autoimmune disease.
    Interaction of neutrophils and endothelial cells in antiphospholipid syndrome (APS).
    Extracellular purine species as regulators of inflammation in systemic lupus erythematosus (SLE).

    Recent Publications See All Publications
    • Journal Article
      Taxifolin inhibits NETosis through activation of Nrf2 and provides protective effects in models of lupus and antiphospholipid syndrome.
      Rysenga CE, May-Zhang L, Zahavi M, Knight JS, Ali RA. Rheumatology (Oxford), 2024 Jul 1; 63 (7): 2006 - 2015. DOI:10.1093/rheumatology/kead547
      PMID: 37815837
    • Journal Article
      Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome.
      Sloan EE, Kmetova K, NaveenKumar SK, Kluge L, Chong E, Hoy CK, Yalavarthi S, Sarosh C, Baisch J, Walters L, Nassi L, Fuller J, Turnier JL, Pascual V, Wright TB, Madison JA, Knight JS, Zia A, Zuo Y. Clin Immunol, 2024 Apr; 261: 109926 DOI:10.1016/j.clim.2024.109926
      PMID: 38355030
    • Journal Article
      Longitudinal plasma proteomics in CAR T-cell therapy patients implicates neutrophils and NETosis in the genesis of CRS.
      Flora C, Olesnavich M, Zuo Y, Sandford E, Madhukar R, Rozwadowski M, Sugur K, Ly A, Canbaz AA, Shedeck A, Li G, Geer MJ, Yanik GA, Ghosh M, Frame DG, Bonifant CL, Jain T, Knight JS, Choi SW, Tewari M. Blood Adv, 2024 Mar 26; 8 (6): 1422 - 1426. DOI:10.1182/bloodadvances.2023010728
      PMID: 38266157
    • Journal Article
      Low ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome.
      NaveenKumar SK, Tambralli A, Fonseca BM, Yalavarthi S, Liang W, Hoy CK, Sarosh C, Rysenga CE, Ranger CH, Vance CE, Madison JA, Orsi FA, Sood SL, Schaefer JK, Zuo Y, Knight JS. Blood, 2024 Mar 21; 143 (12): 1193 - 1197. DOI:10.1182/blood.2023022097
      PMID: 38237140
    • Journal Article
      Non-pharmacological rehabilitation interventions for individuals with antiphospholipid syndrome: A scoping review.
      Harper AE, Chen YT, Tancer S, Rodgers KR, Crumb AD, Townsend WA, Knight JS, Murphy SL. Lupus, 2024 Feb; 33 (2): 101 - 110. DOI:10.1177/09612033231223336
      PMID: 38113856
    • Journal Article
      Calprotectin Impairs Platelet Survival in Patients With Primary Antiphospholipid Syndrome.
      Hoy CK, NaveenKumar SK, Navaz SA, Sugur K, Yalavarthi S, Sarosh C, Smith T, Kmetova K, Chong E, Peters NF, Rysenga CE, Norman GL, Figueroa-Parra G, Nelson D, Girard J, Ahmed AZ, Schaefer JK, Gudjonsson JE, Kahlenberg JM, Madison JA, Knight JS, Crowson CS, Duarte-García A, Zuo Y. Arthritis Rheumatol, 2024 Jun; 76 (6): 928 - 935. DOI:10.1002/art.42801
      PMID: 38225923
    • Journal Article
      Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID.
      Woodruff MC, Bonham KS, Anam FA, Walker TA, Faliti CE, Ishii Y, Kaminski CY, Ruunstrom MC, Cooper KR, Truong AD, Dixit AN, Han JE, Ramonell RP, Haddad NS, Rudolph ME, Yalavarthi S, Betin V, Natoli T, Navaz S, Jenks SA, Zuo Y, Knight JS, Khosroshahi A, Lee FE-H, Sanz I. Nat Commun, 2023 Jul 14; 14 (1): 4201 DOI:10.1038/s41467-023-40012-7
      PMID: 37452024
    • Journal Article
      Interaction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps.
      Kmeťová K, Lonina E, Yalavarthi S, Levine JS, Hoy CK, Sarosh C, Gockman K, Morris AE, Tambralli A, Madison JA, Zuo Y, Subang R, Rauch J, Knight JS. Clin Immunol, 2023 Oct; 255: 109714 DOI:10.1016/j.clim.2023.109714
      PMID: 37527733
    Featured News & Stories What I'm Reading in APS Research
    Research News
    What I'm reading in APS research | June 2024
    What I’m Reading in APS Research, written by Dr. Ajay Tambralli and Dr. Jason Knight, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of these publications. In this month’s edition, Dr. Knight highlights several abstracts presented at the annual EULAR Congress.