Jun Wu, PhD

 Jun Wu, PhD
Jessica Schwartz Collegiate Professor of the Life Sciences
Research Associate Professor
Life Sciences Institute
Associate Professor of Internal Medicine and Associate Professor of Molecular and Integrative Physiology
Medical School
Ann Arbor, Michigan
[email protected]
Available to mentor
Jun Wu, PhD
Jun Wu, PhD
Research Associate Professor
  • About
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  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    Dr. Wu joined the Department of Molecular & Integrative Physiology in 2013. She is currently the Jessica Schwartz Collegiate Professor in the Life Sciences, a research associate professor of Life Sciences Institute (LSI), a member of the Cellular & Molecular Biology Program (CMB), Program in Biomedical Sciences (PIBS) and Center for Cell Plasticity and Organ Design.

    She received her Bachelor of Science in Biology from University of Science and Technology of China and then her Ph.D. in Biological Chemistry from the University of Michigan, respectively. After her Ph.D, Jun subsequently worked with Bruce Spiegelman at Dana-Farber Cancer Institute and Harvard Medical School as a postdoctoral fellow and instructor.

    Links
    • https://www.lsi.umich.edu/science/our-labs/wu-lab

    Qualifications
    • Research Fellow
      Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States
      2008 - 2011
    • PhD, Biological Chemistry
      University of Michigan, Ann Arbor, MI, United States
      2001 - 2007
    • BS
      University of Science & Technology of China, Hefei, China
      1996 - 2001

    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Frankel Institute for Heart and Brain Health
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center

    Research Overview

    Investigating a beige-selective immune-adipose interaction and studying a novel function of nicotinic acetylcholine receptors in energy metabolism (R01DK107583).

    Investigate the mechanistic details how the nonneuronal cholinergic signaling through CHRNA2 is activated, mediated and plays an adaptive/protective role in the context of alcoholic liver disease (ALD) (R01AA028761).

    Recent Publications

     See All Publications
    • Journal Article
      Immune cell cholinergic signaling in adipose thermoregulation and immunometabolism
      Ma Y, Jun H, Wu J. Trends in Immunology, 2023 Jun 2; 43 (9): 718 - 727. DOI:10.1016/j.it.2022.07.006
    • Journal Article
      CHRNA2: a new paradigm in beige thermoregulation and metabolism
      Ma Y, Liu S, Jun H, Wu J. Trends in Cell Biology, 2023 Jun 2; 32 (6): 479 - 489. DOI:10.1016/j.tcb.2021.11.009
    • Journal Article
      Acetylcholine-synthesizing macrophages in subcutaneous fat are regulated by β2-adrenergic signaling
      Knights AJ, Liu S, Ma Y, Nudell VS, Perkey E, Sorensen MJ, Kennedy RT, Maillard I, Ye L, Jun H, Wu J. EMBO Journal, 2021 Dec 15; 40 (24): DOI:10.15252/embj.2020106061
      PMID: 34459015
    • Journal Article
      Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation
      Jun H, Ma Y, Chen Y, Gong J, Liu S, Wang J, Knights AJ, Qiao X, Emont MP, Xu XZS, Kajimura S, Wu J. Developmental Cell, 2020 Jul 6; 54 (1): 106 - 116.e5. DOI:10.1016/j.devcel.2020.05.017
      PMID: 32533922
    • Journal Article
      An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling
      Jun H, Yu H, Gong J, Jiang J, Qiao X, Perkey E, Kim DI, Emont MP, Zestos AG, Cho JS, Liu J, Kennedy RT, Maillard I, Xu XZS, Wu J. Nature Medicine, 2018 Jun 1; 24 (6): 814 - 822. DOI:10.1038/s41591-018-0032-8
      PMID: 29785025
    • Journal Article
      Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming
      Jiang J, Emont MP, Jun H, Qiao X, Liao J, Kim DI, Wu J. Metabolism Clinical and Experimental, 2017 Dec 1; 77: 58 - 64. DOI:10.1016/j.metabol.2017.08.006
      PMID: 29046261
    • Journal Article
      Using a 3D culture system to differentiate visceral adipocytes in vitro
      Emont MP, Yu H, Jun H, Hong X, Maganti N, Stegemann JP, Wu J. Endocrinology, 2015 Dec 1; 156 (12): 4761 - 4768. DOI:10.1210/en.2015-1567
      PMID: 26425808
    • Journal Article
      Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
      Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, Van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM. Cell, 2012 Jul 20; 150 (2): 366 - 376. DOI:10.1016/j.cell.2012.05.016
      PMID: 22796012