Michael Mathis, MD
Anesthesiology
1500 E Medical Center Drive
Ann Arbor, MI 48109
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About
Michael Mathis, MD is an Associate Professor of Anesthesiology in the Division of Adult Cardiac Anesthesia at the University of Michigan. After completing his undergraduate degree in Biomedical Engineering at Duke University in 2006, Dr. Mathis received his MD from University of Michigan in 2010 and completed his residency in Anesthesiology and fellowship in Adult Cardiothoracic Anesthesiology at University of Michigan. He also completed an NIH T32 research fellowship sponsored by the Department of Anesthesiology at University of Michigan.
Dr. Mathis seeks to improve perioperative care of patients with advanced cardiovascular disease, through the use of data science techniques applied to real-world electronic health data. He serves as the Research Director for the Multicenter Perioperative Outcomes Group spanning US academic and community hospitals, amassing data electronic anesthesiology records for research and quality improvement.
Links
Multicenter Perioperative Outcomes Group
Qualifications
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MDUniversity of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, United States
2006 - 2010
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BSEDuke University, Durham, NC, United States
2002 - 2006
Center Memberships
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberAI and Digital Health Innovation
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Center MemberInstitute for Healthcare Policy and Innovation
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Center Membere-Health and Artificial Intelligence Initiative
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Center MemberSamuel and Jean Frankel Cardiovascular Center
Research Overview
Dr. Mathis has research interests in improving perioperative care for patients with advanced cardiovascular disease, particularly for patients with heart failure. As part of the Multicenter Perioperative Outcomes Group (MPOG), an international consortium of perioperative databases for which U-M serves as the coordinating center, he serves as Research Director and plays a lead role in integration of MPOG data with data from national cardiac and thoracic surgery registries. He also has interests in leveraging novel data science methods to understand patterns within highly granular intraoperative physiologic data, studying hemodynamic responses to surgical and anesthetic stimuli as a means for early detection of cardiovascular diseases such as heart failure.
Dr. Mathis is an Affiliated Faculty within the Center of Computational Medicine and Bioinformatics (CCMB), member of the Michigan Integrated Center for Health Analytics & Medical Prediction (MiCHAMP) and member of the Institute for Health Policy and Innovation (IHPI). He has received research funding from the NIH, Department of Defense, and the BCBS Foundation of Michigan.
Recent Publications
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Steck DT, Silliman WL, Li R, O'Reilly-Shah VN, Mathis M, Domino K, Togashi K, Jelacic S. J Clin Anesth, 2026 Mar 4; 111: 112157Journal ArticleIncidence of phosphate abnormalities after cardiac surgery and their association with lactic acidosis: A cohort study from the Multicenter Perioperative Outcomes Group.
DOI:10.1016/j.jclinane.2026.112157 PMID: 41785615 -
Mathis M. 2026 Mar 3;PresentationArtificial Intelligence in Perioperative Care: Barriers and Breakthroughs
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Engoren M, Mathis MR, Douville NJ. Anesth Analg, 2026 Feb 12;Journal ArticleInvestigation of Prolonged Mechanical Ventilation Mediating the Association Between Mechanical Power and Mortality After Cardiac Surgery.
DOI:10.1213/ANE.0000000000007945 PMID: 41698180 -
Bardia A, Lin H-M, Zhao X, Michel G, Wai M, Fisher C, Shuster KM, Colquhoun DA, Mathis MR, McGee M, Kheterpal S, Mhyre J, Schonberger RB. JAMA Netw Open, 2026 Feb 2; 9 (2): e2559349Journal ArticleGuideline Adherence of Perioperative Antibiotics and Surgical Site Infections in Noncardiac Surgery.
DOI:10.1001/jamanetworkopen.2025.59349 PMID: 41706452 -
Rolfzen ML, Colquhoun DA, Shah N, Ma S, Janda AM, Mentz GB, Liu S, Kheterpal S, Mathis MR, Collaborators M, Naik BI, Freundlich RE, Clark JD, Schonberger RB, Pace NL, Karamchandani K, Lou SS, Anders MG. Journal of Cardiothoracic and Vascular Anesthesia, 2026 Feb 23;Journal ArticlePatient-, Clinician-, and Institution-level Variation in Intraoperative Antihypertensive Use: A Multicenter Observational Analysis
DOI:10.1053/j.jvca.2026.02.031 -
Lee SE, Mathis M, Manojlovich M. Am J Nurs, 2026 Jan 1; 126 (1): 11Journal ArticleTitrating Without a Safety Net.
DOI:10.1097/AJN.0000000000000222 PMID: 41437432 -
Norton J, Janda AM, Howie E, Pohl N, Abahuje E, Harrington SD, Popov V, Bauer TM, Borges P, Querejeta Roca G, Mathis MR, Strobel RJ, Airhart A, Pham N, Harari R, Awtry JA, Pagani FD, Dias RD, Likosky DS, Yule S, Video Assessment of CaRdiac Surgery QualITY (VARSITY) Surgery Group . Br J Surg, 2025 Dec 24; 113 (1):Journal ArticleImpact of surgical non-technical skills on clinical outcomes: systematic review.
DOI:10.1093/bjs/znaf271 PMID: PMC12746291 -
Furdyna MJ, Mootz AA, Venkatachalam S, Mathis MR, Klumpner TT, Fields KG, Heydarpour M, Mhyre JM, Bateman BT, Reale SC, Multicenter Perioperative Outcomes Group Collaborators . Anesthesiology, 2025 Dec 23;Journal ArticleFrequency and Management of Maternal Peripartum Cardiac Arrest: A Multicenter Retrospective Cohort Analysis.
DOI:10.1097/ALN.0000000000005905 PMID: 41432376
Featured News & Stories
Michael Mathis, MD, named Kevin K. Tremper, PhD, MD, Research Professor