Carole Parent

headshot of Carole Parent
Raymond and Lynne Ruddon Legacy Professor of Cancer Biology and Pharmacology
Professor of Pharmacology
Professor of Cell and Developmental Biology
Medical School and Research Professor
Life Sciences Institute
University of Michigan–Ann Arbor
Life Sciences Institute
210 Washtenaw Ave, Office 4437
Ann Arbor, MI 48109-2216
[email protected]
Available to mentor
Carole Parent
headshot of Carole Parent
Research Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • Manage Your Profile

  • About

    Dr. Carole A. Parent obtained B.Pharm. and M.Sc. degrees from the Université of Montréal and a Ph.D. degree from the University of Illinois at Chicago. After completing a postdoctoral fellowship in the laboratory of Dr. Peter N. Devreotes in the Department of Biological Chemistry of the Johns Hopkins University School of Medicine Dr. Parent joined the Laboratory of Cellular and Molecular Biology at the NCI in 2000, received tenure in 2006, was appointed Deputy Chief in 2010, and Deputy Director of the Center for Cancer Research at the NCI in 2016. After 17 years at the NCI, Dr. Parent moved to the University of Michigan in 2017 as the inaugural Raymond and Lynne Ruddon Collegiate Professor in Cancer Biology and Pharmacology. She is jointly appointed in the Department of Cell & Developmental Biology. Her laboratory is housed in the Life Sciences Institute of the University of Michigan, where she is a Research Professor. Dr. Parent is a Fellow of the American Society for Cell Biology and of the American Association for the Advancement of Science.

    Links

    • Parent Lab

    Qualifications

    • Instructor
      Johns Hopkins University School of Medicine, Baltimore, United States
      1996 - 2000
      Postdoctoral Research
    • Postdoctoral Fellow
      Johns Hopkins University School of Medicine, Biological Chemistry, Baltimore, United States
      1992 - 1996
      Postdoctoral Research
    • PhD
      Department of Pharmacodynamics, College of Pharmacy University of Illinois at Chicago, Chicago, IL, United States
      1988 - 1992
    • MS
      Department of Pharmacology, Faculty of Medicine Université de Montréal, Montréal, Québec, Canada
      1985 - 1987
    • BS
      Faculty of Pharmacy Université de Montréal, Montréal, Québec, Canada
      1981 - 1985

    Center Memberships

    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Rogel Cancer Center

    Research Overview

    Dr. Parent's research program focuses on identifying the mechanisms that mediate how neutrophils reach infection and injury as well as tumor sites. To do so, her group exploits complementary ex vivo and in vivo model systems, cutting-edge live imaging, and a transdisciplinary approach.

    Recent Publications

    See All Publications
    • Presentation
      Neutrophil Meeting 2026
      Parent C. 2026 Mar 12;
    • Presentation
      Neutrophils, Inflammation and Resolution
      Parent C. 2026 Mar 12;
    • Presentation
      Leukotriene B4 Signaling During Neutrophil Chemotaxis
      Parent C. 2026 Mar 12;
    • Presentation
      Plenary Session Featured Speaker
      Parent C. 2026 Mar 12;
    • Journal Article
      Keratin 16 inhibits type I interferon responses in differentiating keratinocytes of stressed and diseased skin.
      Cohen E, Xu Y, Ghodke S, Orosco A, Wang D, Johnson CN, Steen K, Sarkar MK, Özlü N, Tsoi LC, Gudjonsson JE, Marchal L, Hovnanian A, Parent CA, Coulombe PA. Sci Transl Med, 2026 Apr 8; 18 (844): eadx9123 DOI:10.1126/scitranslmed.adx9123
      PMID: 41950305
    • Preprint
      Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine
      Singhal R, Zhang NW, Lee ZH, Bell HN, Dalal PJ, Solanki S, Huang W, Rebernick R, Sajjakulnukit P, Jasewicz H, Kumar R, Kotla NK, Huber A, Mallappa AV, Arya SB, Takahashi S, Kasano-Camones CI, Carpenter E, di Magliano MP, Moon JJ, Parent CA, Gonzalez FJ, Patterson AD, Green MD, Zou W, Stoffel EM, Lyssiotis CA, Shah YM. 2026 Apr 8; bioRxiv, DOI:10.64898/2026.04.02.716169
    • Preprint
      Spatially Distinct Myosin II Architectures Regulate Protrusion Dynamics and Directional Persistence during Immune Cell Migration
      Melis N, Chen D, Chen E, Madsen T, Ng Y, Subramanian B, Wang W, Parent C, Losert W, Weigert R. 2026 Mar 20; bioRxiv, DOI:10.64898/2026.03.13.711384
    • Presentation
      Advancements in Cancer Research Symposium
      Parent C. 2026 Mar 13;

    Featured News & Stories

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    Department News

    New Publication from the Parent and Coulombe Labs

    New Publication from the Parent and Coulombe Labs, “TGFβ1-TNFα regulated secretion of neutrophil chemokines is independent of epithelial-mesenchymal transition in breast tumor cells,” has been published in MBoC!
    Department News

    New Publication led by Dr. Subhash Arya (Parent Lab) in close collaboration with the Coulombe and Mosalaganti Labs!

    Nature Cell Biology published "Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation." This work was a team effort led by Dr. Subha.sh Arya (Parent Lab), in close collaboration with the Coulombe and Mosalaganti Labs.
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    Department News

    New study reveals how shedding DNA allows pro-inflammatory immune cells to quiet inflammation

    The Life Sciences Institute News reported research from Carole Parent on how "the immune system’s first responders can reverse their own inflammatory response by shedding tiny pieces of their identity."
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    Health Lab

    Study reveals how shedding DNA allows pro-inflammatory immune cells to quiet inflammation

    The immune system’s first responders can reverse their own inflammatory response by shedding tiny pieces of their identity, according to a study.
    Department News

    New Podcast with Carole Parent!

    "Michigan Pioneer Fellows Program: Catalyzing Innovation and Independence," interview with Dr. Carole Parent and Dr. Alex Knights (a program alum) featured in The Wrap weekly podcast from Michigan Medicine Headlines.
    Department News

    New Publication from the Parent Lab

    "The ins-and-outs of exosome biogenesis, secretion, and internalization," has been published in Tends in Cell Biology.