Michael Mathis, MD
Anesthesiology
1500 E Medical Center Drive
Ann Arbor, MI 48109
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About
Michael Mathis, MD is an Associate Professor of Anesthesiology in the Division of Adult Cardiac Anesthesia at the University of Michigan. After completing his undergraduate degree in Biomedical Engineering at Duke University in 2006, Dr. Mathis received his MD from University of Michigan in 2010 and completed his residency in Anesthesiology and fellowship in Adult Cardiothoracic Anesthesiology at University of Michigan. He also completed an NIH T32 research fellowship sponsored by the Department of Anesthesiology at University of Michigan.
Dr. Mathis seeks to improve perioperative care of patients with advanced cardiovascular disease, through the use of data science techniques applied to real-world electronic health data. He serves as the Research Director for the Multicenter Perioperative Outcomes Group spanning US academic and community hospitals, amassing data electronic anesthesiology records for research and quality improvement.
Links
Multicenter Perioperative Outcomes Group
Qualifications
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MDUniversity of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, United States
2006 - 2010
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BSEDuke University, Durham, NC, United States
2002 - 2006
Center Memberships
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Center MemberAI and Digital Health Innovation
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberInstitute for Healthcare Policy and Innovation
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center Membere-Health and Artificial Intelligence Initiative
Research Overview
Dr. Mathis has research interests in improving perioperative care for patients with advanced cardiovascular disease, particularly for patients with heart failure. As part of the Multicenter Perioperative Outcomes Group (MPOG), an international consortium of perioperative databases for which U-M serves as the coordinating center, he serves as Research Director and plays a lead role in integration of MPOG data with data from national cardiac and thoracic surgery registries. He also has interests in leveraging novel data science methods to understand patterns within highly granular intraoperative physiologic data, studying hemodynamic responses to surgical and anesthetic stimuli as a means for early detection of cardiovascular diseases such as heart failure.
Dr. Mathis is an Affiliated Faculty within the Center of Computational Medicine and Bioinformatics (CCMB), member of the Michigan Integrated Center for Health Analytics & Medical Prediction (MiCHAMP) and member of the Institute for Health Policy and Innovation (IHPI). He has received research funding from the NIH, Department of Defense, and the BCBS Foundation of Michigan.
Recent Publications
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Mathis M. 2026 Jul 1;PresentationUsing Machine Learning for Clinical and Health Applications
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El-Khatib M, HajAli T, Zeeni C, Khalili A, Shreim R, Mathis MR, Nafeh NA, Aouad M, Multicentre Perioperative Outcomes Group (MPOG) Perioperative Clinical Research Committee . J Anesth Analg Crit Care, 2026 Jun 2;Journal ArticleIntraoperative mechanical power and postoperative pulmonary complications: association and threshold analysis in adult intra-abdominal surgery.
DOI:10.1186/s44158-026-00423-6 PMID: 42231507 -
Mathis M. 2026 Jul 1;PresentationThe Multicenter Perioperative Outcomes Group Learning Health System
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Cao J, Balczewski E, Ladhania R, Dhillon P, Likosky DS, Janda AM, MPOG Collaborators , Kheterpal S, Mathis MR, Singh K. NPJ Digit Med, 2026 Apr 24;Journal ArticleExploring the limits of localization: federated model stacking improves hospital-level prediction in a national research network.
DOI:10.1038/s41746-026-02634-1 PMID: 42032114 -
Steck DT, Silliman WL, Li R, O'Reilly-Shah VN, Mathis M, Domino K, Togashi K, Jelacic S. J Clin Anesth, 2026 Mar 4; 111: 112157Journal ArticleIncidence of phosphate abnormalities after cardiac surgery and their association with lactic acidosis: A cohort study from the Multicenter Perioperative Outcomes Group.
DOI:10.1016/j.jclinane.2026.112157 PMID: 41785615 -
Mathis M. 2026 Mar 3;PresentationArtificial Intelligence in Perioperative Care: Barriers and Breakthroughs
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Engoren M, Mathis MR, Douville NJ. Anesth Analg, 2026 Feb 12;Journal ArticleInvestigation of Prolonged Mechanical Ventilation Mediating the Association Between Mechanical Power and Mortality After Cardiac Surgery.
DOI:10.1213/ANE.0000000000007945 PMID: 41698180 -
Bardia A, Lin H-M, Zhao X, Michel G, Wai M, Fisher C, Shuster KM, Colquhoun DA, Mathis MR, McGee M, Kheterpal S, Mhyre J, Schonberger RB. JAMA Netw Open, 2026 Feb 2; 9 (2): e2559349Journal ArticleGuideline Adherence of Perioperative Antibiotics and Surgical Site Infections in Noncardiac Surgery.
DOI:10.1001/jamanetworkopen.2025.59349 PMID: 41706452
Featured News & Stories
Michael Mathis, MD, named Kevin K. Tremper, PhD, MD, Research Professor