Michael Mathis, MD

Michael Mathis
Kevin K Tremper Ph.D.
M.D. Research Professor
Associate Professor of Anesthesiology and Program Director
Medical School
University of Michigan
Anesthesiology
1500 E Medical Center Drive
Ann Arbor, MI 48109
[email protected]
Available to mentor
Michael Mathis, MD
Michael Mathis
Associate Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Michael Mathis, MD is an Associate Professor of Anesthesiology in the Division of Adult Cardiac Anesthesia at the University of Michigan. After completing his undergraduate degree in Biomedical Engineering at Duke University in 2006, Dr. Mathis received his MD from University of Michigan in 2010 and completed his residency in Anesthesiology and fellowship in Adult Cardiothoracic Anesthesiology at University of Michigan. He also completed an NIH T32 research fellowship sponsored by the Department of Anesthesiology at University of Michigan.

    Dr. Mathis seeks to improve perioperative care of patients with advanced cardiovascular disease, through the use of data science techniques applied to real-world electronic health data. He serves as the Research Director for the Multicenter Perioperative Outcomes Group spanning US academic and community hospitals, amassing data electronic anesthesiology records for research and quality improvement.

    Links

    • Multicenter Perioperative Outcomes Group

    Qualifications

    • MD
      University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, United States
      2006 - 2010
    • BSE
      Duke University, Durham, NC, United States
      2002 - 2006

    Center Memberships

    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      AI and Digital Health Innovation
    • Center Member
      Institute for Healthcare Policy and Innovation
    • Center Member
      e-Health and Artificial Intelligence Initiative
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center

    Research Overview

    Dr. Mathis has research interests in improving perioperative care for patients with advanced cardiovascular disease, particularly for patients with heart failure. As part of the Multicenter Perioperative Outcomes Group (MPOG), an international consortium of perioperative databases for which U-M serves as the coordinating center, he serves as Research Director and plays a lead role in integration of MPOG data with data from national cardiac and thoracic surgery registries. He also has interests in leveraging novel data science methods to understand patterns within highly granular intraoperative physiologic data, studying hemodynamic responses to surgical and anesthetic stimuli as a means for early detection of cardiovascular diseases such as heart failure.

    Dr. Mathis is an Affiliated Faculty within the Center of Computational Medicine and Bioinformatics (CCMB), member of the Michigan Integrated Center for Health Analytics & Medical Prediction (MiCHAMP) and member of the Institute for Health Policy and Innovation (IHPI). He has received research funding from the NIH, Department of Defense, and the BCBS Foundation of Michigan.

    Recent Publications

    See All Publications
    • Journal Article
      Incidence of phosphate abnormalities after cardiac surgery and their association with lactic acidosis: A cohort study from the Multicenter Perioperative Outcomes Group.
      Steck DT, Silliman WL, Li R, O'Reilly-Shah VN, Mathis M, Domino K, Togashi K, Jelacic S. J Clin Anesth, 2026 Mar 4; 111: 112157 DOI:10.1016/j.jclinane.2026.112157
      PMID: 41785615
    • Presentation
      Artificial Intelligence in Perioperative Care: Barriers and Breakthroughs
      Mathis M. 2026 Mar 3;
    • Journal Article
      Investigation of Prolonged Mechanical Ventilation Mediating the Association Between Mechanical Power and Mortality After Cardiac Surgery.
      Engoren M, Mathis MR, Douville NJ. Anesth Analg, 2026 Feb 12; DOI:10.1213/ANE.0000000000007945
      PMID: 41698180
    • Journal Article
      Guideline Adherence of Perioperative Antibiotics and Surgical Site Infections in Noncardiac Surgery.
      Bardia A, Lin H-M, Zhao X, Michel G, Wai M, Fisher C, Shuster KM, Colquhoun DA, Mathis MR, McGee M, Kheterpal S, Mhyre J, Schonberger RB. JAMA Netw Open, 2026 Feb 2; 9 (2): e2559349 DOI:10.1001/jamanetworkopen.2025.59349
      PMID: 41706452
    • Journal Article
      Patient-, Clinician-, and Institution-level Variation in Intraoperative Antihypertensive Use: A Multicenter Observational Analysis
      Rolfzen ML, Colquhoun DA, Shah N, Ma S, Janda AM, Mentz GB, Liu S, Kheterpal S, Mathis MR, Collaborators M, Naik BI, Freundlich RE, Clark JD, Schonberger RB, Pace NL, Karamchandani K, Lou SS, Anders MG. Journal of Cardiothoracic and Vascular Anesthesia, 2026 Feb 23; DOI:10.1053/j.jvca.2026.02.031
    • Journal Article
      Titrating Without a Safety Net.
      Lee SE, Mathis M, Manojlovich M. Am J Nurs, 2026 Jan 1; 126 (1): 11 DOI:10.1097/AJN.0000000000000222
      PMID: 41437432
    • Journal Article
      Impact of surgical non-technical skills on clinical outcomes: systematic review.
      Norton J, Janda AM, Howie E, Pohl N, Abahuje E, Harrington SD, Popov V, Bauer TM, Borges P, Querejeta Roca G, Mathis MR, Strobel RJ, Airhart A, Pham N, Harari R, Awtry JA, Pagani FD, Dias RD, Likosky DS, Yule S, Video Assessment of CaRdiac Surgery QualITY (VARSITY) Surgery Group . Br J Surg, 2025 Dec 24; 113 (1): DOI:10.1093/bjs/znaf271
      PMID: PMC12746291
    • Journal Article
      Frequency and Management of Maternal Peripartum Cardiac Arrest: A Multicenter Retrospective Cohort Analysis.
      Furdyna MJ, Mootz AA, Venkatachalam S, Mathis MR, Klumpner TT, Fields KG, Heydarpour M, Mhyre JM, Bateman BT, Reale SC, Multicenter Perioperative Outcomes Group Collaborators . Anesthesiology, 2025 Dec 23; DOI:10.1097/ALN.0000000000005905
      PMID: 41432376

    Featured News & Stories

    Michael Mathis
    Department News

    Michael Mathis, MD, named Kevin K. Tremper, PhD, MD, Research Professor

    Michael Mathis, MD, has been appointed as the Kevin K. Tremper, PhD, MD, Research Professor within the University of Michigan Medical School Department of Anesthesiology.
    Michael Mathis
    Department News

    Michael Mathis, MD, awarded NIH grant to compare inotrope practice variation in cardiac surgery

    A new study led by Michael Mathis, MD, is setting out to better understand variation in inotrope decision-making and outcomes across hospitals, as well as the barriers and facilitators to inotrope practice change. Mathis recently received National Institutes of Health funding through the National Heart, Lung and Blood Institute to support this research.
    Department News

    Fourteen faculty promotions announced

    The University of Michigan Regents approved 14 Department of Anesthesiology faculty promotions during their May 2023 meeting. Promotions will go into effect September 1.
    Department News

    Department receives perioperative transesophageal echocardiography accreditation by IAC

    IAC accreditation is a “seal of approval” and indicator to patients of consistent quality care and a dedication to continuous improvement.